Neural Control of Respiration - Abnormal Breathing Patterns - Sanjoy SanyalSanjoy Sanyal
Neural control of respiration (like neural control of many other physiological functions, micturition, for example) is highly complex and not fully elucidated. Research is still going on to determine the centers in the brain and their complex interactions. There may be variations of opinion between different researchers depending on newer findings.
Every effort has been made to keep this information as current and authoritative as possible, yet in a simple enough form for the student to understand and digest the information.
Dr Sanjoy Sanyal, Professor and Course Director of Neuroscience and FCM-III Neurology in Caribbean created this PPTX after studying this complex topic for a very long time.
Tags: Respiration, Breathing, Respiratory Centers, Brainstem, Apneustic Breathing, Biots Breathing, Cheyne-Stokes, Ataxic, Agonal, Kussmaul, Brainstem Reticular Nuclei, NTS, Locus Ceruleus, Fastigial, Raphe nucleus, Vagus, RTN nucleus, pFRG nucleus, Kolliker-Fuse, PBC nucleus, RVL nucleus
"Copyright Disclaimer Under Section 107 of the Copyright Act 1976, allowance is made for "fair use" for purposes such as criticism, comment, news reporting, teaching, scholarship, and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Non-profit, educational or personal use tips the balance in favor of fair use."
Educational Value: A very complex and poorly understood topic has been rendered in as simple a format and style as possible, so as to make it easily digestible to any Basic Science medical student and Medical Resident
Ventilation perfusion ratio (The guyton and hall physiology)Maryam Fida
Ventilation perfusion ratio is :
“The ratio of alveolar ventilation and the amount of blood that perfuse the alveoli”.
FORMULA
It is expressed as VA/Q.
VA is alveolar ventilation
Q is the blood flow (perfusion)
Normal value of ventilation perfusion ratio is about
0.8
VA is 4.2 L /min
Q is 5.5 L/min (Same as Cardiac output)
So VA/Q = 4.2/5.5 = 0.8
If VA becomes zero ratio becomes zero
If Q becomes zero ratio becomes infinite.
If ratio becomes zero or infinite then there is no gaseous exchange. So this ratio indicates the efficiency of gaseous exchange in lungs.
In standing or sitting position this ratio is not uniform in all parts of the lungs.
In standing position, in upper parts of lungs there is almost no blood flow so normally in upper parts of lungs the ratio is higher may be near 3.
In lower part of lungs, there is more blood flow so the ratio is decreased may be 0.6.
In certain diseases the VA/Q ratio is higher which means perfusion is inadequate i.e. in some parts of lungs the alveoli are non functional or partially functional. This is seen in cases of pulmonary thrombosis or embolism.
When there is higher VA/Q ratio, PO2 and PCO2 in the alveolar air resembles the values in the inspired air.
When exchange is not occurring because of lack of perfusion, inspired air goes to alveoli, as there is no exchange occurring so the same values of PCO2 and PO2 as in inspired air.
Neural Control of Respiration - Abnormal Breathing Patterns - Sanjoy SanyalSanjoy Sanyal
Neural control of respiration (like neural control of many other physiological functions, micturition, for example) is highly complex and not fully elucidated. Research is still going on to determine the centers in the brain and their complex interactions. There may be variations of opinion between different researchers depending on newer findings.
Every effort has been made to keep this information as current and authoritative as possible, yet in a simple enough form for the student to understand and digest the information.
Dr Sanjoy Sanyal, Professor and Course Director of Neuroscience and FCM-III Neurology in Caribbean created this PPTX after studying this complex topic for a very long time.
Tags: Respiration, Breathing, Respiratory Centers, Brainstem, Apneustic Breathing, Biots Breathing, Cheyne-Stokes, Ataxic, Agonal, Kussmaul, Brainstem Reticular Nuclei, NTS, Locus Ceruleus, Fastigial, Raphe nucleus, Vagus, RTN nucleus, pFRG nucleus, Kolliker-Fuse, PBC nucleus, RVL nucleus
"Copyright Disclaimer Under Section 107 of the Copyright Act 1976, allowance is made for "fair use" for purposes such as criticism, comment, news reporting, teaching, scholarship, and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Non-profit, educational or personal use tips the balance in favor of fair use."
