This document defines and compares different types of emulsions including multiple emulsions, microemulsions, nanoemulsions, and nanosuspensions. It explains that emulsions are mixtures of two immiscible liquids stabilized by an emulsifying agent, while microemulsions are more thermodynamically stable with smaller droplet sizes. Nanoemulsions have droplets between 5-200nm and are kinetically stable. Nanosuspensions are solid drug particles less than 1um suspended in water stabilized by surfactants to improve dissolution and bioavailability. The document provides details on identification tests, preparation methods, advantages and disadvantages of these various emulsion systems.
Microemulsion is an isotropic mixture of oil, surfactant, Cosurfactant and drug.
Upon mild agitation followed by dilution in aqueous media, such as gastrointestinal (GI) fluids, the systems can form fine oil in water (O/W) Microemulsions which usually have a droplet size less than 100 nm.
Microemulsion have been successfully used to improve the solubility, chemical stability, and oral bioavailability of many poorly water soluble drugs.
They have characteristic properties such as a low interfacial tension, large interfacial area and capacity to solubilize both aqueous and oil-soluble compounds.
Microemulsion is an isotropic mixture of oil, surfactant, Cosurfactant and drug.
Upon mild agitation followed by dilution in aqueous media, such as gastrointestinal (GI) fluids, the systems can form fine oil in water (O/W) Microemulsions which usually have a droplet size less than 100 nm.
Microemulsion have been successfully used to improve the solubility, chemical stability, and oral bioavailability of many poorly water soluble drugs.
They have characteristic properties such as a low interfacial tension, large interfacial area and capacity to solubilize both aqueous and oil-soluble compounds.
Introduction
Structure
Niosomes Vs. Liposome
Advantages & Disadvantages
Properties of Niosomes
Method of Manufacturing
Evaluation of Niosomes
Applications
Marketed products
A Nanosuspension is a submicron colloidal dispersion of drug particles. A pharmaceutical nanosuspension is defined as very finely colloid, Biphasic, dispersed, solid drug particles in an aqeous vehicle , size below 1µm ,without any matrix material, stabilized by surfactants and polymers , prepared by suitable methods for Drug Delivery applications, through various routes of administration like oral ,topical ,parenteral ,ocular and pulmanary routes.
Nanoemulsions are emulsions with droplet size on the order of
100 nm. A typical nanoemulsion contains oil, water and an
emulsifier. The addition of an emulsifier is critical for the
creation of small sized droplets as it decreases the interfacial
tension i.e., the surface energy per unit area, between the oil
and water phases of the emulsion. The emulsifier also plays a
role in stabilizing nanoemulsions through repulsive electrostatic
interactions and steric hindrance.1 The emulsifier used is
generally a surfactant, but proteins and lipids have also been
effective in the preparation of nanoemulsions.2–12 Over the past
decade or more, the research focus has been on preparing nanoemulsions
through various methods, broadly classified into two
primary categories: high-energy and low-energy methods.13–15
High energy methods such as high pressure homogenization
(HPH) and ultrasonication15 consume significant energy
(B108
–1010 W kg1
) to make small droplets.
liposomes are novel drug delivery dosage systems, where the drug is entrapped in phospholipid bilayered vesicles. the release of drug from the vesicles can be controlled or sustained.
the follwing presentation contain structure, classification and preparation methods, characterization and applications of liposomes.
This will help in find out the difference between micro and nano emulsions. Contain good explanations of their thermdynamic and kinetic stability also ternary phase diagram.
Introduction
Structure
Niosomes Vs. Liposome
Advantages & Disadvantages
Properties of Niosomes
Method of Manufacturing
Evaluation of Niosomes
Applications
Marketed products
A Nanosuspension is a submicron colloidal dispersion of drug particles. A pharmaceutical nanosuspension is defined as very finely colloid, Biphasic, dispersed, solid drug particles in an aqeous vehicle , size below 1µm ,without any matrix material, stabilized by surfactants and polymers , prepared by suitable methods for Drug Delivery applications, through various routes of administration like oral ,topical ,parenteral ,ocular and pulmanary routes.
