This document provides information about packing soft gelatin capsules. It discusses the advantages and disadvantages of soft gel capsules. The anatomy and composition of the capsule shell and content are described. The manufacturing process involves making the gelatin mass, filling the capsules, drying and packaging them. Quality is ensured through ingredient specifications, in-process testing of shell thickness, fill weight and moisture levels. Finished products are tested for appearance, assay, content uniformity and microbiology. Vegicaps are introduced as an animal-free alternative with benefits such as being natural and free of animal derivatives.
A comprehensive interpretation of pellets based on their definitions, advantages, disadvantages, mechanism of pellet formation and growth, pelletization techniques, formulation requirements, and the equipment system for manufacture of pellets.
I Omkar B. Tipugade , M-Pharm, Sem 4th , Department of Pharmaceutics , Shree Santkrupa College Of Pharmacy, Ghogaon. Today I published the hard gelatin & Soft Gelatin Capsule in brief .
Pharmaceutical Aerosols: Definition, propellants, containers, valves, types of aerosol systems; formulation and manufacture of aerosols; Evaluation of aerosols; Quality control and stability studies
The presentation deals with a detailed study of soft gelatin capsules. this involves the production of soft gelatin capsule based on the importance of base adsorption factor and minim/gram factor. also quality control studies was also elaborated.
A comprehensive interpretation of pellets based on their definitions, advantages, disadvantages, mechanism of pellet formation and growth, pelletization techniques, formulation requirements, and the equipment system for manufacture of pellets.
I Omkar B. Tipugade , M-Pharm, Sem 4th , Department of Pharmaceutics , Shree Santkrupa College Of Pharmacy, Ghogaon. Today I published the hard gelatin & Soft Gelatin Capsule in brief .
Pharmaceutical Aerosols: Definition, propellants, containers, valves, types of aerosol systems; formulation and manufacture of aerosols; Evaluation of aerosols; Quality control and stability studies
The presentation deals with a detailed study of soft gelatin capsules. this involves the production of soft gelatin capsule based on the importance of base adsorption factor and minim/gram factor. also quality control studies was also elaborated.
University Institute of Pharmaceutical Sciences is a flag bearer of excellence in Pharmaceutical education and research in the country. Here is another initiative to make study material available to everyone worldwide. Based on the new PCI guidelines and syllabus here we have a presentation dealing with the types of parenteral formulation including the types of parenteral route for administration along withcomponents of parenteral formulation.
Thank you for reading.
Hope it was of help to you.
UIPS,PU team
University Institute of Pharmaceutical Sciences is a flag bearer of excellence in Pharmaceutical education and research in the country. Here is another initiative to make study material available to everyone worldwide. Based on the new PCI guidelines and syllabus here we have a presentation dealing with the types of containers and closure systems which are up to par with all the parameters defined by pharmacopoeias for parenterals.
Thank you for reading.
Hope it was of help to you.
UIPS,PU team
These defects can cause serious injury and harm. When this occurs, you should speak with our product liability attorneys in Denver. You may have a viable claim to file a product liability lawsuit against the negligent manufacturer.Capsules are solid dosage forms in which the drug substance is enclosed within either a hard or soft soluble shell. Generally the shells are formed from gelatin. The capsule may be regarded as “container” drug delivery system, which provides a tasteless/odorless dosage form without the need of a secondary coating step, as may be required for tablets.Capsules are one of the essential components of the pharmaceutical sector. They are mainly used to hold dry powder or little pellets of medication and are made using specific machinery and techniques. The capsule's production method entails pharmaceutically active ingredients, additives, and a cover. Every pharmaceutical business understands capsule manufacturing takes time, and the reason is the critical measures.
Hard gelatin capsules - a detailed studyTeny Thomas
The presentation involves a descriptive study on hard gelatin capsules which includes the production of the hard gelatin capsule shell, size of the capsules, capsule filling machines and the finishing techniques. The presentation also involves the special techniques of capsule formulation and the quality control tests of hard gelatin capsules
pellets can be defined as multi particulate system or multiunit system
They are spherical particulates manufactured by agglomeration of the powder granules containing drug substance and excipients.
