The document summarizes motor systems and movement disorders. It describes the anatomy and physiology of the motor system, including motor pathways in the brain and spinal cord. The motor cortex, basal ganglia, cerebellum, and brainstem are involved in motor control. Feedback from proprioceptors, the vestibular system, and vision help monitor posture and movement. Movement disorders can result from neural degeneration, injuries, chemicals, infections, tumors or genetics. Specific disorders include hypokinesia, hyperkinesia, spasticity, ataxia, and gait disturbances.
The discipline of Motor Control is the study of human movement and the systems that control it under normal and pathological conditions.
Depends upon -
Environmental result of the movement (Outcome)
Movement pattern
Neuromotor processes underlying movement
2nd and 3rd September 2011,a General Lecture Theatre, Dr Chirantan Mandal, Dr Avik Basu, Dr Dipayan Sen Dr Ushnish Adhikari,Dr Srimanti Bhattacharya, Dr Shubham Presided by Dr Arnab Sengupta (Physiology Dept Medical College Kolkata)
In this powerpoint, i have mentioned all the information with diagrams and functions in a very easy way. I am always there to solve any of the queries. Thank you.
Role of various systems to maintain balance.
Role of sensory systems-vision,proprioceptors,vestibular
Role of Musculoskeletal system
Biomechanics in balance
Contextual factors in balance
Role of nervous system
Strategies-ankle, hip,stepping
The discipline of Motor Control is the study of human movement and the systems that control it under normal and pathological conditions.
Depends upon -
Environmental result of the movement (Outcome)
Movement pattern
Neuromotor processes underlying movement
2nd and 3rd September 2011,a General Lecture Theatre, Dr Chirantan Mandal, Dr Avik Basu, Dr Dipayan Sen Dr Ushnish Adhikari,Dr Srimanti Bhattacharya, Dr Shubham Presided by Dr Arnab Sengupta (Physiology Dept Medical College Kolkata)
In this powerpoint, i have mentioned all the information with diagrams and functions in a very easy way. I am always there to solve any of the queries. Thank you.
Role of various systems to maintain balance.
Role of sensory systems-vision,proprioceptors,vestibular
Role of Musculoskeletal system
Biomechanics in balance
Contextual factors in balance
Role of nervous system
Strategies-ankle, hip,stepping
Neurodevelopmental disorders: are our current diagnostic labels fit for purpose?Dorothy Bishop
Slides from a talk given at University of Western Australia on Tuesday 2nd October 2012, This lecture was co-hosted by the ARC Centre of Excellence in Cognition and
its Disorders and the Institute of Advanced Studies, University of Western Australia
Autonomic Nervous System Physiology II Part 2 II Nervous System Physiology IIHM Learnings
Autonomic Nervous System Physiology II Part 2 II Nervous System Physiology II
The slide will discuss :
1. Difference between preganglionic and postganglionic neuron in parasympathetic and sympathetic nervous system
2. Impulse transmission at autonomic junctions
3. Neurotransmitters at autonomic junctions
4. Acetylcholine receptors
5. Adrenergic receptors
6. Physiological actions of Parasympathetic and sympathetic nervous system
7. Table showing the difference between somatomotor and autonomic nervous system
8. Table showing the difference between parasympathetic and sympathetic nervous system
You can also watch the same topic on HM Learnings Youtube channel.
You can also follow HM Learnings on facebook, instagram and twitter for daily updates
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CDSCO and Phamacovigilance {Regulatory body in India}NEHA GUPTA
The Central Drugs Standard Control Organization (CDSCO) is India's national regulatory body for pharmaceuticals and medical devices. Operating under the Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India, the CDSCO is responsible for approving new drugs, conducting clinical trials, setting standards for drugs, controlling the quality of imported drugs, and coordinating the activities of State Drug Control Organizations by providing expert advice.
Pharmacovigilance, on the other hand, is the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The primary aim of pharmacovigilance is to ensure the safety and efficacy of medicines, thereby protecting public health.
In India, pharmacovigilance activities are monitored by the Pharmacovigilance Programme of India (PvPI), which works closely with CDSCO to collect, analyze, and act upon data regarding adverse drug reactions (ADRs). Together, they play a critical role in ensuring that the benefits of drugs outweigh their risks, maintaining high standards of patient safety, and promoting the rational use of medicines.
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Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
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New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
The Gram stain is a fundamental technique in microbiology used to classify bacteria based on their cell wall structure. It provides a quick and simple method to distinguish between Gram-positive and Gram-negative bacteria, which have different susceptibilities to antibiotics
2. Motor systems
• Motor systems are complex and include
sophisticated control systems the
purpose of which is to serve
locomotion, posture and work.
3. Several feedback systems monitor
muscle activity
The length of muscles and the strength of contractions
are monitored by:
– Input from proprioceptive receptors in muscles, joints
and tendons
– Local feedback from motor nerves (Renshaw
inhibition)
19. Extensive processing of motor
command occurs in the spinal
cord (and brainstem)
• Spinal reflexes play an important
role in all motor functions
• Some functions such as walking is
programmed in the spinal cord
28. Interneuron
Input A
B
A
a motoneuron
Input B
Intracellular
potential in
a motoneuron
Input A
B
A
a motoneuron
Input B
Intracellular
potential in
a motoneuron
Convergence of
excitatory inputs
Convergence of inhibitory
and excitatory inputs
44. Cerebral cortex
(MI and SI)
Thalamus
Cerebellar
nucleus
Pontine
nuclei
Red
nucleus
Cerebellar
cortex
From
spinal cord
Rubrospinal
tract
Involvement of the
cerebellum and
pontine nuclei