Educational Value: A very complex and poorly understood topic has been rendered in as simple a format and style as possible, so as to make it easily digestible to any Basic Science medical student and Medical Resident
Ventilation perfusion ratio (The guyton and hall physiology)Maryam Fida
Ventilation perfusion ratio is :
“The ratio of alveolar ventilation and the amount of blood that perfuse the alveoli”.
FORMULA
It is expressed as VA/Q.
VA is alveolar ventilation
Q is the blood flow (perfusion)
Normal value of ventilation perfusion ratio is about
0.8
VA is 4.2 L /min
Q is 5.5 L/min (Same as Cardiac output)
So VA/Q = 4.2/5.5 = 0.8
If VA becomes zero ratio becomes zero
If Q becomes zero ratio becomes infinite.
If ratio becomes zero or infinite then there is no gaseous exchange. So this ratio indicates the efficiency of gaseous exchange in lungs.
In standing or sitting position this ratio is not uniform in all parts of the lungs.
In standing position, in upper parts of lungs there is almost no blood flow so normally in upper parts of lungs the ratio is higher may be near 3.
In lower part of lungs, there is more blood flow so the ratio is decreased may be 0.6.
In certain diseases the VA/Q ratio is higher which means perfusion is inadequate i.e. in some parts of lungs the alveoli are non functional or partially functional. This is seen in cases of pulmonary thrombosis or embolism.
When there is higher VA/Q ratio, PO2 and PCO2 in the alveolar air resembles the values in the inspired air.
When exchange is not occurring because of lack of perfusion, inspired air goes to alveoli, as there is no exchange occurring so the same values of PCO2 and PO2 as in inspired air.
Regulation of respiration (the guyton and hall physiology)Maryam Fida
Normal respiration is spontaneous and unconscious.
There are 4 groups of neurons on each side in the Pons and medulla oblongata which are involved in regulation of respiration. These include
1. Medullary centers
Dorsal respiratory group of neurons
Ventral respiratory group of neurons
2. Pontine centers
Pneumotaxic centre
Apneustic centre.
It contains “I”neurons which are inspiratory neurons.
It’s located in dorsal portion of medulla oblongata.
It also includes the nucleus of tractus solitarius which is the sensory termination of afferent fibers in 9th ( GLOSSOPHARYNGEAL NERVE) and 10th (VAGUS NERVE) cranial nerves.
They receive impulses from peripheral chemoreceptors, carotid and aortic baroreceptors and also other receptors in the lungs.
In this group inspiratory ramp signals are produced spontaneously.
If we cut the medulla oblongata from other parts of brain and also the afferent nerves which enter the medulla, still inspiratory ramp signals are produced which indicate it’s the inherent property of medulla.
Initially the signal is weak and then it progressively increases and then fades away.
Each ramp signal’s duration is 2 sec and then for 3 seconds there is no ramp signal.
So each cycle lasts for 5 seconds and there are 12 cycles /minute which is the respiratory rate.
Significance of the signal in the form of ramp is that it causes progressive expansion of the lungs. After production, these ramp signals are transmitted to the contra lateral motor neurons supplying the inspiratory muscles.
Rate and duration of inspiratory ramp signals is controlled by impulses from the Pneumotaxic centre and impulses from the lungs via vagi.
Like heartbeat, breathing must occur in a continuous, cyclic pattern to sustain life processes.
Inspiratory muscles must rhythmically contract and relax to alternately fill the lungs with air and empty them.
The rhythmic pattern of breathing is established by cyclic neural activity to the respiratory muscles
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Discussion #11. What physical findings might be indicative of a .docxmecklenburgstrelitzh
Discussion #1
1. What physical findings might be indicative of a patient with emphysema? The diagnosis is made on patients that usually are long term smokers, and they complaint of dyspnea, cough, and mucus expectoration. Most patients seek medical attention late in the course of their disease, usually ignoring smoldering symptoms that start gradually and progress over the course of years. The cough typically is worse in the morning with finite production of clear-to-white sputum. Dyspnea, emphysema's most significant symptom, does not generally occur until the sixth decade of life. However, patients with emphysema due to alpha 1 -antitrypsin deficit will exhibit the following characteristics: early presentation (< 45 y), predilection of emphysematous changes in the lung bases, and the panacinar morphological pattern.