Pellets can be prepared by a special technique called Pelletization.
This technique is referred to an agglomeration process that convert fine powder or granules of bulk drug or excipient in to small , free flowing , spherical or semi spherical pellets .
Multi particular drug delivery system especially suitable for achieving controlled delay released oral formulation with low risk of dose dumping, flexibility of blending to attain different release patterns as well as reproducible and short gastric residence time.
Multi particulate drug delivery system are mainly oral dosage form consisting of a multiplicity of small discrete units each exhibiting some desire characteristics.
In the manufacture of pharmaceuticals, encapsulation refers to a range of dosage forms—techniques used to enclose medicines—in a relatively stable shell known as a capsule, allowing them to, for example, be taken orally or be used as suppositories. The two main types of capsules are:
Hard-shelled capsules, which contain dry, powdered ingredients or miniature pellets made by e.g. processes of extrusion or spheronization. These are made in two halves: a smaller-diameter “body” that is filled and then sealed using a larger-diameter “cap”.
Soft-shelled capsules, primarily used for oils and for active ingredients that are dissolved or suspended in oil.
University Institute of Pharmaceutical Sciences is a flag bearer of excellence in Pharmaceutical education and research in the country. Here is another initiative to make study material available to everyone worldwide. Based on the new PCI guidelines and syllabus here we have a presentation dealing with the types of parenteral formulation including the types of parenteral route for administration along withcomponents of parenteral formulation.
Thank you for reading.
Hope it was of help to you.
UIPS,PU team
University Institute of Pharmaceutical Sciences is a flag bearer of excellence in Pharmaceutical education and research in the country. Here is another initiative to make study material available to everyone worldwide. Based on the new PCI guidelines and syllabus here we have a presentation dealing with the types of containers and closure systems which are up to par with all the parameters defined by pharmacopoeias for parenterals.
Thank you for reading.
Hope it was of help to you.
UIPS,PU team
These defects can cause serious injury and harm. When this occurs, you should speak with our product liability attorneys in Denver. You may have a viable claim to file a product liability lawsuit against the negligent manufacturer.Capsules are solid dosage forms in which the drug substance is enclosed within either a hard or soft soluble shell. Generally the shells are formed from gelatin. The capsule may be regarded as “container” drug delivery system, which provides a tasteless/odorless dosage form without the need of a secondary coating step, as may be required for tablets.Capsules are one of the essential components of the pharmaceutical sector. They are mainly used to hold dry powder or little pellets of medication and are made using specific machinery and techniques. The capsule's production method entails pharmaceutically active ingredients, additives, and a cover. Every pharmaceutical business understands capsule manufacturing takes time, and the reason is the critical measures.
Hard gelatin capsules - a detailed studyTeny Thomas
The presentation involves a descriptive study on hard gelatin capsules which includes the production of the hard gelatin capsule shell, size of the capsules, capsule filling machines and the finishing techniques. The presentation also involves the special techniques of capsule formulation and the quality control tests of hard gelatin capsules
pellets can be defined as multi particulate system or multiunit system
They are spherical particulates manufactured by agglomeration of the powder granules containing drug substance and excipients.
Pellets can be prepared by a special technique called Pelletization.
This technique is referred to an agglomeration process that convert fine powder or granules of bulk drug or excipient in to small , free flowing , spherical or semi spherical pellets .
Multi particular drug delivery system especially suitable for achieving controlled delay released oral formulation with low risk of dose dumping, flexibility of blending to attain different release patterns as well as reproducible and short gastric residence time.
Multi particulate drug delivery system are mainly oral dosage form consisting of a multiplicity of small discrete units each exhibiting some desire characteristics.
In the manufacture of pharmaceuticals, encapsulation refers to a range of dosage forms—techniques used to enclose medicines—in a relatively stable shell known as a capsule, allowing them to, for example, be taken orally or be used as suppositories. The two main types of capsules are:
Hard-shelled capsules, which contain dry, powdered ingredients or miniature pellets made by e.g. processes of extrusion or spheronization. These are made in two halves: a smaller-diameter “body” that is filled and then sealed using a larger-diameter “cap”.
Soft-shelled capsules, primarily used for oils and for active ingredients that are dissolved or suspended in oil.
