Drug dissolution ppt
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This document discusses fast dissolution disintegrating dosage forms (FDDFs). It begins with an introduction to FDDFs, noting they dissolve or disintegrate quickly without water. The needs and advantages of FDDFs are then outlined, including ease of administration for those who have trouble swallowing. Various formulation methods, ingredients, and patented technologies are described. Several example formulations are provided. Clinical studies on bioavailability and pregastric absorption are mentioned. Popular commercial FDDF products are listed before concluding FDDFs can improve compliance by dissolving rapidly in the mouth.
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mouth dissolving tablet
This document provides details on the development of a mouth dissolving tablet formulation of meloxicam. It begins with an introduction on the benefits of mouth dissolving tablets and ideal properties. The document then outlines the aim to develop a solid dispersion technique to enhance the solubility of meloxicam and prepare mouth dissolving tablets. The plan of work, materials, and methods are described for characterizing the drug and excipients, preparing the solid dispersions using a kneading method, and evaluating the tablets. The evaluation would include hardness, thickness, friability, disintegration time, wetting time, drug content, and in vitro dissolution testing. References are also provided.
Shashank Jain
The document discusses oral disintegrating tablets (ODTs), which are oral solid dosage forms that dissolve or disintegrate rapidly in the mouth without water. ODTs offer advantages over traditional tablets like improved patient compliance and bioavailability. Key attributes of ODTs include rapid disintegration (within 30 seconds), good taste masking, and the use of superdisintegrants, sugars, and other excipients to facilitate quick dissolution. Common technologies for producing ODTs involve freeze-drying, direct compression, spray drying, and mass extrusion. Preformulation studies and tests of disintegration time and dissolution profile are important for developing an effective ODT formulation.
Formulation and evaluation of fast dissolving tablet- by aryan and rajesh
This document provides an overview of a study to formulate and evaluate fast dissolving tablets of domperidone. It begins with an introduction that defines fast dissolving tablets and lists their requirements and advantages. It then outlines the objectives, plan of work, drug and excipient profiles, materials, and methodology for the study. The methodology section describes preformulation tests conducted on domperidone as well as evaluation tests that will be performed on the formulated tablets, including disintegration time, drug content, and in vitro drug release. The document provides background information needed to understand and carry out the research project on developing a fast dissolving tablet of domperidone.
Orally disintegrating tablets
Orally disintegrating tablets (ODTs) are solid dosage forms that disintegrate rapidly in the mouth. The first FDA-approved ODT was a Zydis formulation of Claritin in 1996. ODTs are suitable for patients who have difficulty swallowing pills like pediatric and geriatric patients. They have advantages like convenience of administration without water and faster onset of action. ODTs contain active ingredients, disintegrants, binders, flavors and other excipients. Common disintegrants include starches, crospovidone and celluloses. Formulation methods include freeze drying, moulding, sublimation and direct compression. Many drug classes have been formulated into ODTs for improved patient
mouth dissolving tablet by raja
The document provides an overview of mouth dissolving tablets (MDTs), including definitions, significance, requirements, formulation methodologies, patented technologies, and evaluation. MDTs are also called orally disintegrating tablets that dissolve rapidly in the mouth without water within a few seconds. They provide advantages over traditional tablets like ease of administration for those who have difficulty swallowing. Common formulation methods include freeze drying, molding, spray drying, mass extrusion, and compaction. Patented technologies like OraSolv use effervescent agents that release gas upon contact with water to aid rapid disintegration.
Review On Mouth Dissolving Tablet
This presentation include methods of formulation of MDT. Various preformulation studies conducted & IPQC test.
ODT project protocol-Reshma
1. Orally disintegrating tablets (ODTs) are solid dosage forms that disintegrate rapidly, usually within seconds, when placed on the tongue without the need for water.
2. ODTs are appropriate for patients who have difficulty swallowing tablets or capsules, such as elderly patients, children, and bedridden patients. They can improve medication compliance and therapeutic effects.
3. Key factors in developing ODTs include selecting drugs that have appropriate properties, using superdisintegrants and other excipients to enable rapid disintegration, and employing manufacturing techniques like direct compression that avoid moisture.
Final ppt mdt
The document discusses mouth dissolving tablets (MDTs). It defines MDTs as solid dosages that disintegrate rapidly within seconds when placed on the tongue without requiring water or chewing. The ideal properties of MDTs are described. The main ingredients used are superdisintegrants that aid rapid disintegration. Several approaches for manufacturing MDTs are outlined, including freeze drying, sublimation, and direct compression. The criteria for drug selection and various patented technologies are also summarized. The document concludes with an overview of preformulation studies, evaluation methods, and examples of marketed MDT products.
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mouth dissolving tablet
This document provides details on the development of a mouth dissolving tablet formulation of meloxicam. It begins with an introduction on the benefits of mouth dissolving tablets and ideal properties. The document then outlines the aim to develop a solid dispersion technique to enhance the solubility of meloxicam and prepare mouth dissolving tablets. The plan of work, materials, and methods are described for characterizing the drug and excipients, preparing the solid dispersions using a kneading method, and evaluating the tablets. The evaluation would include hardness, thickness, friability, disintegration time, wetting time, drug content, and in vitro dissolution testing. References are also provided.
Shashank Jain
The document discusses oral disintegrating tablets (ODTs), which are oral solid dosage forms that dissolve or disintegrate rapidly in the mouth without water. ODTs offer advantages over traditional tablets like improved patient compliance and bioavailability. Key attributes of ODTs include rapid disintegration (within 30 seconds), good taste masking, and the use of superdisintegrants, sugars, and other excipients to facilitate quick dissolution. Common technologies for producing ODTs involve freeze-drying, direct compression, spray drying, and mass extrusion. Preformulation studies and tests of disintegration time and dissolution profile are important for developing an effective ODT formulation.
Formulation and evaluation of fast dissolving tablet- by aryan and rajesh
This document provides an overview of a study to formulate and evaluate fast dissolving tablets of domperidone. It begins with an introduction that defines fast dissolving tablets and lists their requirements and advantages. It then outlines the objectives, plan of work, drug and excipient profiles, materials, and methodology for the study. The methodology section describes preformulation tests conducted on domperidone as well as evaluation tests that will be performed on the formulated tablets, including disintegration time, drug content, and in vitro drug release. The document provides background information needed to understand and carry out the research project on developing a fast dissolving tablet of domperidone.
Orally disintegrating tablets
Orally disintegrating tablets (ODTs) are solid dosage forms that disintegrate rapidly in the mouth. The first FDA-approved ODT was a Zydis formulation of Claritin in 1996. ODTs are suitable for patients who have difficulty swallowing pills like pediatric and geriatric patients. They have advantages like convenience of administration without water and faster onset of action. ODTs contain active ingredients, disintegrants, binders, flavors and other excipients. Common disintegrants include starches, crospovidone and celluloses. Formulation methods include freeze drying, moulding, sublimation and direct compression. Many drug classes have been formulated into ODTs for improved patient
mouth dissolving tablet by raja
The document provides an overview of mouth dissolving tablets (MDTs), including definitions, significance, requirements, formulation methodologies, patented technologies, and evaluation. MDTs are also called orally disintegrating tablets that dissolve rapidly in the mouth without water within a few seconds. They provide advantages over traditional tablets like ease of administration for those who have difficulty swallowing. Common formulation methods include freeze drying, molding, spray drying, mass extrusion, and compaction. Patented technologies like OraSolv use effervescent agents that release gas upon contact with water to aid rapid disintegration.
Review On Mouth Dissolving Tablet
This presentation include methods of formulation of MDT. Various preformulation studies conducted & IPQC test.
ODT project protocol-Reshma
1. Orally disintegrating tablets (ODTs) are solid dosage forms that disintegrate rapidly, usually within seconds, when placed on the tongue without the need for water.
2. ODTs are appropriate for patients who have difficulty swallowing tablets or capsules, such as elderly patients, children, and bedridden patients. They can improve medication compliance and therapeutic effects.