Although the sensitivity of the physical evaluation in mild-to-moderate disease is relatively poor, the physical signs are quite sensitive and specific in severe disease. Patients with severe disease may experience tachypnea and dyspnea with mild exertion.
The respiratory rate increases in proportion to disease severity with the use of accessory respiratory muscles and paradoxical contraction of lower intercostal spaces becoming evident during exacerbations.
In end-stage emphysema, cyanosis, elevated jugular venous pressure, atrophy of limb musculature, and peripheral edema due to the development of pulmonary hypertension, right-to-left shunting, and/or right heart failure can easily be observed.
Thoracic examination reveals a 2:1 increase in anterior to posterior diameter (“barrel chest”), diffuse or focal wheezing, diffusely diminished breath sounds, hyperresonance upon percussion, prolonged expiration, and/or hyperinflation on chest radiographs.
2. What is the purpose and interpretations of the pulmonary function test? Pulmonary function tests will test the mechanical function of the lungs, chest wall, and respiratory muscles by measuring the total volume of air exhaled from a full lung (total lung capacity [TLC]) to maximal expiration (residual volume [RV]). This volume, the forced vital capacity (FVC) and the forced expiratory volume in the first second of the forceful exhalation (FEV1), In Emphysema, spirometry may show typical obstructive pattern due to the blockage of the air during expiration. As a result of the air trapping, the spirometry will show decreased in FVC, but less than the FEV 1, and increased FRC and RV.(McCance, & Huether, 2013).
3. What are the pathophysiological findings specifying emphysema? As a result of the cellular apoptosis, and early cellular senescence, the alveolar cells are damaged, and a reduced surface of gas exchanged occurred. The destruction of the alveoli creates bullae, which are large spaces in the lung parenchyma and air spaces adjacent to pleurae(blebs). Both elements bullae, and blebs difficult the air exchange. In addition, areas of the lungs that are bad perfused contributes to w.
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Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
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1. PHYSICAL
43 Respiratory Rate and Pattern
SHELDON R . BRAUN
Definition individuals with unchanging metabolic demand, the rate
and pattern are surprisingly constant, only interrupted every
Normal ventilation is an automatic, seemingly effortless in- several minutes by a larger inspiratory effort or sigh . Ven-
spiratory expansion and expiratory contraction of the chest tilation at rest in most individuals requires only the inspi-
cage . This act of normal breathing has a relatively constant ratory muscles . Expiration is usually passive and is secondary
rate and inspiratory volume that together constitute normal to the respiratory system returning to its resting state .
respiratory rhythm . The accessory muscles of inspiration Therefore, with quiet breathing the inspiratory time is the
(sternocleidomastoid and scalenes) and expiration (abdom- period of active respiratory pacemaker output. Adjusting
inal) are not normally used in the resting state . Abnormal- the rate, length, and intensity of neural output from the
ities may occur in rate, rhythm, and in the effort of breathing . pacemaker will lead to changes in the breaths per minute
and the volume of each inspiration or tidal volume . These
final outputs of the respiratory pacemaker, the rate and
Technique tidal volume, are the two components of ventilation . The
expiratory muscles begin to play a role with disease or in-
The establishment of the tidal volume and pattern of res- creased ventilatory demands . When this occurs, the length
piration in normal individuals is a complicated process . Rec- of time it takes to empty the lungs adequately will also lead
ognizing alterations in these factors is an important early to changes in rate and tidal volume .
