The lumbosacral plexus is formed by the ventral rami of lumbar and sacral spinal nerves and provides motor and sensory innervation to the pelvis, hips, thighs, legs and feet. It is comprised of the lumbar plexus, which forms in the psoas major muscle from L1-L4 nerves and the sacral plexus, which forms on the pelvic wall from L4-S4 nerves. Together they distribute nerves that innervate muscles and skin. Damage to the lumbosacral plexus results in neuropathic symptoms like pain, numbness and muscle weakness in the lower limbs.
The sciatic nerve is the longest and largest nerve in the human body. It runs from the lower back through the back of the leg, and down to the toes. Any type of pain and/or neurological symptoms that are felt along the sciatic nerve is referred to as sciatica.
The sciatic nerve is the longest and largest nerve in the human body. It runs from the lower back through the back of the leg, and down to the toes. Any type of pain and/or neurological symptoms that are felt along the sciatic nerve is referred to as sciatica.
The main root from L1 formed Ilioinguinal nerve, but it also form iliohypogastric nerve with contributions from the subcostal (T12) nerve
Illiohypogastric has cutaneous branch supply 2 areas : skin on the pubis and lateral of buttock, for motor supply it innervate transverse abdominis (increased intra-abdominal pressure and force diaphargm to force expiratory procces) and internal oblique muscle which primarily responsible for vertebrae collumn flexion
Branches/roots from L4-L5-S1 join and become superior gluteal nerve giving motor supply to abductor muscle of gluteus medius and gluteus minimus
Branches/roots from L5-S1-S2 join and form inferior gluteal nerve giving motor supply to gluteus maximus, this muscle has 2 function for extension and external rotation of the hip
The sciatic nerves branches from your lower back through your hips and buttocks and down each leg. Sciatica refers to pain that travels along the path of the sciatic nerve
Nerve roots: L4-S3.
Motor functions:
Innervates the muscles of the posterior thigh (biceps femoris, semimembranosus and semitendinosus) and the hamstring portion of the adductor magnus (remaining portion of which is supplied by the obturator nerve).
Indirectly innervates (via its terminal branches) all the muscles of the leg and foot.
Sensory functions: No direct sensory functions. Indirectly innervates (via its terminal branches) the skin of the lateral leg, heel, and both the dorsal and plantar surfaces of the foot.
The main root from L1 formed Ilioinguinal nerve, but it also form iliohypogastric nerve with contributions from the subcostal (T12) nerve
Illiohypogastric has cutaneous branch supply 2 areas : skin on the pubis and lateral of buttock, for motor supply it innervate transverse abdominis (increased intra-abdominal pressure and force diaphargm to force expiratory procces) and internal oblique muscle which primarily responsible for vertebrae collumn flexion
Branches/roots from L4-L5-S1 join and become superior gluteal nerve giving motor supply to abductor muscle of gluteus medius and gluteus minimus
Branches/roots from L5-S1-S2 join and form inferior gluteal nerve giving motor supply to gluteus maximus, this muscle has 2 function for extension and external rotation of the hip
The sciatic nerves branches from your lower back through your hips and buttocks and down each leg. Sciatica refers to pain that travels along the path of the sciatic nerve
Nerve roots: L4-S3.
Motor functions:
Innervates the muscles of the posterior thigh (biceps femoris, semimembranosus and semitendinosus) and the hamstring portion of the adductor magnus (remaining portion of which is supplied by the obturator nerve).
Indirectly innervates (via its terminal branches) all the muscles of the leg and foot.
Sensory functions: No direct sensory functions. Indirectly innervates (via its terminal branches) the skin of the lateral leg, heel, and both the dorsal and plantar surfaces of the foot.
