Discussion on the 2 kinds of Disperse Systems 1. Suspensions 2. Emulsions. The principles of emulsification, types and examples of emulsifying agents used.
The presentation provides a concise information regarding various methods or techniques for enhancing solubility of different drugs and will prove useful to students & researchers.
The presentation provides a concise information regarding various methods or techniques for enhancing solubility of different drugs and will prove useful to students & researchers.
Do you know what is engine, how many types of engines are available now. How conversion of energy takes place from chemical energy to mechanical energy or useful work. Here engine classified according to their combustion, working stroke, arrangement of piston, fuel used for combustion and on the basis of ignition system. 4-stroke petrol engine and 4-stroke diesel engine are described briefly with all 4-strokes which are completed during power conversion process. 2-stroke engine or scooter engine is also described briefly with the complete details of combustion, charge( petrol,diesel ) filling process and how all 4 stroke process(suction, combustion,power stroke, exhaust) completed in 2 stroke engine.
4th (30.10.2014) on eutectic mixture by Diptarco SinghaDiptarco Singha
this ppt is very simple and has immence importance in physical pharmacy. it has been prepared based on the syllabus of WBUT & consists of informations of elimentary label...
Current Compensations in Emulsion Type Pharmaceutical Formulation: An OverviewBRNSS Publication Hub
In modern years, the quantity of medicine and drug treatments has larger extremely which are moderately often more strong. Pharmacy research reveals exclusive data which is growing day by day. Emulsion are important dosage formulation they are continuously used from ancient time. In this overview we discuss the development of emulsion technology also focused on properties of emulsion & formulation methods by different equipment used for this consideration. With different identification tests. Multiple emulsion, Microemulsion, Non-aqueous emulsion, Liposome emulsion, Emulsion polymerization, Nanoemulsion are new trends in emulsion technology.
Theories of dispersion, pharmaceutical dispersion (Emulsion and suspension).pptxDipeshGamare
In this presentation Theories of dispersion, pharmaceutical dispersion (Emulsion and suspension) with their mechanism, methods of preparation and stability studies are mentioned.
Unit 6 Water Content Determination and Moisture analysisMalou Mojares
To my CEU Senior Pharmacy QC 2 students.
Water Content Determination by Karl Fischer method, principle by Bunsen Reaction, types of KF method, Loss on Drying (LOD) moisture content determination.
To my Senior CEU Pharmacy QC 2 Students. Radiopharmacy, Nuclear Pharmacy QC and cGMP protocols in handling, storage and preparation of various radiopharmaceuticals containing various radio-isotopes.
Examples and Medical Applications included.
For my senior CEU pharmacy students in QC 2 with Instrumentation.
The different types and examples of indicator electrodes used in potentiometric titration method of drug analysis.
Weight Management Pharmaceutical Services
Obesity and Overweight: Definition, causes, prevention
Obese and Overweight patient counseling guidelines
Exercise, Physical activities for obese and overweight people
Introduction to Stability Testing of Drugs and Cosmetics. Includes the 3 types of stability test methods (Real time studies, Accelerated studies and Stress tests). Contains the WHO and ICH Climatic Zones for Real time, Intermediate and Accelerated tests). Classification of Packaging materials. Container- Closure Systems.
Welcome to TechSoup New Member Orientation and Q&A (May 2024).pdfTechSoup
In this webinar you will learn how your organization can access TechSoup's wide variety of product discount and donation programs. From hardware to software, we'll give you a tour of the tools available to help your nonprofit with productivity, collaboration, financial management, donor tracking, security, and more.
The Art Pastor's Guide to Sabbath | Steve ThomasonSteve Thomason
What is the purpose of the Sabbath Law in the Torah. It is interesting to compare how the context of the law shifts from Exodus to Deuteronomy. Who gets to rest, and why?