clue of disease recognition . While frequently it is nonspe- Minute ventilation is the product of rate and tidal vol-
cific, in many instances it can lead directly to a diagnosis . ume . It is important to differentiate between the effect
Careful observation of the respiratory rate and pattern is a changes in rate and tidal volume have on gas exchange . Any
crucial part of the physical examination . given tidal volume is divided into two components . One
Simple inspection of the respiratory cycle, observing rate, part is the dead space . This is the portion of the volume
rhythm, inspiratory volume, and effort of breathing, is all moved into the lungs during ventilation that does not come
that is necessary . The rate is noted by observing the fre- into contact with functioning pulmonary capillaries . An ex-
quency of the inspiratory phase, since this phase is active ample is air at the end of inspiration, which reaches only
and easy to count . Record the number of breaths per min- the trachea or bronchi where there are no capillaries . Since
ute ; this is the respiratory rate . While observing the rate, there is no air-blood interface, 0 2 cannot reach the circu-
note the inspiratory expansion of the chest cage . This ex- lation nor can any CO 2 be removed . The other component
pansion should be the same during each cycle . is called the alveolar volume . This is the part of a tidal breath
Normally, the accessory muscles of inspiration and ex- that enters the air spaces of the lung that are perfused by
piration are not used . Their use should be observed and, functioning capillaries . In normal individuals these air spaces
if found, recorded as "use of accessory muscles on inspi- are the terminal respiratory unit and include the respiratory
ration" and "expiration is active with abdominal muscle bronchioles, alveolar ducts, alveolar sacs, and alveoli . Only
contraction." the alveolar volume component of each tidal breath con-
tributes to gas exchange ; the rest is really wasted ventilation .
If minute ventilation is increased by making the tidal volume
Basic Science larger, it will have a greater effect on gas exchange than if
the same minute ventilation is reached by increasing the
The respiratory system's major functions are to provide an rate .
adequate oxygen (0 2 ) supply to meet the energy production
requirements of the body and maintain a suitable acid-base
status by removing carbon dioxide (CO 2 ) from the body .
Regulation of Pacemaker Output
This is accomplished by moving varying volumes of air into
and out of the lungs . Ventilation, the process of air move- The medullary respiratory control center, or pacemaker,
ment into the lungs, is a carefully controlled modality with receives three kinds of feedback . These impulses are inte-
a wide range of response that enables the markers of gas grated within the control center . The output from the res-
exchange adequacy (Pao 2 , Paco2 , and pH) to be kept within piratory center is then altered in timing or intensity, leading
a relatively small physiologic range . to changes in the rate and tidal volume . The three kinds of
To maintain accurate control the respiratory system has feedback are chemical, mechanical, and input from higher
a central respiratory pacemaker located within the medulla cortical centers .
of the brainstem . Neural output travels from this center The normal individual is able to keep Pao 2 , Paco 2 , and
through the spinal cord to the muscles of respiration . The pH within narrow limits . In order to accomplish this level
changes are effected through two groups of muscles, in- of control, the respiratory center receives input from both
spiratory and expiratory, which contract and relax to pro- peripheral and central chemoreceptors . The major periph-
duce a rhythmic respiratory rate and pattern . In most eral receptors are located within the carotid bodies found
226
2. 43 . RESPIRATORY RATE AND PATTERN 227
in the bifurcation of each common carotid artery . There Receptors in the lung itself appear to contribute to this
are also similar structures in the aorta, but less is known inspiratory limitation . One group is the stretch receptors .
about these aortic bodies . The afferent limb of these re- Efferents from these increase their neural output the larger
ceptors responds to Pao 2 and pH changes . The efferent a given lung volume becomes . In some animals these re-
limb produces changes in minute ventilation through the flexes are very important, but in normal humans they ap-
respiratory control center . The response to changing Pao 2 pear to be less important and can be easily overcome by
levels can be detected as high as 550 mm Hg, but at that other neural inputs . The output of these receptors can,
Pao2 level the resulting change in rate and volume is small . however, limit the degree of inspiration by means of the
As the Pao 2 drops to 55 to 60 mm Hg, there is a much Hering-Breur reflex. Probably in disease states this reflex
greater and more important respiratory response with large plays a more important role in limiting inspiration . The
increases in minute ventilation for each mm Hg change in other lung parenchymal receptors that may play a role in
Pao 2 . The carotid body also responds to small changes in limiting the size of each tidal volume are the juxtapulmona
pH, but approximately two-thirds of the response to pH is r.yTchaepsil tofre,J-cptos
a result of the central chemoreceptors . The response of the when pulmonary capillaries are distended .