Introduction, History types, manufacturing, Machinery used, filling by manual and automatic machines, Formulation, quality control test, Shape and sizes, properties of gelatin etc
Its All About Capsule...
i tried to explain in short...
hope you liked it..
please like and share to all students,
which are want to more study in minimum time..
Thank You..
also join on whatsapp to bring newthings
contact no. 9765763626
"Capsula" is derived from the Latin word & Is defined as a solid dosage form in which the medicament contained is enclosed within small shell or container.
capsules and its types are discussed in this slide. along with their uses and their advantages over one another. preparation of each type is well explained in these slides.
Embracing GenAI - A Strategic ImperativePeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
Biological screening of herbal drugs: Introduction and Need for
Phyto-Pharmacological Screening, New Strategies for evaluating
Natural Products, In vitro evaluation techniques for Antioxidants, Antimicrobial and Anticancer drugs. In vivo evaluation techniques
for Anti-inflammatory, Antiulcer, Anticancer, Wound healing, Antidiabetic, Hepatoprotective, Cardio protective, Diuretics and
Antifertility, Toxicity studies as per OECD guidelines
2024.06.01 Introducing a competency framework for languag learning materials ...Sandy Millin
http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
A Strategic Approach: GenAI in EducationPeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
Francesca Gottschalk - How can education support child empowerment.pptxEduSkills OECD
Francesca Gottschalk from the OECD’s Centre for Educational Research and Innovation presents at the Ask an Expert Webinar: How can education support child empowerment?
Model Attribute Check Company Auto PropertyCeline George
In Odoo, the multi-company feature allows you to manage multiple companies within a single Odoo database instance. Each company can have its own configurations while still sharing common resources such as products, customers, and suppliers.
The French Revolution, which began in 1789, was a period of radical social and political upheaval in France. It marked the decline of absolute monarchies, the rise of secular and democratic republics, and the eventual rise of Napoleon Bonaparte. This revolutionary period is crucial in understanding the transition from feudalism to modernity in Europe.
For more information, visit-www.vavaclasses.com
Unit 8 - Information and Communication Technology (Paper I).pdfThiyagu K
This slides describes the basic concepts of ICT, basics of Email, Emerging Technology and Digital Initiatives in Education. This presentations aligns with the UGC Paper I syllabus.
The Roman Empire A Historical Colossus.pdfkaushalkr1407
The Roman Empire, a vast and enduring power, stands as one of history's most remarkable civilizations, leaving an indelible imprint on the world. It emerged from the Roman Republic, transitioning into an imperial powerhouse under the leadership of Augustus Caesar in 27 BCE. This transformation marked the beginning of an era defined by unprecedented territorial expansion, architectural marvels, and profound cultural influence.
The empire's roots lie in the city of Rome, founded, according to legend, by Romulus in 753 BCE. Over centuries, Rome evolved from a small settlement to a formidable republic, characterized by a complex political system with elected officials and checks on power. However, internal strife, class conflicts, and military ambitions paved the way for the end of the Republic. Julius Caesar’s dictatorship and subsequent assassination in 44 BCE created a power vacuum, leading to a civil war. Octavian, later Augustus, emerged victorious, heralding the Roman Empire’s birth.
Under Augustus, the empire experienced the Pax Romana, a 200-year period of relative peace and stability. Augustus reformed the military, established efficient administrative systems, and initiated grand construction projects. The empire's borders expanded, encompassing territories from Britain to Egypt and from Spain to the Euphrates. Roman legions, renowned for their discipline and engineering prowess, secured and maintained these vast territories, building roads, fortifications, and cities that facilitated control and integration.
The Roman Empire’s society was hierarchical, with a rigid class system. At the top were the patricians, wealthy elites who held significant political power. Below them were the plebeians, free citizens with limited political influence, and the vast numbers of slaves who formed the backbone of the economy. The family unit was central, governed by the paterfamilias, the male head who held absolute authority.
Culturally, the Romans were eclectic, absorbing and adapting elements from the civilizations they encountered, particularly the Greeks. Roman art, literature, and philosophy reflected this synthesis, creating a rich cultural tapestry. Latin, the Roman language, became the lingua franca of the Western world, influencing numerous modern languages.