BACK AND AUTONOMIC NERVOUS SYSTEM
EMBRYOLOGY
GROSS ANATOMY
PIA MATER, ARACHNOID, DURA MATER
ANATOMIC NERVOUS SYSTEM. SYMPATHETIC NERVOUS SYSTEM AND PARASYMPATHETIC NERVOUS SYSTEM.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
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These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
2. The Nervous System
The nervous system can be defined as the network of nerve cells and fibers
that sends messages for controlling movement and feeling between the
brain and the other parts of the body. This nervous system is divided into
two main parts, the central nervous system (CNS), which consists of the
brain and spinal cord , and the peripheral nervous system (PNS) , which
consists of 12 pairs of cranial nerves and 31 pairs of spinal nerves and their
associated ganglia.
Functionally, the nervous system can be further divided into the somatic
nervous system, which controls voluntary activities, and the autonomic
nervous system, which controls involuntary activities.
3. functions of the nervous system
The three basic functions of the nervous system:
Motor output: Respond via muscle or glandular action
Sensory input: Receive sensations from inside and outside the
body
Integration: Process and interpret sensations and make
decisions.
The nervous system, together with the endocrine system,
controls and integrates the activities of the different parts of
the body.
5. Nerve plexus
plexus /pleksəs/ noun a network of nerves, blood vessels or lymphatics.
A nerve plexus is a system of connected nerve fibers that link spinal nerves
with specific areas of the body. Fibers in a plexus connect the spinal cord and
the body by grouping themselves into one larger nerve. The human body
consists of several nerve plexuses, including the brachial plexus, the cervical
plexus, the coccygeal plexus, the lumbar plexus, the sacral plexus, and the
solar plexus.
A plexus is like an electrical junction box, which distributes wires to different
parts of a house. In a plexus, nerve fibers from different spinal nerves (which
connect the spinal cord to the rest of the body) are sorted. The fibers are
recombined so that all fibers going to a specific body part are put together
one nerve. Damage to nerves in the major plexuses causes problems in the
arms or legs that these nerves supply.
6. NERVE PLEXUS
ANATOMY
The nerve plexus is actually made up
of a multitude of nerve branches.
These branches come from the spinal
nerves, except for the thoracic spinal
nerves 2 through 12. The remaining
nerves donate their anterior rami,
which branch off from the spinal
nerves only to adjoin with each other
. A nerve plexus is composed of
afferent and efferent fibers that arise
from the merging of the anterior
rami of spinal nerves and blood
vessels.
7. NERVE PLEXUS STRUCTURE
Once they connect, they break off again and develop the network of
nerve fibers known as the nerve plexus. There are actually 4 of these
nerve plexuses in the human body, the brachial plexus, cervical plexus,
the sacral plexus and the lumbar plexus.
At the root of the limbs, the anterior rami join one another to form
complicated nerve plexus. The cervical and brachial plexuses are
found at the root of the upper limbs, and the lumbar and sacral
plexuses are found at the root of the lower limbs.
The nerves which come out of the various plexus are typically named
either for the specific area which they innervate or the basic course
which can be traced along the way.
8. The main function of a nerve plexus
The main function of a nerve plexus is to ensure that all areas of the
body are innervated, thereby equipping each region with the ability
to send and receive messages from the peripheral nervous system.
The different plexuses are charged with innervating different portions
of the body and help to control the functions unique to each portion.
A nerve plexus is formed during development, when disparate
muscles of the skeleton fuse together and result in large muscles
requiring innervation . The nerves that arise from the plexuses have
both sensory and motor functions. These functions include muscle
contraction, the maintenance of body coordination and control, and
the reaction to sensations such as heat, cold, pain and pressure.
10. 1. Spinal plexus
At each vertebral level, paired spinal
nerves leave the spinal cord via
the intervertebral foramina of the
vertebral column.
There are five spinal nerve plexuses
11. Lumbar plexus
Lumbar Plexus—Serves the Back,
Abdomen, Groin, Thighs, Knees,
and Calves
The lumbar plexus is formed by
the ventral rami of L1–L5 spinal
nerves with a contribution of T12
form the lumbar plexus. This
plexus lies within the psoas major
muscle.
lumbar plexus one formed by the
ventral branches of the second to
fifth lumbar nerves in the psoas
major muscle (the branches of the
first lumbar nerve often are
included).
