This document discusses congestive heart failure in children. It defines heart failure as the heart's inability to pump enough blood to meet the body's needs. The main causes are ventricular dysfunction from volume or pressure overload. Symptoms depend on whether there is right or left ventricular failure. Treatment involves addressing the underlying cause, managing precipitating factors, restricting fluids, using diuretics and other medications, and considering interventions like transplantation for refractory cases.
This Slideshare includes the introduction of congestive heart failure, signs and symptoms, pathogenesis, epidemiology, etiology, pathophysiology, classification of drugs which is used to manage CHF, and recent drugs used to manage CHF.
This document discusses cardiomyopathy in neonates and children. It covers the classification, epidemiology, causes, pathophysiology, clinical presentation, diagnostic evaluation, and management of various types of cardiomyopathy including dilated, hypertrophic, restrictive, and ischemic cardiomyopathy. The key points are:
1. Cardiomyopathy can present as recurrent wheezing in children and has an incidence of 1 in 100,000 with higher rates in infancy. Common causes include viral myocarditis, genetic factors, and metabolic disorders.
2. Diagnostic evaluation involves ECG, echocardiogram, blood tests, and cardiac catheterization. Echocardiogram can identify features like ventricular dilation or hypertrophy
This document discusses congestive cardiac failure (CHF) in infants and children. It defines CHF and lists various causes that can lead to CHF depending on the age of onset, including structural heart defects, metabolic abnormalities, and acquired heart conditions. The pathophysiology, symptoms, signs, investigations, and treatment approaches for CHF are described. Treatment involves addressing underlying causes, precipitating factors, and controlling the heart failure state using diuretics, inotropic agents, afterload-reducing drugs, and other medications like digoxin.
This document discusses heart failure, including:
- Heart failure affects over 26 million people worldwide and 1% of the Indian population.
- Common symptoms include fatigue, shortness of breath, orthopnea, paroxysmal nocturnal dyspnea, and Cheyne-Stokes respiration.
- Echocardiography, cardiac MRI, biopsy and BNP levels are important for diagnosis and evaluating the etiology and severity of heart failure.
- Treatment involves lifestyle modifications like diet, exercise and medication including diuretics, ACE inhibitors, ARBs, beta blockers, aldosterone antagonists and sacubitril-valsartan which have been shown to reduce symptoms and mortality in heart
Congestive heart failure can be caused by conditions that weaken the heart muscle or overload it. The main symptoms are shortness of breath, fatigue, cough, and fluid retention. Treatment focuses on correcting reversible causes, reducing fluid overload with diuretics, and inhibiting the renin-angiotensin-aldosterone system with ACE inhibitors. Other medications like beta blockers, digitalis, and vasodilators may also be used depending on the individual case. Monitoring through physical exams, labs, and imaging can help guide management and prevent exacerbations.
This document discusses the stages and types of shock. It begins by outlining the stages of shock as compensated, uncompensated, and irreversible. It then defines the main types of shock as hypovolemic, distributive, cardiogenic, and obstructive. For each type of shock, the document provides the etiology, clinical presentation, differentiation from other types, and general management approach. It particularly focuses on hypovolemic/hemorrhagic, cardiogenic, and septic shock, outlining their specific therapies which include fluid resuscitation, vasopressors, antibiotics, and other targeted interventions.
Congestive heart failure occurs when the heart is unable to pump enough blood to meet the body's needs. It can be caused by conditions present at birth like hypoplastic left heart syndrome. Symptoms include poor weight gain, fast breathing, and edema. Diagnosis involves chest x-ray, electrocardiogram, echocardiogram, and sometimes cardiac catheterization. Treatment focuses on underlying causes, medications to control symptoms like diuretics and digoxin, and surgery when possible to correct structural heart defects.
This Slideshare includes the introduction of congestive heart failure, signs and symptoms, pathogenesis, epidemiology, etiology, pathophysiology, classification of drugs which is used to manage CHF, and recent drugs used to manage CHF.
This document discusses cardiomyopathy in neonates and children. It covers the classification, epidemiology, causes, pathophysiology, clinical presentation, diagnostic evaluation, and management of various types of cardiomyopathy including dilated, hypertrophic, restrictive, and ischemic cardiomyopathy. The key points are:
1. Cardiomyopathy can present as recurrent wheezing in children and has an incidence of 1 in 100,000 with higher rates in infancy. Common causes include viral myocarditis, genetic factors, and metabolic disorders.
2. Diagnostic evaluation involves ECG, echocardiogram, blood tests, and cardiac catheterization. Echocardiogram can identify features like ventricular dilation or hypertrophy
This document discusses congestive cardiac failure (CHF) in infants and children. It defines CHF and lists various causes that can lead to CHF depending on the age of onset, including structural heart defects, metabolic abnormalities, and acquired heart conditions. The pathophysiology, symptoms, signs, investigations, and treatment approaches for CHF are described. Treatment involves addressing underlying causes, precipitating factors, and controlling the heart failure state using diuretics, inotropic agents, afterload-reducing drugs, and other medications like digoxin.
This document discusses heart failure, including:
- Heart failure affects over 26 million people worldwide and 1% of the Indian population.
- Common symptoms include fatigue, shortness of breath, orthopnea, paroxysmal nocturnal dyspnea, and Cheyne-Stokes respiration.
- Echocardiography, cardiac MRI, biopsy and BNP levels are important for diagnosis and evaluating the etiology and severity of heart failure.
- Treatment involves lifestyle modifications like diet, exercise and medication including diuretics, ACE inhibitors, ARBs, beta blockers, aldosterone antagonists and sacubitril-valsartan which have been shown to reduce symptoms and mortality in heart
Congestive heart failure can be caused by conditions that weaken the heart muscle or overload it. The main symptoms are shortness of breath, fatigue, cough, and fluid retention. Treatment focuses on correcting reversible causes, reducing fluid overload with diuretics, and inhibiting the renin-angiotensin-aldosterone system with ACE inhibitors. Other medications like beta blockers, digitalis, and vasodilators may also be used depending on the individual case. Monitoring through physical exams, labs, and imaging can help guide management and prevent exacerbations.
This document discusses the stages and types of shock. It begins by outlining the stages of shock as compensated, uncompensated, and irreversible. It then defines the main types of shock as hypovolemic, distributive, cardiogenic, and obstructive. For each type of shock, the document provides the etiology, clinical presentation, differentiation from other types, and general management approach. It particularly focuses on hypovolemic/hemorrhagic, cardiogenic, and septic shock, outlining their specific therapies which include fluid resuscitation, vasopressors, antibiotics, and other targeted interventions.
Congestive heart failure occurs when the heart is unable to pump enough blood to meet the body's needs. It can be caused by conditions present at birth like hypoplastic left heart syndrome. Symptoms include poor weight gain, fast breathing, and edema. Diagnosis involves chest x-ray, electrocardiogram, echocardiogram, and sometimes cardiac catheterization. Treatment focuses on underlying causes, medications to control symptoms like diuretics and digoxin, and surgery when possible to correct structural heart defects.
This document provides an overview of congestive cardiac failure presented by Shivani S. Shrivastava. It defines congestive cardiac failure, discusses its etiology and risk factors such as abnormal loading conditions and muscle function. It also examines the anatomy, physiology, pathophysiology, clinical manifestations, diagnostic evaluation, medical and surgical management, nursing management, and complications of congestive cardiac failure. Current trends discussed include the inability of the adult heart to regenerate and the potential of regenerative approaches for heart failure treatment.