Roman architecture and engineering achievements were monumental. They perfected the arch, vault, and dome, constructing enduring structures like the Colosseum, Pantheon, and aqueducts. These engineering marvels not only showcased Roman ingenuity but also served practical purposes, from public entertainment to water supply.
Thesis Statement for students diagnonsed withADHD.ppt
Soft gelatin capsules
1. A SEMINOR ON :
Packing Of Soft Gelatin Capsules
Presented By: V. Mahesh
M.Pharmacy 1st year 1st sem
pharmaceutics
Hall ticket no: 13CH1S0364
Pragathi Pharmacy College,
Janagon.
2.
3. contents
1. Introduction.
2. Advantages.
3. Disadvantages.
4. Shapes Of Capsules.
5. Anatomy Of Soft Gelatin Capsule.
6. The Nature Of Capsule Shell.
7. The Nature Of Capsule Content.
8. Encapsulation Plant Layout
4. 9. Manufacturing Process Of Soft Gelatin Capsule.
10. Product Quality Considerations.
11. In Process Testing.
12. Finished Product Testing.
13. Vegicaps Soft Capsule.
14. Benefits of Vegicaps®Soft capsules
5. Soft gelatin capsule
DEFINITION:-
soft Gelatin capsules are one piece, hermetically sealed, soft
gelatin shells containing a liquid, a suspension, or a
semisolid.
The Nomenclature for this dosage form has now
been changed to soft gel
They have long been preferred dosage form for
those, taking Health & Nutritional supplements.
6. ADVANTEGES
Easy to administer
Easy to Manufacture
Liquids can be encapsulated ( non water soluble)
Small to large sizes possible
Elegance
Portability
Odour and taste masking
Ready availability of drug hence faster action.
Specialised dosage forms can be made e.g. chewable,
extended release, captabs etc.
Can be used for ophthalmic preparations e.g. aplicaps,
vaginal / rectal suppositories
7. DISADVANTEGES
Water soluble material are difficult to incorporate
Highly Moisture sensitive
Efflorescent material cannot be incorporated, they may
cause softening / leaching
Deliquescent materials cannot be incorporated, they may
cause hardening or brittle capsules..
10. CAPSULE SHELL
The capsule shell is basically composed of Gelatin, a
plasticizer & water, it may contain additional ingredients
such as preservative ,coloring &opacifying agents,
flavorings, sugars, acids & medicaments to achieve
desired effects.
GELATIN:- Obtain from partial hydrolysis of collagen
derived from the skin, connective tissue & Bones of
animals. may have viscosity of 38 mpa
Bloom strength:-150-250
cost of gelatin α Bloom strength
11. CAPSULE SHELL
WATER:-n.m.t. 45% w/w
The ratio by weight of water to dry gelatin can vary from 0.7
to1.3(water) to 1.0(dry gelatin) depending on the viscosity of
the gelatin being used.
PLASTICIZER:-Used to make the soft gel shell elastic &
pliable.
Ratio used is between 0.3 to 1.8 for soft to hard shell on dry
basis.
E.g. glycerin , sorbitol
12. Colour used in shell has to be darker than colour of
encapsulating material
Colours may be natural or synthetic.
Opacifier, usually titanium dioxide, may be added to
Produce An Opaque Shell ,when the fill formulation is a
Suspension or to prevent photo degradation of light
sensitive fill ingredients. Conc. Of opacifier may be up to
0.5%
13. • Chelating Agents:- Iron is always present in raw gelatin, &
should not contain iron more than 15 ppm
• Additionally chelating agent may be used for preventing the
reaction of iron with materials or colours.
14. Typical formula for gelatin sheet
Glycerin I.P. 52.0 Kg
PropMethyl Paraben I.P. 0.512Kg
Methyl Paraben I.P. 0.128Kg
Gelatin 120 Bloom I.P. 152.000Kg
Brilliant Blue Ponceau 4R 0.300Kg
Sunset Yellow I.P. 0.300Kg
TiO2 I.P. 16.000Kg
Water I.P. 120.00Ltr
Sorbitol Liq I.P. 16.00Kg
15. Gelatin Mass Manufacture
The gel is prepared in a 300-litre stainless steel
vessel.