3. Key factors in developing ODTs include selecting drugs that have appropriate properties, using superdisintegrants and other excipients to enable rapid disintegration, and employing manufacturing techniques like direct compression that avoid moisture.
Final ppt mdt
The document discusses mouth dissolving tablets (MDTs). It defines MDTs as solid dosages that disintegrate rapidly within seconds when placed on the tongue without requiring water or chewing. The ideal properties of MDTs are described. The main ingredients used are superdisintegrants that aid rapid disintegration. Several approaches for manufacturing MDTs are outlined, including freeze drying, sublimation, and direct compression. The criteria for drug selection and various patented technologies are also summarized. The document concludes with an overview of preformulation studies, evaluation methods, and examples of marketed MDT products.
ORAL DISINTEGRATION / DISPERSIBLE TABLET
This document provides an overview of orally disintegrating tablets (ODTs), including:
1. The definition and ideal properties of ODTs according to regulatory agencies.
2. The large market potential and growth of ODTs globally, especially for drugs treating central nervous system and gastrointestinal conditions.
3. Important patented technologies for developing ODTs, such as Zydis® technology which uses a lyophilization process to create a porous structure for rapid disintegration.
4. Common excipients and formulation methods used in ODTs, including lyophilization, molding, and mass extrusion.
Mouth dissolving tablet seminar
MDT is fast dissolving tablet in mouth only ,give quick action ,with pleasant test mainly used in journey without use of water.
Orally disintegrating tablets 1
Orally disintegrating tablets (ODTs) are solid dosage forms that disintegrate rapidly in the mouth, allowing drugs to be administered without water. They are useful for patients who have difficulty swallowing. ODTs disintegrate within seconds when placed on the tongue due to the use of superdisintegrants and effervescent agents in their formulation. Common methods for manufacturing ODTs include lyophilization, tablet molding, sublimation, and direct compression. Ideal drug candidates for ODTs are those that are bitter tasting, have a low dose, and have good solubility and permeability. Taste masking methods and the use of excipients that provide rapid disintegration have enabled the development of many
SSDN SACHIN LPU GUIDE MR. NARENDRA PANDEY
This document provides an overview of mouth dissolving tablets (MDT), including promising drug candidates, popular disintegrants used, formulation techniques, marketed products, and evaluation methods. MDTs are designed to dissolve rapidly in the mouth within 3 minutes before swallowing for improved patient compliance. Common techniques for MDT formulation include lyophilization, moulding, direct compression, and sublimation. Evaluation of MDTs involves testing of granules, tablets, and dissolution properties. Future research aims to identify suitable drug candidates and excipients while improving dissolution times and patient acceptability.
Mouth dissolving tablets- A unique dosage form curtailed for special purpose:...
The concept of mouth dissolving tablets known as MDTs has emerged with an objective to improve patient’s compliance. Methods to improve patient’s compliance have always attracted scientists towards the development of fancy oral drug delivery systems. Among them, mouth dissolving drug delivery systems (MDDDS) have obtained an important position in the market by overcoming previously encountered administration problems and contributing to extension of patent life. These dosage forms rapidly disintegrate in contact with saliva even within <60 seconds, an attribute that makes them highly attractive for paediatric, geriatric, bedridden patients and for active patients who are busy and in travelling may not have access to water. This special dosage form has some prerequisite criteria for formulation and this also involves the use of special techniques for large scale industrial production. The aim of this article is to review the advantages and disadvantages of MDTs, common excipients used in the formulation especially highlighting the use of superdisintegrating agents and taste masking agents in formulation and finally the popular methods used to produce large scale tablets for commercial purpose.
Oral Dispersible Tablets - A Review
This document provides a review of oral dispersible tablets. It begins with an introduction that defines oral dispersible tablets as solid dosages that disintegrate rapidly, usually within seconds, when placed on the tongue. It describes the advantages of these tablets for patients who have difficulty swallowing conventional tablets. The document then reviews various technologies used to manufacture oral dispersible tablets, including lyophilization, molding, cotton candy process, and spray drying. It also discusses commonly used excipients and superdisintegrants and their mechanisms of action in rapidly disintegrating tablets.
Oral Dispersible Tablets
This document provides an overview of oral disintegrating tablets (ODTs), including their development, technologies used in their production, and evaluation methods. ODTs are solid dosage forms that disintegrate rapidly in the mouth, typically within 3 minutes, without water. They offer advantages over conventional tablets for patients who have difficulty swallowing. The document reviews various ODT production technologies such as freeze drying, spray drying, mass extrusion, and direct compression. It also discusses ideal properties, advantages, and limitations of ODTs.
Formulation and Evaluation of Ondansetron Oral Dispersible Tablet using Diffe...
Objective: The aim of this study was to develop a simple method for manufacturing oral dispersible tablets of ondansetron hydrochloride using direct compression method and to study the effect of different types and concentration of natural disintegrant (Isabgol mucilage, fenugreek mucilage and dehydrated banana powder) on the disintegrating characteristics of the tablets.
Method: Disintegrants extracted from Isabgol, fenugreek and banana powder were used in formulation of tablet using placket burman design in minitab. Then 13 different formulations (F1- F13) were prepared varying the concentration of selected natural disintegrant (Isabgol mucilage extract 6-15%). Formulated tablets were investigated for weight variation, hardness, thickness, disintegration, drug content, friability.
Result: The result obtained from disintegration study of tablets prepared using natural disintegrant obtained from isabgol mucilage indicates that the Isabgol with concentration 11.47% shows the disintegration time of 27 seconds.
Conclusion: Orodispersible tablet of ondansetron hydrochloride was found to be effective with natural disintegrant obtained from isabgol mucilage
Challenges in development of orally disintegrating and dispersible
The document discusses challenges in developing orally disintegrating and dispersible tablets (ODTs). It outlines several formulation and manufacturing challenges including ensuring palatability while taste-masking drugs, achieving adequate mechanical strength given the porous nature of ODTs, limiting the tablet size, and protecting against moisture. It also reviews various formulation techniques for ODTs such as tablet molding, direct compression, spray drying, and freeze drying/lyophilization.
Tablets
This document provides information about tablets, including their definition, advantages, disadvantages and types. It discusses the main components of tablets, including active ingredients and excipients. It describes different types of tablets based on their route of administration and production process. The purposes and examples of various excipients like diluents, binders, disintegrants, lubricants and coloring agents are outlined. Granulation is introduced as a process to prevent segregation and improve flow of powder mixtures that are then compressed into tablets.
Development and Characterisation of Fast Dissolving Oral Films
For My review article on Fast Dissolving Oral Films, click on this link http://www.ijupbs.com/Uploads/2.%20RPA13140283015.pdf or copy paste this link in browser.
Pardeep Kumar Jangra
Fast dissolving tablets
This document defines and discusses fast dissolving tablets (FDTs). FDTs disintegrate rapidly in the mouth without water. Their history dates back to the 1970s when scientists developed Zydis, an early FDT formulation. FDTs provide advantages like accurate dosing, easy administration for patients who can't swallow, and a faster onset of action compared to normal tablets. They are made through freeze drying or spray drying which creates a highly porous structure for rapid dissolution. While FDTs offer benefits, their use is limited by formulation challenges like bitter tasting drugs and large doses. The future of FDTs depends on overcoming these difficulties.
Orodispersible tablets
This document provides an overview of orodispersible tablets. It discusses their history, formulation strategies, evaluation parameters and benefits over conventional tablets. Orodispersible tablets are designed to dissolve rapidly in the mouth without water. They were developed to help patients like children, elderly and those with swallowing difficulties. The key ingredients are superdisintegrants which cause the tablet to break apart quickly. Evaluation tests include hardness, friability, wetting time and in vitro dissolution studies. Orodispersible tablets offer ease of administration, accurate dosing and enhanced bioavailability compared to other dosage forms.
