This document discusses emulsion and self-microemulsifying drug delivery systems (SMEDDS). It defines emulsions as mixtures of two immiscible liquids, while SMEDDS are isotropic mixtures of oils, surfactants, and cosurfactants that generate microemulsions upon gentle mixing with water. The document outlines the differences between emulsions and microemulsions, provides examples of formulations for various components of SMEDDS, and discusses stability testing and advantages such as improved drug solubility, stability, and patient compliance compared to other formulations.
This slide share includes the introduction about smedds, difference between emulsion and smedd and sedds and smedds, composition and its formulation aspects.
SMEDDS- Self Micro Emulsifying Drug Delivery System.pptxTanmai25
smedds is a lipid based drug delivery system , which uses a lipid as a carrier to deliver poorly soluble drug. Thereby increasing its dissolution and bioavailability.
This slide share includes the introduction about smedds, difference between emulsion and smedd and sedds and smedds, composition and its formulation aspects.
SMEDDS- Self Micro Emulsifying Drug Delivery System.pptxTanmai25
smedds is a lipid based drug delivery system , which uses a lipid as a carrier to deliver poorly soluble drug. Thereby increasing its dissolution and bioavailability.
SELF-EMULSIFYING DRUG DELIVERY SYSTEM (SEDDS).pptxDipeshGamare
SELF-EMULSIFYING DRUG DELIVERY SYSTEM (SEDDS) is a type of novel drug delivery system, in this presentation all aspect regarding SEDDS are covered with some novel points.
SMEDDS consists of a mixture of drugs, oils, surfactants and co- surfactants. Gentle mixing of these ingredients in aqueous media generates micro emulsions with a droplet size in a range of 10-100 nm.
SELF-EMULSIFYING DRUG DELIVERY SYSTEM (SEDDS).pptxDipeshGamare
SELF-EMULSIFYING DRUG DELIVERY SYSTEM (SEDDS) is a type of novel drug delivery system, in this presentation all aspect regarding SEDDS are covered with some novel points.
SMEDDS consists of a mixture of drugs, oils, surfactants and co- surfactants. Gentle mixing of these ingredients in aqueous media generates micro emulsions with a droplet size in a range of 10-100 nm.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
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- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
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STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
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3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
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Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
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Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
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1. EMULSION AND SMEDDS
SEPARATION AND
STABILITY
Presented by – Guided by -
AKASH DOMALE Dr. Abhijeet D Kulkarni Sir
Roll no – 02
Sanjivani College of Pharmaceutical
Education and Research
3. EMULSION: Emulsion is mixture of two or
more liquid that are normally immiscible
SMEDDS:
SMEDDS are defined as isotropic mixtures of
natural or synthetic oils, solid and liquid
surfactants.
DEFINITIONS
6. BACKGROUND
Concept introduced by hoar and schulman in 1940’s who
generated a clear single phase solution by titrating a milky
emulsion with hexanol
alternative names for these systems are often used such as
transparent emulsion ,swollen micelle,micellar solution and
solubilized oil.
Schulman and co worker in 1959 subsequently coined the term
microemulsion.
7. In recent years , much attention has been focused on oral
dosage form using a self micro-emulsifying drug delivery
system [SMEDDS] for the purpose of improving the
solubilityAnd absorption of poorly water soluble drug
SMEDDS consists of a mixture of drug, oils ,surfactants and
other additives gentle mixing of these ingredients in aqueous
media generates microemulsion with droplet size in a range
of 10-100nm
SMEDDS has been shown to improve absorption of drugs by
rapid self micro emulsification in the stomach ,with the micro
emulsion droplets subsequently dispersing in the
gastrointestinal tract to reach site of absorption
INTRODUCTION SMEDDS
8.
9. Emulsion
1. Emulsion consists of roughly spherical
droplets of one phase dispersed to
other.
2. They are non transparent as the
particle/droplet size varies from 1-
20mm.
3. Formulation requires shaking.
4. They are thermodynamically unstable.
5. They are various formulation.
6. they are lyophobic.
1. They constantly evolve between
various structures ranging from
droplet to bi continuous structure
2. They are transparent as the particle/
droplet size is only 10-100nm.
3. It is constant formulation.
4. They are thermodynamically stable.
5. They can accommodate 20-40%
without increase in viscosity.
6. They are on the borderline between
lyophobic and lyophilic colloids.
Microemulsion
10. Composition of SMEDDS formulation
• Typically, a SMEDDS formulation comprises of drug,
oil, surfactant and co-surfactant
• Drug Lipophilicity and dose of the drug are the main
criteria to be considered before development of
SMEDDS formulation. Ideally, drug should have low
dose, log P 2 and should not possess extensive first
pass metabolism. The drug should show substantial
solubility in pharmaceutically accepted lipids,
surfactants and co-solvents
11. • Oils Medium chain triglycerides (MCT) having carbon
atoms between 6 and 12 are directly transported by portal
blood to the systemic circulation. Whereas, long chain
triglycerides (LCT) having carbon atoms greater than 12
are transported via intestinal lymphatics. As MCT have
higher solvent capacity and are also not subjected to
oxidation, they are widely used in lipid based formulations
Oils
12. • Surfactants form the interfacial film and lower the interfacial tension to
a small value which facilitates dispersion process.
