This document provides an overview of different classes of antibiotics, including their mechanisms of action, uses, and side effects. It discusses beta-lactam antibiotics like penicillins and cephalosporins, as well as macrolides, fluoroquinolones, aminoglycosides, tetracyclines, chloramphenicol, glycopeptides and others. Each class is described in terms of its antimicrobial spectrum and applications for treating various bacterial infections. Potential adverse effects are also outlined for safety considerations.
Antibiotics and their classification, Part - 1Zunaira Gillani
What are Antibiotics, Classification of antibiotics on the basis of Spectrum, Chemical Composition, Route of administration, Mechanism of action and effects of their action.
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Antibacterial Agents/ antibiotics (Ocular Pharmacology)
PRESENTATION LAYOUT
Introduction to antimicrobial drugs
Classification of antimicrobial drugs
Antibacterial drugs:
- Classification
- Indications
- Side effects
Antibacterial Resistance
Antimicrobial drugs are chemotherapeutic drugs
Two categories: – Antibiotics : Antimicrobial drugs produced by microorganisms
– Synthetic drugs : Antimicrobial drugs synthesized in the lab
..............................................
For Further Reading
oTextbook of microbiology by Ananthanarayan & Paniker
o Essentials of Medical Pharmacology KD Tripathi
o Basic & Clinical Pharmacology by Bertram G. Katzung
o Ophthalmic Drugs by Graham Hopkins and Richard Pearson
o Internet
Antibiotics and their classification, Part - 1Zunaira Gillani
What are Antibiotics, Classification of antibiotics on the basis of Spectrum, Chemical Composition, Route of administration, Mechanism of action and effects of their action.
Direct Download Link ❤❤https://healthkura.com/antibacterial-agents/❤❤
Dear viewers Check Out my other piece of works at ❤❤❤ https://healthkura.com ❤❤❤
Antibacterial Agents/ antibiotics (Ocular Pharmacology)
PRESENTATION LAYOUT
Introduction to antimicrobial drugs
Classification of antimicrobial drugs
Antibacterial drugs:
- Classification
- Indications
- Side effects
Antibacterial Resistance
Antimicrobial drugs are chemotherapeutic drugs
Two categories: – Antibiotics : Antimicrobial drugs produced by microorganisms
– Synthetic drugs : Antimicrobial drugs synthesized in the lab
..............................................
For Further Reading
oTextbook of microbiology by Ananthanarayan & Paniker
o Essentials of Medical Pharmacology KD Tripathi
o Basic & Clinical Pharmacology by Bertram G. Katzung
o Ophthalmic Drugs by Graham Hopkins and Richard Pearson
o Internet
Pharmacology of Penicllins (Beta lactam antibiotics), description of their mechanism of action, mechanism of resistance, classification, indications and adverse effects
Microbiology is the study of microorganisms.
The overall theme of the Microbiology course is to study the relationship between microbes and our lives.
Microorganisms (microbes) are organisms that are too small to be seen with the unaided eye, and usually require a microscope to be seen.
This relationship involves harmful effects such as diseases and food spoilage as well as many beneficial effects.
synthetic antimicrobials having a quinolone structure that are active primarily against gram-negative bacteria, though newer fluorinated compounds also inhibit gram-positive ones.
This ppt deals with the sulfonamide group of drugs with classification, mechanism, spectrum, resistance, uses and adverse effects discussed in detail. It also discusses in detail about Cotrimoxazole
Tetracyclines slide contains full information about uses, adverse effect, marketed preparation, precaution, route of drug administration, antimicrobial spectrum, mechanism of action, pharmacokineticks and pharmacodynamics of tetracyclines. This slide is very helpful for pharmacy and pharmacology student for the study about tetracyclines.
Pharmacology of Penicllins (Beta lactam antibiotics), description of their mechanism of action, mechanism of resistance, classification, indications and adverse effects
Microbiology is the study of microorganisms.