2.review of litreature
The literature review summarizes research on developing fast-dissolving/disintegrating oral tablets using various superdisintegrants. Several studies found that combinations of superdisintegrants like crospovidone and sodium starch glycolate or croscarmellose sodium produced tablets with shorter disintegration times and higher drug dissolution rates compared to single superdisintegrants. Other studies concluded that natural superdisintegrants like banana powder were as effective as synthetic polymers. Tablet properties like hardness, porosity and taste could be optimized using sweeteners or different fillers and binders. Some research also explored producing orally disintegrating films for drugs like ondansetron.
Formulation and evaluation of
This document summarizes the formulation and evaluation of fast dissolving tablet dosages of felodipine. It discusses the drug profile, aim/objectives of developing fast dissolving tablets, materials/equipment used, preparation of formulations using different superdisintegrants (crospovidone, crosscarmellose sodium, sodium starch glycolate), and evaluation of tablet properties (thickness, hardness, friability) and performance (disintegration time, dissolution). 9 formulations were developed and evaluated, with F3 showing the fastest disintegration time of 116 seconds and highest drug release of 90.58% within 30 minutes. The study demonstrated the potential of using superdisintegrants to develop fast dissolving felodipine tablets for improved patient compliance and
Fast dissolving oral films
Fast dissolving oral films are thin oral strips that rapidly disintegrate in the mouth without water. They were developed in the 1970s as an alternative to tablets and capsules. The document discusses the key features of oral films including their thin elegant shape, excellent mucoadhesion, and ability to rapidly release drugs. It also covers general properties like thickness, formulation methods like solvent casting, and evaluation tests for properties like disintegration and mechanical strength. The advantages of oral films are convenient dosing without water and potential for taste masking and avoidance of first pass metabolism. However, they are easily fragile and require special packaging.
Direct Compressible Filler
Direct Compression is the simplest form of oral dosage production as it contains the fewest process stages, leading to a shorter process cycle and faster production times.
Challenges in development of orally disintegrating and dispersible tablets
The document discusses orally disintegrating tablets (ODTs), including definitions, advantages over conventional tablets, challenges in formulation, materials required, mechanisms of drug release, formulation techniques, marketed products, evaluation tests, and future developments. It provides details on the conventional methods used to produce ODTs such as tablet molding, direct compression, spray drying, and freeze drying. It also discusses patented technologies for producing ODTs.
3 solid dosage forms
Tablets are solid oral dosage forms produced by compressing powder mixtures into small discs or cylinders. They contain a single dose of an active ingredient along with excipients to aid tableting and drug release. Tablets offer accurate dosing, stability, low manufacturing costs and ease of administration compared to liquids. However, some drugs are not suitable for tablets due to poor solubility, instability to compression, or irritation of the GI tract. Tablets are classified based on drug release patterns and manufacturing methods.
Formulation Development and Evaluation of Oral Fast Dissolving Films of Metac...
Metaclopromide HCl is an Anti emetic used to treat nausea, vomiting and to increase gastric motility. The present work aimed at preparing oral fast dissolving films of Metaclopromide HCl with the purpose of developing a dosage form for a very quick onset of action, which is very convenient for administration, without the problem of swallowing and using water. Oral fast dissolving films of Metaclopromide HCl were prepared using HPMC E5, E15 polymers as film forming agents and polyethylene glycol 400 as plasticizer by solvent casting method. FTIR showed that there is no interaction between drug and excipients. Dissolution of prepared fast dissolving oral films of Metaclopromide HCl was performed using USP type II apparatus in pH 6.8 phosphate buffer medium at 50 rpm with temperature being maintained at 37 0.5º C. The films prepared were evaluated for various parameters like thickness, drug content uniformity, weight variation, disintegration time, folding endurance and in vitro drug release and were showed satisfactory results. In conclusion, development of oral fast dissolving oral films using HPMC polymer gives rapid drug delivery and rapid onset of action. Zeenath Ruhy "Formulation Development and Evaluation of Oral Fast Dissolving Films of Metaclopromide HCL" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-1 , December 2019, URL: https://www.ijtsrd.com/papers/ijtsrd29702.pdf Paper URL: https://www.ijtsrd.com/pharmacy/novel-drug-delivery-sys/29702/formulation-development-and-evaluation-of-oral-fast-dissolving-films-of-metaclopromide-hcl/zeenath-ruhy
drug dissolution
This document discusses drug dissolution, including definitions, theories, mechanisms, factors affecting dissolution, intrinsic dissolution rate, and in-vitro dissolution testing models. It defines dissolution as the mass transfer of a solid substance into a liquid solvent. The key theories discussed are the diffusion layer model, Danckwert's penetration model, and the interfacial barrier model. Factors affecting dissolution include properties of the drug, test conditions, and dosage form characteristics. Common in-vitro dissolution testing models described are non-sink and sink methods that utilize natural or forced convection with varying degrees of agitation.
Dissolution
Dissolution, factors affecting drug dissolution, methods to evaluate dissolution, advantages and disadvantages, recent approaches--these are the topics covered in this presentation.
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This document provides an overview of orally disintegrating tablets (ODTs), including:
1. The definition and ideal properties of ODTs according to regulatory agencies.
2. The large market potential and growth of ODTs globally, especially for drugs treating central nervous system and gastrointestinal conditions.
3. Important patented technologies for developing ODTs, such as Zydis® technology which uses a lyophilization process to create a porous structure for rapid disintegration.
4. Common excipients and formulation methods used in ODTs, including lyophilization, molding, and mass extrusion.
Mouth dissolving tablet seminar
MDT is fast dissolving tablet in mouth only ,give quick action ,with pleasant test mainly used in journey without use of water.
Orally disintegrating tablets 1
Orally disintegrating tablets (ODTs) are solid dosage forms that disintegrate rapidly in the mouth, allowing drugs to be administered without water. They are useful for patients who have difficulty swallowing. ODTs disintegrate within seconds when placed on the tongue due to the use of superdisintegrants and effervescent agents in their formulation. Common methods for manufacturing ODTs include lyophilization, tablet molding, sublimation, and direct compression. Ideal drug candidates for ODTs are those that are bitter tasting, have a low dose, and have good solubility and permeability. Taste masking methods and the use of excipients that provide rapid disintegration have enabled the development of many
SSDN SACHIN LPU GUIDE MR. NARENDRA PANDEY
This document provides an overview of mouth dissolving tablets (MDT), including promising drug candidates, popular disintegrants used, formulation techniques, marketed products, and evaluation methods. MDTs are designed to dissolve rapidly in the mouth within 3 minutes before swallowing for improved patient compliance. Common techniques for MDT formulation include lyophilization, moulding, direct compression, and sublimation. Evaluation of MDTs involves testing of granules, tablets, and dissolution properties. Future research aims to identify suitable drug candidates and excipients while improving dissolution times and patient acceptability.
Mouth dissolving tablets- A unique dosage form curtailed for special purpose:...
The concept of mouth dissolving tablets known as MDTs has emerged with an objective to improve patient’s compliance. Methods to improve patient’s compliance have always attracted scientists towards the development of fancy oral drug delivery systems. Among them, mouth dissolving drug delivery systems (MDDDS) have obtained an important position in the market by overcoming previously encountered administration problems and contributing to extension of patent life. These dosage forms rapidly disintegrate in contact with saliva even within <60 seconds, an attribute that makes them highly attractive for paediatric, geriatric, bedridden patients and for active patients who are busy and in travelling may not have access to water. This special dosage form has some prerequisite criteria for formulation and this also involves the use of special techniques for large scale industrial production. The aim of this article is to review the advantages and disadvantages of MDTs, common excipients used in the formulation especially highlighting the use of superdisintegrating agents and taste masking agents in formulation and finally the popular methods used to produce large scale tablets for commercial purpose.
