This document summarizes Acute Zonal Occult Outer Retinopathy (AZOOR). It is characterized by photopsia, acute visual field loss, and minimal funduscopic changes. It typically affects young women and stabilizes within 4-6 months. Fellow eye involvement can occur. Imaging like FFA, ICGA, and OCT can reveal changes over time from RPE migration and atrophy. ERG shows receptor involvement depending on severity. Treatment is typically observation but antivirals and steroids may be used given the presumed viral etiology.
Heard of people being unable to see other people's faces if not fr failure of recognition of people's faces (prosapagnosia)...then they need to get their retina in particular macula checked! And a bunch of other macular disorders are enlisted nd elaborated in the presentation
Heard of people being unable to see other people's faces if not fr failure of recognition of people's faces (prosapagnosia)...then they need to get their retina in particular macula checked! And a bunch of other macular disorders are enlisted nd elaborated in the presentation
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
2. Acute Zonal Occult Outer Retinopathy (AZOOR)
• Young women
• Photopsia(fireworks, blinking lights, movement of microbes under a microscope,
the TV screen being off signal, flashes of light, heat waves coming off the road,
and other visual phenomenon-movement associated with all these
phenomenons)
• Acute onset visual field loss
• Minimal or no funduscopic changes
• Sometimes inflammation of vitreous –if large visual field is affected.
• Electroretinographic abnormalities affecting one or both eyes.
3. • Some patients - antecedent viral-like illness.
• The symptoms and the visual field loss generally stabilized within four to six
months and in a small percentage of cases improved.
• The fellow eye was involved soon after or even years later.
• A late recurrence in the same eye occurred occasionally.
4. A 26-year-old highly myopic male with sudden onset of large blind spot including the center and temporal field
with photopsia in OD of one day duration. Best corrected visual acuity 6/12 OD and 6/6 OS. Normal fundi OU
5. FFA and ICGA
• At early stage-usually normal when fundus is also normal
• If the receptor cell death occurs, pigmentary change at the level of the RPE
ensues
• RPE migration to the inner retina results in bone spicule appearance, akin to
retinitis pigmentosa late in the course of the disease.
• FFA done at this time would show-transmission defects corresponding to the area
of pigment epithelial changes
• ICGA- hypofluroscence corresponding to zone of RPE changes
6. Late fundus changes showing pigment epithelial migration
into the inner retina
7.
8. Fundus autofluorescence (FAF) image reveals normal autofluorescence in the area outside the demarcation line (zone 1), speckled
hyperautofluorescence within the AZOOR lesion (zone 2), and hypoautofluorescence corresponding to the development of choroidal
atrophy (zone 3)
ICGA outside the AZOOR lesion is normal (zone 1). Inside the AZOOR line, the subacute area shows minimal late extrachoroidal leakage
(zone 2). Hypocyanescence is observed together with the absence of leakage of the ICG molecule into the choroid corresponding to
choriocapillaris atrophy (zone 3)
SD-OCT is normal outside the AZOOR line (zone 1). Inside the AZOOR line, multifocal material is present in the subretinal space
resembling subretinal drusenoid deposits (zone 2). Photoreceptor, retinal pigment epithelium and choroidal atrophy is evident in the
more advanced or long-standing area of the lesion (zone 3).
9. ERG
• Depend on degree of receptor involvement
VISUAL FIELDS
• 90%-enlarged blind spot
10. PATHOGENESIS
• Viral or other infectious agent in the photoreceptors.
• Preclinical stage-cell to cell spread of the virus occurs with retention of normal
function of the photoreceptors.
• “Acute symptomatic phase”- the infected cell dysfunction is triggered by the host
immune response.
• 90% of eyes with AZOOR have visual field defects that include one or both blind
spots and the peripheral isopters, suggests that the ora serrata and optic disk
margin are possible sites for invasion of a virus into the receptor cells
• Few patients-many months or years later - delayed visual field loss may occur as a
result of resetting of the cells’ apoptotic clock during the initial acute phase of
AZOOR.
11. • Some patients-immune response results in early receptor cell death,
development of a variable degree of inflammation including vitreous cells,
perivascular exudation, and occasionally optic disc oedema.
• These inflammatory signs typically develop within several weeks following the
onset of AZOOR, appear to be proportional to the size of the affected retinal
zones, and probably result from an inflammatory response to the dead retinal
receptor cells.
12. • Weeks or months later, narrowing of the retinal vessels, particularly the retinal
arteries, perivascular sheathing and reactive changes in the RPE occur.
• The loss of interaction of the microvilli of the RPE with the photoreceptors causes
migration of the RPE into the inner retina to line up along the blood vessel wall
giving the typical bone-spicule appearance