The overall theme of the Microbiology course is to study the relationship between microbes and our lives.
Microorganisms (microbes) are organisms that are too small to be seen with the unaided eye, and usually require a microscope to be seen.
This relationship involves harmful effects such as diseases and food spoilage as well as many beneficial effects.
synthetic antimicrobials having a quinolone structure that are active primarily against gram-negative bacteria, though newer fluorinated compounds also inhibit gram-positive ones.
This ppt deals with the sulfonamide group of drugs with classification, mechanism, spectrum, resistance, uses and adverse effects discussed in detail. It also discusses in detail about Cotrimoxazole
Tetracyclines slide contains full information about uses, adverse effect, marketed preparation, precaution, route of drug administration, antimicrobial spectrum, mechanism of action, pharmacokineticks and pharmacodynamics of tetracyclines. This slide is very helpful for pharmacy and pharmacology student for the study about tetracyclines.
Rational Use of Antibiotics. Infection was a major cause of morbidity and mortality, before the development of antibiotics.
The treatment of infections faced a great challenge during those periods.
Later in 1928, the discovery of Penicillin, a beta-lactam antibiotic, by Alexander Fleming opened up the golden era of antibiotics.
It marked a revolution in the treatment of infectious diseases and stimulated new efforts to synthesize newer antibiotics.
The period between the 1950s and 1970s is considered the golden era of discovery of novel antibiotic classes, with very few classes discovered since then.
Values are enduring beliefs or attitudes about the worth of a person, object, idea, or action. Values are important because they influence decisions and actions, including
Nurses ethical decision making.
Nurses who understand how patients’ values and their own values shape nurse-patient interactions, and who continually develop sensitivity to the ethical dimensions of nursing practices, are best able to provide quality care and advocate for their patients.
Define the bio-medical waste.
List out the sources of bio-medical waste.
Tell the composition of biomedical waste.
Understood the classification of biomedical waste.
Discuss the category of waste for segregation.
Explain the steps in the management of biomedical waste.
Describe the role of nurse.
SCOPE OF NURSING , ROLES & RESPONSIBILITIES OF VARIOUS NURSING PERSONNEL, QUA...Krishna Gandhi
COMMUNITY HEALTH NURSE
TEACHING IN NURSING
SCOPE OF NURSING
ROLES & RESPONSIBILITIES OF VARIOUS NURSING PERSONNEL
QUALITIES OF A NURSE
INDUSTRIAL NURSE
MILITARY NURSE
NURSING SERVICE ABROAD
NURSING SERVICE ADMINISTRATIVE POSITION
NURSING AS A PROFESSION, CHARACTERISTICS OF NURSE,NURSING PRINCIPLES.pptxKrishna Gandhi
NURSING AS A PROFESSION, NURSING PRINCIPLES
Profession has been defined as that requires extensive education or a calling that requires special knowledge, skill and preparation.
Professional nurse is a health worker, a graduate from a recognized school who is identified by law as a registered nurse whether graduated from a baccalaureate (BSc) or a diploma program.
Specialized education is an important aspect of professional status. In modern times, the trend in education for the professions has shifted towards programs in colleges and universities.
Nursing is indeed an art and science.
Science helps to explain the work of a nurse, while art addresses the human connections, empathetic communication, and dedicated care and compassion that make nursing a critical element of healthcare.
HISTORY OF NURSING and NURSING AS A PROFESSION.pptxKrishna Gandhi
HISTORY OF NURSING and NURSING AS A PROFESSION
Knowledge of the profession‘s history increases the nurse‘s awareness and promotes an understanding of the social and intellectual origins.
From its earliest history nursing was a form of community service to protect and preserve the family.
definition
indication
purpose
articles
components:
====
Level of consciousness
Mental status examination
Sensory cerebral function
Cranial nerves
Reflexes
Motor system
Sensory system
Cerebellar function
---
role of nurse
Definitiom
indication
Explain the value of the Glasgow Coma Scale for patient care.