Palestine last event orientationfvgnh .pptxRaedMohamed3
An EFL lesson about the current events in Palestine. It is intended to be for intermediate students who wish to increase their listening skills through a short lesson in power point.
Ethnobotany and Ethnopharmacology:
Ethnobotany in herbal drug evaluation,
Impact of Ethnobotany in traditional medicine,
New development in herbals,
Bio-prospecting tools for drug discovery,
Role of Ethnopharmacology in drug evaluation,
Reverse Pharmacology.
We all have good and bad thoughts from time to time and situation to situation. We are bombarded daily with spiraling thoughts(both negative and positive) creating all-consuming feel , making us difficult to manage with associated suffering. Good thoughts are like our Mob Signal (Positive thought) amidst noise(negative thought) in the atmosphere. Negative thoughts like noise outweigh positive thoughts. These thoughts often create unwanted confusion, trouble, stress and frustration in our mind as well as chaos in our physical world. Negative thoughts are also known as “distorted thinking”.
Students, digital devices and success - Andreas Schleicher - 27 May 2024..pptxEduSkills OECD
Andreas Schleicher presents at the OECD webinar ‘Digital devices in schools: detrimental distraction or secret to success?’ on 27 May 2024. The presentation was based on findings from PISA 2022 results and the webinar helped launch the PISA in Focus ‘Managing screen time: How to protect and equip students against distraction’ https://www.oecd-ilibrary.org/education/managing-screen-time_7c225af4-en and the OECD Education Policy Perspective ‘Students, digital devices and success’ can be found here - https://oe.cd/il/5yV
The Roman Empire A Historical Colossus.pdfkaushalkr1407
The Roman Empire, a vast and enduring power, stands as one of history's most remarkable civilizations, leaving an indelible imprint on the world. It emerged from the Roman Republic, transitioning into an imperial powerhouse under the leadership of Augustus Caesar in 27 BCE. This transformation marked the beginning of an era defined by unprecedented territorial expansion, architectural marvels, and profound cultural influence.
The empire's roots lie in the city of Rome, founded, according to legend, by Romulus in 753 BCE. Over centuries, Rome evolved from a small settlement to a formidable republic, characterized by a complex political system with elected officials and checks on power. However, internal strife, class conflicts, and military ambitions paved the way for the end of the Republic. Julius Caesar’s dictatorship and subsequent assassination in 44 BCE created a power vacuum, leading to a civil war. Octavian, later Augustus, emerged victorious, heralding the Roman Empire’s birth.
Under Augustus, the empire experienced the Pax Romana, a 200-year period of relative peace and stability. Augustus reformed the military, established efficient administrative systems, and initiated grand construction projects. The empire's borders expanded, encompassing territories from Britain to Egypt and from Spain to the Euphrates. Roman legions, renowned for their discipline and engineering prowess, secured and maintained these vast territories, building roads, fortifications, and cities that facilitated control and integration.
The Roman Empire’s society was hierarchical, with a rigid class system. At the top were the patricians, wealthy elites who held significant political power. Below them were the plebeians, free citizens with limited political influence, and the vast numbers of slaves who formed the backbone of the economy. The family unit was central, governed by the paterfamilias, the male head who held absolute authority.
Culturally, the Romans were eclectic, absorbing and adapting elements from the civilizations they encountered, particularly the Greeks. Roman art, literature, and philosophy reflected this synthesis, creating a rich cultural tapestry. Latin, the Roman language, became the lingua franca of the Western world, influencing numerous modern languages.
Roman architecture and engineering achievements were monumental. They perfected the arch, vault, and dome, constructing enduring structures like the Colosseum, Pantheon, and aqueducts. These engineering marvels not only showcased Roman ingenuity but also served practical purposes, from public entertainment to water supply.
The Indian economy is classified into different sectors to simplify the analysis and understanding of economic activities. For Class 10, it's essential to grasp the sectors of the Indian economy, understand their characteristics, and recognize their importance. This guide will provide detailed notes on the Sectors of the Indian Economy Class 10, using specific long-tail keywords to enhance comprehension.