carotid bodies to Paco2 is secondary to changes in pH re- A final modulator of the central respiratory drive is input
sulting from the Paco 2 change . from higher centers . For example, the state of being awake
The medullary chemoreceptor is located on the ventral is associated with important neural inputs to the respiratory
surface of the medulla . This receptor responds to changes center that will play a large role in determining an individ-
in pH and is the most important receptor regarding res- ual's respiratory rate and pattern . When an individual falls
piratory changes to acid-base alterations . It responds to asleep, the cortical input decreases, as does the respiratory
changes in cerebrospinal fluid rather than blood and is very center output . During nondreaming or non-rapid-eye-
sensitive to very small changes in the hydrogen ion concen- movement sleep, the input from the chemical receptors be-
tration in the cerebrospinal fluid . Since CO2 rapidly crosses comes increasingly important. If absent, apnea may result .
the blood-brain barrier, it rapidly alters the pH of the spinal During sleep associated with rapid eye movements or
fluid . An increase of 1 mm Hg of Pco 2 in the cerebrospinal dreaming, the breathing patterns may be related to the
fluid leads to an increased ventilation of 2 to 3 liters per contents of the dreams and again reflect input from higher
minute . The medullary chemoreceptor also adjusts the res- cortical centers . Higher center input also accounts for hy-
piratory response to altered pH secondary to metabolic aci- perventilation associated with anxiety and other behavioral
dosis or alkalosis . With the slower equilibration of hydrogen factors .
or bicarbonate across the blood-brain barrier, however, these
changes are not as quick as the rapid respiratory changes
produced by a change in Pco2 .
Alterations in Rate and Tidal Volume
Another neural input to the respiratory pacemaker comes
from receptors in the lung and is related to the mechanical All three types of input are integrated in the medullary
properties of the lung . An individual who elected to breathe respiratory center and lead to changes in the minute ven-
at a rate of 5 breaths per minute with a large tidal volume tilation . These changes are seen as changes in rate, volume,
would have efficient gas exchange because the ratio of dead or both . Table 43 .1 demonstrates how these factors may
space to tidal volume would be low . The larger the inspi- interrelate in normal individuals . If the ventilation during
ratory lung volume, however, the greater becomes the elas- a minute (minute ventilation) was 6 liters and was done at
tic recoil of the lung . At greater lung volumes, chest wall a rate of 60 breaths with a tidal volume of 100 cc each, there
elasticity is also added and must be overcome . Therefore, would be no alveolar ventilation at all . This is because the
the larger the inspiratory lung volume, the greater the in- normal dead space consisting of the trachea and some bron-
spiratory pressure needed to overcome the elastic recoil and chi is about 150 cc. Even if the rate was slowed to 30 breaths
expand the lung . The greater the inspiratory pressure, the per minute, the result would be an alveolar ventilation of
greater is the work of breathing by the respiratory muscles . only 1 .50 L . This would be inadequate to meet CO 2 pro-
The respiratory system appears to choose a rate that re- duction and would lead to an elevation of the Paco 2 and a
quires the least amount of mechanical work while main- lowering of the pH . Both the central and peripheral chemo-
taining adequate gas exchange . There is a wide range of receptors would be stimulated . There might also be a con-
tidal volumes before the mechanical limitation comes into comitant fall in Pao 2 , which would lead to increased neural
effect, but there appear to be lower limits of rates that are output from the carotid bodies . The result of the increase
not tolerated because of the required increase in inspiratory of input to the central center would be an alteration in the
work . rate and pattern of breathing .
