This document discusses different types of herpetic viral retinitis, including acute retinal necrosis (ARN) syndrome, progressive outer retinal necrosis (PORN), cytomegalovirus (CMV) retinitis, and non-necrotizing herpetic retinopathies (NNHR). It provides details on the clinical characteristics, pathogenesis, diagnosis, and treatment of each condition. The conditions vary in symptoms, affected immune status of patients, lesion location and progression, and treatment approaches including antiviral medications and corticosteroids. Diagnosis involves analysis of clinical features along with PCR or antibody testing of ocular fluids.
Retinal vasculitis refers to the inflammation of the retinal vessel resulting in evident clinical manifestations i.e. vascular sheathing, leakage and occlusion. This presentation covers the etiology, pathogenesis, clinical features, diagnosis and management of this spectrum of retinal disease.
Retinal artery occlusion is an ophthalmic emergency which requires urgent management. Its a vision threatening condition which requires prompt diagnosis.
Branched Retinal Vein Occlusion (BRVO) for undergraduate MBBS Students.
Covers the basics of Aetiology, pathophysiology, clinical features, types, associated conditions and management of BRVO.
Also encompasses salient points for PGMEE
This seminar is for medical graduates..it describes inflammation of posterior part of uvea i.e choroid along with retina.it describes symptoms, signs and how to diagnose such patient and treatment.
Retinal vasculitis refers to the inflammation of the retinal vessel resulting in evident clinical manifestations i.e. vascular sheathing, leakage and occlusion. This presentation covers the etiology, pathogenesis, clinical features, diagnosis and management of this spectrum of retinal disease.
Retinal artery occlusion is an ophthalmic emergency which requires urgent management. Its a vision threatening condition which requires prompt diagnosis.
Branched Retinal Vein Occlusion (BRVO) for undergraduate MBBS Students.
Covers the basics of Aetiology, pathophysiology, clinical features, types, associated conditions and management of BRVO.
Also encompasses salient points for PGMEE
This seminar is for medical graduates..it describes inflammation of posterior part of uvea i.e choroid along with retina.it describes symptoms, signs and how to diagnose such patient and treatment.
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
2. ARN SYNDROME
• Acute primarily peripheral, necrotizing retinitis, retinal arteriolitis and mild to severe
vitritis.
• Usually unilateral
• Caused by – HSV, HZV, CMV
• Immunocompetent
Clinical characteritics –
• focal, well-demarcated areas of retinal necrosis located in the peripheral retina,
• rapid, circumferential progression of necrosis,
• evidence of occlusive vasculopathy
• prominent inflammatory reaction in the vitreous and anterior chamber.
3. Other features-
• Disc edema
• Granulomatous anterior uveitis with secondary glaucoma
• Exudative RD
• Rhegmatogenous RD
4. PROGRESSIVE OUTER RETINITAL NECROSIS
• Forster et al.
• Immunocompromised
• Minimal nongranulomatous anterior uveitis
• No vitritis
• Necrotizing retinitis
• Starting at the posterior pole and spreading toward the peripheral retina.
• Foci of lesions become rapidly confluent and involve the entire retina
• Unlike ARN syndrome, retinal vasculitis and optic neuritis are less common, but
retinitis is often bilateral.
• RD may occur
5. Extensive confluent retinal whitening,
retinal exudation, intraretinal
hemorrhage, consistent with infectious
retinitis such as progressive outer
retinal necrosis (PORN). • retinal vasculature is minimally involved, at leastinitially
• Perivascular clearing of the retinal opacification is characteristic of
PORN syndrome
6.
7. CYTOMEGALOVIRUS RETINITIS
• Immunocompromised- HIV patients
• CD4 lymphocytes 50-100/mm3
• passage of the virus across the blood retinal barrier, when local defense
mechanisms are almost completely abolished.
• Viral progression into the retina seems to occur in a polarized manner(inner to
outer)---
internal blood-retinal barrier is disrupted after primary replication in endothelial cells
viral particles to reach retinal glial cells.