For more information, visit-www.vavaclasses.com
Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
2. DISPERSE SYSTEMS:
COMPONENTS
DISPERSED PHASE
The undissolved or immiscible drug
(suspensoid) distributed
throughout the liquid vehicle.
Also called the
“internal phase”
3. DISPERSE SYSTEMS:
COMPONENTS
DISPERSION MEDIUM
The liquid vehicle, to which the
insoluble drug is distributed.
Also called
“external phase”
4. DISPERSE SYSTEMS:
COMPONENTS
DISPERSING /SUSPENDING
AGENT
Stabilizes the suspension,
maintains the homogeneity of
the internal and external
phases, after agitation of the
contents.
6. DISPERSE SYSTEMS
PARTICLE SIZES
Colloidal dispersions – 1 nm to
0.5 nm
Coarse dispersions
(suspensions and emulsions) –
10 um to 50 um
Fine dispersions ( magmas and
gels) – 0.5 um to 10 um
7. SUSPENSIONS: DEFINITION
Disperse systems containing
finely divided, insoluble drug
particles (“suspensoids’)
distributed somewhat uniformly
throughout a liquid vehicle.
8. SUSPENSIONS: DEFINITION
Ready to use liquid form
(antacids and analgesics)
Labeled as “Oral Suspension”
Dry powders for Reconstitution
(antibiotics and other drugs that
are unstable in liquid form for
longer time)
9. REASONS for SUSPENSIONS
1. For improving product stability
2. Ease of administration and
flexibility in administration of a
range of doses
3. For masking unpleasant taste of
10. Features desired in
Pharmaceutical Suspension
1. Particles should settle slowly and
should be readily re-dispersed
upon shaking of the container.
2. The particle size of the
suspensoid should remain fairly
constant throughout long periods
of undisturbed standing.
3. The suspension should pour
readily and evenly from its
11. DISPERSED PHASE:
PHYSICAL FEATURES
Particle diameter is 1 to 50 m
Particle size reduction is
accomplished by:
Micropulverization – 10-50 m
Fluid energy grinding (jet milling
or micronization) – under 10 m
12. SUSPENDING AGENTS:
TYPES AND EXAMPLES
1. HYDROPHILIC COLLOIDS
Increase the viscosity of water by binding
water molecules
Support the growth of microorganisms
Mostly anionic, except methylcellulose
(neutral) and chitosan (cationic)
Incompatible with quaternary antibacterial
agents
13. HYDROPHILIC COLLOIDS:
EXAMPLES
Acacia –used as 35% mucilage;
form colored complex with organic
compounds due to peroxidase
Tragacanth – used as 5%
dispersion in water; does not
contain peroxidase
Methylcellulose (MC)
Carboxymethylcellulose (CMC)
14. SUSPENDING AGENTS:
TYPES AND EXAMPLES
2. CLAYS
Silicates that are anionic in
aqueous dispersion
Strongly hydrated
Exhibit thixotropy
Bentonite (as 5% magma), Veegum
15. SUSPENDING AGENTS:
TYPES AND EXAMPLES
3. OTHER AGENTS
Agar
Chondrus(carrageenan)
Gelatin
Pectin
Gelatinized Starch
16. TYPES OF SUSPENSION
1. ORAL SUSPENSIONS
Ready to use
Dry powders for reconstitution
Uses: Antacid,Anthelmintic,
Antibacterial
(see table 14.1 pp.390-391)
17. TYPES OF SUSPENSION
2. SUSPENSIONS FOR INJECTION
Particles must exhibit
“SYRINGEABILITY”
The product must have the ability
to be successfully administered
by a syringe and appropriate
needle.