Congestive heart failure (CHF) is a clinical syndrome where the heart is unable to pump enough blood to meet the body's demands. It is a major public health problem and most common in the elderly. CHF results from conditions that increase the heart's workload like valvular diseases or decrease the heart's ability to contract effectively from issues such as a myocardial infarction. As the heart fails to meet circulatory demands, compensatory mechanisms activate but eventually fail, leading to symptoms of fluid overload and organ congestion. Treatment involves controlling symptoms with medications that lower preload and afterload on the heart like diuretics, ACE inhibitors, and beta blockers as well as addressing any underlying causes of heart muscle dysfunction.
Heart failure is a condition where the heart cannot pump enough blood to meet the body's needs. It affects over 5 million Americans. The prevalence increases with age, reaching nearly 10% in those over 80. Symptoms include fatigue, shortness of breath, swelling, and more. Treatment focuses on reducing cardiac workload through diuretics, beta blockers, ACE inhibitors, and other drugs. Device therapies like CRT can also help certain patients. Lifestyle changes and strict medication adherence are important for managing the condition.
The document discusses congestive cardiac failure (heart failure) and its management. It provides details on:
- The high prevalence and mortality of heart failure.
- Current medical therapies including ACE inhibitors, beta-blockers, and aldosterone antagonists that have been shown to improve survival.
- Device therapies like cardiac resynchronization therapy and implantable cardioverter defibrillators that treat symptoms and reduce mortality.
- The benefits of multidisciplinary and integrated care approaches including telehealth monitoring in improving outcomes for heart failure patients.
This document summarizes management of congestive cardiac failure. It discusses current medical therapies including ACE inhibitors, beta blockers, and aldosterone antagonists which have been shown to improve survival. Device therapies like biventricular pacing and implantable cardioverter defibrillators are also used to treat heart failure and reduce mortality and sudden death. Lifestyle modifications and multidisciplinary management in the community can further benefit patients.
download link : https://www.dropbox.com/s/a8ug16pfkvv1bzp/Cardiorenal%20syndrome.ppt?m
Join us on our facebook group: NephroTube...............Follow our blog: www.nephrotube.blogspot.com
Heart failure, also known as cardiac decompensation or cardiac insufficiency, occurs when the heart is unable to pump enough blood to meet the body's needs. It can be caused by conditions that impair the heart muscle's ability to contract effectively or limit ventricular filling. Symptoms vary depending on whether the left or right ventricle is primarily affected and include dyspnea, fatigue, edema and others. Diagnostic tests may include echocardiography, ECG, chest x-ray and BNP level. Treatment focuses on managing symptoms, slowing disease progression, and preventing hospitalizations through lifestyle changes and medication.
Congestive cardiac failure (CHF) refers to systemic and pulmonary congestion resulting from the heart's inability to pump enough blood for the body's needs. It has multiple causes in infants and children, including structural heart defects, arrhythmias, infections, and cardiomyopathies. Presentation depends on the degree of cardiac reserve but includes symptoms like tachypnea, tachycardia, poor feeding, and hepatomegaly. Diagnosis involves history, physical exam, chest x-ray, ECG, echocardiogram and other tests. Treatment focuses on correcting underlying causes, managing precipitants, and controlling heart failure through diuretics, inotropic drugs, afterload reducers, and other
The document discusses several common acute complications that can occur during hemodialysis treatments. It notes that hypotension occurs in 25-55% of patients and is the most frequent complication. Other common complications include muscle cramps (5-20% of patients), nausea/vomiting (5-15%), chest pain (2-5%), and back pain (2-5%). The document provides details on the causes, risk factors, prevention, and treatment of these complications, particularly hypotension and muscle cramps. It also discusses less common but potentially life-threatening issues like dialysis disequilibrium syndrome, air embolism, and seizures.
This document discusses heart failure, including causes, symptoms, classifications, treatment options and guidelines. It covers systolic and diastolic heart failure, risk factors, physical findings, NYHA functional classes, medications like ACE inhibitors, beta blockers, ARBs and more. It also discusses device options, special populations like African Americans, and the cardio-renal syndrome.
This document provides information on cardiac heart failure, including its definition, epidemiology, etiology, pathophysiology, types, signs and symptoms, diagnostic tests, treatment goals, and management approaches. Some key points:
- Heart failure is a clinical syndrome where the heart cannot pump enough blood to meet the body's needs due to problems with ventricular filling or contractility.
- Common causes include ischemic heart disease, cardiomyopathy, hypertension, and valvular disease.
- Treatment aims to improve oxygenation, reduce cardiac workload, and enhance contractility through diuretics, vasodilators, beta-blockers, and other drugs, as well as lifestyle modifications.
- Management requires a multif
The document discusses various types of cardiomyopathies including dilated cardiomyopathy (DCM), hypertrophic cardiomyopathy (HCM), and restrictive cardiomyopathy (RCM). It provides details on the definition, causes, symptoms, diagnostic criteria and treatment options for each type. DCM is the most common cardiomyopathy, usually caused by idiopathic or viral factors, leading to ventricular dilation and dysfunction. HCM is a genetic disease causing left ventricular hypertrophy that can lead to obstruction of blood flow. RCM involves restrictive filling of the ventricles with normal wall thickness.
This document defines cardiac failure and heart failure, describes the types and causes, and discusses the pathophysiology, clinical features, investigations, and treatment. Heart failure is a clinical syndrome where the heart cannot pump enough blood to meet the body's needs, or can only do so with elevated filling pressures. It can be systolic or diastolic in nature. Common causes include ischemic heart disease, cardiomyopathy, valvular disease, and hypertension. Symptoms include breathlessness, fatigue, and fluid retention. Echocardiography, biomarkers like BNP, and cardiac imaging are used in diagnosis and assessment. Treatment aims to relieve symptoms, improve quality of life, and reduce mortality through medications, device therapies, and lifestyle changes.
The document discusses congestive heart failure (CHF), including its pathophysiology, recent advances in management, and therapeutic approaches. It describes how CHF results from the heart's inability to pump enough blood to meet the body's needs. Over time, compensatory mechanisms like increased neurohormonal activity can damage the heart further. Treatment aims to alleviate symptoms, improve quality of life, and decrease mortality through a combination of lifestyle changes, medications, and devices.
1. Heart failure is the inability of the heart to pump sufficient blood to meet the tissues' needs for oxygen and nutrients.
2. It can be caused by mechanical abnormalities of the heart, myocardial abnormalities, or altered cardiac rhythm/conduction disturbances.
3. Symptoms of heart failure depend on whether the left or right side of the heart is affected and include shortness of breath, edema, fatigue, cough, and liver/spleen enlargement.
1. Heart failure is the inability of the heart to pump sufficient blood to meet the tissues' needs for oxygen and nutrients.
2. It can be caused by mechanical abnormalities of the heart, myocardial abnormalities, or altered cardiac rhythm/conduction disturbances.
3. Symptoms of heart failure depend on whether the left or right side of the heart is affected and include shortness of breath, edema, fatigue, cough, and liver/spleen enlargement.
The term ischemic heart disease (IHD) describes a group of clinical syndromes characterized by myocardial ischemia, an imbalance between myocardial blood supply and demand.
Because the fundamental pathophysiologic defect in the ischemic myocardium is inadequate perfusion, ischemia is associated not only with insufficient oxygen supply, but also with reduced availability of nutrients and inadequate removal of metabolic end products.
Ischemic heart disease (IHD) caused by atherosclerosis of the epicardial vessels leading to coronary heart disease (CHD) is the main etiology of IHD.
Leading cause of death
Resulting from myocardial ischemia—an imbalance between the supply (perfusion) and demand of the heart for oxygenated blood.
