Hey guys, here is a comparison between the Tablet and Gel form of Metronidazole in regards to the marketing aspect of the drug. //KUDOS

1. Metronidazole

2. Metronidazole is an antimicrobial and antiprotozoal
medication. It is used either alone or with other
antibiotics to treat pelvic inflammatory diseases,
endocarditis and bacterial vaginosis.
Formula- C6H9N3O3 | ChemSpider
ATC Code- J01XD01
Common route of administration- Oral, Intravenous,
Topical.

3. Usage- Used most commonly to treat a certain type of vaginal infection
(bacterial vaginosis) in women who are not pregnant. Thus stopping
the growth of bacteria.
Brand names under which it is sold
Flagyl- delayed release
Flagyl ER- extended release

4. Side effects
• Appetite loss
• Headache
• Candidiasis (Yeast infection)
• Nausea
• Vomiting
Stevens – Johnson Syndrome :
Metronidazole alone rarely
causes stevens – Johnson
syndrome, but is reported to
occur at high rates when
combined with mebendazole.
Very rare Fewer than 20k US
cases per year

5. Mechanism of action
It acts by inhibiting nucleic acid synthesis by disrupting the DNA of
microbial cells. Though, this function only occurs when metronidazole
is partially reduced.
Contraindications
• Hypersensitivity to metronidazole or other nitroimidazoles(although
cautions desensitization has been applied)
• Pregnancy, 1st trimester.

6. Metrogyl
400mg tablet

7. BRAND NAME Metrogyl 400 Tablet
MANUFACTURER Lekar Pharma Ltd.
PRICE INR 10.46 (15 tablets 1 strip)
ROUTE OF ADMINISTRATION Oral
AMINISTRATION TDS
PRESCRIBED FOR Intestinal amoebiasis
SIDE EFFECTS Nausea, vomiting, diseases (gastric irritation)
OVERDOSE SYMPTOMS unsteadiness

8. Advantages Disadvantages
No specialist required to administer Already if nausea, vomiting in patient it might not
serve the purpose.
Can be taken at home(no hospitalisation required) Small dose limit, inconvenience for some patients.
Easiest route of administration Children can be fussy to handle during administration
through this route.
Non-invasive techniques Not useful in extremely apprehensive patients.

9. Metrogyl Gel

10. BRAND NAME Metrogyl Gel 30 gms
MANUFACTURER Lekar Pharma Ltd.
PRICE INR 69.38
ROUTE OF ADMINISTRATION Topical
AMINISTRATION Apply over the affected area
PRESCRIBED FOR Skin infection, vaginal infection
SIDE EFFECTS May cause skin rashes if allergic to nitroimidazoles
OVERDOSE SYMPTOMS

11. Advantages Disadvantages
Low risk if systemic adverse reaction Less penetration in affected area
High concentration of drug at affected area Allergic contact dermatitis
Small amount of drug is used Can be ineffective If contact with water
Ease of administration in children Less affective in regard to oily skin
Prolonged contact time Less stable than a solid dosage form

12. Thank you