Oral Dispersible Tablets - A Review
This document provides a review of oral dispersible tablets. It begins with an introduction that defines oral dispersible tablets as solid dosages that disintegrate rapidly, usually within seconds, when placed on the tongue. It describes the advantages of these tablets for patients who have difficulty swallowing conventional tablets. The document then reviews various technologies used to manufacture oral dispersible tablets, including lyophilization, molding, cotton candy process, and spray drying. It also discusses commonly used excipients and superdisintegrants and their mechanisms of action in rapidly disintegrating tablets.
Oral Dispersible Tablets
This document provides an overview of oral disintegrating tablets (ODTs), including their development, technologies used in their production, and evaluation methods. ODTs are solid dosage forms that disintegrate rapidly in the mouth, typically within 3 minutes, without water. They offer advantages over conventional tablets for patients who have difficulty swallowing. The document reviews various ODT production technologies such as freeze drying, spray drying, mass extrusion, and direct compression. It also discusses ideal properties, advantages, and limitations of ODTs.
Formulation and Evaluation of Ondansetron Oral Dispersible Tablet using Diffe...
Objective: The aim of this study was to develop a simple method for manufacturing oral dispersible tablets of ondansetron hydrochloride using direct compression method and to study the effect of different types and concentration of natural disintegrant (Isabgol mucilage, fenugreek mucilage and dehydrated banana powder) on the disintegrating characteristics of the tablets.
Method: Disintegrants extracted from Isabgol, fenugreek and banana powder were used in formulation of tablet using placket burman design in minitab. Then 13 different formulations (F1- F13) were prepared varying the concentration of selected natural disintegrant (Isabgol mucilage extract 6-15%). Formulated tablets were investigated for weight variation, hardness, thickness, disintegration, drug content, friability.
Result: The result obtained from disintegration study of tablets prepared using natural disintegrant obtained from isabgol mucilage indicates that the Isabgol with concentration 11.47% shows the disintegration time of 27 seconds.
Conclusion: Orodispersible tablet of ondansetron hydrochloride was found to be effective with natural disintegrant obtained from isabgol mucilage
Challenges in development of orally disintegrating and dispersible
The document discusses challenges in developing orally disintegrating and dispersible tablets (ODTs). It outlines several formulation and manufacturing challenges including ensuring palatability while taste-masking drugs, achieving adequate mechanical strength given the porous nature of ODTs, limiting the tablet size, and protecting against moisture. It also reviews various formulation techniques for ODTs such as tablet molding, direct compression, spray drying, and freeze drying/lyophilization.
Tablets
This document provides information about tablets, including their definition, advantages, disadvantages and types. It discusses the main components of tablets, including active ingredients and excipients. It describes different types of tablets based on their route of administration and production process. The purposes and examples of various excipients like diluents, binders, disintegrants, lubricants and coloring agents are outlined. Granulation is introduced as a process to prevent segregation and improve flow of powder mixtures that are then compressed into tablets.
Development and Characterisation of Fast Dissolving Oral Films
For My review article on Fast Dissolving Oral Films, click on this link http://www.ijupbs.com/Uploads/2.%20RPA13140283015.pdf or copy paste this link in browser.
Pardeep Kumar Jangra
Fast dissolving tablets
This document defines and discusses fast dissolving tablets (FDTs). FDTs disintegrate rapidly in the mouth without water. Their history dates back to the 1970s when scientists developed Zydis, an early FDT formulation. FDTs provide advantages like accurate dosing, easy administration for patients who can't swallow, and a faster onset of action compared to normal tablets. They are made through freeze drying or spray drying which creates a highly porous structure for rapid dissolution. While FDTs offer benefits, their use is limited by formulation challenges like bitter tasting drugs and large doses. The future of FDTs depends on overcoming these difficulties.
Orodispersible tablets
This document provides an overview of orodispersible tablets. It discusses their history, formulation strategies, evaluation parameters and benefits over conventional tablets. Orodispersible tablets are designed to dissolve rapidly in the mouth without water. They were developed to help patients like children, elderly and those with swallowing difficulties. The key ingredients are superdisintegrants which cause the tablet to break apart quickly. Evaluation tests include hardness, friability, wetting time and in vitro dissolution studies. Orodispersible tablets offer ease of administration, accurate dosing and enhanced bioavailability compared to other dosage forms.
2.review of litreature
The literature review summarizes research on developing fast-dissolving/disintegrating oral tablets using various superdisintegrants. Several studies found that combinations of superdisintegrants like crospovidone and sodium starch glycolate or croscarmellose sodium produced tablets with shorter disintegration times and higher drug dissolution rates compared to single superdisintegrants. Other studies concluded that natural superdisintegrants like banana powder were as effective as synthetic polymers. Tablet properties like hardness, porosity and taste could be optimized using sweeteners or different fillers and binders. Some research also explored producing orally disintegrating films for drugs like ondansetron.
Formulation and evaluation of
This document summarizes the formulation and evaluation of fast dissolving tablet dosages of felodipine. It discusses the drug profile, aim/objectives of developing fast dissolving tablets, materials/equipment used, preparation of formulations using different superdisintegrants (crospovidone, crosscarmellose sodium, sodium starch glycolate), and evaluation of tablet properties (thickness, hardness, friability) and performance (disintegration time, dissolution). 9 formulations were developed and evaluated, with F3 showing the fastest disintegration time of 116 seconds and highest drug release of 90.58% within 30 minutes. The study demonstrated the potential of using superdisintegrants to develop fast dissolving felodipine tablets for improved patient compliance and
Fast dissolving oral films
Fast dissolving oral films are thin oral strips that rapidly disintegrate in the mouth without water. They were developed in the 1970s as an alternative to tablets and capsules. The document discusses the key features of oral films including their thin elegant shape, excellent mucoadhesion, and ability to rapidly release drugs. It also covers general properties like thickness, formulation methods like solvent casting, and evaluation tests for properties like disintegration and mechanical strength. The advantages of oral films are convenient dosing without water and potential for taste masking and avoidance of first pass metabolism. However, they are easily fragile and require special packaging.
Direct Compressible Filler
Direct Compression is the simplest form of oral dosage production as it contains the fewest process stages, leading to a shorter process cycle and faster production times.
Challenges in development of orally disintegrating and dispersible tablets
The document discusses orally disintegrating tablets (ODTs), including definitions, advantages over conventional tablets, challenges in formulation, materials required, mechanisms of drug release, formulation techniques, marketed products, evaluation tests, and future developments. It provides details on the conventional methods used to produce ODTs such as tablet molding, direct compression, spray drying, and freeze drying. It also discusses patented technologies for producing ODTs.
3 solid dosage forms
Tablets are solid oral dosage forms produced by compressing powder mixtures into small discs or cylinders. They contain a single dose of an active ingredient along with excipients to aid tableting and drug release. Tablets offer accurate dosing, stability, low manufacturing costs and ease of administration compared to liquids. However, some drugs are not suitable for tablets due to poor solubility, instability to compression, or irritation of the GI tract. Tablets are classified based on drug release patterns and manufacturing methods.
Formulation Development and Evaluation of Oral Fast Dissolving Films of Metac...
Metaclopromide HCl is an Anti emetic used to treat nausea, vomiting and to increase gastric motility. The present work aimed at preparing oral fast dissolving films of Metaclopromide HCl with the purpose of developing a dosage form for a very quick onset of action, which is very convenient for administration, without the problem of swallowing and using water. Oral fast dissolving films of Metaclopromide HCl were prepared using HPMC E5, E15 polymers as film forming agents and polyethylene glycol 400 as plasticizer by solvent casting method. FTIR showed that there is no interaction between drug and excipients. Dissolution of prepared fast dissolving oral films of Metaclopromide HCl was performed using USP type II apparatus in pH 6.8 phosphate buffer medium at 50 rpm with temperature being maintained at 37 0.5º C. The films prepared were evaluated for various parameters like thickness, drug content uniformity, weight variation, disintegration time, folding endurance and in vitro drug release and were showed satisfactory results. In conclusion, development of oral fast dissolving oral films using HPMC polymer gives rapid drug delivery and rapid onset of action. Zeenath Ruhy "Formulation Development and Evaluation of Oral Fast Dissolving Films of Metaclopromide HCL" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-1 , December 2019, URL: https://www.ijtsrd.com/papers/ijtsrd29702.pdf Paper URL: https://www.ijtsrd.com/pharmacy/novel-drug-delivery-sys/29702/formulation-development-and-evaluation-of-oral-fast-dissolving-films-of-metaclopromide-hcl/zeenath-ruhy
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Mouth dissolving tablets- A unique dosage form curtailed for special purpose:...
