The document discusses the lymphoid organs of the immune system. It describes the bone marrow and thymus as the primary lymphoid organs, where lymphocytes develop and mature. The bone marrow is the site of generation for all blood cells including B lymphocytes, and is where B cell maturation occurs. The thymus is the site of T cell maturation and selection. Secondary lymphoid organs include the lymph nodes, spleen, and mucosal-associated lymphoid tissues, which harbor mature lymphocytes.
the presentation tells you about hematopoiesis which is the process of formation of blood cells i.e. RBC’S, WBC’S and platelets is called as hematopoiesis and the sites where it occurs are known as hematopoietic tissues or organs.
the presentation tells you about hematopoiesis which is the process of formation of blood cells i.e. RBC’S, WBC’S and platelets is called as hematopoiesis and the sites where it occurs are known as hematopoietic tissues or organs.
This Power Point provides quality information about the cells and organs of the human immune system and how these cell and organs work and coordinate with other organ-system in the body.
Identify the organs of primary and secondary immune system- lymphoid organs, Know the functions of lymphoid organs, Understand the importance of lymphoid organs and Lymphatic circulatory system
Humoral immunity is defined as the immunity mediated by antibodies, which are secreted by B lymphocytes.
B lymphocytes secrete the antibodies into the blood and lymph
Immune system consists of two organs primary and secondary lymphoid organs.
1-Primary (Central) lymphoid organs.
2-Secondary (Peripheral) lymphoid organs.
1-Thymus Gland.
2-Bone Marrow.
They consist of ….
Spleen.
Lymph nodes.
Mucosa- associated lymphoid tissue.
The sites of immune cell birth and the locations where they mature are considered primary lymphatic organs.
Locations in the body where immune cells become activated, reside, or carry out their functions are called secondary lymphatic organs
This Power Point provides quality information about the cells and organs of the human immune system and how these cell and organs work and coordinate with other organ-system in the body.
Identify the organs of primary and secondary immune system- lymphoid organs, Know the functions of lymphoid organs, Understand the importance of lymphoid organs and Lymphatic circulatory system
Humoral immunity is defined as the immunity mediated by antibodies, which are secreted by B lymphocytes.
B lymphocytes secrete the antibodies into the blood and lymph
Immune system consists of two organs primary and secondary lymphoid organs.
1-Primary (Central) lymphoid organs.
2-Secondary (Peripheral) lymphoid organs.
1-Thymus Gland.
2-Bone Marrow.
They consist of ….
Spleen.
Lymph nodes.
Mucosa- associated lymphoid tissue.
The sites of immune cell birth and the locations where they mature are considered primary lymphatic organs.
Locations in the body where immune cells become activated, reside, or carry out their functions are called secondary lymphatic organs
This presentation gives you the detailed description of various cells & organs of immune systems that participates (particularly, in combination), make communication between themselves to regulate the whole immune system very precisely.
LYMPHOID ORGANS DEFINITION:The organs concerned with the production, maturation and proliferation of lymphocytes are called as lymphoid organs.Types of Lymphoid organsPrimary or central lymphoid organs
and
Secondary or peripheral lymphoid organs, Thymus, THYMUS-CORTEX,CORTICOMEDULLARY JUNCTION,Thymus- Medulla,Functions of Thymus,Thymectomy,Bone marrow (BM),FUNCTIONS OF BONE MARROW,BM functions as both primary and secondary lymphoid organs.
LYMPHOID ORGANS,DEFINITION-The organs concerned with the production, maturation and proliferation of lymphocytes are called as lymphoid organs.1°(central) lymphoid organs,thymus and bone marrow.
A number of morphologically and functionally diverse organs and tissue organs and tissue contribute to the development of immune responses .
These organs can be distinguished by function as the primary and secondary lymphoid organs .
Immunology is the study of the immune system and is a very important branch of the medical and biological sciences. The immune system protects us from infection through
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
2. ORGANS OF IMMUNE SYSTEM
Bone marrow
Thymus
Spleen
lymph node
Tonsils
Small intestine & appendix
aggregated lymphoid nodules
Lymphoid Organs
3. Lymphoid system:
1.Lymphoid organs are stationed throughout the body
2. They are concerned with the growth, development and
differeciation of lymphocytes.
3.There are structurally and functionally
diverse lymphoid organs and tissues
4.They are interconnected by the blood vessels and lymphatic
vessels through which lymphocytes circulate.
5.These organs are involved in specific as well as non-specific
immunity
CLASSIFICATION
Based upon the functional development of the lymphatic cells
the lymphoid organs are classified into 2 groups
1.PRIMARY LYMPHOID ORGANS / central/ generative organs
2. SECONDARY LYMPHOID ORGANS /perpheral
7. Bone marrow is the primary lymphoid organ .It is a
soft tissue within the cavity of bones .Bone marrow is
divisible into 2
1.vascular region 2, haemtopoietic region.
…..Vascular region is the circulatory system that supplies
nutrient and removes waste from actively growing blood
vessels.