18. TYPES OF SUSPENSION
3. OPHTHALMIC SUSPENSIONS
Particle size must not exceed 10
microns
19. TYPES OF SUSPENSION
4. SUSPENSIONS FOR TOPICAL USE
Fine particles (impalpable) are
desired to avoid grittiness when
applied to the skin
The smaller the particle size, the
greater the covering and protective
power of the preparation.
20. TYPES OF SUSPENSION
3. OPTHALMIC SUSPENSIONS
Particle size must not exceed 10
microns
Particles must be “impalpable”
21. TYPES OF SUSPENSION
4. SUSPENSIONS FOR TOPICAL USE
Fine particles are desired to avoid
grittiness when applied to the skin
The smaller the particle size, the
greater the covering and protective
power of the preparation.
22. TYPES OF SUSPENSION
5. RECTAL SUSPENSIONS
Barium Sulfate for
Suspension, USP
May be employed orally or
rectally for diagnostic
visualization of the GIT.
23. TYPES OF SUSPENSION
MesalamineSuspension (Rowasa)
For the treatment of Crohn’s
disease, distal ulcerative colitis,
proctosigmoiditis, and proctitis.
No longer commercially available
but is compounded by
pharmacist.
24. PREPARATION OF
SUSPENSIONS
I. WETTING OF PARTICLES
Wetting agents are employed for
hydrophobic (non-wetting) powders
II. BLENDING OF ALL THE INGREDIENTS
All soluble components must have
been dissolved in the dispersion
medium
26. LOTIONS
Suspensions for external
application.
A low to medium viscosity, topical
product, intended to be applied on
“unbroken” skin.
Lotions have lower viscosity than
Creams and Gels.
27. LOTIONS
Prepared by:
(1) Trituration method
(2) By chemical reaction method
29. TYPES of LOTIONS
NON MEDICATED LOTIONS
1. Jergen’s Lotion
- emollient
2. Aveeno Lotion
- moisturizer
30. EMULSIONS: DEFINITION
A dispersion in which the
dispersed phase is composed
of small globules of liquid
distributed throughout another
liquid, in which it is immiscible.
A two-phase system in which
one immiscible liquid is
intimately dispersed in another
liquid (as droplets).
31. PHASES OF EMULSIONS
DISPERSED PHASE
– the liquid droplet, internal phase, or
discontinuous phase.
DISPERSION MEDIUM
– the liquid vehicle, external phase,
or continuous phase
32. TYPES OF EMULSIONS
W/O emulsion
- water is the internal phase
- oil is external phase
O/W emulsion
- oil is the internal phase
- water is external phase
33. EMULSIFYING AGENTS
Any compound that lowers the
interfacial tension and forms a film
at the interface
TYPES:
1. Natural emulsifying agents –
acacia, tragacanth, agar, pectin,
gelatin, methylcellulose
2. Synthetic emulsifying agents –
anionic, cationic, or nonionic
34. SYNTHETIC EMULSIFIERS
ANIONIC AGENTS – include
sulfuric acid esters, sulfonic acid
derivatives, and soaps
Alkali soaps – form O/W emulsion
Metallic soaps – form W/O
emulsion
Monovalent and Polyvalent soaps
– form W/O emulsion
36. SYNTHETIC EMULSIFIERS
NONIONIC EMULSIFIERS
Resistant to the addition of acids and
electrolytes
Examples:
Sorbitan esters – SPANS, hydrophobic,
low HLB values, form W/O emulsions
Polysorbates – TWEENS, hydrophilic,
high HLB values, form O/W emulsions
37. HLB SYSTEM
HYDROPHILE – LIPOPHILE BALANCE
Used to classify non-ionic surfactants
All NON –IONIC surfactants have an
HLB value.
The higher the HLB number, the more
hydrophilic
The lower the HLB number, the more
lipophilic
38. HLB SYSTEM
HYDROPHILIC SURFACTANTS
High HLB values (>10)
Form O/W emulsion
LIPOPHILIC SURFACTANTS
Low HLB values (1-10)
Form W/O emulsion
40. METHODS OF PREPARATION
1. WET GUM METHOD
(English method)
4:2:1 of oil : water : gum
Formation of Primary Gum as the
nucleus of the emulsion.