Mouth dissolving tablets- A unique dosage form curtailed for special purpose:...
Formulation and Evaluation of Ondansetron Oral Dispersible Tablet using Diffe...
Formulation and Evaluation of Ondansetron Oral Dispersible Tablet using Diffe...
Challenges in development of orally disintegrating and dispersible
Challenges in development of orally disintegrating and dispersible
Development and Characterisation of Fast Dissolving Oral Films
Development and Characterisation of Fast Dissolving Oral Films
Challenges in development of orally disintegrating and dispersible tablets
Challenges in development of orally disintegrating and dispersible tablets
Formulation Development and Evaluation of Oral Fast Dissolving Films of Metac...
Formulation Development and Evaluation of Oral Fast Dissolving Films of Metac...
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drug dissolution
This document discusses drug dissolution, including definitions, theories, mechanisms, factors affecting dissolution, intrinsic dissolution rate, and in-vitro dissolution testing models. It defines dissolution as the mass transfer of a solid substance into a liquid solvent. The key theories discussed are the diffusion layer model, Danckwert's penetration model, and the interfacial barrier model. Factors affecting dissolution include properties of the drug, test conditions, and dosage form characteristics. Common in-vitro dissolution testing models described are non-sink and sink methods that utilize natural or forced convection with varying degrees of agitation.
Dissolution
Dissolution, factors affecting drug dissolution, methods to evaluate dissolution, advantages and disadvantages, recent approaches--these are the topics covered in this presentation.
Preparation by solubility enhancement of domperidone oro dispersible tablets ...
Preparation by solubility enhancement of domperidone oro dispersible tablets ...MAHENDRA PRATAP SWAIN
This document presents a proposal and plan for preparing oro-dispersible tablets (ODTs) of domperidone using solubility enhancement techniques. The key points are:
- Domperidone was selected as a model drug due to its low solubility. Solubility enhancement techniques like inclusion complexation with cyclodextrin and surfactant SDS will be used.
- Six formulations of domperidone ODTs will be prepared by direct compression method using different superdisintegrants like SSG, crospovidone, and croscarmellose.
- The prepared ODTs will be evaluated for properties like hardness, friability, disintegration time, wetting timeTheories of drug dissolution
Best slides ever of theories of drug dissolution, film teory, dankwerts model, interfacial model of dissolution, noyes whitneys equation, modified noyes whitney equation, sink condition, 1st order & zero order kinetics of drug dissolution, conclution, references
Bcs classification system
The Biopharmaceutics Classification System (BCS) classifies drug substances based on their aqueous solubility and intestinal permeability. The BCS defines four classes of drugs based on whether a drug is highly soluble/highly permeable (Class I), low solubility/high permeability (Class II), high solubility/low permeability (Class III), or low solubility/low permeability (Class IV). The classification system provides a scientific framework for predicting a drug's absorption based on its solubility and permeability characteristics. It is used to guide drug development and determine if in vitro dissolution testing can substitute for in vivo bioequivalence studies.
Bioavailability and bioequivalence – problems and pitfalls
PharmaCon2007 Congress, Dubrovnik, Croatia "New Technologies and Trends in Pharmacy, Pharmaceutical Industry and Education" http://www.pharmacon2007.com
Abstract is available at http://www.pharmaconnectme.com
M pharm dissolution
1. Dissolution is the process by which a solid substance dissolves in a solvent to form a solution. The rate of dissolution depends on factors like temperature, solvent composition, and the liquid/solid interface area.
2. There are several theories that describe the drug dissolution process, including the diffusion layer model, penetration or surface renewal theory, and interfacial barrier model. The most common model is the diffusion layer model, which involves the formation of a saturated film at the solid/liquid interface and diffusion of the drug through this layer.
3. Key factors that affect drug dissolution include the solubility and permeability of the drug substance, the pH and volume of the dissolution medium, and the design of
Theories of dissolution
The document discusses three main theories of drug dissolution:
1) Diffusion layer/film theory which describes dissolution as a two step process of drug dissolving from the solid to form a saturated film and then diffusing out of the film. The rate of dissolution is given by the Noyes-Whitney equation.
2) Danckwert's/surface renewal theory which accounts for eddies in the solution exposing new surface areas for dissolution. The rate is expressed as the product of the surface renewal rate and concentration gradient.
3) Interfacial barrier model which assumes the reaction at the solid surface is slower than diffusion, making interfacial transport the rate limiting step described by another equation.
Recent advances in tablet copy
1) Recent advances in tablet formulation include new techniques like 3D printing for layered tablets, melt granulation, and foam granulation.
2) New types of tablets have been developed like mouth dissolving tablets, microtablets, and fast-melting tablets using plastic granules.
3) Automation of tablet production equipment and new tablet printing machines that can print up to 750,000 tablets per hour with in-line verification have also been introduced.
Preformulation testing of solid dosage forms
The document discusses preformulation testing, which is the first step in developing solid dosage forms and involves investigating a drug's physical and chemical properties alone and with excipients to generate useful information for formulating stable and bioavailable dosage forms. It outlines various characterization tests and properties that should be evaluated including solubility, particle size, purity, and surface area to guide formulation development and ensure batch-to-batch consistency.
Evaluation of Controlled Drug Delivery Systems
This slide outlines the evaluation methods of various Controlled Drug Delivery Systems (CDDS) used in the pharmaceutical industry. The controlled Drug Delivery Systems release the drug to the plasma at a controlled, pre-determined level to ensure prolonged and adequate drug supply for a longer time. The slide analyses the various evaluation methods, its pharmacokinetic properties and applications of the evaluation methods in various scenario.
Sagar grdds final ppt pd
GRDDS(gastro retentive drug delivery systems) a novel approch for drug delivery..
sagar bansal
m.pharma.
Estimation of pharmacokinetic parameters
This document discusses key pharmacokinetic parameters that can be estimated including those related to absorption, distribution, and elimination of drugs in the body. It provides definitions and formulas for parameters such as bioavailability, absorption rate constant, volume of distribution, clearance, and half-life. Methods for measuring the area under the plasma concentration-time curve are also outlined. Factors that can influence bioavailability like pharmaceutical properties and physiological factors are briefly explained.
Ich guidelines
This document discusses guidelines for stability testing of pharmaceuticals according to the International Conference on Harmonization (ICH). It describes the ICH guidelines for stability testing, including stability protocols, reports, and studies. The key points covered include stability testing procedures, factors affecting drug stability, types of stability studies, and organizations that regulate stability guidelines such as the ICH.
bioavailability & bioequivalence
Bioavailability refers to the amount of drug that enters systemic circulation after administration. It is measured using pharmacokinetic methods like plasma concentration-time profiles and urinary excretion studies, or pharmacodynamic methods like measuring physiological responses. Key parameters include AUC, Cmax, Tmax, which provide information on extent and rate of absorption. Absolute bioavailability compares oral and intravenous dosing, while relative bioavailability compares different oral formulations. Multiple dose studies can assess steady-state characteristics. Bioavailability studies are important for drug development and quality control.
Pharmacology of absorption and bioavailability
Pharmacokinetics is the study of how drugs move through the body, including absorption, distribution, metabolism, and excretion. Absorption is the process by which drugs enter systemic circulation from the site of administration. Several factors influence a drug's absorption, including its physicochemical properties, dosage form characteristics, and patient factors. The document discusses various mechanisms of drug absorption like passive diffusion, facilitated diffusion, active transport, and endocytosis. It also covers concepts like pH partition theory, factors affecting dissolution, and the importance of a drug's ionization for absorption.