Red marrow is actively involved in haemtopoiesis
Red marrow contains titipoent cells called stem cells. The
devlopment of blood cells from stem cells is called
Haematopoies.
Haematopoies is forms RBC,WBC- granulocytes,
lymphocytes, monocytes and platlets.
BONE MARROW
8.
9.
10. Majority of lymphid progenitors develop into B-
lyphocytes in the bone marrow.
Some of lymphoid progenitors migrate into the
thymus , where they develop into the
T-lypmhocytes.
During secondary immune response large number
of plasma cells are produced in the bone marrow.
They secrete large amount of abs. So bone marrow
is a source of ab synthesis.
The bone marrow is the site of generation of all
circulating blood cells in the adult including
lympocytes and is the site of B- cell maturation
11. Bone marrow
The bone marrow is the site of generation of all
circulating blood cells in the adult, including
immature lymphocytes, and is the site of B cell
maturation.
Functions of bone marrow
The site of generation of all immunocytes
The site of differentiation and maturation of
immunocytes
The site of immune response of B cell,
specifically in secondary immune response.
12. All the cells of the immune system are initially derived from
the bone marrow through a process called
hematopoiesis
BONE MARROW
In human bone marrow is the site for B- cell origin
It is the site for B-cell maturation
Immature B cells arise from lymphoid progenitors,
proliferate and differentiate within the bone marrow
The stromal cells in the bone marrow interact with B cells and
secrete cytokines and help in the maturation of b-cells .
In Birds – B-cell development in Bursa of Fabricus
In cattle and sheep –fetal stage- spleen
Later- small intestine
In Rabbit- gut associated tissue- appendix
Specific immune organs in birds
The site of differentiation and proliferation
of B cells in birds.
13. THYMUS:
Thymus is the site of T cell differentiation and maturation
It is a bilobed gland, Situated above heart in the thorax region
each lobe is encapsulated and it is divided into lobules
which are separated by strands of connective tissue –
called trabeculae
Each lobule contains – lymphocytes & each lobule organized into
2 compartments 1…Outer cortex 2.Inner medulla
Site of T cell
maturation.
Relative Size
Greatest in
Newborn
Absolute Size
Greatest at
Puberty
14.
15. The cortex contains mostly immature & proliferating thymocytes, Medulla is
sparly populated with thymocytes.
some of which mature and migrate to the medulla -
in medulla they learn to discriminate between self and non-self during fetal
development and for a short time after birth.
T cells leave the medulla to enter the peripheral blood circulation, through which
they are transported to the secondary lymphoid organs
About 95% of all T cells die in the thymus.
Besides lymphoid cells it is composed of
1.Epithelial cells (cortical and medullary)
2. Macrophages
3. Dendritic cells
4. Nurse cells
5. Hassall’s corpuscles
Lymphocytes in the thymus are called thymocytes
16.
17. Function of the thymus
Generate and select T- cells
Through clonal selection mechanism , thymus cause the death of
those T- cells that cannot recognize Ag- MHC- complexes and
those that react with self Ag- MHC & stop danger of causing autoimmune
diseases.
Thus about 95% of all T cells die in the thymus.
Role Of Thymus In Immune Function
Thymectomy.
Thymectomy is the surgical removal of thymus
Thymectomized mice show decrease
in circulating lymphocytes & absence of
cell mediated immunity
18. Digeorge’s syn.
A Mutation on the 22nd
Chromosome
Absence of thymus and so T- cell deficiency
Congenital birth defect in humans
Nude mice
Nude mice
Thymus fails to develop
Nude mouse is unable to produce T-cells,
and is, therefore, immunodeficient & increase
in infections
Mutation in the gene encoding a transcription
factor
19. Aging and thymic function
Thymus diminishes in size with age
Thymus attains maximum size at puberty
Then degenerates with decrease in both
cortical & medullary cells
An increase in total fat content
In infants the average wt. of thymus is 70g
In elders the average wt. is 3g
The age dependent involutions leaves an organ the reduced wt.
Evidence for the effect of age on the immune function
Thymus from 1day old mouse and 33 month was removed
and grafted to thymectomized adult.
Thymus form 1day –old- mouse showed large improvement in immune function
than mice receiving the 33 month old thymus
20. One way system: to the heart
Return of collected excess tissue fluid
Return of leaked protein
“Lymph” is this fluid
Edema results if system blocked or
surgically removed
Lymph capillaries
Have one way minivalves
allowing excess fluid to enter
but not leave
Picks up bacteria and viruses
as well as proteins,
electrolytes
and fluid
(lymph nodes destroy
most pathogens)
21. Primary follicle
Unactivated lymphoid
follicle
Secondary follicle
Follicle that is activated
by antigen
Ring of B cells that
surround germinal center
Proliferating B cells and
T helper cells
22. Interstitial fluid (the portion that doesn’t enter
venous system) is returned to circulatory
system by lymphatic vessels
Largest lymphatic vessel – thoracic duct
○ Enters left subclavian vein
○ Lymph from right arm and right side of head enters
through right lymphatic duct, drains into right subclavian
Antigen is carried by lymph to lymph nodes