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Fatty acids are carboxylic acids with
hydrocarbon side chain

R

COOH
Occurrence

Esterified

Free

•Esterified with various lipids
•Common
•FFA
•Blood
D/U Length of
hydrocarbon
chain

D/U Nature of
hydrocarbon
chain

Short chain FA

Saturated FA

Medium chain FA

Unsaturated FA

Long chain FA

D/U Total no of
carbon atoms

Branched chain FA

Very long chain FA

Hydroxy FA

Even chain FA

Odd chain FA
Most of the fatty acids that occur in natural
lipids are even carbons.
Seen in milk and microbial cell walls

Propionic acid
• 3 Carbon

Valeric acid
• 5 Carbon
In which hydrocarbon side chain is saturated (no double bonds).
Subclassified according to number of double bonds
Monounsaturated
FA
•One double
bond

Polyunsaturated
FA
•2 or more
double bonds
Numbering of carbon atoms in FA

Palmitic acid

Methyl end

Carboxyl end
Nomenclature of Fatty Acids

Saturated FA have both trivial names and systematic names.
Nomenclature of Fatty Acids

They have trivial names, systematic names, ω-end
names and shorthand forms.
Nomenclature of Fatty Acids

Representation of double bonds of FA

1. CSystem

2 systems

2. ω-or nSystem
1. C-System

2. ω-or n-System
ESSENTIAL FATTY ACIDS
Functions of EFA
1.Synthesis of Ecosanoids
2.Maintenance of structural
integrity of cells
3.Development of retina and brain
4.Antiatherogenic effect
Leukotrienes

Prostaglandins
Thromboxanes
EFA deficiency

The syndrome in humans characterized by
Horny eruptions on the posterior and lateral
parts of limbs, on the back and buttocks.
Phrynoderma

Dermatitis

Poor wound healing
Chemistry of lipids fatty acids (feb 2014)

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Chemistry of lipids fatty acids (feb 2014)

Editor's Notes

  1. 1) fatty acids• The simplest with structural formula of R-COOH where R = hydrocarbon chain. • They differ from each other by the length of the tail, degree of unsaturation, and position of double bonds.
  2. B. Essential Fatty AcidsAlthough most lipids required for cell structure, fuel storage, or hormone synthesiscan be synthesized from carbohydrates or proteins, we need a minimal level of cer-tain dietary lipids for optimal health. These lipids, known as essential fatty acids, arerequired in our diet because we cannot synthesize fatty acids with these particulararrangements of double bonds. The essential fatty acids -linoleic and -linolenicacid are supplied by dietary plant oils, and eicosapentaenoic acid (EPA) and docosa-hexaenoic acid (DHA) are supplied in fish oils. They are the precursors of theeicosanoids (a set of hormone-like molecules that are secreted by cells in small quan-tities and have numerous important effects on neighboring cells). The eicosanoidsinclude the prostaglandins, thromboxanes, leukotrienes, and other related compounds. C. Protein