Nanoemulsions are emulsions with droplet size on the order of
100 nm. A typical nanoemulsion contains oil, water and an
emulsifier. The addition of an emulsifier is critical for the
creation of small sized droplets as it decreases the interfacial
tension i.e., the surface energy per unit area, between the oil
and water phases of the emulsion. The emulsifier also plays a
role in stabilizing nanoemulsions through repulsive electrostatic
interactions and steric hindrance.1 The emulsifier used is
generally a surfactant, but proteins and lipids have also been
effective in the preparation of nanoemulsions.2–12 Over the past
decade or more, the research focus has been on preparing nanoemulsions
through various methods, broadly classified into two
primary categories: high-energy and low-energy methods.13–15
High energy methods such as high pressure homogenization
(HPH) and ultrasonication15 consume significant energy
(B108
–1010 W kg1
) to make small droplets.
liposomes are novel drug delivery dosage systems, where the drug is entrapped in phospholipid bilayered vesicles. the release of drug from the vesicles can be controlled or sustained.
the follwing presentation contain structure, classification and preparation methods, characterization and applications of liposomes.
This will help in find out the difference between micro and nano emulsions. Contain good explanations of their thermdynamic and kinetic stability also ternary phase diagram.
Nanotechnology in nutraceuticals and cosmetics, Prof. Dr. Basavaraj K. Nanjwade, KLE University College of Pharmacy, Belgavi/Belgaum, Karnataka, India.
Microemulsion, Nanoemulsion and Self emulsifying drug delivery systems Pawan Kumar Pandey
Microemulsion, Nanoemulsion and Self emulsifying drug delivery systems and lipidic systems. Difference between emulsions based on the size of the globule. Preparation methods for emulsions used in industry.
Discussion on the 2 kinds of Disperse Systems 1. Suspensions 2. Emulsions. The principles of emulsification, types and examples of emulsifying agents used.
Introduction
Need of Nanosuspension
Advantages of Nanosuspension
Disadvantages of Nanosuspension
Method Of Preparation
Formulation Considerations
Characterization of Nanosuspension
Current Marketed Formulations
Pharmaceutical Applications
In present presentation information related emulsion like definition of emulsion it's types , theories and other information is covered.also it include the information about SMEDDS.
SELF-EMULSIFYING DRUG DELIVERY SYSTEM (SEDDS).pptxDipeshGamare
SELF-EMULSIFYING DRUG DELIVERY SYSTEM (SEDDS) is a type of novel drug delivery system, in this presentation all aspect regarding SEDDS are covered with some novel points.
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Brief introduction to multiple emulsion, microemulsion,
1. BRIEF INTRODUCTION TO
MULTIPLE EMULSION,
MICROEMULSION,
NANOEMULSION &
NANOSUSPENSION
Presented by- Md . Shariq Ansari
B.Pharm 5th sem
Under the guidance: Mr. Dilip Kr. Patel
2. CONTENT
• Defination
• Emulsion
• Types Of Emulsions
• Identification test for emulsion
• Emulsifying agent
• Method of preparation of emulsion
• Microemulsion
• Nanoemulsion
• Nanosuspension
3. DEFINATION
• An Emulsion is a mixture of two or more liquids that
are normally Immiscible.
OR
• Emulsion, is a mixture of two or more liquids in which
one is present as droplets, of microscopic or
ultramicroscopic size, distributed throughout the other.
OilOil
WaterWater
Oil
Water
Agitation
Separate rapidly into two
clear defined layers
OilOil
WaterWater
Oil
Water
Agitation
Separate rapidly into two
clear defined layers
4. Emulsion
Microemulsion
Nanoemulsion
Thermodynamically unstable
Opaque
High energy required to form
Thermodynamically stable
Clear
It forms spontaneously
Thermodynamically or kinetically stable
Clear
High shear application to form
Int. J. Nanomed. 2014,9,pp 1-8
5.
6. Internal Phase or External Phase in
Emulsions:
The dispersed liquid is known as the Internal or
Discontinuous phase.
whereas the dispersion medium is known as
the External or Continuous phase.
7. Based on size of liquid droplets:
0.2 – 50 mm Macroemulsions
0.01 – 0.2 mm Microemulsions
8.