Applications of pharmacokinetics in new drug development,dosage form design &...
Applications of pharmacokinetics in new drug development,dosage form design &...Malla Reddy College of Pharmacy
The document discusses the applications of pharmacokinetics in new drug development, dosage form design, and novel drug delivery systems (NDDS). It covers key topics such as:
1) How pharmacokinetic principles can be applied to the design and development of new drugs, controlled release formulations, and the selection of appropriate routes of administration.
2) The important pharmacokinetic parameters used in characterization and the approaches used for dosage regimen design.
3) How pharmacokinetics can aid in formulation development, bioavailability/bioequivalence testing, and the development of various NDDS.
4) Considerations for dosing adjustments based on patient factors like obesity, age, hepatic or renal impairmentBiopharmaceutics lecture1
1. Biopharmaceutics is concerned with the relationship between a drug's physicochemical properties, its dosage form, and the resulting therapeutic response after administration.
2. Factors like a drug's properties, dosage form characteristics, administration route and site of absorption influence the time course of the drug in plasma and its bioavailability.
3. Drug absorption can be influenced by physiological factors like membrane permeability, as well as physicochemical drug properties and dosage form design features.
Dissolution and In Vitro In Vivo Correlation (IVIVC)
This presentation gives a bird's eye view on Dissolution in context with IVIVC. It discusses various levels of Correlations currently in practice. IVIVC are explained in light of biowaivers It also touches upon IVIVR, IVIVM etc.
Physicochemical Properties effect on Absorption of Drugs
This document discusses factors affecting drug absorption from oral dosage forms. It covers physiological factors like gastric emptying time and pH, as well as physicochemical drug properties including solubility, dissolution rate, and polymorphism that influence drug absorption. Particle size and surface area are emphasized, with smaller particles increasing absorption for hydrophilic drugs but potentially decreasing it for hydrophobic drugs. The pH partition hypothesis and importance of drug stability are also summarized.
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Preparation by solubility enhancement of domperidone oro dispersible tablets ...
Preparation by solubility enhancement of domperidone oro dispersible tablets ...
Bioavailability and bioequivalence – problems and pitfalls
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Applications of pharmacokinetics in new drug development,dosage form design &...
Applications of pharmacokinetics in new drug development,dosage form design &...
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Physicochemical Properties effect on Absorption of Drugs
Physicochemical Properties effect on Absorption of Drugs
Similar to Drug dissolution ppt
LORNOXICAM
This document discusses the development of fast dissolving tablets of lornoxicam using different techniques. It begins with introducing the need for fast dissolving drug delivery systems for patients who have difficulty swallowing traditional tablets. It then reviews various technologies that are used to produce fast dissolving tablets, including conventional methods like freeze drying as well as patented technologies. The document proposes to develop lornoxicam fast dissolving tablets using methods like direct compression, sublimation, solid dispersion, and an effervescent approach. It will evaluate the tablets for various properties and release studies and compare the results to determine the best formulation for lornoxicam fast dissolving tablets.
Oral thin film
This document discusses oral dissolving films (ODFs), which are thin films that dissolve quickly in the mouth. ODFs offer benefits like rapid onset of action, avoidance of first-pass metabolism, improved patient compliance, and ease of administration without water. The document reviews the process of ODF production, current products on the market, potential drugs that could be delivered via ODF, and a study developing a pantoprazole ODF using hydroxypropyl methylcellulose polymers. The study found that the lower viscosity HPMC LV polymer was more effective for rapid film disintegration and drug dissolution compared to the higher viscosity HPMC E 15 polymer.
Formulation and Evaluation of Amlodipine Fast Dissolving Tablets
Fast dissolving tablet is a new era for successful development of controlled release formulation along with various features to provide successful drug delivery. In the present study, an attempt was made to design and evaluate fast dissolving tablets of Amlodipine besylate, which is used commonly for the treatment of angina pectoris. The tablets were prepared by direct compression method followed by sublimation method using super disintegrants sodium starch glycolate, crosspovidone and croscarmellose sodium. The prepared powder blends were evaluated for preformulation parameters. The tablets were evaluated for thickness, hardness, weight variation, drug content uniformity, friability and in vitro drug release studies. In vitro drug release studies were performed by using USP type II apparatus paddle method at 50 rpm in 900 ml of 0.1N HCl as dissolution medium for 30 minutes at 37±0.5°C. The formulation F9 containing Croscarmellose sodium 7 showed better disintegration and dissolution up to 30 minutes. Hence, formulation F9 was considered as optimized formulation which showed the best drug release profile up to 30 minutes. The results of mathematical model fitting of data obtained indicated that, the best fit model in all the cases the release was found to be by diffusion and fickian release. The results of FTIR analysis showed that there was no physical and chemical interaction between drug and other excipients. The study indicates that the fast dissolving tablets of Amlodipine besylate can effectively reduce the adverse effects and frequency of administration of the drug. Aparna. P | Dr. Subash Chandran M. P | Remya S B "Formulation and Evaluation of Amlodipine Fast Dissolving Tablets" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-1 , December 2019, URL: https://www.ijtsrd.com/papers/ijtsrd29563.pdfPaper URL: https://www.ijtsrd.com/pharmacy/pharmaceutics/29563/formulation-and-evaluation-of-amlodipine-fast-dissolving-tablets/aparna-p
Formulation Development and Evaluation of Carbamazepine Fast Dissolving Tablets
Formulation Development and Evaluation of Carbamazepine Fast Dissolving TabletsDr. Raghavendra Kumar Gunda
Background: The main objective of present research work is to formulate the Carbamazepine Fast Dissoving tablets. Carbamazepine, an
antiepileptic, belongs to BCS Class-II and used to control some types of seizures in the treatment of epilepsy and Neuropathic Pain by
blocking use-dependent sodium channels. Methods: The Fast Dissoving tablets of Carbamazepine were prepared employing different
concentrations of Crospovidone and Croscarmellose sodium in different combinations as a Sperdisintegrants by Direct Compression technique
using 32
factorial design. The concentration of Crospovidone and Croscarmellose sodium was selected as independent variables, X1
and X2 respectively whereas, wetting time, Disintegration time, t
50% ,t90%were selected as dependent variables. Results and Discussion:
Totally nine formulations were designed and are evaluated for hardness, friability, thickness, Assay, Wetting time, Disintegration time, Invitro
drug release. From the Results concluded that all the formulation were found to be with in the Pharmacopoeial limits and the In-vitro
dissolution profiles of all formulations were fitted in to different Kinetic models, the statistical parameters like intercept (a), slope (b) &
regression coefficient (r) were calculated. Polynomial equations were developed for Wetting time, Disintegration time, t50%, t90%. Validity of
developed polynomial equations were verified by designing 2 check point formulations (C1
, C2
). According to SUPAC guidelines the
formulation (F5
) containing combination of 9.375% Crospovidone and 9.375% Croscarmellose, is the most similar formulation (similarity factor
f
2
=82.675, dissimilarity factor f1
= 2.049 & No significant difference, t= 0.041) to marketed product (TEGRETOL-100). Conclusion: The
selected formulation (F5
) follows First order, Higuchi’s kinetics, mechanism of drug release was found to be Non-Fickian Diffusion (n= 0.665).
KEYWORDS: Carbamazepine, 3
2Factorial Design, Crospovidone , croscarmellose Sodium, Wetting Time, Disintegration Time.International Journal of Pharmaceutical Science Invention (IJPSI)
International Journal of Pharmaceutical Science Invention (IJPSI) is an international journal intended for professionals and researchers in all fields of Pahrmaceutical Science. IJPSI publishes research articles and reviews within the whole field Pharmacy and Pharmaceutical Science, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online
Oral dipsersible film
Oral Dispersible Film is a Novel Drug Delivery System intended to bypass the hepatic first pass metabolism and also many other benefits over the conventional oral dosage forms. It provides the user to administer the drug without the use of water and without ant expertise in administration.
