Flagyl is used to treat bacterial infections of the vagina, stomach, skin, joints, and respiratory tract. This medication will not treat a vaginal yeast infection.

1. Metronidazole Tablets
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Flagyl (Metronidazole Tablets) is used to treat
bacterial infections of the vagina, stomach, skin,
joints, and respiratory tract. This medicine will not
treat a vaginal yeast infection.

2. Flagyl Tablets
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Flagyl Tablets are manufactured by
Abbott India Limited
(Website: www.abbott.com)

3. Metronidazole Tablets – Brand Names
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Metronidazole tablets are available as
Flagyl, Nidagyl, Mepagyl, RTU, Metro
I.V., Protostat, Flagyl I.V. and Metryl.

4. Active Ingredient
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The active ingredient contained in Flagyl is
Metronidazole. Each Flagyl tablet contains
200 mg or 400 mg of Metronidazole USP.

5. Chemical Structure
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The structure of Metronidazole is given
below:

6. Uses of Metronidazole Tablets
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Flagyl (Metronidazole Tablets) is used in the
prevention of post-operative infections due to
anaerobic bacteria, particularly species of
Bacteroides and anaerobic streptococci.
This medicine is also used in the treatment
of septicaemia, bacteraemia, peritonitis,
brain abscess, necrotising pneumonia,
osteomyelitis, puerperal sepsis, pelvic
abscess, pelvic cellulitis, and post-operative
wound infections from which pathogenic
anaerobes have been isolated.

7. Uses of Metronidazole Tablets
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Other Flagyl indications include
Urogenital trichomoniasis in the female
(trichomonal vaginitis) and in the male.
Bacterial vaginosis (also known as
non-specific vaginitis, anaerobic
vaginosis or Gardnerella vaginitis), all
forms of amoebiasis (intestinal and
extraintestinal disease and that of
symptomless cyst passers); giardiasis
and acute ulcerative gingivitis.

8. Flagyl Dosage
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➢ Trichomoniasis:In Female Adult Patients:
One-day treatment - two grams of Flagyl, given
either as a single dose or in two divided doses
of one gram each, given in the same day.
➢Seven-day course of treatment - 250 mg
three times daily for seven consecutive days.
➢Pregnant patients should not be treated
during the first trimester.
Flagyl dosage should be individualized as per
the requirement of the individual patient.
The dosage of Flagyl tablets (Metronidazole
Tablets) for various indications is given below:

9. Flagyl Dosage
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➢Recommended Adults Dosage for Amebiasis: For
acute intestinal amebiasis (acute amebic dysentery):
750 mg of Metronidazole orally three times daily for 5
to 10 days.
➢For amebic liver abscess: 500 mg or 750 mg orally
three times daily for 5 to 10 days.
➢Pediatric patients: 35 to 50 mg/kg/24 hours, divided
into three doses, orally for 10 days.
➢Anaerobic Bacterial Infections: In the treatment of
most serious anaerobic infections, FLAGYL I.V.
(metronidazole hydrochloride) or FLAGYL I.V. RTU®
(metronidazole) is usually administered initially.
The dosage of Flagyl tablets (Metronidazole)
is given below:

10. Storage Instructions
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Flagyl (Metronidazole Tablets) have to
be stored at controlled room temperature
i.e. from 20°C to 25°C (68°F to 77°F) .
Keep this as well as all other medicines
away from children and pets.

11. Warnings
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Metronidazole has been shown to be
carcinogenic in mice and rats.
Unnecessary use of this medicine should
be avoided.
Cases of encephalopathy and peripheral
neuropathy (including optic neuropathy)
have been reported with Metronidazole.
Encephalopathy has been reported in
association with cerebellar toxicity
characterized by ataxia, dizziness, and
dysarthria.

12. Warnings
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Peripheral neuropathy, mainly of sensory
type has been reported and symptoms
include numbness or paresthesia of an
extremity.
Convulsive seizures have been reported
in patients treated with Metronidazole.
Cases of Aseptic Meningitis have been
reported with metronidazole.
Symptoms can occur within hours of
dose administration and generally
resolve after Metronidazole therapy is
discontinued.

13. Flagyl Tablets Contraindications
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Flagyl is contraindicated in patients with a
hypersensitivity to Metronidazole or any
other component of this medication.
In patients with trichomoniasis, Flagyl
Tablets are contraindicated during the first
trimester of pregnancy. Use of
Metronidazole tablets is associated with
psychotic reactions in alcoholic patients
who were using Disulfiram concurrently.
Patients who have taken Disulfiram within
the last two weeks should not be
administered Metronidazole tablets.

14. Flagyl Tablets
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Contraindications
Use of Metronidazole tablets is
associated with a Disulfiram-like
reaction to alcohol, including
abdominal cramps, nausea, vomiting,
headaches, and flushing.
Stop consumption of alcohol or
products containing Propylene Glycol
during and for at least three days after
therapy with Flagyl tablets.

15. Metronidazole Side Effects
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➢Common Metronidazole side effects with an
incidence rate 1% or more of those treated with the
medicine include nausea, diarrhea, weight loss,
abdominal pain, vomiting, headache, dizziness, and
metallic taste in the mouth.
➢Infrequent side effects include hypersensitivity
reactions (rash, itch, flushing, fever), headache,
dizziness, vomiting, glossitis, stomatitis, dark urine, and
paraesthesia.
➢High doses and long-term systemic treatment with
Metronidazole are associated with the development of
leucopenia, neutropenia, increased risk of peripheral
neuropathy, and central nervous system toxicity
➢Metronidazole has been associated with cancer in
animal studies.

16. Metronidazole Overdose
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Single oral doses of Metronidazole tablets,
up to 15 gm, have been reported in
suicide attempts and accidental overdoses.
Symptoms reported include nausea,
vomiting, and ataxia.
Metronidazole tablets has been studied as
a radiation sensitizer in the treatment of
malignant tumors.
Neurotoxic effects, including seizures and
peripheral neuropathy, have been reported
after 5 to 7 days of doses of 6 gm to 10.4 gm
every other day.

17. Flagyl Overdose
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There is no specific antidote for Flagyl
overdose. Therefore, treatment of the
patient should consist of symptomatic
and supportive therapy.

18. Metronidazole During Pregnancy
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Flagyl (Metronidazole Tablets) has been
classified by the US FDA as Pregnancy
Category B.
Animal reproduction studies have failed to
demonstrate a risk to the fetus and there
have been no adequate and well controlled
studies of Flagyl in pregnant women.
Use of Flagyl tablets (Metronidazole) for
treatment of trichomoniasis in pregnancy
should be carefully evaluated because
Metronidazole crosses the placental barrier
and its effects on the human fetal
organogenesis are not known.

19. Flagyl Tablets
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Flagyl Tablets click here
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Flagyl (Metronidazole Tablets) by
Abbott India Limited.