90% of cases, the cause of myocardial ischemia is reduced blood flow due to obstructive atherosclerotic lesions in the coronary arteries.
IHD is often termed coronary artery disease (CAD) or coronary heart disease.
There is a long period (up to decades) of silent, slow progression of coronary lesions before symptoms appear.
IHD are only the late manifestations of coronary atherosclerosis that may have started during childhood or adolescence
Myocardial infarction, the most important form of IHD, in which ischemia causes the death of heart muscle.
Angina pectoris, in which the ischemia is of insufficient severity to cause infarction, but may be a harbinger of MI.
Chronic IHD with heart failure.
Sudden cardiac death.
The dominant cause of the IHD syndromes is insufficient coronary perfusion relative to myocardial demand, due to • Chronic, progressive atherosclerotic narrowing of the epicardial coronary arteries, and • Variable degrees of superimposed acute plaque change, thrombosis, and vasospasm
Clinical manifestations of coronary atherosclerosis are generally due to • Progressive narrowing of the lumen leading to stenosis (“fixed” obstructions) or • Acute plaque disruption with thrombosis, both of which compromise blood flow.
A fixed lesion obstructing 75% or greater of the lumen is generally required to cause symptomatic ischemia precipitated by exercise (most often manifested as chest pain, known as angina)
Obstruction of 90% of the lumen can lead to inadequate coronary blood flow even at rest.
This document discusses dilated cardiomyopathy (DCM), the most common type of cardiomyopathy. It provides details on:
1) The causes, symptoms, signs, diagnostic tests and goals of treatment for DCM. The mainstay of therapy includes vasodilators, digoxin and diuretics.
2) The morphological and microscopic features of DCM which involve enlargement and spherical dilation of the heart chambers.
3) Disease progression can lead to marked left ventricular dilatation and circulatory failure if left untreated. Management aims to relieve symptoms and slow progression.
Hypersensitive drug reaction in children.pptxSabonaLemessa2
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a potentially life-threatening adverse drug reaction characterized by a rash, hematologic abnormalities including eosinophilia and atypical lymphocytes, lymphadenopathy, and involvement of internal organs. It has a long latency of 2-8 weeks between drug exposure and onset. Common culprit drugs include anticonvulsants, allopurinol, and sulfonamides. The pathogenesis involves an interplay of genetic susceptibility, virus reactivation, and immune responses. Diagnosis is based on clinical presentation along with supportive lab findings and exclusion of other conditions.
This document discusses renal replacement therapy (RRT) in children, including peritoneal dialysis (PD). It provides an overview of indications for RRT, including refractory fluid overload, severe hyperkalemia, signs of uremia, severe metabolic acidosis, and certain drug intoxications. Modalities of RRT discussed include PD, intermittent hemodialysis, and continuous renal replacement therapy. PD is described as exchanging solutes and water between the blood and peritoneal membrane using a dialysis solution. Advantages of PD include being simple to perform and not requiring anticoagulation, while disadvantages include slow removal and unreliable ultrafiltration.
This document provides an overview of congestive cardiac failure presented by Shivani S. Shrivastava. It defines congestive cardiac failure, discusses its etiology and risk factors such as abnormal loading conditions and muscle function. It also examines the anatomy, physiology, pathophysiology, clinical manifestations, diagnostic evaluation, medical and surgical management, nursing management, and complications of congestive cardiac failure. Current trends discussed include the inability of the adult heart to regenerate and the potential of regenerative approaches for heart failure treatment.
Congestive heart failure (CHF) is a clinical syndrome where the heart is unable to pump enough blood to meet the body's demands. It is a major public health problem and most common in the elderly. CHF results from conditions that increase the heart's workload like valvular diseases or decrease the heart's ability to contract effectively from issues such as a myocardial infarction. As the heart fails to meet circulatory demands, compensatory mechanisms activate but eventually fail, leading to symptoms of fluid overload and organ congestion. Treatment involves controlling symptoms with medications that lower preload and afterload on the heart like diuretics, ACE inhibitors, and beta blockers as well as addressing any underlying causes of heart muscle dysfunction.
Heart failure is a condition where the heart cannot pump enough blood to meet the body's needs. It affects over 5 million Americans. The prevalence increases with age, reaching nearly 10% in those over 80. Symptoms include fatigue, shortness of breath, swelling, and more. Treatment focuses on reducing cardiac workload through diuretics, beta blockers, ACE inhibitors, and other drugs. Device therapies like CRT can also help certain patients. Lifestyle changes and strict medication adherence are important for managing the condition.
The document discusses congestive cardiac failure (heart failure) and its management. It provides details on:
- The high prevalence and mortality of heart failure.
- Current medical therapies including ACE inhibitors, beta-blockers, and aldosterone antagonists that have been shown to improve survival.
- Device therapies like cardiac resynchronization therapy and implantable cardioverter defibrillators that treat symptoms and reduce mortality.
- The benefits of multidisciplinary and integrated care approaches including telehealth monitoring in improving outcomes for heart failure patients.
This document summarizes management of congestive cardiac failure. It discusses current medical therapies including ACE inhibitors, beta blockers, and aldosterone antagonists which have been shown to improve survival. Device therapies like biventricular pacing and implantable cardioverter defibrillators are also used to treat heart failure and reduce mortality and sudden death. Lifestyle modifications and multidisciplinary management in the community can further benefit patients.
download link : https://www.dropbox.com/s/a8ug16pfkvv1bzp/Cardiorenal%20syndrome.ppt?m
Join us on our facebook group: NephroTube...............Follow our blog: www.nephrotube.blogspot.com
Heart failure, also known as cardiac decompensation or cardiac insufficiency, occurs when the heart is unable to pump enough blood to meet the body's needs. It can be caused by conditions that impair the heart muscle's ability to contract effectively or limit ventricular filling. Symptoms vary depending on whether the left or right ventricle is primarily affected and include dyspnea, fatigue, edema and others. Diagnostic tests may include echocardiography, ECG, chest x-ray and BNP level. Treatment focuses on managing symptoms, slowing disease progression, and preventing hospitalizations through lifestyle changes and medication.
Congestive cardiac failure (CHF) refers to systemic and pulmonary congestion resulting from the heart's inability to pump enough blood for the body's needs. It has multiple causes in infants and children, including structural heart defects, arrhythmias, infections, and cardiomyopathies. Presentation depends on the degree of cardiac reserve but includes symptoms like tachypnea, tachycardia, poor feeding, and hepatomegaly. Diagnosis involves history, physical exam, chest x-ray, ECG, echocardiogram and other tests. Treatment focuses on correcting underlying causes, managing precipitants, and controlling heart failure through diuretics, inotropic drugs, afterload reducers, and other
The document discusses several common acute complications that can occur during hemodialysis treatments. It notes that hypotension occurs in 25-55% of patients and is the most frequent complication. Other common complications include muscle cramps (5-20% of patients), nausea/vomiting (5-15%), chest pain (2-5%), and back pain (2-5%). The document provides details on the causes, risk factors, prevention, and treatment of these complications, particularly hypotension and muscle cramps. It also discusses less common but potentially life-threatening issues like dialysis disequilibrium syndrome, air embolism, and seizures.
This document discusses heart failure, including causes, symptoms, classifications, treatment options and guidelines. It covers systolic and diastolic heart failure, risk factors, physical findings, NYHA functional classes, medications like ACE inhibitors, beta blockers, ARBs and more. It also discusses device options, special populations like African Americans, and the cardio-renal syndrome.