41. METHODS OF PREPARATION
2. DRY GUM METHOD
(Continental method)
4:2:1 ratio of oil: water: gum
Formation of Primary Mucilage as
the nucleus of the emulsion
42. METHODS OF PREPARATION
3. BOTTLE METHOD – (Forbes
Bottle method or 2:2:1 method)
2:2: 1 ratio of oil : water : gum
Applicable to emulsions
containing Volatile Oils.
43. METHODS OF PREPARATION
4. NASCENT SOAP METHOD
The soap is formed first by mixing
equal volumes of oil and alkali
The soap acts as emulsifying
agent
A 50:50 ratio of oil to water
ensures sufficientemulsion
44. THEORIES OF EMULSIFICATION
1. SURFACE-TENSION THEORY
Initially, when oil and water are
mixed it becomes immiscible due
to the presence of surface
tension.
The use of surfactants result in
the lowering of interfacial tension
between two immiscible liquids.
45. THEORIES OF EMULSIFICATION
2. ORIENTED WEDGE THEORY
This theory assumes
monomolecular layers of
emulsifying agent curved around a
droplet of the internal phase.
46. THEORIES OF EMULSIFICATION
3. PLASTIC FILMOR INTERFACIAL
FILM THEORY
This theory places the emulsifying
agent at the interface between the
oil and water, surrounding the
droplets of the internal phase as a
thin layer of film adsorbed on the
surface of the drops.
47. THEORIES OF EMULSIFICATION
4. VISCOSITY THEORY
The final product will exhibit
increased viscosities.
When the contents are agitated, it
will have a thick, creamy
consistency which will make the
emulsion acceptable for use.
48. METHODS OF DETERMINING
THE TYPE OF EMULSION
DYE SOLUBILITY TEST
Uses methylene blue or brilliant
blue
If the dye is dissolve and uniformly
diffuse – O/W
If the particle of the dye lie in
clumps on the surface – W/O
49. METHODS OF DETERMINING
THE TYPE OF EMULSION
DILUTION TEST
If freely mixes with water – O/W
If not diluted with water – W/O
50. METHODS OF DETERMINING
THE TYPE OF EMULSION
ELECTRIC CONDUCTIVITY TEST
O/W conducts electric current
W/O do not conduct electric
current
53. AEROSOLS
Pressurized dosage forms
designed to deliver drug
systemically or topically with the
aid of a liquefied or propelled gas
(propellant).
A dispersion of solid, liquid or gas
forms of a drug in gas.
56. ADVANTAGES
Convenience of application
Stability
Wide range of products to be
dispensed as sprays, foams, or
semisolids
DISADVANTAGES
Environment hazard
Inadvertent inhalation of the gas
57. FILLING METHODS of
AEROSOLS
I. Cold Filling Method
Product concentrate and
propellant are cooled at -34.5
to -40°C
Dry ice and Acetone are the
cooling systems used.
58. FILLING METHODS of
AEROSOLS
II. Pressure Filling Method
1.Product concentrate is
quantitatively placed in the
aerosol container.
2.Valve assembly inserted and
crimped in place.
3. Liqiefied gas (under pressure) is
metered into the valve system.
59. ACTUATOR MOUNTING CUP WITH
FLOWED-IN GASKET
STEM
HOUSING
SPRING
DIP TUBE
GASKET
59
60. PARTS of the VALVE ASSEMBLY
ACTUATOR
MOUNTING
CUP
SPRING
GASKET
HOUSING
62. METERED DOSE INHALERS
(MDI’s)
These devices allow a drug to be
inhaled as a fine mist of drug or
drug-containing particles for
systemic or pulmonary delivery
Use special metering valves to
regulate the amount of formulation
and the drug that is dispensed in