Outline the three areas the Glascow Coma Scales assesses.
Summarize the severity findings for each range of the Glascow Coma Scale.
Review how the interprofessional team can use the Glasgow Coma Scale to communicate regarding a patients condition.
case scenerio
FRACTURE
DEFINITION
CAUSES
TYPES
CLASSIFICATION
SIGN AND SYMPTOMS
5 P
CARE
NURSES ROLE
SPLINT
SLING
NONINVASIVE METHODS
PHARMACOLOGY METHOD
SURGERY
NURSING DIAGNOSIS
INTRODUCTION
TO DEFINE ICP
TO ENLIST FACTORS CAUSING INC ICP
TO ENLIST INDICATION ANDCONTRA INDICATION OF ICP MONITORING
TO BRIEF CONSIQUENCIES OF INC ICP
TO EXPLAIN ASSESSMENT OF INC ICP
TO BRIED WARNING SIGN OF ICPMONITORING
TO EXPLAIN VARIOUS INVASIVE AND NON INVASIVE METHOD OF ICP MONITORING
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
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micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
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Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
2. What is an antibiotic?
“Antibiotic” is from antibiosis, meaning against life.
Substances derived from a microorganismor produce synthetically
(Sulfonamides & Quinolones) to kill or suppress the growth of
other microorganisms.
3. Classification of Antibiotics
Antibiotics are classified by several ways:
• On the basis of mechanism of action
• On the basis of spectrum of activity
• On the basis of mode of action
4. Mechanism of action of antimicrobial agents
1. Inhibition of cell wall synthesis:
• Penicillins, Cephalosporins, Bacitracin & Vancomycin
2. Inhibition of functions of cellular membrane:
• Polymyxins
3. Inhibition of protein synthesis:
• Chloramphenicol, Macrolides & Clindamycin
• Tetracyclines & Aminoglycosides
4. Inhibition of nucleic acid synthesis:
• Quinolones
• Rifampin
5. Inhibition of folic acid synthesis:
• Sulfonamides & trimethoprim
6. Antimicrobial Spectrum
Antimicrobial spectrum: the scope that a drug kills
or suppresses the growth of microorganisms.
Narrow-spectrum: The drugs that only act on one
kind or one strain of bacteria.
(Isoniazide)
Broad-spectrum: The drugs that have a
wide antimicrobial scope.
(Tetracycline & Chloramphenicol)
10. Misuse of Antibiotics
Antibiotic misuse, sometimes called antibiotic abuse or antibiotic
overuse
The misuse or overuse of antibiotics, may produce serious effects on
health.
It is a contributing factor to the creation of multidrug- resistant bacteria,
informally called “super bugs”.
11. Antibiotic Resistancesand
Cross Resistances
Antibiotic resistance is the phenomenon that susceptibility of
pathogenic microorganisms
to antibiotic becomes lower or even loses after the microorganisms
contact with antibiotic many times.
When the bacteria show resistance to one antibiotic, they are
also resistant to some other antibiotics. This phenomenon is
called cross antibiotic resistance.
12. General Principles of Antimicrobial
Therapy
• Identification of the infecting organism should precede
antimicrobial therapy when possible.
• The pathogenic microorganism susceptibility to
antimicrobial agents should be determined, if a suitable
test exists.
• Factors that influence the choice of an antimicrobial agent
or its dosage for a patient include the age, renal & hepatic
function, pregnancy status and the site of infection, etc.