Table 43 .1
The Effect of Changes of Respiratory Rate and Tidal Volume on Alveolar Ventilation
Minute Respiratory Tidal Dead space° Alveolar ventilation
ventilation (L) rate volume (L) (L/min) (L/min)
6 .0 60 0 .1 6 .0 0
6 .0 30 0 .2 4 .5 1 .5
6 .0 15 0 .4 2 .25 3 .75
6 .0 2 3 .0 0 .3 5 .7
'A dead space of 150 ml/breath is assumed .
3. 228 III . THE PULMONARY SYSTEM
A third breathing alternative would be choosing a res- Mechanical properties also are altered by diseases . In-
piratory rate of 2 per minute . This would give an extremely terstitial disease probably enhances the stretch receptor re-
efficient breath with very little wasted as dead space . The sponse, leading to rapid shallow ventilation . This is efficient
problem with the large volume is it would require increased because the lung with interstitial disease is less compliant,
work of breathing and stimulate stretch receptors . There- requiring more distending pressure per unit of volume than
fore, unless a constant conscious effort was maintained, the normal . By breathing at lower tidal volumes, the work of
respiratory central center would inhibit inspiratory effect breathing is diminished . Congestive heart failure can pro-
before reaching tidal volumes of 3 liters . Furthermore, the duce a similar effect . This is partly related to the reduced
very efficient gas exchange could lead to a lowered Paco 2 . compliance, but also may be a result of stimulation of the
The resulting increased pH would produce less drive to J-receptors, which lie right next to the capillaries .
breathe and lower minute ventilation . The best alternative The respiratory center feedback from the higher cortical
in a normal individual would be to choose an intermediate centers can also be modulated with diseases . Anxiety can
rate of 10 to 20 breaths per minute . The example of 15 increase the respiratory rate and pattern . The acute hy-
breaths per minute would meet metabolic needs effectively . perventilation syndrome is an example where drive from
In normal individuals, multiple factors affect the respi- higher centers can maintain a high minute ventilation in
ratory rate and pattern at rest . Normal people also must face of an elevated pH . Increased intracranial pressure leads
adjust to changing metabolic demands, as seen with exer- to a rapid and deep breathing pattern . This pattern is fre-
cise . Using the input from various receptors, the respiratory quently seen with head trauma . Pain contributes to a rapid
center finely adjusts both rate and pattern to keep Pao 2 and respiratory rate . A fractured rib produces pain on inspi-
pH within a relatively small range in spite of increased meta- ration and therefore leads to a low-volume, rapid-rate pat-
bolic demands of 15 or more times the needs at rest . tern . Tachypnea is commonly part of any chest pain and is
partly modulated through higher cortical input .
The central controlling center can be affected directly .
Clinical Significance Any central nervous system depressing drug will reduce the
respiratory rate and pattern . It will also blunt the response
Abnormal Central Respiratory Control to other neural inputs . The patient with obstructive lung
disease who receives a narcotic frequently will elevate the
Altered respiratory rate and pattern often accompany a Paco 2 even further. The same is true for many drug ov-
variety of disease states . These diseases frequently lead to erdoses . If the central nervous system is depressed by drugs,
alterations in one of the three kinds of feedback to the the depression of the respiratory center leads to CO 2 re-
central respiratory control center or in the control center tention .
itself. For example, pathological conditions altering Pao2,
Paco2, or pH can obviously alter the input from both the
carotid body and the medullary chemoreceptors . The usual
response to any altered chemoreceptor input is, first, a Central Nervous System Abnormalities
change in tidal volume, followed by change in respiratory The changing rate and pattern of respiration can often
rate . Therefore, lung diseases that cause acute hypoxemia suggest localization of CNS changes . Understanding of the
to a level lower than 55 to 60 mm Hg will usually produce areas of the brain involved with specific patterns have come
increased ventilation . The response to increasing Paco 2 and from animal studies . Lesions or cuts made in various parts
lowered pH can produce rapid changes in minute ventila- of the brain lead to specific breathing patterns . Transection
tion also by stimulating the chemoreceptors . The elevation of the pons will not affect normal breathing if the vagi are
of Paco 2 is not always associated with the expected increase intact . If vagi are cut, however, larger tidal volumes with a
in minute ventilation, however . Elevation of PaCO2 can lead slower rate are observed . A midpons transection will lead
to CO 2 narcosis and depression of the respiratory center . to maintenance of spontaneous breathing but with a slow
Metabolic acidosis, in contrast, will most likely increase the and regular pattern . If the vagi are cut, apneustic breathing
ventilation predominantly by increasing the tidal volume . occurs . This is sustained inspiratory spasm . Pontomedullary
Kussmaul respiration, the classic pattern seen in diabetic junction transection will lead to an irregular, ataxic breath-
ketoacidosis, consists of slow, deep breaths that reflect the ing pattern .