06_IJPBA_1946_21_20211221_V5.pdf
This document describes the formulation and in vitro evaluation of oral disintegrating tablets containing the drug mirtazapine using the sublimation method. Sodium starch glycolate and croscarmellose sodium were used as disintegrants. The results showed no chemical interaction between mirtazapine and the excipients used. Formulation F9, containing camphor at 30 mg, showed the fastest drug release of 99.13% within 20 minutes and was selected as the optimized formulation. The drug release from F9 followed first-order kinetics. Overall, an oral disintegrating tablet of mirtazapine was successfully developed using the sublimation method that showed rapid disintegration and drug release.
journal publication
The Indo-American Journal of Pharma and Bio Sciences is an online international journal that publishes articles quarterly.It's important to note that the specific policies, guidelines, and the editorial board of IAJPB may change over time, so it's advisable to visit the journal's official website or contact the journal of the journal publication.
06_IJPBA_1946_21_20211221_V5.pdf
This document summarizes the formulation and in vitro evaluation of oral disintegrating tablets containing the drug mirtazapine using the sublimation method. Key points:
1) Orally disintegrating tablets were formulated using sodium starch glycolate as a disintegrant via the sublimation method to produce a tablet that disintegrates rapidly in the mouth.
2) Drug-excipient compatibility studies showed no chemical interactions between mirtazapine and the excipients used.
3) Tablets were evaluated for properties like hardness, friability, drug content and in vitro drug release. The optimized formulation showed 99% drug release within 20 minutes and followed first-order release kinetics.
Film dosage form
Detailed about film dosage form from Introduction to Marketed regulation. Different types of Formulations and techniques were described very well.
fast disintegrating oral thin films
This document provides an overview of fast dissolving oral thin films (FDOTF). It begins with an introduction describing FDOTFs as thin polymeric strips that dissolve quickly in the mouth without water. The document then covers special features of FDOTFs, compares them to fast dissolving tablets, and describes their mechanism of action, classifications, properties, advantages, disadvantages, formulations, manufacturing methods, evaluation, and concludes with references.
Preparation and Evaluation of Immediate Release Tablets
Background Tablet is that the preferred among all dosage forms existing today thanks to its convenience of self administration, compactness and simple manufacturing however in many cases immediate onset of action is required than conventional therapy. There are novel kinds of dosage form.The scenario of pharmaceutical drug delivery are expeditiously challenging, but conventional pharmaceutical dosage forms are still dominating. Immediate release dosage forms are those wherein =85 of labeled amount dissolves within 30 min. Superd is integrants are accustomed improve the efficacy of solid dosage forms. orms that act very quickly after administration To overcome these drawbacks, immediate release pharmaceutical dosage form has emerged as alternative oral dosage forms. There are novel forms of dosage forms that act very quickly after administration. the fundamental approach utilized in development tablets is that the use of superdisintegrants like Cross linked carboxymelhylcellulose Croscarmeliose , Sodium starch glycolate Primogel, Explotab , Polyvinylpyrrolidone Polyplasdone etc. which give instantaneous disintegration of tablet after administration. Immediate release liquid dosage forms and parenteral dosage form have also been introduced for treating patients. Dosage form can be suspensions with typical dispersion agents like hydroxypropylmethylcellulose, dioctylsulfosuccinate etc. a replacement dosage form allows a manufacturer to increasemarket exclusivity, while offering its patient population a more convenient dosage form or dosing regimen.These superdisintegrants provide instantaneous disintegration of the tablet after administration within the stomach. This article provide an exhaustive account illustrating the significances of superdisintegrant within the immediate release of tablets and therefore the mechanism of disintegration together with various conventional techniques and novel granulation technology wont to prepare immediate release tablets. ach. Thus, decreasing the disintegration time which successively enhances drug dissolution rate. Results From this review, we can ready to develop and evaluate immediate release tablets.also we must always understand role of immediate release tablets.Conclusion Most of the patients need quick therapeutic action of the drug, leading to poor compliance with conventional drug therapy which results in reduced overall therapy effectiveness. For this we will conclude that immediate release tablets are simpler. because immediate release tablet shows quick effect. Sakshi Ghuge | Prof. Smita More "Preparation and Evaluation of Immediate Release Tablets" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-1 , December 2020, URL: https://www.ijtsrd.com/papers/ijtsrd35867.pdf Paper URL : https://www.ijtsrd.com/pharmacy/pharmaceutics/35867/preparation-and-evaluation-of-immediate-release-tablets/sakshi-ghuge
A Review on Fast Dissolving Oral Film
Recently, fast dissolving oral films have started gaining fame and acceptance as new drug delivery systems, which aim to enhance safety and efficacy of a drug molecule to achieve better patient compliance. It is a robust form a drug delivery system where the film is placed on the top or the floor of the tongue. When put on the tongue, this film dissolves instantaneously, releasing the drug which dissolves in the saliva. Buccal drug delivery has lately become an important route of drug administration. But many of the patients paediatrics and geriatrics are unwilling to take solid preparations due to fear of choking. This has made the pharmaceutical industry look for alternatives routes of drug delivery like film drug delivery. Fast dissolving oral drug delivery system have started gaining popularity and acceptance as new drug delivery system, because they are easy to administer, better patient compliance, rapid drug absorption, and sudden onset of drug action with instant bioavailability is possible. This review reflects information regarding formulation ingredient, technologies and evaluation test employed in the preparation of fast dissolving oral films. Mr. Vijay P. Ingle | Prof. Sharad D. Tayade | Dr. Shirish P. Jain "A Review on: Fast Dissolving Oral Film" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd43836.pdf Paper URL: https://www.ijtsrd.com/pharmacy/other/43836/a-review-on-fast-dissolving-oral-film/mr-vijay-p-ingle
FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLETS OF CARVEDILOL
ABSTRACT
The aim of the present research work was to enhance the solubility of
Carvedilol by solid dispersion method and to formulate a mouth
dissolving tablet. Drugs are more frequently taken by oral
administration. The solubility of Carvedilol enhanced with different
ratios of PVP by the solvent evaporation method .In-vitro release
profile of solid dispersion obtained in SGF without enzymes and Ph
6.8 phosphate buffer indicate that 100% drug release found within 20
min. These solid dispersion were directly compressed into tablets using
Crospovidone, sodium starch glycol ate, croscarmellose sodium and
polyacrylic potassium in different concentrations as a super
disintegrants. The prepared tablets containing the solid dispersion of
Carvedilol having sufficient strength of 2.5-4 kg/cm2. The
disintegrated in the oral cavity with in 21 sec. contain Crospovidone
(5%) as super disintegrant.
KEYWORDS: Carvedilol, PVP, Super Disintegrants, Mouth Dissolving Tablet.
Review on Formulation Approaches and Evaluation Parameters of Mouth Dissolvin...
Since the past decade, oral administration has received substantially more attention for the treatment or management of disorders. Mouth dissolving tablets MDTs , a novel idea in oral delivery, are now widely used. Mouth dissolving tablets are solid dosage forms that dissolve and release the active ingredient when placed in the mouth for a short period of time without the use of water. Geriatric, paediatric, and bedridden patients are particularly affected by it since they have swallowing issues, like those with dysphasia. This article discusses the various excipients evaluation tests, marketed formulations, and drugs used in his research area, along with the many formulation aspects and technologies developed for MDTs. The advancement in this field allows the development of an affordable and improved method of disease management with avoidance of numerous issues associated to the other delivery systems. Kamlesh R. Deshmane | Dr. V. U. Barge | Pratiksha B. Avhad "Review on Formulation Approaches and Evaluation Parameters of Mouth Dissolving Tablet" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-7 | Issue-2 , April 2023, URL: https://www.ijtsrd.com.com/papers/ijtsrd55178.pdf Paper URL: https://www.ijtsrd.com.com/pharmacy/pharmaceutics/55178/review-on-formulation-approaches-and-evaluation-parameters-of-mouth-dissolving-tablet/kamlesh-r-deshmane
Tablet
This document provides information about tablet formulations and manufacturing. It discusses the main components of tablets including active ingredients and excipients like diluents, binders, disintegrants and lubricants. It describes different types of tablets and coating methods. Tablet evaluation methods are outlined including tests for hardness, friability, drug content and dissolution. The advantages and disadvantages of tablet formulations are also summarized.