13. Selection of Antimicrobial Agent
• Empiric therapy - prior to identification of
Organism- critically ill patients
• Organism’s susceptibility to the antibiotic
• Patient factors - immune system,
renal/hepatic function
• Effect of site of infection on therapy - blood
brain barrier
• Safety of the agent
• Cost of therapy
14. Complications of Antibiotic Therapy
• Resistance due to inappropriate use of antibiotics
• Hypersensitivity (Penicillin)
• Direct toxicity (Aminoglycosides = ototoxicity)
• Super infections (broad spectrum antimicrobials
cause alteration of the normal flora; often
difficult to treat)
15. Classes of Antibiotics
The main classes of antibiotics are:
• Beta-Lactams
Penicillins
Cephalosporins
Carbapenems
Monobactams
• Macrolides & Ketolides
• Aminoglycosides
• Fluoroquinolones
• Tetracyclines,
Amphenicols
16. Penicillins
• The penicillins are the oldest class of antibiotics.
Penicillins have a common chemical structure
which they share with the Cephalosporins.
• Penicillins are generally bactericidal, inhibiting
formation of the cell wall.
17. Uses :
Penicillin's are
used to treat
• Skin infections,
• Dental infections,
• Ear infections,
• Respiratory tract infections,
• Urinary tract infections,
• Gonorrhea.
18. Types of penicillins
• The natural penicillins
Penicillin G
• Penicillinase-resistant
penicillins
Methicillin & Oxacillin
• Aminopenicillins
Ampicillin & Amoxicillin
19. Penicillin's Side Effects
• Diarrhea, nausea, vomiting, and upset
stomach
• In rare cases Penicillins can cause immediate
and delayed allergic reactions - specifically
skin rashes, fever & anaphylactic shock.
• Penicillins are classed as category B
during pregnancy.
20. Cephalosporins
• Cephalosporins have a mechanism of action
identical to that of the Penicillins.
• Interferes with synthesis of the bacterial cell wall
and so are bactericidal.
21. Cephalosporins are used to treat
pneumonia, staph infections, tonsillitis,
bronchitis, otitis media, various types of
skin infections, gonorrhea, urinary tract
infections.
Cephalosporins antibiotics are also
commonly used for surgical
prophylaxis.
Cephalexin can also be used to treat bone
infections.
1.
3.
2.
22. The first generation Cephalosporins
• They possess generally excellent coverage against
most Gram-positive pathogens and variable to poor
coverage against most Gram-negative pathogens.
• The first generation
includes: Cephradine
(Velosef) Cephalexin
(Ceporex) Cefadroxil
(Biodroxil, Duricef)
23. The second generation Cephalosporins
• In addition to the Gram-positive spectrum of the
first generation Cephalosporins, these agents have
expanded Gram-negative spectrum.
• Cefoxitin and Cefotetan also have good activity
against Bacteroides fragilis.
• The second generation
includes: Cefaclor
(Bacticlor) Cefuroxime
(Zinnat)
24. The third generation Cephalosporins
• They have much expanded gram negative activity. However,
some members of this group have decreased activity against
gram-positive organisms. They have the advantage of
convenient administration, but they are expensive.
• The third generation
includes: Ceftazidime
(Fortum) Cefixime
(Suprax) Cefoperazone
(Cefobid) Cefotaxime
(Claforan, Cefotax)
Ceftriaxone (Ceftriaxone,
Rociphen) Cefdinir (Omnicef)
25. The fourth generation Cephalosporins
• They are extended-spectrum agents with similar
activity against Gram-positive organisms as first-
generation cephalosporins. They also have a greater
resistance to beta- lactamases than the third generation
cephalosporins.
• Many fourth generation cephalosporins can cross
blood brain barrier and are effective in meningitis.
• The fourth generation
includes: Cefepime
(Maxipime)
26. The Fifth generation Cephalosporins
• Used to treat MRSA (methicillin-resistant
Staphylococcus aureus), penicillin-resistant
Streptococcus pneumoniae, Pseudomonas aeruginosa,
and enterococci.
• The fifth generation includes:
Ceftaroline (Teflaro)
Ceftobiprole (Zeftera)
27. Cephalosporins Side Effects
• Diarrhea, nausea, mild stomach upset
• Approximately 5–10% of patients with
allergic hypersensitivity to penicillins will
also have cross- reactivity with
cephalosporins.