This document provides information on cardiac heart failure, including its definition, epidemiology, etiology, pathophysiology, types, signs and symptoms, diagnostic tests, treatment goals, and management approaches. Some key points:
- Heart failure is a clinical syndrome where the heart cannot pump enough blood to meet the body's needs due to problems with ventricular filling or contractility.
- Common causes include ischemic heart disease, cardiomyopathy, hypertension, and valvular disease.
- Treatment aims to improve oxygenation, reduce cardiac workload, and enhance contractility through diuretics, vasodilators, beta-blockers, and other drugs, as well as lifestyle modifications.
- Management requires a multif
The document discusses various types of cardiomyopathies including dilated cardiomyopathy (DCM), hypertrophic cardiomyopathy (HCM), and restrictive cardiomyopathy (RCM). It provides details on the definition, causes, symptoms, diagnostic criteria and treatment options for each type. DCM is the most common cardiomyopathy, usually caused by idiopathic or viral factors, leading to ventricular dilation and dysfunction. HCM is a genetic disease causing left ventricular hypertrophy that can lead to obstruction of blood flow. RCM involves restrictive filling of the ventricles with normal wall thickness.
This document defines cardiac failure and heart failure, describes the types and causes, and discusses the pathophysiology, clinical features, investigations, and treatment. Heart failure is a clinical syndrome where the heart cannot pump enough blood to meet the body's needs, or can only do so with elevated filling pressures. It can be systolic or diastolic in nature. Common causes include ischemic heart disease, cardiomyopathy, valvular disease, and hypertension. Symptoms include breathlessness, fatigue, and fluid retention. Echocardiography, biomarkers like BNP, and cardiac imaging are used in diagnosis and assessment. Treatment aims to relieve symptoms, improve quality of life, and reduce mortality through medications, device therapies, and lifestyle changes.
The document discusses congestive heart failure (CHF), including its pathophysiology, recent advances in management, and therapeutic approaches. It describes how CHF results from the heart's inability to pump enough blood to meet the body's needs. Over time, compensatory mechanisms like increased neurohormonal activity can damage the heart further. Treatment aims to alleviate symptoms, improve quality of life, and decrease mortality through a combination of lifestyle changes, medications, and devices.
1. Heart failure is the inability of the heart to pump sufficient blood to meet the tissues' needs for oxygen and nutrients.
2. It can be caused by mechanical abnormalities of the heart, myocardial abnormalities, or altered cardiac rhythm/conduction disturbances.
3. Symptoms of heart failure depend on whether the left or right side of the heart is affected and include shortness of breath, edema, fatigue, cough, and liver/spleen enlargement.
1. Heart failure is the inability of the heart to pump sufficient blood to meet the tissues' needs for oxygen and nutrients.
2. It can be caused by mechanical abnormalities of the heart, myocardial abnormalities, or altered cardiac rhythm/conduction disturbances.
3. Symptoms of heart failure depend on whether the left or right side of the heart is affected and include shortness of breath, edema, fatigue, cough, and liver/spleen enlargement.
The term ischemic heart disease (IHD) describes a group of clinical syndromes characterized by myocardial ischemia, an imbalance between myocardial blood supply and demand.
Because the fundamental pathophysiologic defect in the ischemic myocardium is inadequate perfusion, ischemia is associated not only with insufficient oxygen supply, but also with reduced availability of nutrients and inadequate removal of metabolic end products.
Ischemic heart disease (IHD) caused by atherosclerosis of the epicardial vessels leading to coronary heart disease (CHD) is the main etiology of IHD.
Leading cause of death
Resulting from myocardial ischemia—an imbalance between the supply (perfusion) and demand of the heart for oxygenated blood.
90% of cases, the cause of myocardial ischemia is reduced blood flow due to obstructive atherosclerotic lesions in the coronary arteries.
IHD is often termed coronary artery disease (CAD) or coronary heart disease.
There is a long period (up to decades) of silent, slow progression of coronary lesions before symptoms appear.
IHD are only the late manifestations of coronary atherosclerosis that may have started during childhood or adolescence
Myocardial infarction, the most important form of IHD, in which ischemia causes the death of heart muscle.
Angina pectoris, in which the ischemia is of insufficient severity to cause infarction, but may be a harbinger of MI.
Chronic IHD with heart failure.
Sudden cardiac death.
The dominant cause of the IHD syndromes is insufficient coronary perfusion relative to myocardial demand, due to • Chronic, progressive atherosclerotic narrowing of the epicardial coronary arteries, and • Variable degrees of superimposed acute plaque change, thrombosis, and vasospasm
Clinical manifestations of coronary atherosclerosis are generally due to • Progressive narrowing of the lumen leading to stenosis (“fixed” obstructions) or • Acute plaque disruption with thrombosis, both of which compromise blood flow.
A fixed lesion obstructing 75% or greater of the lumen is generally required to cause symptomatic ischemia precipitated by exercise (most often manifested as chest pain, known as angina)
Obstruction of 90% of the lumen can lead to inadequate coronary blood flow even at rest.
This document discusses dilated cardiomyopathy (DCM), the most common type of cardiomyopathy. It provides details on:
1) The causes, symptoms, signs, diagnostic tests and goals of treatment for DCM. The mainstay of therapy includes vasodilators, digoxin and diuretics.
2) The morphological and microscopic features of DCM which involve enlargement and spherical dilation of the heart chambers.
3) Disease progression can lead to marked left ventricular dilatation and circulatory failure if left untreated. Management aims to relieve symptoms and slow progression.
Hypersensitive drug reaction in children.pptxSabonaLemessa2
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a potentially life-threatening adverse drug reaction characterized by a rash, hematologic abnormalities including eosinophilia and atypical lymphocytes, lymphadenopathy, and involvement of internal organs. It has a long latency of 2-8 weeks between drug exposure and onset. Common culprit drugs include anticonvulsants, allopurinol, and sulfonamides. The pathogenesis involves an interplay of genetic susceptibility, virus reactivation, and immune responses. Diagnosis is based on clinical presentation along with supportive lab findings and exclusion of other conditions.
This document discusses renal replacement therapy (RRT) in children, including peritoneal dialysis (PD). It provides an overview of indications for RRT, including refractory fluid overload, severe hyperkalemia, signs of uremia, severe metabolic acidosis, and certain drug intoxications. Modalities of RRT discussed include PD, intermittent hemodialysis, and continuous renal replacement therapy. PD is described as exchanging solutes and water between the blood and peritoneal membrane using a dialysis solution. Advantages of PD include being simple to perform and not requiring anticoagulation, while disadvantages include slow removal and unreliable ultrafiltration.
This document provides an overview of pulmonary edema in children, including definitions, classifications, pathogenesis, clinical manifestations, diagnosis, management, and prognosis. Pulmonary edema can be cardiogenic, caused by elevated pressures in the heart, or non-cardiogenic (ARDS). Common causes in children include pneumonia, sepsis, and congestive heart failure. Symptoms include fast breathing and cough. Chest x-rays and BNP levels help diagnose the type. Treatment focuses on oxygen, ventilation if needed, and addressing the underlying cause such as using diuretics, vasodilators, and inotropes for cardiogenic edema. Outcomes depend on the severity of the primary condition but ARDS mortality can be over 50% without treatment.
This document provides an overview of autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) in children. It defines ASD and outlines its diagnostic criteria, including persistent deficits in social communication/interaction and restricted/repetitive behaviors. Risk factors for ASD are discussed, such as genetic factors, maternal health conditions, and advanced parental age. The document also reviews ASD prevalence, onset patterns, co-occurring conditions, and treatment options.