CMV then spreads towards the retinal pigment epithelium
8. • Systematic fundus examination should be performed every 3 months if CD4
lymphocytes counts are below 50/mm3.
• Few cases - CMV retinitis – immunocompetent patients after intravitreal injection of
Triamcinolone or after Fluocinolone acetonide implant.
• White fluffy areas of necrotizing retinitis associated with hemorrhages and vascular
sheating.
• Early CMV retinitis may begin with a small, white retinal infiltrate.
• The lesion may masquerade as a cotton-wool spot present in HIV-related
microvasculopathy.
9. Two subtypes of CMV retinitis
Fulminant or Edematous variant
Dense, white confluent opacifications
of the retina without any central atrophic
lesion occur usually along vessels, associated
with retinal hemorrhages and inflammatory
vascular sheating.
Indolent or Granular variant of disease associates
granular foci of retinal necrosis with a central atrophic
zone, fewer hemorrhages and less vascular sheating.
Papillitis may occur. Border of retinal necrosis is usually
irregular in both variants, surrounded by satellite
infiltrates.
10. • Slow progression
• Destruction of the entire retina occurs within 3 to 6 months in the absence of
anti-CMV therapy.
• Cicatricial lesions –atrophic retina with vessel rarefaction
T/T
• Anti viral, ART
• maintainance anti-CMV therapy to be continued till CD4 increase
11. Non-necrotizing Herpetic Retinopathies
(NNHR)
• Molecular analysis applied to ocular fluids confirmed the presence of herpes virus
DNA in patients presenting with different forms of chronic and atypical posterior
uveitis, such as Behçet disease, retinal vasculitis and birdshot retinochoroidopathy .
• May be associated with hemmorhages
• Generally bilateral
• Pt is generally steroid resistant or steroid dependent at high dose.
FFA-papillitis, retinal vasculitis and cystoid
macular edema in a case of HHV-8-associated
nonnecrotic herpetic retinopathy
12. • Children-acute retinochoroiditis with diffuse hemorrhages
• Adults - chronic choroiditis or vasculitis
• PCR-based assays – herpes viral etiology in 13% of cases deemed
“idiopathic posterior uveitis
• Initially resistant to conventional therapy with systemic corticosteroids or (IMT),
but favorable response is achieved when patients are switched to systemic
antiviral medication
13. DIAGNOSIS
• The diagnosis of herpetic intraocular inflammation is initially based on the
analysis of clinical features.
• PCR of ocular fluids.
• Other method -intraocular antibody production against different herpes viruses-
ELISA
• Witmer Goldmann Coefficient.
• Diagnostic vitrectomy-(vitreous tap)
• Amount of ocular fluids is a limiting factor to perform diagnostic tests in patients
with a suspicion of viral intraocular inflammation.
14. ARN
• Bilateral disease / systematic involvement-systemic antiviral
• Unilateral –local intravitreal
• Maintanance therapy-continued lifelong / if CD4 >100 /cumm and undetectable viral
load in immunocompromised individual.
• In immunocompetent –mainatinance upto 1-3 months
16. • Lesions must be stabilized after a mean period of 48 hours.
• In resistant cases, more aggressive antiviral therapy should be initiated based on
intravenous foscarnet or ganciclovir.
• with intravitreal injections of ganciclovir effective in immunocompromised.(ADR
Macular infarction)
17. PROGRESSIVE OUTER RETINAL NECROSIS
• Aggressive antiviral therapy - intravenous foscarnet or ganciclovir and intravitreal
ganciclovir are the mainstay treatment.
• Corticosteroids must be avoided in the majority of cases
IMMUNE RECOVERY UVEITIS
• Systemic or periocular steroids under clinical control of HIV load and CD4 count
18. NNHR
• High dose steroids and conventional immunosuppressors fail to control ocular
inflammation.
• After viral confirmation, the use of intravenous acyclovir or oral valacyclovir
reduces inflammation and allow discontinuing immunosuppressors.
• However, low-dose oral prednisone is necessary in the majority of cases.
• Alpha interferon may be proposed in severe cases