• Cephalosporin antibiotics are classed as
pregnancy category B.
28. Carbapenems
• A class of β-Lactam antibiotics with a broad spectrum of
antibacterial activity.
• Highly resistant to most β-lactamases.
• Active against both Gram-positive and Gram-
negative bacteria, and anaerobes, with the exception of
intracellular bacteria (atypical), such as the Chlamydia.
• Agents:
Imipenem/Cilastatin (Tienem)
Meropenem (Meronem)
29. Adverse effects to Carbapenems include
• Headache
• Rash
• GI upset
• Phlebitis
• Hypotension
• Seizures in patients with renal dysfunction.
30. Monobactams
• They are β-lactam compounds.
• They work only against aerobic Gram
negative bacteria (Neisseria,
Pseudomonas).
• The only commercially available Monobactams
antibiotic is Aztreonam (Azactam).
• Adverse effects to Monobactams can include skin
rash and occasional abnormal liver functions.
31. Macrolides
• Macrolides are bacteriostatic, binding with bacterial
ribosomes to inhibit protein synthesis.
• Macrolides antibiotics are:
Erythromycin (Erythrocin)
Clarithromycin (Klacid)
Azithromycin (Zithromax)
Roxithromycin (Roxicin)
32. Macrolides antibiotics are used to treat
Respiratory tract infections (such as
pharyngitis, sinusitis, and bronchitis), genital,
gastrointestinal tract & skin infections.
33. Macrolides Side Effects
• Nausea, vomiting, diarrhea; infrequently, there may
be temporary auditory impairment.
• Oral Erythromycin may be highly irritating to the
stomach and when given by injection may cause severe
phlebitis.
• Macrolides antibiotics should be used with caution
in patients with liver dysfunction.
• Pregnancy category B: Azithromycin,
Erythromycin.
• Pregnancy category C: Clarithromycin
34. Ketolides
• Antibiotics belonging to the Macrolides group.
• Much broad spectrum than other Macrolides.
• Ketolides are effective against Macrolides-resistant
bacteria, due to their ability to bind at two sites at the
bacterial ribosome as well as having a structural
modification that makes them poor substrates for
efflux- pump mediated resistance.
• The only Ketolide on the market at this moment
is telithromycin, which is sold under the brand
name of Ketek.
35. Lincosamides (e.g. lincomycin, clindamycin)
• Lincosamides prevent bacteria replicating by
interfering with the synthesis of proteins.
• They are normally used to treat
staphylococci and streptococci, and have
proved useful in treating Bacteroides
fragilis and some other anaerobes.
36. • They are used in the treatment of Toxic Shock
Syndrome.
• Lincosamides antibiotics are one of the classes of
antibiotics most associated with pseudomembranous
colitis caused by C. difficile.
37. Aminoglycosides
• The Aminoglycosides are bactericidal and work by
stopping bacteria from making proteins.
• Aminoglycosides antibiotics are used to treat
infections caused by Gram-negative bacteria.
• Aminoglycosides may be used along with penicillins
or cephalosporins to give a two-pronged attack on
the bacteria.
• Since Aminoglycosides are broken down easily in
the stomach, they can't be given by mouth and
must be injected.
38. Generally, Aminoglycosides are given for short time
periods.
Aminoglycosides group includes:
Amikacin (Amikin)
Gentamicin (Garamycin)
Neomycin (Neomycin)
Streptomycin (Streptomycin)
Tobramycin (Nebcin)
40. Fluoroquinolones
• They are synthetic antibiotics, not derived from bacteria.
• Fluoroquinolones are broad-spectrum bactericidal drugs
that are chemically unrelated to the penicillins or the
cephalosporins.
• Fluoroquinolones inhibit bacteria by interfering with their
ability to make DNA. This effect is bactericidal.