This document discusses a case of infective endocarditis in a 6-year-old female child presenting with fatigue, joint pain, fast breathing, and other symptoms. After examination and testing, vegetative mass was discovered on the septal tricuspid valve. The child was diagnosed with tricuspid valve infective endocarditis. The document then provides definitions, classifications, clinical features, diagnostic criteria, management guidelines, and complications of infective endocarditis in children. It emphasizes the importance of blood cultures, echocardiography, and long-term antibiotic treatment along with monitoring for complications like embolism.
The document discusses child maltreatment, including definitions, classifications, signs and prevalence. It defines child maltreatment as any physical or emotional ill-treatment, sexual abuse, neglect or exploitation that results in actual or potential harm. The main types are physical abuse, neglect, sexual abuse and emotional abuse. Signs include injuries, developmental delays, behavioral changes, and sexualized behaviors. Studies show high rates of physical punishment and sexual abuse of children in Ethiopia. The document calls for prohibiting corporal punishment and strengthening child protection laws.
This document outlines guidelines for pain and sedation management in the pediatric intensive care unit (PICU). It defines pain and its classification, and discusses the causes of pain in the ICU and its effects. Assessment tools for pain and sedation are described. The goals of sedation are discussed as well as principles for management including use of analgesics, opioids, and prevention of withdrawal syndrome. Challenges around delirium and sleep disruption in the PICU are also covered.
The document provides information about nephrotic syndrome in children, including:
- A case presentation of a 2-year-old male toddler with nephrotic syndrome presenting with fever, cough, facial swelling, decreased urine output, and hypoalbuminemia.
- Definitions of nephrotic syndrome as characterized by massive proteinuria, hypoalbuminemia, edema, and hyperlipidemia. The most common cause is idiopathic nephrotic syndrome.
- Histologic classifications of nephrotic syndrome including minimal change disease, focal segmental glomerulosclerosis, mesangial proliferative glomerulonephritis, and membranoproliferative
Approach to Lymphadenopathy in children.pptxSabonaLemessa2
This document provides an overview of lymphadenopathy in children. It defines lymphadenopathy and classifies primary and secondary lymphoid tissues. Common causes of generalized lymphadenopathy in infants, children and adolescents are discussed. The diagnostic approach involves taking a thorough history, physical exam, and testing based on concerning symptoms. Localized adenopathy is typically first treated with a trial of antibiotics. Biopsy is indicated if nodes persist or worsen despite treatment or show worrying characteristics. Management depends on the underlying diagnosis.
This document provides an overview of acute renal failure (ARF) in children. It defines ARF as a sudden deterioration in renal function resulting in the inability to maintain fluid and electrolyte homeostasis. The causes of ARF are classified as prerenal, intrinsic renal, or postrenal. Prerenal ARF is due to decreased renal perfusion, intrinsic ARF involves direct kidney damage, and postrenal ARF results from urinary tract obstruction. Clinical presentation, evaluation, and management of ARF in children are discussed with a focus on fluid management, electrolyte control, and renal replacement therapy when needed. ARF in neonates is also reviewed.
Nutrition support in critically ill children.pptxSabonaLemessa2
This document discusses nutrition support in critically ill children. It outlines the importance of proper nutrition for critically ill children and some of the risks of undernutrition or overnutrition. Specific conditions discussed include refeeding syndrome, hypercatabolism, obesity, and metabolic responses to critical illness. The document also covers nutritional assessment of critically ill children and management of their nutrition through monitoring of fluid, energy, electrolyte, carbohydrate, and fat intake. Accurately estimating caloric needs and avoiding overfeeding or underfeeding are emphasized.
This document discusses perinatal asphyxia and hypoxic-ischemic encephalopathy. It begins by defining key terms like hypoxia, anoxia, ischemia and the perinatal period. It then describes the objectives, epidemiology, etiologies, risk factors, pathophysiology, neuropathology, clinical manifestations, diagnosis and management of perinatal asphyxia. Specifically, it notes the incidence is higher in developing countries, most cases are caused by placental insufficiency, and management involves supportive care, temperature control, ventilation, fluid management and seizure control.
This document provides an overview of upper airway obstruction (UAO) in children. It discusses the definition and causes of UAO, as well as specific conditions that can cause acute UAO like croup, epiglottitis, and bacterial tracheitis. For each condition, it describes characteristics, risk factors, symptoms, diagnosis, and management approaches. The document is intended to educate medical professionals about pediatric UAO and guide them in appropriately diagnosing and treating the underlying conditions.
Neonatal Jaundice and Hyperbilirubinemia.pptxSabonaLemessa2
This document discusses neonatal jaundice. It begins with definitions of terms like hyperbilirubinemia and jaundice. It then covers the physiology of bilirubin metabolism. The document outlines the etiologies and types of hyperbilirubinemia, including physiologic jaundice and breast milk jaundice. Risk factors, evaluation, and management approaches are reviewed. Potentially preventable causes of kernicterus are listed. Clinical manifestations of acute bilirubin encephalopathy are described.
Computer in pharmaceutical research and development-Mpharm(Pharmaceutics)MuskanShingari
Statistics- Statistics is the science of collecting, organizing, presenting, analyzing and interpreting numerical data to assist in making more effective decisions.
A statistics is a measure which is used to estimate the population parameter
Parameters-It is used to describe the properties of an entire population.
Examples-Measures of central tendency Dispersion, Variance, Standard Deviation (SD), Absolute Error, Mean Absolute Error (MAE), Eigen Value
The biomechanics of running involves the study of the mechanical principles underlying running movements. It includes the analysis of the running gait cycle, which consists of the stance phase (foot contact to push-off) and the swing phase (foot lift-off to next contact). Key aspects include kinematics (joint angles and movements, stride length and frequency) and kinetics (forces involved in running, including ground reaction and muscle forces). Understanding these factors helps in improving running performance, optimizing technique, and preventing injuries.
Are you looking for a long-lasting solution to your missing tooth?
Dental implants are the most common type of method for replacing the missing tooth. Unlike dentures or bridges, implants are surgically placed in the jawbone. In layman’s terms, a dental implant is similar to the natural root of the tooth. It offers a stable foundation for the artificial tooth giving it the look, feel, and function similar to the natural tooth.
Giloy in Ayurveda - Classical Categorization and SynonymsPlanet Ayurveda
Giloy, also known as Guduchi or Amrita in classical Ayurvedic texts, is a revered herb renowned for its myriad health benefits. It is categorized as a Rasayana, meaning it has rejuvenating properties that enhance vitality and longevity. Giloy is celebrated for its ability to boost the immune system, detoxify the body, and promote overall wellness. Its anti-inflammatory, antipyretic, and antioxidant properties make it a staple in managing conditions like fever, diabetes, and stress. The versatility and efficacy of Giloy in supporting health naturally highlight its importance in Ayurveda. At Planet Ayurveda, we provide a comprehensive range of health services and 100% herbal supplements that harness the power of natural ingredients like Giloy. Our products are globally available and affordable, ensuring that everyone can benefit from the ancient wisdom of Ayurveda. If you or your loved ones are dealing with health issues, contact Planet Ayurveda at 01725214040 to book an online video consultation with our professional doctors. Let us help you achieve optimal health and wellness naturally.
Osvaldo Bernardo Muchanga-GASTROINTESTINAL INFECTIONS AND GASTRITIS-2024.pdfOsvaldo Bernardo Muchanga
GASTROINTESTINAL INFECTIONS AND GASTRITIS
Osvaldo Bernardo Muchanga
Gastrointestinal Infections
GASTROINTESTINAL INFECTIONS result from the ingestion of pathogens that cause infections at the level of this tract, generally being transmitted by food, water and hands contaminated by microorganisms such as E. coli, Salmonella, Shigella, Vibrio cholerae, Campylobacter, Staphylococcus, Rotavirus among others that are generally contained in feces, thus configuring a FECAL-ORAL type of transmission.