• HLB value and concentration of surfactant is essential to be
considered while selecting a surfactant.
• For attaining high emulsifying performance, the emulsifier involved in
the formulation of SMEDDS should have high HLB greater than 12
which assists in formation of small o/w droplets and rapid spreading of
formulation in aqueous media.
• Generally, non-ionic surfactants with HLB412 are suggested for design
of self-dispersing systems as these are less toxic than ionic
surfactants
Surfactants
13. • Co-surfactants ensures flexibility of the interfacial layer,
i.e. it reduces the interfacial tension to a negative value.
• Co-surfactants form a flexible interfacial film in order to
acquire different curvatures required to form
microemulsion over a wide range of composition.
• Medium chain length alcohols (C3–C8) are commonly
employed as co-surfactants
CO-SURFACTANTS
16. (1) Storage: SMEDDS has the same advantage as emulsions, of facilitating the solubility of
hydrophobic drugs. Microemulsions undergo creaming over a period of time, whereas SMEDDS
being thermodynamically stable can be stored easily
(2) Stability: In contrast to micro/nanoemulsions, SMEDDS do not contain water and hence, they
have improved physical and/or chemical stability on long-term storage. Self-nanoemulsifying
tablets of carvedilol showed successful incorporation of carvedilol within the SNEDDS. This
resulted in improvement of the stability of carvedilol on dilution with aqueous media in the presence
of cellulosic polymers
(3)Compliance: Most of the SMEDDS formulations are in capsule or tablet dosage forms, thus
occupying smaller volume, easy to administer and hence improved patient compliance (
Advantages
17. (1) Drug precipitation on dilution: Diluted SMEDDS undergo precipitation of drug in
gastrointestinal fluid.
A common requirement for the lipid formulations is that they should be able to keep the
drug in the solubilized form in the gastrointestinal tract (GIT). Precipitation of the drug
from the system nullifies the advantage offered
by the lipid-based formulation system.
(2) The precipitation tendency of the drug on dilution is higher due to the dilution effect
of the hydrophilic solvent. It thereby requires incorporation of polymers to minimize drug
precipitation.
(3)Storage and handling: Liquid SMEDDS exhibit problems in handling, storage and
stability. Thus, formulating solid SMEDDS seems to be a logical solution to address
these problems.
DISADVANTAGE
18. Thermodynamic Stability Studies
• These studies are useful to evaluate the consequence of
temperature change on formulation.
• Formulation is diluted with aqueous phase and subjected to
centrifugation at 15,000 rpm for 15 min or at 3500 rpm for
30 min .
• The samples in which the phase separation is not observed
are subjected to freeze thaw cycles (−20°C and 40°C
temperature, resp.) and observed visually.
• The thermodynamically stable formulations will not show
any change in visual description .
.
19. In Vitro Dissolution Profile
• Drug release from formulation can be evaluated after filling the
formulation in a hard gelatin capsule using USP XXIII apparatus
I at 100 rpm [44, 64, 65] or USPXXIII apparatus II at 50 rpm or
with dialysis method [66] at °C.
• Samples at regular intervals should be withdrawn from the
medium and drug content is estimated and compared with the
control.
• The polarity of oil droplet has impact on drug release from the
diluted SMEDDS.
• The higher the polarity, the faster the drug release from the oil
droplet into the aqueous phase.
• Polarity is mainly dependent on the HLB of surfactant,
molecular weight of hydrophilic part of the surfactant, and its
concentration along with the degree of unsaturation of fatty
acid of lipid phase
20. 6.4.16. Stability Assessment
• Stability studies are performed as per the ICH
guidelines on the formulation which is filled in
gelatin capsules.
• At regular intervals the samples should be
collected and tested for appearance, color,
drug content, pH of diluted formulation, and
dissolution profile.
• If there is no change in all these properties
during storage conditions, formulation can be
concluded as stable formulation
21.
22. 1. Spernath A, Aserin A (December 2006). "Microemulsions as carriers for drugs
and nutraceuticals".
Adv Colloid Interface Sci 128-130: 47–64. doi:10.1016/j.cis.2006.11.016. PMID
17229398.
2. Tang J: Self-Emulsifying Drug Delivery Systems: strategy for improving oral
delivery of poorly
soluble drugs. Cur Drug Th 2007; 2: 85-93.
3. Burcham DL, Maurin MB, Hausner EA and Huang SM: Improved oral
bioavailability of the
hypocholesterolemic DMP 565 in dogs following oral dosing in oil and glycol
solutions. Biopharmaceutics &
REFERENCES