13. Branches of the Lumbar Plexus and their
Distribution
Iliohypogastric nerve : External oblique, internal oblique, transversus abdominis muscles of
anterior abdominal wall skin over lower anterior abdominal wall and buttock.
Ilioinguinal nerve : External oblique, internal oblique, transversus abdominis muscles of
anterior abdominal wall ; skin of upper medial aspect of thigh; root of penis and scrotum in
the male; mons pubis and labia majora in the female.
Lateral cutaneous nerve of the thigh: Skin of anterior and lateral surfaces of the thigh.
Genitofemoral nerve (L1, 2): Cremaster muscle in scrotum in male; skin over anterior
surface of thigh; nervous pathway for cremasteric reflex.T A B L E 5 . 1
14. Branches of the Lumbar Plexus and their
Distribution
Femoral nerve (L2, 3, 4): Iliacus, pectineus, sartorius, quadriceps femoris
muscles, and intermediate cutaneous branches to the skin of the anterior
surface of the thigh and by saphenous branch to the skin of the medial side of
the leg and foot; articular branches to hip and knee joints
Obturator nerve (L2, 3, 4): Gracilis, adductor brevis, adductor longus, obturator
externus, pectineus, adductor magnus (adductor portion), and skin on medial
surface of thigh; articular branches to hip and knee joints
Segmental branches : Quadratus lumborum and psoas muscles
15. Lumbar stenosis
The term "stenosis" comes from the Greek word meaning "choking" and is often the
result of degenerative conditions such as osteoarthritis and/or degenerative
spondylolisthesis. When the spinal nerves in the lower back are choked, lumbar spinal
stenosis occurs and most often leads to leg pain and other symptoms.
Lumbar Spinal Stenosis Symptoms : The typical symptom is increased pain in the legs
with walking (pseudoclaudication), which can markedly diminish one's activity level.
Patients with lumbar spinal stenosis are typically comfortable at rest but cannot walk far
without developing leg pain. Pain relief is achieved, sometimes almost immediately, when
they sit down again.
The cause of spinal stenosis in the lumbar spine is commonly associated with aging. The
facet joints (small stabilizing joints located between and behind vertebrae) tend to get
larger as they degenerate and can compress the spinal nerve roots in the lower back,
often producing lumbar stenosis symptoms of pain, especially with activity.
16. sacral plexus
Sacral Plexus—Serves the Pelvis,
Buttocks, Genitals, Thighs, Calves,
and Feet
The sacral plexus is formed by the
ventral rami of L4-S3, with parts
of the L4 and S4 spinal nerves. It
is located on the posterior wall of
the pelvic cavity.
sacral plexus a plexus arising from
the ventral branches of the last
two lumbar and first four sacral
spinal nerves.
17. Gross Anatomy
The sacral plexus is formed
by the union of the
lumbosacral trunk (from the
anterior rami of L4 and L5)
and the anterior rami of the
first, second, third, and
fourth sacral nerves. The
anterior rami of the upper 4
sacral nerves enter the
pelvis through the anterior
sacral foramina; the
anterior rami of the fifth
sacral nerve enter between
the sacrum and coccyx. [1]
(See the following image.)
18. Gross Anatomy
The nerves forming the sacral plexus converge toward the lower part of the
greater sciatic foramen and unite to form a flattened band.The band continues
primarily as the sciatic nerve, which splits in the back of the thigh into the tibial
nerve and common fibular nerve. These 2 nerves sometimes arise separately from
the plexus, and in all cases their independence can be shown by dissection . The
anterior rami of the first and second sacral nerves are large; the third, fourth, and
fifth diminish progressively in size. Each receives a gray ramus communicans from
the corresponding ganglion of the sympathetic trunk. From the second, third, and
fourth sacral nerves, a pelvic splanchnic nerve is given to the inferior hypogastric
plexus. These are parasympathetic fibers that supply the hindgut and the pelvic
viscera.