Among the factors that lead to the occurrence of gastrointestinal infections are the hygienic and sanitary deficiencies that characterize our markets and other places where raw or cooked food is sold, poor environmental sanitation in communities, deficiencies in water treatment (or in the process of its plumbing), risky hygienic-sanitary habits (not washing hands after major and/or minor needs), among others.
These are generally consequences (signs and symptoms) resulting from gastrointestinal infections: diarrhea, vomiting, fever and malaise, among others.
The treatment consists of replacing lost liquids and electrolytes (drinking drinking water and other recommended liquids, including consumption of juicy fruits such as papayas, apples, pears, among others that contain water in their composition).
To prevent this, it is necessary to promote health education, improve the hygienic-sanitary conditions of markets and communities in general as a way of promoting, preserving and prolonging PUBLIC HEALTH.
Gastritis and Gastric Health
Gastric Health is one of the most relevant concerns in human health, with gastrointestinal infections being among the main illnesses that affect humans.
Among gastric problems, we have GASTRITIS AND GASTRIC ULCERS as the main public health problems. Gastritis and gastric ulcers normally result from inflammation and corrosion of the walls of the stomach (gastric mucosa) and are generally associated (caused) by the bacterium Helicobacter pylor, which, according to the literature, this bacterium settles on these walls (of the stomach) and starts to release urease that ends up altering the normal pH of the stomach (acid), which leads to inflammation and corrosion of the mucous membranes and consequent gastritis or ulcers, respectively.
In addition to bacterial infections, gastritis and gastric ulcers are associated with several factors, with emphasis on prolonged fasting, chemical substances including drugs, alcohol, foods with strong seasonings including chilli, which ends up causing inflammation of the stomach walls and/or corrosion. of the same, resulting in the appearance of wounds and consequent gastritis or ulcers, respectively.
Among patients with gastritis and/or ulcers, one of the dilemmas is associated with the foods to consume in order to minimize the sensation of pain and discomfort.
Debunking Nutrition Myths: Separating Fact from Fiction"AlexandraDiaz101
In a world overflowing with diet trends and conflicting nutrition advice, it’s easy to get lost in misinformation. This article cuts through the noise to debunk common nutrition myths that may be sabotaging your health goals. From the truth about carbohydrates and fats to the real effects of sugar and artificial sweeteners, we break down what science actually says. Equip yourself with knowledge to make informed decisions about your diet, and learn how to navigate the complexities of modern nutrition with confidence. Say goodbye to food confusion and hello to a healthier you!
Summer is a time for fun in the sun, but the heat and humidity can also wreak havoc on your skin. From itchy rashes to unwanted pigmentation, several skin conditions become more prevalent during these warmer months.
STUDIES IN SUPPORT OF SPECIAL POPULATIONS: GERIATRICS E7shruti jagirdar
Unit 4: MRA 103T Regulatory affairs
This guideline is directed principally toward new Molecular Entities that are
likely to have significant use in the elderly, either because the disease intended
to be treated is characteristically a disease of aging ( e.g., Alzheimer's disease) or
because the population to be treated is known to include substantial numbers of
geriatric patients (e.g., hypertension).
Travel vaccination in Manchester offers comprehensive immunization services for individuals planning international trips. Expert healthcare providers administer vaccines tailored to your destination, ensuring you stay protected against various diseases. Conveniently located clinics and flexible appointment options make it easy to get the necessary shots before your journey. Stay healthy and travel with confidence by getting vaccinated in Manchester. Visit us: www.nxhealthcare.co.uk
Breast cancer: Post menopausal endocrine therapyDr. Sumit KUMAR
Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
Nutritional deficiency Disorder are problems in india.
It is very important to learn about Indian child's nutritional parameters as well the Disease related to alteration in their Nutrition.
3. Definition
Heart failure is a clinical syndrome in which the heart
unable to pump enough blood to the body to meet its needs
to dispose of systemic or pulmonary circulation or
venous return adequately or a combination of the two.
accompanied by molecular abnormalities
cause progressive deterioration of the failing heart
premature myocardial cell death
8/12/2022 3
4. Cont..
It is a clinical condition that results from
Ventricular dysfunction
volume or pressure overload alone or
in combination
Typical symptoms and signs associated with specific circulatory,
neurohormonal and molecular abnormalities.
systolic HF” with reduced ejection fraction, Systolic dysfunction
Diastolic HF with preserved systolic function, poor relaxation
combined systolic and diastolic HF
8/12/2022 4
5. Pathophysiology of Heart Failure
HF may be viewed as a progressive disorder that is initiated after an index event
either;
Damages the heart muscle
loss of functioning cardiac myocytes or
Disruption of the ability of the myocardium to generate force
preventing the heart from contracting normally.
8/12/2022 5
6. Cont…
In HF, low cardiac output leads to reduced baroreceptor stimulation,
sensed by baroreceptors in the left ventricle, aortic arch, carotid sinus,
and renal afferent arterioles
Activation of the sympathetic nervous system
Increases heart rate and cardiac contractility
vasoconstriction.
These mechanisms provide helpful support for the heart as a transitory
compensation when the myocardium starts to fails.
8/12/2022 6
7. Cont…
Chronically increased sympathetic stimulation can have deleterious effects
Hypermetabolism
increased afterload
Arrhythmogenesis and
increased myocardial oxygen requirements.
Peripheral vasoconstriction
decreased renal, hepatic and GIT function.
Decreased blood flow to hypertrophied heart muscle
direct myocardial cell damage.
promotes myocardial fibrosis which is maladaptive response.
8/12/2022 7
8. Cont…
8/12/2022 8
Frank-Starling principle
CO=SV x HR
LVED increase CO increase but
when maximum reached, no
augmentation
pulmonary or systemic venous
congestion
induce neurohormonal responses
9. Cont…
Fig-2 Pathophysiology of chronic Heart Failure
8/12/2022 9
Dec CO
Dec arterial pressure
Dec pulse pressure
Modify carotid and
aortic BR discharge
13. Clinical Features
The clinical picture of HF is directly related to age
Symptoms of HF depend upon whether there is congestion due to chronic right HF or
hypo-perfusion due to acute left HF.
8/12/2022 13
15. Stages of heart failure in infants and children
Stage A
patients who are at high risk for HF
Cardio toxic chemotherapeutic agents
CKD requiring dialysis
Stage B
Patients with abnormal cardiac morphology or cardiac function
no symptoms of HF, past or present
8/12/2022 15
16. Cont…
Stage C
Patients with functional heart disease with prior or current symptoms of heart
failure
goals of therapy are to provide symptomatic relief and limit progression of the
disease.
Stage D
Symptomatic HF that is refractory to optimized oral therapies
characterized by frequent hospitalizations for fluid overload or low cardiac
output
Has comorbidities such as anemia, renal impairment and hyponatremia
long-term survival requires cardiac transplant and/or mechanical circulatory
support (MCS)
8/12/2022 16
17. Table-3 Stages of heart failure in infants and children
Stage Definition Example
A Patients with increased risk of developing HF
normal cardiac function and chamber size
Exposure to cardiotoxic agents,
family history of heritable cardiomyopathy,
univentricular heart, congenitally corrected
transposition of the great arteries
B Patients with abnormal cardiac morphology
or function, with no symptoms of HF, past or
present
Aortic insufficiency with LV enlargement,
history of anthracycline exposure with decreased
LV systolic function
C Patients with structural or functional heart
disease, and past or current symptoms of HF
Symptomatic cardiomyopathy or
congenital heart defect with ventricular pump
dysfunction
D Patients with end-stage HF requiring
specialized interventions
Marked symptoms at rest despite maximal
medical therapy
8/12/2022 17
19. Management of Heart Failure
The underlying cause of cardiac failure must be removed or alleviated if
possible.
