Abortion is the expulsion of the products of conception before viability at 28 weeks of pregnancy. There are different types of abortion including early, late, spontaneous, induced, therapeutic, threatened, inevitable, incomplete, and complete. Criminal abortion is the unlawful termination of a pregnancy, often done by widows seeking remarriage, unmarried girls, or married women avoiding additional children. Methods to induce criminal abortion include mechanical violence, abortifacient drugs, and instruments that can cause immediate complications like hemorrhage or perforation and delayed complications such as sepsis, tetanus, or sterility.
Criminal abortion is commonly practiced in India as access to legal abortion and society fear are still great barrier. Approach of the physician and government should favorable.
infanticide are quite common in India because of illiteracy as well as the female child unwanted . Now a days female sexual assault and murder is getting common in north Indian society
Criminal abortion is commonly practiced in India as access to legal abortion and society fear are still great barrier. Approach of the physician and government should favorable.
infanticide are quite common in India because of illiteracy as well as the female child unwanted . Now a days female sexual assault and murder is getting common in north Indian society
FORENSIC MEDICINE BOOKS OF
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FORENSIC MEDICINE BOOKS OF
REDDY
GOUTAM BISWAS
MAGENDRAN
OTHERS
TOPICS :-
COLD INJURY
HEAT INJURY
BURN INJURY
SCALDS
ELECTROCUTION
LIGHTENING INJURY
THIS IS ONE OF MY BEST AND FAVORITE PRESENTATIONS. IT WILL SURELY HELP YOU A LOT DURING YOUR EXAMS (PROF/OTHERS). IF YOU FIND IT HELPFUL THEN LIKE IT. MY EMAIL ID IS GIVEN ON THE 2ND PAGE OF THIS PRESENTATION, IF YOU WANT PRESENTATIONS ON OTHER TOPICS (ANY MEDICAL SUBJECTS) THEN MAIL ME. I WILL WORK ON IT LOT AND WILL BE TRYING TO SHARE WITH YOU GUYS...
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Pathophysiology of Normal Labor:
A series of events that take place in female genital organs to expel the product of conception that are fetus, placenta, membranes) out of womb through the vagina into the outer world. We further describe pathogenesis and features of different stages of labor
It is the expulsion or extraction from its mother of an embryo or fetus weighing 500 gm or less when it is not capable of independent survival (WHO).
The 500gm of fetal development is attained approximately at 22 weeks of gestation.
Expelled fetus- Abortus
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
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- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
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Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
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Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
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MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
2. Definition:
Abortion means spontaneous or induced expulsion of products of conception
before viability (28 weeks) whereas premature labor is delivery of fetus after
28 weeks of pregnancy up to 40th week.
In medical practice, the abortion occurs in1st trimester, miscarriage in the
2nd trimester premature labor in the 3rd trimester.
Legally all the above terms are synonymous.
4. Type Definition
Early Abortion before 12 wk gestation
Late Abortion between 12 and 20 wk gestation
Spontaneous Noninduced abortion
Induced Termination of pregnancy for medical or elective reasons
Therapeutic Termination of pregnancy because the woman’s life or health is endangered
or because the fetus is dead or has malformations incompatible with life
Threatened Vaginal bleeding occurring before 20 wk gestation without cervical dilation
and indicating that spontaneous abortion may occur
Inevitable Vaginal bleeding or rupture of the membranes accompanied by dilation of
the cervix
Incomplete Expulsion of some products of conception
Complete Expulsion of all products of conception
Recurrent or habitual ≥ 2 to 3 consecutive spontaneous abortions
Missed Undetected death of an embryo or a fetus that is not expelled and that
causes no bleeding (also called blighted ovum, anembryonic pregnancy, or
intrauterine embryonic demise)
Septic Serious infection of the uterine contents during or shortly before or after
an abortion
http://www.msdmanuals.com/professional/gynecology-and-obstetrics/abnormalities-of-pregnancy/spontaneous-abortion#v1074677
6. Criminal Abortion
Criminal abortion is the induced destruction or expulsion of the foetus from the womb of the
mother unlawfully that is where there is no therauptic indication for operation.
Criminal abortion is usually undertaken by the
1. Widows for remarriage.
2. Unmarried girls.
3. Married woman of educated middle class to avoid addition to the family. Nowadays it is less due to
widespread knowledge of contraceptives.
4. The abortion may be undertaken solely for the purpose of sex determination to avoid female child.
7. Methods to induce Criminal Abortion
1. Mechanical violence ( general and local).
2. Abortifacient drugs.
3. Instruments.
8. Mechanical violence
General Mechanical Violence
These methods may act directly on the uterus or act indirectly by promoting congestion
of pelvic organs and causing haemorrhage between uterus and pelvic membranes. These
methods are:
1. Severe pressure over the abdomen as caused by the (blows, kicks, tight lacing and jumping)
2. Violent exercise such as (riding, cycling, jumping from height, jolting and lifting heavy weights.
3. Cupping: Cupping is placing a lighted wick over the hypogastric area and turning a brass mug over
the wick. The traction is applied over the mug that results in separation of placenta. The method is
usually employed in advanced months of pregnancy.
4. Very hot and cold baths alternatively.
5. Massaging the uterus through abdominal wall.
Local Mechanical Violence
While correcting the retroverted uterus bimanually
9. Abortifacient Drugs
The abortifacient drugs are:
1) Ecbolics:
They act directly on the uterus and increase the uterine contraction that causes abortion.
2) Emmenogogues:
They produce an increase menstrual blood flow and act as abortifacient when given in large doses.
3) Irritants of genitourinary tract:
these agents produce inflammation of genitourinary tract and irritates the uterus and induce uterine
contractions
4) Irritants of the Gastrointestinal tract:
They will excite uterus to contract “in sympathy” with the violent contractions of stomach and colon.
5) Drugs having poisonous effect on the body:
i. Inorganic irritants such as copper, mercury.
ii. Organic irritants such as unripe fruits of Papaya and Pineapple.
iii. Abortion Pill F-6103. It concentrates in the corpus luteum and acts by stimulating a woman's natural inclination to
menstruate even after presence of fertilized ovum and causes incomplete abortion.
10. Instruments
The instruments are used for the purpose of:
1. Rupture of membranes by introduction of penetrating instrument such as uterine sound,
catheter, pencil, knitting needle, hairpin, stick and even fingers.
2. Abortion stick: Abortion stick is a thin wood or bamboo stick, 12 to 18 cm (5-8 in) long and
its one end is wrapped with cotton wool or a piece of rag whose greater part is soaked with
juice of Marking nut, or a paste made of Arsenic oxide, sulphide etc.
Instead of stick, a twig of irritant plant such as calotropis.
3.Air insufflation: The air is instilled into vagina by means of syringes or pumps.
11. 4. Electricity: Negative pole is applied over the cervix and positive pole over sacrum
or lumber vessels and then the current is passed that results in uterine contractions
and subsequent abortion.
5. Paste: The paste containing iodine, thymol or mercury into the uterus
6. Syringing: Enema syringe with a hard bulb is commonly used to inject fluid in to
the uterus. A mixture of air and fluid is forced into uterine cavity at a higher
pressure than uterine veins. The fluid detaches parts of amniotic sac and placenta
from the uterine walls. The uterus contracts causing haemorrhage and thus abortion.
14. Immediate:
Hemorrhage
Perforation of uterus
Air embolism
Amniotic fluid embolism
Incomplete abortion
Local injury
Shock due to vagal inhibition resulting from instrumentation