Congestive heart failure (CHF) is a clinical syndrome where the heart is unable to pump enough blood to meet the body's demands. It is a major public health problem and most common in the elderly. CHF results from conditions that increase the heart's workload like valvular diseases or decrease the heart's ability to contract effectively from issues such as a myocardial infarction. As the heart fails to meet circulatory demands, compensatory mechanisms activate but eventually fail, leading to symptoms of fluid overload and organ congestion. Treatment involves controlling symptoms with medications that lower preload and afterload on the heart like diuretics, ACE inhibitors, and beta blockers as well as addressing any underlying causes of heart muscle dysfunction.
Angina also known as angina pectoris is a medical condition characterized by chest pain usually left sided due to inadequate blood supply (ischemia) to the heart muscles due to obstruction (like presence of blood clot), narrowing or contraction (vasospasm) of the supplying coronary arteries.
Heart failure (HF) is a common cardiovascular condition with increasing incidence and prevalence. Unlike western countries where heart failure is predominantly a disease of elderly, in India it affects younger age group. Heart failure is a chronic condition in which the heart cannot pump enough blood and oxygen to support other organs in your body.
Angina also known as angina pectoris is a medical condition characterized by chest pain usually left sided due to inadequate blood supply (ischemia) to the heart muscles due to obstruction (like presence of blood clot), narrowing or contraction (vasospasm) of the supplying coronary arteries.
Heart failure (HF) is a common cardiovascular condition with increasing incidence and prevalence. Unlike western countries where heart failure is predominantly a disease of elderly, in India it affects younger age group. Heart failure is a chronic condition in which the heart cannot pump enough blood and oxygen to support other organs in your body.
Myocardial infarction (MI), commonly known as a heart attack, occurs when blood flow decreases or stops to a part of the heart, causing damage to the heart muscle. The most common symptom is chest pain or discomfort which may travel into the shoulder, arm, back, neck, or jaw.
Acute kidney failure happens when your kidneys suddenly lose the ability to eliminate excess salts, fluids, and waste materials from the blood. Acute kidney failure is also called acute kidney injury or acute renal failure. It's common in people who are already in the hospital. It may develop rapidly over a few hours.
CHRONIC RENAL FAILURE (CRF) or CHRONIC KIDNEY DISEASE (CKD)
Chronic or irreversible renal failure is a progressive reduction of functioning of renal tissue such that the remaining kidney mass can no longer maintain the body’s internal environment.
Myocardial infarction (MI), commonly known as a heart attack, occurs when blood flow decreases or stops to a part of the heart, causing damage to the heart muscle. The most common symptom is chest pain or discomfort which may travel into the shoulder, arm, back, neck, or jaw.
Acute kidney failure happens when your kidneys suddenly lose the ability to eliminate excess salts, fluids, and waste materials from the blood. Acute kidney failure is also called acute kidney injury or acute renal failure. It's common in people who are already in the hospital. It may develop rapidly over a few hours.
CHRONIC RENAL FAILURE (CRF) or CHRONIC KIDNEY DISEASE (CKD)
Chronic or irreversible renal failure is a progressive reduction of functioning of renal tissue such that the remaining kidney mass can no longer maintain the body’s internal environment.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
ABDOMINAL TRAUMA in pediatrics part one.drhasanrajab
Abdominal trauma in pediatrics refers to injuries or damage to the abdominal organs in children. It can occur due to various causes such as falls, motor vehicle accidents, sports-related injuries, and physical abuse. Children are more vulnerable to abdominal trauma due to their unique anatomical and physiological characteristics. Signs and symptoms include abdominal pain, tenderness, distension, vomiting, and signs of shock. Diagnosis involves physical examination, imaging studies, and laboratory tests. Management depends on the severity and may involve conservative treatment or surgical intervention. Prevention is crucial in reducing the incidence of abdominal trauma in children.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
2. C H F
Definition: It is a clinical syndrome
resulting from the inability of heart
to pump enough blood at rest or
during exercise even though the
filling pressures are adequate.