Treatment of the precipitating or contributing causes.
General Measures
bed rest
Oxygen supplementation
Fluid intake restriction to 80% of basal metabolic requirements
Nutritional support
CHF follow chart(V/s, UOP, Liver size, Daily weight…)
Medical therapy
Surgical management
8/12/2022 19
20. Nutrition in children with HF
Growth impairment caused by
Insufficient caloric intake(amino acids, carbohydrates and
lipids)
Malabsorption of the ingested calories
Causing an increase in energy expenditure of patients with the
disease
FTT and malnutrition
Increased metabolic rate
Repeated vomiting
Increased caloric requirement
8/12/2022 20
21. Nutritional support
The required calorie intakes may be as high as 150 to 160 kcal/kg/day for
infants in CHF.
In children and adolescents, current recommendations suggest that 25-30
kcal/kg/d is a reasonable target for most patients.
Human milk fortifier (Enfamil, Mead Johnson), 1 packet per 25 mL of breast milk =
24 kcal/oz
Formula concentration to 24 kcal/oz by:-
1 cup powdered formula + 3 cups water or
4 oz ready-to-feed + ½ scoop powdered formula
8/12/2022 21
25. Diuretic resistant heart failure
Braking phenomenon that occurs when the magnitude of natriuresis
following each diuretic dose declines.
1. ECF volume contraction- caused by all diuretics
Increase in filtration fraction (GFR/renal blood flow)
stimulating the vascular mechanism of renin secretion
also inhibits the secretion of atrial natriuretic peptide
fluid reabsorption in the proximal tubule
Enhances proximal solute and fluid reabsorption by decreasing the
renal interstitial pressure
2. Stimulation of efferent sympathetic nerves
reduces urinary NaCl excretion
stimulating tubule NaCl reabsorption.
8/12/2022 25
26. Cont…
3. Loop diuretics stimulate renin secretion
by inhibiting NaCl uptake into macula densa cells.
stimulates renin secretion directly
leading to a volume-independent increase in Ang II and
aldosterone secretion.
4. Diuretics increase solute delivery to distal segments
Cause epithelial cells to undergo both hypertrophy and
hyperplasia at DCT
increased reabsorption of sodium in this segment
blunting the natriuretic effect and
shifting the dose-response curve downward and to the right
8/12/2022 26
27. Treatment
noncompliance should be excluded
Restriction of sodium intake
higher doses and more frequent administration of loop diuretics
Combination therapy.
DCT diuretics to loop diuretics
Prevent or attenuate postdiuretic NaCl retention
Inhibit salt transport along the proximal tubule.
Inhibit NaCl transport along the renal distal tubule
Continuous Diuretic Infusion(furosemide 0.1-0.4mg/kg/hr)
avoid troughs of diuretic concentration
prevent postdiuretic NaCl retention.
8/12/2022 27
28. Cardiogenic Shock
Cardiac pump impairment that results in
Insufficient delivery of blood flow to tissues to meet resting
metabolic demands
Considered the most severe expression of left ventricular failure
End-organ dysfunction can mimic other forms of severe shock
Tachycardia, cold peripheral, impaired mental status, fast breathing,
cyanosis, hyperventilation due to acidosis.
Oliguria (less than 1 mL/kg/h)
Hypotension is typically a late finding.
8/12/2022 28
30. Treatment
ABC of life
Oxygen supplementation
Elevate head of bed to reduce pulmonary pooling (infant chair)
Boluses of fluid (5-10 mL/kg/hr)
To replace deficits (preload)
shouldn’t be given if there is pulmonary edema
If deteriorate restrict fluid and salt.
8/12/2022 30
31. Cont…
Positive pressure ventilation
Improve blood gas tension and
Reduce work of breathing
Reduction in afterload.
CPAP can be used
Heart transplantation
A history of repeated hospitalizations for HF
Escalation in the intensity of medical therapy
Refractory cardiogenic shock
Continued dependence on intravenous inotropes to maintain
adequate organ perfusion….
8/12/2022 31
32. Cont…
In advanced HF, ACEI therapy introduction:-
should occur after stabilization of HF symptoms with diuretic
simultaneous to inotropic support withdrawal.
Up titration can proceed safely over 3-10 days in most inpatients
Can be more gradual in outpatients.
8/12/2022 32
35. Cont…
Drugs Dose(μg/kg/min) effect advantage
Dopamine 0.5-2 Renal vasodilation NE release from cardiac adrenergic nerve endings
2-10 ↑Cardiac index
>10-20 Vasoconstriction
Dobutamine 1-20 ↑Cardiac index
Vasoconstriction
not dependent on the release of stored
norepinephrine
Milrinone Loading 10–50 μg/kg
over 10 min; then
0.1–1 μg/kg/min
↑Cardiac index
↓SVR, PVR
↓= Filling pressures
Arrhythmia, ↓BP
Epinephrine 0.05–0.3 Positive inotrope
↑HR, ↓ renal flow
↑O2 consumption
Arrhythmia
In the treatment of shock and hypotension
unresponsive to fluid resuscitation
useful in patients with accompanied bradycardia
preferable to dopamine in cases with marked
circulatory instability, particularly in
infants
Sodium
nitroprusside
0.5–10 Vasodilator Arteries
and veins
↑Cardiac index
8/12/2022 35
36. Heart failure in SAM
Has a reduced output and impaired contractility
Results from-
Electrolyte disturbance like Hypokalemia, Hypomagnesiumia
Selenium deficiency- degeneration and necrosis of cardiac muscle,
necrotizing cardiomyopathy
Anemia
Infection
Fluid overload
Treatment complication
8/12/2022 36
37. Cont…
DIAGNOSIS
Physical deterioration with weight gain, sudden increase in liver size,
tenderness of the liver
Increased respiratory rate, ‘grunting’ breathing, crepitation in lungs,
prominent superficial and
Increased edema or reappearance of edema.
When weight gain precedes or is associated with signs of respiratory distress,
heart failure should be the first than pneumonia.
8/12/2022 37
38. Treatment
Stop all intake of oral or IV fluids.
No fluid or food should be given until heart failure has improved (even if
this takes 24 to 48 hrs)
Small amounts of sugar-water can be given orally to prevent hypoglycemia
Give Furosemide (1 mg/kg) single dose, repeat if necessary
If it is due to severe anemia, manage accordingly.
8/12/2022 38
41. Reference
Joseph W. Rossano, heart failure Nelson 21st edition.
Myung K. Park, MD, FAAP, FACC, park Cardiology 5th edition.
Bibhuti B. Das, Review Current State of Pediatric Heart Failure, 2018(PubMed).
Jack F. Price, Congestive Heart Failure in Children, Pediatrics in Review 2019.
Rosenthal et al, Journal of Heart and Lung Transplantation Rosenthal Volume 23,
Number 12.
CATHERINE A. LEITCH, Section of Neonatal–Perinatal Medicine, pediatric Heart
Failure, 2015.
Dr Lode De Bruyne, Department of Cardiology article review.
Paul F. Kantor & Luc L. Mertens, Heart failure in children,February, 2010
Robert E. Shaddy, Daniel J. Penny, Andersons pediatric Cardiology, 4th Edition
Kantor et al, Canadian Journal of Cardiology 29, Canadian Cardiovascular Society
Guidelines, 2013.