19. Gross Anatomy
The sacral plexus lies in the back of the pelvis between the piriformis muscle and
the pelvis fascia. In front of it are the internal iliac artery, internal iliac vein, the
ureter, and the rectum. The superior gluteal artery and vein usually run between the
lumbosacral trunk and the first sacral nerve, and the inferior gluteal artery and vein
often runs between the second and third sacral nerves.All the nerve roots entering
the plexus split into anterior and posterior divisions, and the nerves arising from
these are as follows (see the image below):Nerve to quadratus femoris and
gemellus inferior: L4-S1Nerve to obturator internus and gemellus superior: L5-
S2Nerve to piriformis: S1, S2Superior gluteal nerve: L4-S1Inferior gluteal nerve: L5-
S2Posterior femoral cutaneous nerve: S1-S3Tibial nerve: L4-S3Common fibular
(peroneal): L4-S2
21. Natural Variants
Range of variation
The sacral plexus is liable to vary in its attachments, its nerves of
origin having a tendency to arise higher or lower. [2] Slight degrees
of variation can be shown by a difference in the size of the
contributing roots, so that a given trunk derives a larger share of its
fibers from an upper spinal nerve and a smaller share from a lower
spinal nerve, or vice versa. In the more marked degrees, the origin
may be shifted upward or downward to the extent of one spinal
nerve. Thus, 2 forms of sacral plexus variations exist, called high
(prefixed) and low (postfixed). In some instances, the extreme forms
are associated with irregularities of the vertebral column. The
lumbosacral plexus is frequently asymmetric from one side to the
other
22. Usual form of plexus
See the list below:
Nerve to quadratus femoris: L4, L5, S1
Nerve to obturator internus: L5, S1, S2
Tibial: L4, L5, S1, S2, S3
Superior gluteal: L4, L5, S1
Inferior gluteal: L5, S1, S2
Nerve to piriformis: S1, S2
Common fibular (peroneal): L4, L5, S1, S2
Posterior femoral cutaneous: S1, S2, S3
Pudendal: S2, S3, S4
23. High form of plexus
See the list below:
Nerve to quadratus femoris: L4, L5
Nerve to obturator internus: L4, L5, S1, S2
Tibial: L3, L4, L5, S1, S2
Superior gluteal: L4, L5, S1
Inferior gluteal: L4, L5, S1
Nerve to piriformis: L5, S1, S2
Common fibular (peroneal): L3, L4, L5, S1
Posterior femoral cutaneous: L5, S1, S2
Pudendal: S1, S2, S3
24. Low form of plexus
See the list below:
Nerve to quadratus femoris: L5, S1
Nerve to obturator internus: S1, S2, S3
Tibial: L5, S1, S2, S3, S4
Superior gluteal: L5, S1, S2
Inferior gluteal: L5, S1, S2
Nerve to piriformis: S1, S2, S3
Common fibular (peroneal): L5, S1, S2, S3
Posterior femoral cutaneous: S2, S3, S4
Pudendal: S2, S3, S4
25.
26. Lumbosacral plexus
Because the lumbar and sacral
plexuses are interconnected,
they are sometimes referred to
as the lumbosacral plexus. The
spinal nerves in the chest do
not join a plexus. They are the
intercostal nerves, which are
located between the ribs.
27. lumbosacral plexopathy
A lumbosacral plexopathy is a disorder affecting either the lumbar or sacral plexus of nerves. They
are rare syndromes, caused by damage to the nerve bundles.
A plexopathy is suspected if the symptoms cannot be localised to a single nerve. Patients may
complain of neuropathic pains, numbness or weakness and wasting of muscles.
One of the main causes of lumbosacral plexopathy is diabetic amyotrophy, also known
as lumbosacral radioplexus neurophagy. In this condition, the high blood sugar levels damage the
nerves. Idiopathic plexopathy is another cause, being the lumbosacral equivalent of Parsonage-
Turner syndrome (which affects the brachial plexus). Tumours and other local invasions can cause
the plexopathy due to the compression of the plexus.
Treatment depends on what is causing the symptoms. For tumours and space-occupying lesions,
they should be removed if possible. For diabetic and idiopathic causes, treatment with high-dose
corticosteroids can be useful.