4. Etiology
Divided in to 3 subgroups
-Abnormal loading conditions
-Abnormal muscle function
-Precipitating factors
5. Etiology (contd..)
Abnormal loading conditions
Increased preload
Refers to the length of the ventricular
myocardial fibers just before ventricular
contraction and EDV
-Valvular regurgitation
-Hypervolemia
-Congenital diseases
(ASD,VSD,PDA)
6. Etiology (contd..)
Increased after load
Correspond to the amount of intra
myocardial wall tension that the heart
must generate to overcome systolic
pressure and allows ventricular emptying.
-Aortic valvular stenosis
-pulmonary valve stenosis
-Systemic and pulmonary hypertension
-Increased PVR
-Increased blood viscosity
7. Etiology (contd.)
Abnormal muscle function
-Conditions that interfere with myocardial
contractibility
MI
Myocarditis
Cardiomyopathy
ventricular aneurism
-External compression
(constrictive pericarditis,cardiac
tamponade)
11. Pathophysiology (contd…)
Increased pressure in pulmonary
vascular system
Right ventricular dilation&hypertrophy
Fails
Engorgement of systemic venous
system
Congestion in GIT,Liver
viscera,Kidneys,Legs,sacrum
13. Pathophysiology (contd..)
Cardiac reserve (Hearts ability to
increase the output in response to
stress(5 the times the normal)
But in the diseased heart, it fails to
respond to body’s increased
demands
Compensatory mechanism will be
initiated
14. Pathophysiology contd..
Compensatory mechanisms are
-Ventricular dilation: Lengthening of
the muscle fibers Increased
volume of heart chambers
Increased preload and cardiac out
put leads to reduced contractibility
when stretched beyond capacity
Increased oxygen demand
hypoxia
15. Pathophysiology (contd..)
Ventricular hypertrophy-Increase in
the diameter of muscle fibers
Size and weight of heart increases
Increased oxygen demand
Hypoxia and reduced contractibility
16. Pathophysiology(contd..)
Increased sympathetic stimulation
Increased heart rate and peripheral
vascular resistance
Reduced renal flow and increased
renal conservation of water and
sodium
Fluid overload and increased workload
17. Forms of heart failure
Systolic versus diastolic failure
Systolic-Inability to contract normally
Diastolic-Inability to relax or fill normally
High output versus low output
Low output-IHD,
HT,cardiomyopathy,pericardial diseases
Highoutput-
Hyperthyroidism,anemia,pregnancy,paget
disease
18. Forms (contd..)
Acute versus chronic
Acute –Acute large MI
Chronic-Dilated cardiomyopathy
multivalvular heart disease
Right sided versus left sided
RVF-PAH,Pulmonary
stenosis,pulmonary embolism,
LVF-Aortic stenosis,Post MI
19. Types (contd..)
Backward versus forward H F
backward-ventricles fail to fill
normally Increased pressure in
the atrium and venous system
sodium and water retention edema
Forward-Inadequate discharge of
blood in to the arterial system
29. Medical management
Removal of precipitating factors
Correction of underlying causes
Prevention of deterioration of cardiac
function
Control of CHF state
31. Management contd
Digitalis-Increses ventricular emptying,
slow conduction of impulses through AV
node, Increases stroke volume and
cardiac output
-effective in systolic heart failure
-0.25 6 hourly for adults, for elderly o.125
mg 6 hourly
-Reduce dose in renal impairement
-Should not be given in heart failure with
high output
-Digitalis toxicity should be monitered
37. Management contd
Reduction of cardiac workload
Reducing the physical activity
Emotional rest and reduction of
anxiety
Diet: sodium 1 gm / day
Water 1000 ml / day
potassium supplements
vasodilators – sodium nitroprusside and
Isosorbid dinitrate
Aminophylline 240- 480 mg IV
38. Surgical management
Surgical correction of valvular disorders
Heart transplantation
Cardiopulmonary bypass
Intra aortic balloon pump
39. Nursing management
Impaired gas exchange related to to fluid
in the alveoli
Decreased cardiac output related to heart
failure and Dysrrhythmias
Fluid volume excess related to reduced
cardiac output and Na and water retention
Decreased peripheral tissue perfusion
related to reduced cardiac output
Activity intolerance related to reduced
cardiac output
40. Nursing management
High risk for impaired skin integrity
related to reduced peripheral tissue
perfusion
High risk for digitalis toxicity related
to impaired excretion
Anxiety and fear of death related to
reduced cardiac output and hypoxia