The concept of mouth dissolving drug delivery systems (MDDDS) or fast dissolving tablets emerged with an objective to improve patient’s compliance. These dosage forms rapidly disintegrate and/or dissolve to release the drug as soon as they come in contact with saliva, thus obviating the need for water during administration, an attribute that makes them highly attractive for pediatric and geriatric patients.

1. FORMULATION AND
EVALUATION OF FAST
DISSOLVING TABLETS
By
Suryakant verma
Under the Supervision of
Dr. VIKESH KUMAR SHUKLA
Assistant Director
DEPARTMENT OF PHARMACEUTICS
IIMT COLLEGE OF MEDICAL SCIENCE
GANGA NAGAR, MAWANA ROAD, MEERUT,
UTTAR PRADESH, INDIA

2. Sr .no . Topic Slide no
1. INTRODUCTION 1
2. AIM AND OBJECTIVE 2
3. FORMULATION REVIEW 3-5
4. LITERATURE REVIEW 6-7
5. PLAN OF WORK 8-10
6. EXPECTED OUTCOMES 11
7. REFERENCE 12
Content

3. INTRODUCTION

4. The concept of mouth dissolving drug delivery
systems (MDDDS) or fast dissolving tablets emerged
with an objective to improve patient’s compliance.
These dosage forms rapidly disintegrate and/or
dissolve to release the drug as soon as they come in
contact with saliva, thus obviating the need for water
during administration, an attribute that makes them
highly attractive for pediatric and geriatric patients.
Difficulty in swallowing conventional tablets and
capsules is common among all age groups, especially in
elderly and dysphagic patients.

5. AIM AND OBJECTIVE

6. To improve patient’s compliance.
These dosage forms design to rapidly
disintegrate and/or dissolve to release the
drug as soon as they come in contact with
saliva, thus
Obviating the need for water during
administration,
An attribute that makes them highly
attractive for pediatric and geriatric
patients.

7. FORMULATION REVIEW

8. Techniques of MDT Formulation
The fast-dissolving property of the MDTs is attributed
to quick ingress of water into tablet matrix resulting
in rapid disintegration. Hence, the basic approaches to
develop MDTs include:
•Maximizing the porous structure of the tablet
matrix.
•Incorporating the appropriate disintegrating
agent/agents.
•Using highly water-soluble excipients in the
formulation.

9. PATENTED TECHNOLOGY TABLETS
Zydis
Quicksolv
Lyoc
Flashtab
Orasolv
Durasolv
Wowtab
Ziplets
Advatab
Flashdose
Oraquick

10. Various manufacturing techniques for MDDDS include:
1. Lyophilization
2. Moulding
3. Direct Compression
4. Cotton Candy Process
5. Spray Drying
6. Sublimation
7. Mass Extrusion
8. Nanonization
9. Fast Dissolving Films

11. LITERATURE REVIEW

12. •Panigrahi et al (2012) have formulated fast dissolving tablet of gliclazide for
rapid action by direct compression method and evaluated for post
compression parameter like hardness, disintegration time, weight variation,
friability, wetting time, water absorption ratio and mouth feel. The mouth feel
was done by taking human volunteers in a panel scale method. Different
formulation was prepared using the superdisintegrants in three individual
concentration i.e. (3%, 5%, and 10%). The result obtained showed that at 10%
concentration superdisintegrants showed less disintegration time and good
hardness. It was concluded that formulation containing crosspovidone at 10%
was selected to be the best formulation.
•Rizwanulla et al (2011) have prepared fast dissolving tablet by using direct
compression method and evaluated for hardness, friability, weight variation,
water absorption ratio, dissolution and assay. And concluded that among the
four groups (B) containing AC-Di-Sol emerged as the best formulation and
showed maximum dissolution rate.

13. •Kumar et al (2010) have developed oral fast dissolving tablets of
promethazine HCl by direct compression method using camphor as subliming
agent in three concentrations of 2%, 5%, & 10%. Sodium starch glycolate,
crosscarmellose and tulsion 414 are used as superdisintegrants in different
ratio (5%, 10%) and evaluated evaluated for weight variation, hardness,
friability, drug content, disintegration time, wetting time and in vitro
dissolution. The result revealed that tablets containing camphor had a good
dissolution profile.
•Ghorwade et al (2011) have prepared by solvent casting method using
HPMC as film base with different concentration of superdisintegrants like
microcrystalline cellulose and crospovidone using PEG400 as plasticizer and
concluded that the release of drug from the film has followed first order
kinetics. No change in the physical parameter in vitro disintegration time and
drug content of F2. The data demonstrated that 4% crospovidone and 10%
MCC with 4% HPMC as a film base was suitable for developing fast
dissolving film of montelukast sodium.

14. PLAN OF WORK

15. STAGE 1)
•REVIEW OF LITERATURE
•Survey
•Review of articles
•Review of old Resources
STAGE 2)
•PREFORMULATION STUDIES
•Solubility Profile of drug
•Melting Point of the drug
•Preparation of Standard Caliberation curve
•Drug Excipient Compatibility Studies

16. STAGE 3)
•FORMULATION AND OPTIMIZATION METHODS
•Zydis
•Quicksolv
•Lyoc
•Flashtab
•Orasolv
•Durasolv
•Wowtab
•Ziplets
•Advatab
•Flashdose
•Oraquick

17. STAGE 4)
•PHYSICAL PROPERTIES
•Weight variation test
•Surface ph determination
•Drug content uniformity
•Mechanical strength
•Particle size
•Solubility
STAGE 5) CHARACTERISATION
•Weight variation test
•Surface ph determination
•Drug content uniformity
•Friability
•Hardness test
•Water absorption test
•Porosity determination
•Effervescent test
•In-vitro and in-vivo disintegration test.
•In-vitro and in-vivo dissolution test.
•Acid neutralisation test

18. EXPECTED OUTCOMES

19. With continued innovations in pharmaceutical
excipients, one can expect the emergence of more novel
technologies for FDTs in the days to come.
These innovations may involve modifying
formulation composition and processing to achieve new
performance end-points or the merger of new
technological advances with traditional pharmaceutical
processing techniques for the production of novel
mouth dissolving dosage forms.
It is reasonable to expect that future trends in
innovations of drug delivery systems will continue to
bring together different technological disciplines to
create novel technologies.

20. REFERENCES

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