8/12/2022 41
Mechanical Factors
The ability of heart muscle to increase contraction in response
to stretching of its fibers was demonstrated in intact heart
preparations by Frank in 1895 (17) and by Starling in 1918
(21). They first described the relationship between ventricular
diastolic volume and pressure and stroke output. Subsequently,
the concept of the ventricular function curve was
developed to define cardiac function (19) and the important
role of sympathetic nerve stimulation in increasing cardiac
contractility was demonstrated by showing an upward shift
of the function curve (20).
When myocardial damage or disease occurs and inotropy
is impaired, increasing ventricular filling provides only a
limited increase in cardiac output and at relatively high
end-diastolic pressure, no further increase in output is
achieved. The high end-diastolic pressure results in an
increase of atrial and venous pressures. An increase in afterload
on the normal ventricle reduces stroke volume, but in the
presence of myocardial dysfunction, the reduction of stroke
volume with elevation of afterload is greatly exaggerated (21).
In congenital cardiac lesions with left-to-right shunts, an
excessive volume load is placed on the ventricle. Depending
on the lesion, the output of the left or right or both ventricles
is increased. To achieve this increased output, ventricular
end-diastolic volume and pressure are increased, based on
the Frank–Starling mechanism. Although myocardial performance
may be normal, the elevated diastolic pressure may
result in pulmonary or systemic venous congestion and may
induce neurohormonal responses (see below).
Lesions that obstruct ventricular outflow impose a pressure
load on the ventricle. The increased afterload produced
by the obstruction reduces ventricular stroke volume. In an
attempt to maintain systemic blood flow, based on the
Frank–Starling mechanism, ventricular end-diastolic pressure
is raised to increase stroke volume.
Although not as common in infants and children as in
adults, diastolic filling of the ventricle may be impaired. This
Heart Failure—A Historical Perspective 9
altered lusitropy may result from myocardial fibrosis or
marked hypertrophy, and from restraint on the ventricle from
external factors. Systolic function may be normal, but interference
with filling of the ventricle restricts stroke volume.
Ventricular diastolic volume enhancement is achieved only
by very large increases in diastolic pressure, resulting in
atrial distension and venous congestion.
The observations indicating that cardiac output is extremely
sensitive to the increased afterload in patients with
cardiac failure, and that afterload is often markedly increased
as a result of the increased sympathetic activity and the effect
of A II, introduced the concept that the reducing afterload
could decrease loading on the ventricle and possibly improve
output. Several vasodilators have been used, but inhibition
of production of A II by administering inhibitors of ACE has
been favored in recent years. Several studies in adults, using
captopril or enalapril, in addition to digitalis and diuretic
therapy, have shown symptomatic improvement and prolongation
of survival (51,52). The ACE inhibitors have also been
administered to infants and children with cardiac failure with
beneficial effect (53,54).
Although the reduction of afterload may be responsible
for the effects of ACE inhibitors, it is now evident that they
may influence the effect of A II on cardiac muscle. A II, which
is produced locally in cardiac myocytes in response to stretch,
has been shown to induce hypertrophy of myocytes, unrelated
to any general hemodynamic effect, as well as apoptosis
(55,56). A II directly stimulates fibroblasts and also increases
fibrosis in cardiac muscle (57). Restriction of A II production
by use of ACE inhibitors, or blockade of A I receptors with
losartan limits the development of cardiac hypertrophy, as
well as apoptosis and fibrosis.
Furthermore, inhibition of A II effects may not only limit
myocardial damage, but may reverse it by inducing regression
of fibrosis (58).
CARDIAC
Cardiomyopathy
Arrhythmias
Chemotherapy:
• Daunorubicin
• Doxorubicin
• Idarubicin
Female sex
Age <5 yr at time of treatment
Higher doses of chemotherapy
(≥300 mg/m2)
Higher doses of cardiac radiation
(≥30 Gy)
Combined-modality therapy with
cardiotoxic chemotherapy and
irradiation
A creatinine rise of greater than 50% over baseline value
in any patient requires a reassessment of fluid balance
and diuretic therapy, and consideration for a dosage
reduction or withdrawal of ACEi therapy
Aldosterone antagonist
SIDE EFFECT- Hyperkalemia
- painful Gynacomastia
- worsening of RF.
CONTRA Ix – Cr- > 2.5mg/dl
- serum K+ > 5.5 mmol/lit
- worsening of RFT=> STOP
Restriction of A II production
by use of ACE inhibitors, or blockade of A I receptors with
losartan limits the development of cardiac hypertrophy, as
well as apoptosis and fibrosis.
Furthermore, inhibition of A II effects may not only limit
myocardial damage, but may reverse it by inducing regression
of fibrosis (58)
Simplified decision-making in symptomatic acute decompensated heart failure management. Groups A-D correspond to those designated
in Figure 1. It is usual to admit all patients who are symptomatic at their initial presentation. Those with mild symptoms and no vomiting/
gastrointestinal symptoms might respond to oral therapy, although IV diuretics are typically required. It is usual to reserve IV inotropic/vasodilator
therapy for those who have underperfusion and volume overload. Most patients should be able to achieve oral maintenance therapy, at least on
a temporary basis. , with or without; ACEi, angiotensin-converting enzyme inhibitor; BNP, brain natriuretic peptide; EF, ejection fraction; IV,
intravenous; LV, left ventricular; NPPV, noninvasive positive pressure ventilation; RV, right ventricular.
PATHOPHYSIOLOGY
Cardiogenic shock results from an impairment of cardiac
output (CO), elevated systemic vascular resistance (SVR), orboth. Recall that cardiac output is equal to the product of
heart rate (HR) and stroke volume (SV) (Eq 1). Stroke
volume is influenced by contractility and left ventricular
filling pressure. In infants and children, cardiac output is
primarily driven by heart rate due to a lack of ventricular
muscle mass and thus a lack of improved contractility.
Elevations in SVR hinder left ventricular ejection through
increased afterload [5].
CO = HR x SV (Eq. 1)
There are four major determinants of ventricular
function: contractility, heart rate, preload, and afterload. The
Frank-Starling relationship is a series of curves detailing the
relationship between preload and ventricular function (Fig.
1). As preload increases, so then must cardiac output. At the
point when the myocytes are stretched beyond their ability to
generate increased force, ventricular function worsens. At
the extremes of impaired ventricular function, the heart
failure may result in cardiogenic shock. In the normal heart,
intracellular calcium shifts determine contractility. In the
case of decreased myocardial performance, calcium handling
is abnormal, leading to both systolic and diastolic
dysfunction.
Compensatory responses that protect the body in other
forms of shock can contribute to worsening of heart failure
by further depressing cardiac function. The body naturally
responds to a low output state by increasing systemic
vascular resistance. However, this increase in systemic
vascular resistance imparts an increase in ventricular
afterload, adding to increased cardiac work and further
decreasing function. In an effort to increase blood flow to
end-organs, the renin-angiotensin II-aldosterone pathway is
activated, thereby encouraging renal juxtaglomerular cells to
increase reabsorption of water and salt. This process furtherincreases preload and in a cardiogenic shock state,
contributes to pulmonary and peripheral edema via excessive
ventricular end diastolic volume. Another effect of decreased
cardiac output is the activation of the sympathetic nervous
system, releasing catecholamines. The immediate effect of
this in early shock is to increase heart rate, thereby
increasing cardiac output. In the long-term, however, the
vasoconstrictive properties of endogenous catecholamines
increase afterload, thereby contributing to heart failure and
further organ dysfunction.