Indomethacin is a non-selective COX inhibitor NSAID that can be taken orally, as eye drops, or as a suppository. It works by inhibiting prostaglandin synthesis and neutrophil migration to reduce inflammation, fever, and pain. Indomethacin is used to treat ankylosing spondylitis, acute gout, and psoriatic arthritis but can cause gastrointestinal irritation, bleeding, headaches, dizziness, and rashes as side effects. It is contraindicated in patients with epilepsy, psychiatric conditions, renal disease, pregnancy, or children.

1. INDOMETHACIN
GENERIC NAME : INDOMETHACIN
ROUTE : Oral, Eye drops, and suppository
DOSE : 25 -50 mg BD-TDS .
PHARMACOLOGICAL CLASS: NSAIDS ; non- selective COXinhibitors (indole derivatives)
MECHANISM OF ACTION:
 It has potent anti inflammatory effect
 It is highly potent inhibitor of prostaglandin (PG) synthesis
 It inhibits the migration of neutrophils to inflamed area
 It prompt the antipyretic action
 It relieves only inflammatory or tissue injury related pain
 In toxic doses it uncouples oxidative phosphorylation
THERAPEUTIC USES :
 Ankylosing spondylitis
 Acute gout
 Psoriatic arthritis
ADVERSE EFFECTS :
 GIT : gastric irritation, nausea, anorexia, GI bleeding, diarrhoea
 CNS : frontal headache,dizziness, ataxia, mental confusion, hallucination, depression and
psychosis
 Leucopenia, rashes,hypersensitivity reactions
 Increased bleeding due to decreased platelet aggregability
CONRAINDICATION :
 Epileptic patients
 Psychiatric patients
 Patients with renal disease, pregnant women, and in children .