This document defines and discusses fast dissolving tablets (FDTs). FDTs disintegrate rapidly in the mouth without water. Their history dates back to the 1970s when scientists developed Zydis, an early FDT formulation. FDTs provide advantages like accurate dosing, easy administration for patients who can't swallow, and a faster onset of action compared to normal tablets. They are made through freeze drying or spray drying which creates a highly porous structure for rapid dissolution. While FDTs offer benefits, their use is limited by formulation challenges like bitter tasting drugs and large doses. The future of FDTs depends on overcoming these difficulties.

2. CONTENT
 DEFINITION
 HISTORY
 SIGNIFICANCE
 HOW IT IS MADE ( METHODOLOGY)
 FUTURE SCOPE
 WHAT DOCTOR’S SAY ?
 CONCLUSION
 REFERENCES

3. DEFINITION
 FAST DISSOLVING TABLETS (FDT) or
MOUTH DISSOLVING TABLETS(MDT) are
those which disintegrates or dissolves rapidly
without water within few seconds in mouth .

4. Mouth Dissolving Tablets are also
called as
 Orodispersible Tablets
 Fast Disintegrating Tablets
 Orally Disintegrating Tablet
 Fast Dissolving Tablets
 Rapid Dissolving Tablets
 Porous Tablets
 Quick/Rapid melt Tablets

5. HISTORY
 Orally disintegrating drug delivery systems
were originally devised by scientists at
Wyeth Laboratories in the UK during the 1970s
.
 Research lead to the outcome of Zydis, a
patented formulation technology.

6. Why use FDT ?
Clinical Formulation Marketing
• Faster onset
• Better results
• Bioequivalen
ce
• Convenience
• Stability
• Ease of use
• New
presentation
• Extend
exclusivity
• Broader
application

7. SIGNIFICANCE (
ADVANTAGES/DISADVANTAGES )
 ADVANTAGES :-
 Accurate dosing , easy manufacturing , small
packaging size & easy to handle.
 No need of water to swallow the tablet.
 No risk of choking or suffocation.
 Good mouth feel (Not a “Bitter Pill”)
 Ease for patients who refuse to swallow a
tablet. Such as mentally ill (PSYCHIATRIC),
disabled and uncooperative patients.

8. FDT VS NORMAL DRUG DELIVERY
RATE

9.  DISADVANTAGES :-
 The tablets usually have insufficient
mechanical strength. Hence, careful
handling is required.
 The tablets may leave unpleasant taste
and/or grittiness in mouth if not
formulated properly.
 Drugs with larger doses are difficult to
formulate into FDT.

10. METHODOLOGY
 Freeze drying or Lyophilization.
 Spray drying.

11. Freeze drying or Lyophilization
 Lyophilization means drying at low
temperature under condition that involves the
removal of water by sublimation.
 The tablets prepared by lyophilization
disintegrate rapidly in less than 5 seconds
due to quick penetration of saliva in pores
when placed in the oral cavity.
 Lyophilization is useful for heat sensitive
drugs i.e. thermo-labile substances.
 Example – Antacids

12. Spray drying
 Spray drying can produce highly porous and fine powders that
dissolve rapidly.
 It is based on support matrix, which is prepared to form a highly
porous powder, then mix with active Ingredients and compressed
into tablets.
Picture Reference – Google
Images

13. Scanning Electron Microscopy
Picture Reference – Zydis® Fast-Dissolve
Technologies

14. FUTURE SCOPE
Now there are various products available
commercially in market which is produced by
fast dissolving tablet technologies. Still there is
wide area for research on this technology.
 Some of the challenges like formulating a drug
of bitter taste and moisture absorbing nature
create problems for formulation scientist.
 When the dose of drug is large it causes
problem of increased disintegration time.

15. WHAT DOCTOR’S SAY ?
Although FDT’S are not quite successful in India,
still finding way to enter Indian Pharma. Market but
as soon as people start using them their result will
make patient to believe in allopathy medication , as
it shows result quickly and effectively .
Dr. VINAY KUMAR VERMA
M.B.B.S (U.S.A GOLD MEDALIST)
RAJARAM HOSPITAL

16. CONCLUSION
 Fast dissolving dosage forms have acquired
tremendous significance recently. Rapidly
dissolving films (FDF) have already gained
popularity in the form of breath freshener
products.
 These films are to be placed on patient’s
tongue where due to instant wetting by saliva, it
rapidly disintegrates and dissolves to release
the medicament.

17. REFERENCE
 International Journal of Pharmaceutical Science Invention
Fast Dissolving Dosage Forms by Avinash Kumar Gali ,
www.ijpsi.org Volume 2 Issue 11‖ November 2013 .
 International Journal of Pharmaceutical and Medicinal Research
Fast Dissolving Tablets – Future Aspects by Satvinder Singh.
 http://www.ijpmr.org/pdf/Fast-Dissolving-Tablets–Future-Aspects.pdf
 https://en.wikipedia.org/wiki/Spray_drying
 Research paper of Sublingual fast dissolving niosomal films for
enhanced bioavailability and prolonged effect of metoprolol tartrate
By - Allam A, Fetih G Published on - 2 August 2016 Volume 2016
https://www.dovepress.com/sublingual-fast-dissolving--niosomal-films-
for-enhanced-bioavailabilit-peer-reviewed-fulltext-article-DDDT
 Internet

18. QUESTIONS ?
Thank You For Listening ..!!