This document discusses the process of capsule formulation and production. It involves several steps: 1) Developing and preparing the formulation and selecting the capsule size. 2) Filling the capsule shells using either a punch method by hand or automated capsule filling machines. 3) Optionally sealing the capsules using heat-welding or a liquid wetting agent. 4) Cleaning and polishing the filled capsules, either individually by hand or using an industrial cleaning apparatus.

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TOPIC NAME :
CAPUSLE
• Sumitted to:
Dr.Khizar Hayyat
Submitted By:
Zulcaif Ahmad & Saqib Hafeez
(696) (719)

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• Developing and preparing the
formulation and selecting the capsule
size
• Filling the capsule shells
• Capsule sealing(optional)
• Cleaning and polishing the filled
capsules

3. Slide 3
Developing and preparing the
formulation and selecting the
capsule size
uniform powder
Diluent or filler
Disintegrants
Lubricant or
Glidant
Wetting and
Solublizing
agent
Coating agent

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000 00 o
1 2 3
4 5

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Filling Hard Capsule Shells
Punch
method.
• When filling a small number of capsules in
the pharmacy
• takes the precise number of empty capsules
to be filled from the stock container.
Machines
• Machines developed for industrial use
automatically separate the caps from empty
capsules, fill the bodieS

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Filling Hard Capsule Shells
Punched vertically
Hold capsule between the thumb and forefinger
Mix with spatula
Powder place on a clean paper or glass or porcelain plate
Punch method
Empty capsules

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Filling Hard Capsule Shells
 Hand-operated capsule filling machines or Feton capsule filling
machine
 Consist of a couple of plates are capable of producing about
200 to 2000capsules/hr.

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OSAKA MODEL R-180
SEMI AUTOMATIC CAPSULE
FILLING MACHINE

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Capsule Sealing
• that fuses the capsule cap to the body
through the double wall thickness at
their juncture The process results in a
distinctive ring around the capsule
where heat welded.
Heat-
welding
process
• that lowers the melting point in the
contact areas of the capsule’s cap and
body and then thermally bonds the two
parts using low temperatures
Liquid
wetting
agent

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Capsule Sealing
Heat-welding
process
Fuse the cap & body
through double wall
thickness at their juncture
distinctive ring around the
capsule where heat
welded
Liquid wetting
agent
lowers the melting point in
contact areas
thermally bonds two parts
using low temperatures
(40 C–45 C).

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Cleaning and Polishing Capsules
• On a small scale, capsules
may be cleaned individually
or in small numbers by
rubbing them with a clean
gauze or cloth.
On small
Scale
• Many capsule-filling machines are
affixed with a cleaning vacuum that
removes any extraneous material
from the capsules as they exit the
equipment. industrial cleaning and
polishing of filled hard capsules
using the Accela-Cota apparatus.
On large
scale

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Cleaning and Polishing Capsules
On small scale
Cleaned individually
in small numbers
Rubbing with a clean
gauze or cloth.
On large scale
Cleaning vacuum affixed
with filling machine
cleaning and polishing by
Accela-Cota apparatus.

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CAPSULE
POLISHING
MACHINE
AUTO MATIC
CAPSULE
ARRANGEMNT

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Preparation of Soft Gelatin Capsules
Preparation of
Soft Gelatin
Capsules
Plate process
Reciprocating
die process

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Molds Filling with gelatin and
medicament on bottom plate
Second sheet of gelatin is
carefully placed on top of the
medication
Top plate of the mold is put
into place
Pressure & heat is applied to
seal the capsules
Washing

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References:-
• Pharmaceutical Dosage forms and Drug delivery
Systems, Ansel’s, Chapter 7, Page 203-214, Ninth
Edition, 2011, 2005 Wolters Kluwer / Lippincott Williams &
Wilkins.
• Martin’s physical pharmacy and pharmaceutical sciences, Patrick
J. Sinko, Chapter No.22, Page No. 580-581, Sixth Edition
2011, 2006 Lippincott Williams & Wilkins, Wolters Kluwer
Business.
• Pharmaceutical preformulation and formulation , Mark
Gibson, Page 451-453, 2004, Printed in USA, By Interpharm /
CRC.
• Pharmaceutics The design and manufacture of
Mediicines, Michael E.Aulton, Third Edition.
• Text book of Pharmaceutics, Bentley’s, Chapter 19 page 310-
314, Eight Edition, Edited by: E.A.Rawlins, Published by
A.I.T.B.S

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