Development and Evaluation of High Loading oral dissolving film of aspirin an...
This document describes the development and evaluation of high loading oral dissolving films containing aspirin (81 mg) and acetaminophen (80 mg). Films were produced using a solvent casting method with hydroxypropyl cellulose, polyvinylpyrrolidone, and hydroxypropyl methylcellulose as polymers and glycerin and triacetin as plasticizers. The films were evaluated for mechanical properties, dissolution, and stability and showed faster dissolution than commercial tablets with comparable mechanical properties to other oral dissolving strips. The results suggest these high loading oral dissolving films are a stable and efficient dosage form for delivering aspirin and acetaminophen.
Oro dispersible films
The document discusses orodispersible films as a drug delivery system. It provides an introduction to orodispersible films, describes their advantages over other dosage forms like tablets, and discusses various aspects of formulation such as polymers, plasticizers, and drug loading. The document also summarizes evaluation methods for orodispersible films and provides examples of marketed products in this category. In conclusion, it states that orodispersible films are considered a promising drug delivery system, especially for pediatric and geriatric patients due to their ease of administration.
FORMULATION DEVELOPMENT AND EVALUATION OF CARVEDILOL PHOSPHATE GASTRO RETENTI...
FORMULATION DEVELOPMENT AND EVALUATION OF CARVEDILOL PHOSPHATE GASTRO RETENTI...Dr. Raghavendra Kumar Gunda
This document describes the development and evaluation of carvedilol phosphate gastroretentive floating tablets using a 32 factorial design. Carvedilol phosphate is a drug that belongs to BCS Class II and is indicated for hypertension and heart failure. Floating tablets were prepared using varying concentrations of guar gum and sodium bicarbonate as polymers to control the release of the water soluble drug. Nine formulations were designed and evaluated for properties like drug content, floating lag time, and in vitro drug release using kinetic models. The results showed that all formulations met pharmacopeial standards and formulation F8 containing 25% guar gum and 3.75% sodium bicarbonate best matched the marketed product with respect to drug release.Achieving high drug load with rapid dispersion using 3D printing technology
This document discusses Aprecia Pharmaceuticals' ZipDose technology, which is a 3D printed orally disintegrating tablet that can contain up to 1000mg of active pharmaceutical ingredient. It provides advantages over other fast-melting technologies by allowing higher drug loads while rapidly dispersing in the mouth. The first FDA-approved drug using this technology is SPRITAM, an anti-seizure medication. ZipDose tablets are designed to be porous through 3D printing which enables quick dissolution in liquid in the mouth within seconds, even at higher doses. This technology could help improve medication adherence by reducing the number of pills patients need to take.
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Drug dissolution ppt
- 1. FAST DISSOLUTION DISINTEGRATION DOSAGE FORM Submitted by –RAHUL KUL BHUSHAN Enroll No-2012/1333 B.Pharma 4thyear Submitted to- MANISH DEV INDORIYA ASSOCIATE PROF. (DEPT. OF Pharmaceutics)
- 2. INTRODUCTION OF FDDF NEEDS AND ADVANTAGES OF FDDF Classification of FDDF Ingredients to be used for FDDTs METHODS OF PREPARATION OF FDDT PATENTED TECHNOLOGIES Formulations of FDDF’s CLINICAL STUDIES COMMERCIAL PRODUCTS OF FDDT’S CONCLUSION
- 3. INTRODUCTION OF FDDF The most popular dosage form like Tablets, Capsules, and Solutions have an important prerequisite that drug should have an “Optimum solubility” to avoid bioavailability problems . The solid dosage forms that dissolve or disintegrate quickly in the oral cavity, resulting in solution or suspension without the need of administration of water are known as fast dissolving/disintegrating dosage forms (FDDFs).
- 4. NEEDS AND ADVANTAGES OF FDDF Needs of FDDF:- Infants, children and elderly people have difficulty in swallowing oral solid unit dosage e.g. Tablets and capsules . The current needs of the industry are improved solubility/stability, biological half-life and bioavailability enhancement of poorly absorbed drugs. Fast-dissolving/disintegrating tablet formulations are similar to many sustained release formulations that are now commonly available and these are most appropriate dosage forms with ease
- 5. Advantages of Mouth dissolving tablets:- Ease of administration for patients who are mentally ill, disabled and uncooperative. Requires no water Quick disintegration and dissolution of the dosage form. Overcomes unacceptable taste of the drugs. Can be designed to leave minimal or no residue in the mouth after administration and also to provide a pleasant mouth feel. Allows high drug loading.
- 6. Classification of FDDF :- 1. Fast dissolving/disintegrating tablets. ( FDT’s) 2. Fast dissolving wafers (FDW’S) 3. Fast dissolving films (FDF’S)
- 7. Ingredients to be used for FDDTs Important ingredients that are used in the formulation of FDDTs should allow quick release of the drug, resulting in faster dissolution. This includes both the actives and the excipients. Excipients balance the properties of the actives in FDDTs. This demands a thorough understanding of the chemistry of these excipients to prevent interaction with the actives. These inactive food-grade ingredients, when incorporated in the formulation, impart the desired organoleptic properties and product efficacy.
- 8. METHODS OF PREPARATION OF FDDT Direct compression method Spray Drying Tablet molding Freeze-drying Sublimation Sugar based excipients Taste Masking Three-dimensional printing technology
- 9. PATENTED TECHNOLOGIES A. Zydis Technology B. Durasolv Technology C. Orasolv Technology D. Flash Dose Technology E. Wowtab Technology F. Flashtab Technology G. Oraquick Technology H. Quick –Dis Technology
- 11. Formulations of FDDF’s Formulation 1 In this example, the pharmaceutical substance is chlorpheniramine maleate and the natural gum component is a mixture of guar gum and acacia gum. The formulation for the dosage form is as follows:
- 12. Formulation2 :- In this example, two batches, were prepared which differed only in the weight percents of mannitol and water, the mannitol being 12.5% w/w in the first and 15% w/w in the second. Each formulation produced wafers that were crisp and exhibited a good snap and good dissolution time, each dissolving in water at 37 .degree. C. in less than 10 seconds .
- 13. Formulation 3 :- In this example, in addition to chlorpheniramine, a second medication, phenylephrine, is added to the formulation. The wafers had good body (snap/crispness) and the disintegration time was less than 10 seconds in water at 37.degree. C.
- 14. CLINICAL STUDIES Various clinical studies for bioavailability, bioequivalence and pregastric absorption of drugs have been reported in the literature. Gamma scientigraphic studies in human volunteers to compare oesophageal clearance and and behaviour of freeze dried FDDFs clearly demonstrated no evidence of oesophageal adhesion (Wilson et al, 1987, 1988). Propyphenazone lyophilized tablets (FDDF) were more advantageous for analgesic antipyretic therapy when compared with tablets prepared by simple compression.
- 15. COMMERCIAL PRODUCTS OF FDDT’S
- 16. CONCLUSION Besides delivering drug to the body, a drug delivery system aim to improve patient compliance and convenience, and fast dissolving tablets are no exception. FDDFs dissolve or disintegrate very rapidly in the oral cavity in close proximity to the taste buds. Various technologies fast dissolving tablet technologies, taste masking, optimization by artificial neuron networks and fluidized bed technology, and microencapsulation advances the formulation development and processing technologies to design more patient friendly and sophisticated drug delivery systems
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