41. • Because of their excellent absorption Fluoroquinolones
can be administered not only by intravenous but orally
as well.
• Fluoroquinolones are used to treat most common
urinary tract infections, skin infections, and
respiratory infections (such as sinusitis, pneumonia).
• Fluoroquinolones group includes:
Ciprofloxacin (Ciprobay, Ciprocin)
Levofloxacin (Tavanic, Alfacef)
Norfloxacin (Noracin)
Ofloxacin (Tarivid)
Moxifloxacin(Avalox)
42. Fluoroquinolones Side Effects
• Nausea, vomiting, diarrhea, abdominal
pain
• Irreversible damage to central nervous
system (uncommon)
• Tendinosis (rare)
• Fluoroquinolones are classed as
pregnancy category C.
43. Trimethoprim/sulfamethoxazole or Co-
trimoxazole
• An antibiotic used in the treatment of a variety of
bacterial, fungal and protozoal infections.
• Co-trimoxazole is generally considered bactericidal,
although its components are individually
bacteriostatic.
• Its actions are antifolate in nature,
inhibiting both de novo folate biosynthesis and
metabolism.
44. Co-trimoxazole side effects
• Nausea, vomiting
• An allergic reaction and infection with Clostridium
difficile, a type of diarrhea
• Co-trimoxazole is classed as pregnancy category C.
• it should not be used during breastfeeding.
45. Tetracyclines
• Broad-spectrum bacteriostatic agents and work by
inhibiting the bacterial protein synthesis.
• Tetracyclines may be effective against a wide variety of
microorganisms, including Rickettsia and Amoebic
parasites.
• Tetracyclines are used in the treatment of infections of the
respiratory tract, sinuses, middle ear, urinary tract, skin,
intestines.
• Their most common current use is in the treatment of
moderately severe acne and rosacea.
46. • Tetracyclines also are used to treat Gonorrhea, Rocky
Mountain spotted fever, Lyme Disease, Typhus.
• Tetracycline antibiotics are:
Tetracycline
Doxycycline
(Vibramycin)
Minocycline
Oxytetracycline (Oxytetracid)
47. Tetracyclines side effects
• Cramps or burning of the stomach, diarrhea, sore mouth
or tongue
• Skin photosensitivity
• Allergic reactions
• Tetracycline antibiotics should not be used in children
under the age of 8 and specifically during periods of
tooth development.
• Tetracyclines are classed as pregnancy category D.
Use during pregnancy may cause alterations in
bone development.
48. Chloramphenicol
• It is a bacteriostatic.
• It is considered a prototypical broad-spectrum
antibiotic, alongside the tetracyclines, and as it is both
cheap and easy to manufacture, it is frequently an
antibiotic of choice in the developing world.
• Effective against a wide variety of Gram-positive and
Gram- negative bacteria, including most anaerobic
organisms.
49. • Due to resistance and safety concerns, it is no longer
a first- line agent for any infection in developed
nations, with the notable exception of topical
treatment of bacterial conjunctivitis.
50. Chloramphenicol side effects
• The most serious adverse effect associated with
chloramphenicol treatment is bone marrow toxicity.
• Use of intravenous chloramphenicol has also been
associated with gray baby syndrome.
• Other less serious reactions include fever, rashes,
headache, confusion.
51. Glycopeptides (e.g. vancomycin, teicoplanin)
• These antibiotics are effective principally against
Gram- positive cocci.
• This class of drugs inhibit the synthesis of cell walls
in susceptible microbes by inhibiting peptidoglycan
synthesis.
• Vancomycin is used if infection with
methicillin- resistant Staphylococcus aureus
(MRSA) is suspected.
52. • Due to their toxicity, use of glycopeptides antibiotics
is restricted to patients who are critically ill, who
have a demonstrated hypersensitivity to the β-
lactams, or who are infected with β-lactam-resistant
species.