9. IDENTIFICATION TEST FOR
EMULSIONS:
By using Naked eye, it is very difficult to
differentiate between o/w or w/o emulsions. Thus, the
following methods have been used to identify the
type of emulsions.
1) Dye Test
2) Dilution Test
3) Electrical conductivity Test
4) Fluorescence Test.
10. EMULSIFYING AGENT:
• Emulsions are stabilized by adding an emulsifying agent.
• These agents have both a hydrophilic and a Lipophilic
part in their chemical structure.
• All emulsifying agents get adsorbed onto the Oil : water
interface to provide a protective barrier around the
dispersed droplets.
• In addition to this protective barrier, emulsifiers stabilize
the emulsion by reducing the interfacial tension of the
system.
• E.g. agar, albumin, cholic acid, glycerol, gums, soaps,
casein, ox bile extract.
11. METHODS OF PREPARATION
OF EMULSIONS:
• Commercially, emulsions are prepared in large
volume mixing tanks and refined and stabilized
by passage through a colloid mill or homogenizer.
Extemporaneous production is more concerned
with small scale methods.
1) Dry Gum Methods
2) Wet Gum Methods
3) Bottle Method
12.
13.
14.
15. MICROEMULSION
• Micro Emulsions are dispersions of oil and water made
with surfactant, co-surfactant molecules. In many respects,
they are small-scale versions of emulsions. However, the
droplet sizes are very small, typically 100 A, about 100
times smaller than typical emulsion droplet sizes.
W/O O/W
16. OR
• “Microemulsions are liquid dispersions of water and oil that
are made homogenous, transparent (or translucent) and
thermodynamically stable by the addition of relatively large
amounts of a surfactant and a co-surfactant and having
diameter of the droplets in the range of 100 – 1000 A (10 –
100 nm).
(Figure :
Microemulsion
Structure)
17. Advantages of Microemulsions:
.These are thermodynamically stable .
. Require minimum energy for formation.
. Easy of manufacturing .
. Improved drug solubilization and bioavailability.
. Wide applications in colloidal drug delivery systems.
. The formation of microemulsion is reversible.
. Improve the efficacy of a drug & Minimum side effects.
Disadvantages of Microemulsions:
•Use of a large concentration of surfactant and co-surfactants.
• Limited solubilizing capacity for high-melting substances.
• The surfactant must be nontoxic for using pharmaceutical
applications.
• Microemulsion stability is influenced by environmental parameters
such as temperature and pH.
18. NANOEMULSIONS
• Dispersion of two immiscible liquids stabilized
by a surfactant
• Thermodynamically and kinetically stable
• Droplets from 5 to 200 nm
20. Nanoemulsions - Drug Delivery
Advantages
Increase drug loading
Enhance drug solubility
Bioavailability
Controlled drug delivery
Protection of drug
Disadvantages
Expensive process
Stability
Solubility
Lack of understanding of interfacial chemistry
J. Phys. Chem. C 2008, 112 (33), 12669-12676.
21. NANOSUSPENSION
Definition:
“A very finely dispersed solid drug particles in an
aqueous vehicle in which diameter of suspended particle is
less than 1 µm in size, stabilized by surfactants, for either
oral and topical use or parentral and pulmonary
administration, with reduced particle size, leading to an
increased dissolution rate and therefore improved
bioavailability”.
Average particle size ranges from 200-600 nm.
In nanosuspension technology, the drug is
maintained in the required crystalline state with reduced
particle size, Improved bioavailability leading to an
increased dissolution rate.
22. ADVANTAGES
Can be applied for the poorly water soluble
drugs.
Rapid dissolution and tissue targeting can be
achieved by IV route of administration.
Oral administration of nanosuspensions provide
rapid and improved bioavailability.
Long-term physical stability due to the
presence of stabilizers.
Nanosuspensions can be incorporated in
tablets, pellets, hydrogels.
22
23. DISADVANTAGES
Physical stability, sedimentation and
compaction can causes problems.
It is bulky sufficient care must be taken during
handling and transport.
Uniform and accurate dose cannot be
achieved unless suspension .
23