Clindamycin is a semisynthetic antibiotic effective against various infections, including skin, bone, joint, dental, respiratory, abdominal, pelvic, septicemia, and endocarditis. It works by inhibiting bacterial protein synthesis and is administered in doses varying by infection severity, typically starting at 300 mg every 12 hours. Caution is advised for patients with gastrointestinal history, and it has notable efficacy against MRSA and other resistant infections.

1. WeLcOmE To AlL

2. About Clindamycin
• Clindamycin is a semisynthetic antibiotic produced by a 7(S)-chloro-
substitution of the 7(R)-hydroxyl group of the parent compound
lincomycin.
• After oral administration (মুখে োওয়ার পর) Clindamycin
Hydrochloride is well absorbed (ভাখ া ভাখে শ াষিত হয়).
• Clindamycin hydrochloride is the hydrated hydrochloride salt of
clindamycin.
• Approximately 95% of serum Clindamycin is bound to protein. The
average biological half-life is 2.4 hours.
• After oral administration of clindamycin hydrochloride, elimination
half-life is increased to approximately 4.0 hours (range 3.4 to 5.1 h) in
the elderly compared to 3.2 hours (range 2.1 to 4.2 h) in younger adults.
• The extent of absorption, however, is not different between age groups
and no dosage alteration is necessary for the elderly with normal
hepatic function and normal (age-adjusted) renal function.
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3. Clindamycin
Mode of action:
Clindamycin inhibits bacterial
protein synthesis by binding with
50s ribosomal subunit of the
bacteria, causing cell death

5. Clindamycin

7. Indication
–Skin and Skin-Structure Infections.
–Bone and Joint Infections.
–Lower respiratory tract infections.
–Dental infections.
–Intra-abdominal infections.
–Pelvic infections.
–Septicemia and Endocarditis.

8. Dosage & Administration
Adults: Clindamycin 300 mg capsule
every 12 hours/ twice daily particularly in SSTIs and
RTIs.
In some Serious Infections: 150 mg - 300 mg every six
hours. More severe infections: 300 mg - 450 mg
every 6 hours. To avoid the possibility of esophageal
irritation, Clindamycin hydrochloride capsules
should be taken with a full glass of water.
However incase of bone and joint infections, diabetic
foot infections dose of Clindamycin should be 300
mg capsule 6 hours daily.

9. Adverse effects
–CNS: Headache, dizziness.
–GI: Nausea, vomiting, diarrhea,
oesophagitis, abdominal pain,
flatulence, and oesophagial ulcer.
–Hypersensitivity: Skin rashes and
urticaria are reported.

10. Clindamycin
Precautions
Clindamycin should be prescribed
with caution in individuals with a
history of gastrointestinal disease,
particularly colitis.

11. Clindamycin
Key Selling Points:
• Effectively eradicates MRSA in Skin and soft tissue infections.
• Successfully treats all type of dental infections.
• Effective treatment option in skin and soft tissue infections (SSTIs).
• Effective in bone and joint infections (Osteomyelitis and septic
arthritis).
Note:
• MRSA (Methicillin-resistant Staphylococcus aureus infection is
caused by a type of staph bacteria that's become resistant to many
of the antibiotics used to treat ordinary staph infections.
• Endocarditis is inflammation of the inside lining of the heart
chambers and heart valves (endocardium).
• Septicemia is an infection of the blood, also known as bacteremia
(bacteria in the blood) or blood poisoning.

12. Clinical Study
100%
Dental
infection
100%
Diabetic foot
infection
99%
SSTI
98%
Bone and
Joint
infection