Gelatin powder is mixed with water and glycerine.
Heating Stirring
The molten gelatin mass is formed.
It is decanted into 200-kg mobile vessels.
Turbine mixing
where colours and flavours can be added.
16. It ensures consistency of gelatin mass.
This mass is kept at a constant temperature until it is
needed for the next stage of the process.
17. Capsule content
Content may be liquid, or a combination of miscible liquids,
A solution of a solid(s) in a liquid(s) or a suspension of a
solid(s) in a liquid(s).
It can be a liquid like a volatile oil composition
e.g.Pudin hara.
Vegetable oils like arachis oil or aromatic or aliphatic
hydrocarbons, ethers, esters, or alcohols.
18. Solids that are not Sufficiently soluble in
liquids or in combination of liquids are
capsulated as Suspension.
Suspending agents used are
Lecithin, Soyabean oil, yellow wax.
19.
20. Manufacturing process
The gel and fill mmoobbiillee vveesssseellss aarree tthheenn ttaakkeenn ttoo tthhee
eennccaappssuullaattiioonn bbaayyss..
WWhheerree eeaacchh eennccaappssuullaattiioonn mmaacchhiinnee iiss sseeggrreeggaatteedd iinn
iinnddiivviidduuaall bbaayyss..
TThhee mmoolltteenn ggeell iiss ppuummppeedd ttoo tthhee mmaacchhiinnee..
TTwwoo tthhiinn rriibbbboonnss ooff ggeell aarree ffoorrmmeedd,, oonnee eeiitthheerr ssiiddee ooff tthhee
mmaacchhiinnee..
21. These ribbons then pass over a series of rollers and over
a set of dies that determine the size and shape of the
capsules
24. Capsule Manufacturing
Encapsulation
Tumble Drying :- Dry, sterile air is forced across the tumbler
and removes the moisture from the outer surface of the
capsules.
Supplemental Drying (curing):- After the tumbler dryers, the
soft capsules are placed on special trays for final drying in the
drying room. For a period up to 48 hrs.
25. Sizing:- Automatic capsule sizing machine eliminates
undersized and oversized capsules.
Inspection:- includes visual inspection to check
malformed, damaged or improperly filled capsules.
Packaging:- capsule may be packaged in glass or plastic
containers or may be strip-packaged, so long as such
packaging involves tight closures & plastics having a low
moisture vapor transfer rate.
26. PRODUCT QUALITY CONSIDERATIONS
1. Ingredient specifications all ingredients of a soft gel are
controlled and tested to ensure compliance with
pharmacopoeial specifications.
E.g. Impurities such as aldehydes & peroxides which may
be present in polyethylene glycols. Presence of high levels
of these impurities gives rise to cross-linking of the
gelatin polymer, leading to insolubilization through
further polymerization.
27. 22.. IInn--pprroocceessss tteessttiinngg
During the encapsulation process the four most important
tests are:-
a. The gel ribbon thickness;
b. Soft gel seal thickness at the time of encapsulation;
c. Fill matrix weight & capsule shell weight;
d. Soft gel shell moisture level and soft gel hardness at the
end of the drying stage.
28. FFiinniisshheedd pprroodduucctt tteessttiinngg
These normally includes
Capsule appearance,
active ingredient assay & related substances assay
Fill weight
Content uniformity and
Microbiological testing.
29. VEGICAPS SOFT CAPSULES
Vegicaps Soft capsules are an alternative animal free
capsule.
The shell is made from seaweed extract and gluten
free starch, and contains no modified sugars or
artificial ingredients.
The shell can be clear or coloured and there is a wide
range of shapes, sizes and colours available.
30. An alternative to gelatin for those who prefer an animal free
product
Those with a level of concern about animal-derived
products
Vegetarians
Those with religious or cultural restrictions
Consumers looking for the most natural alternative.
31. Benefits of Vegicaps Soft capsules
Free of all animal derivatives – no pork or beef content.
Easy to swallow
Soft
Natural
Perception of a healthier product
Plant based shell
Low shell odour.