• They exhibit a narrow spectrum of action,
and are bactericidal only against the
enterococci.
53. Vancomycin side effects
• Vancomycin is usually given intravenously, as an
infusion, and can cause tissue necrosis and phlebitis
at the injection site.
• Red man syndrome, an idiosyncratic reaction to bolus
dose caused by histamine release
• Nephrotoxicity including renal failure and
interstitial nephritis
• Blood disorders including neutropenia, and deafness,
which is reversible once therapy has stopped
• Risk of accumulation in patients with renal impairment
54. Streptogramins
• Effective in the treatment of vancomycin-
resistant Staphylococcus aureus (VRSA) and
vancomycin- resistant Enterococcus (VRE), two of the
most rapidly growing strains of multidrug-resistant
bacteria.
• Members include:
Quinupristin/dalfopristin
Pristinamycin
Virginiamycin
55. Adverse effects include:
Related to administration via peripheral vein
Inflammation, pain, edema, infusion site reaction,
thrombophlebitis
Non-venous adverse effects
• Nausea, vomiting, diarrhea
• Rash
• Headache
• Pain, ill-defined focal or generalized discomfort
• Pruritus
• Arthralgia, myalgia
• Asthenia
• Conjugated hyperbilirubinaemia
56. Oxazolidinones (e.g. linezolid)
• Linezolid inhibits ribosomal protein synthesis by inhibiting
formation of the initiation complex.
• It is used for the treatment of serious infections caused
by Gram-positive bacteria that are resistant to several other
antibiotics.
• Linezolid is active against most Gram-positive bacteria that
cause disease, including streptococci, vancomycin-resistant
enterococci (VRE), and methicillin-resistant Staphylococcus
aureus (MRSA).
57. • The main indications of linezolid are infections of the skin
& soft tissues and pneumonia (particularly hospital-
acquired pneumonia).
• Common adverse effects of short-term use
include headache, diarrhea & nausea.
Long-term use, however, has been associated with
serious adverse effects; linezolid can cause bone marrow
suppression and low platelet counts, particularly when
used for more than two weeks. If used for longer periods
still, it may cause sometimes irreversible chemotherapy-
induced peripheral neuropathy and optic nerve damage,
and lactic acidosis.
58. Metronidazole
• A nitroimidazole antibiotic medication used particularly
for anaerobic bacteria and protozoa.
• It is antibacterial against anaerobic organisms, an
amoebicide and an antiprotozoal.
• It inhibits nucleic acid synthesis by disrupting the DNA of
microbial cells. This function only occurs when
Metronidazole is partially reduced, and because this
reduction usually happens only in anaerobic cells, it has
relatively little effect upon human cells or aerobic bacteria.
59. Metronidazole is primarily used to treat:
• Bacterial vaginosis, pelvic inflammatory disease (along
with other antibacterials like ceftriaxone),
pseudomembranous colitis,
• Aspiration pneumonia,
• Rosacea (topical),
• Fungating wounds (topical),
• Intra-abdominal infections,
• Lung abscess,
• Gingivitis,
• Amoebiasis, giardiasis, trichomoniasis, and infections
caused by susceptible anaerobic organisms such as
Bacteroides.
60. • It is also often used to eradicate Helicobacter
pylori along with other drugs and to prevent
infection in people recovering from surgery.
• Adverse effects include:
Discolored urine, headache, metallic taste ,
nausea. Metronidazole is classed as
pregnancy category B.
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13th Edition, New York; New Delhi, Tatamcgraw-hill Education, 2017.
3. Katzung B. G, Basic And Clinical Pharmacology, 14th Edition, New York; New
Delhi, Tatamcgraw-hill Education, 2017.
4. Tara V Shanbhaug “Pharmacology For Medical Graduates”(2014),elsevier
Publication,third Edition,2015
5. Tripathi K.D, Essentials Of Medical Pharmacology, 7th Edition, New Delhi,
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