increased tidal volume and actual slowing of rate . The oc-
currence of respiratory compensation for a metabolic change
may be slowed because cerebrospinal fluid changes lag be-
hind blood changes . An acute pH drop in the blood will Abnormal Respiratory Patterns
stimulate the peripheral chemoreceptors, leading to hyper- Cheyne-Stokes breathing is a classic breathing pattern seen in
ventilation and acutely lowering the Paco 2 . This will lead both normal individuals at altitude and individuals with
to a lowered Pco 2 in the cerebrospinal fluid . Since the hy- severe neurological or cardiac disease. The pattern (Figure
drogen ion associated with the metabolic acidosis does not 43 .1) demonstrates periods of hyperventilation alternating
cross the blood-brain barrier immediately, the medullary with periods of apnea . The apneic spells can last as long as
chemoreceptors may initially reduce respiration because the 45 seconds . The abnormality appears to be related to a slow
reduced Pco 2 will make the cerebrospinal fluid alkalotic . In feedback loop and an enhanced response to Paco 2 . During
a matter of hours the spinal fluid pH is decreased, and the periods of hyperventilation, the Paco2 is at its highest, while
appropriate response will occur . Ventilation will also be the Pao, is at its lowest . As ventilation slows, the Paco 2 drops
slowed with metabolic alkalosis . This change may not be and reaches its lowest level during apnea . It is important to
detectable on routine physical examination . Nevertheless, observe that Paco 2 levels do not exceed the normal range
it can also lead to enough slowing that the Paco 2 becomes during any part of the cycle .
markedly elevated .
4. 43 . RESPIRATORY RATE AND PATTERN 229
These individuals can frequently keep their rate more
rhythmic if they try consciously . The abnormality is in the
medullary chemoreceptor or the medullary respiratory con-
trol center .
One other aspect of respiratory pattern must be consid-
ered . This is the coordination between the chest wall and
abdomen . Normal individuals contract both the diaphragm
and external intercostal muscles during inspiration . On
physical examination the action of both inspiratory muscle
Figure 43.1 actions can be determined . The diaphragm, when contract-
Cheyne-Stokes breathing . ing normally, moves the abdominal contents downward and
outward . In Figure 43 .2 this is represented by an upward
deflection of the abdominal curve . On physical examination
There are several probable causes of this abnormal it is felt as an anterior movement of the abdomen . The
breathing pattern . Many cases have diffuse cerebral dam- other major groups of inspiratory muscles, the external in-
age, whereas some individuals are in congestive heart fail- tercostals, move the chest wall outward . This can also be
ure . It is seen in normal individuals during sleep at altitude . determined by feeling an anterior movement of the chest
It has been shown in dogs that a markedly prolonged cir- wall during inspiration and is reflected in the figure as an
culation time from the left ventricle back to the brain can upward deflection . In normal persons, therefore, there is
also induce Cheyne-Stokes respiration . In individuals with a coordinated movement of the chest wall and abdomen
either neurological or cardiac disease it frequently is a poor moving outward on inspiration and inward on expiration .
prognostic sign . Treatment is usually improvement of the Alterations in this pattern will allow diagnosis of changing
underlying disease, but aminophylline has been effective in respiratory muscle contribution to the tidal breath .
some cases . Paralysis of the intercostals results from cervical spinal
A Cheyne-Stokes respiratory pattern can also be seen in cord injury . In this group of patients on physical exam there
individuals with much more severe neurological depression . is a paradoxical movement of the chest wall inward and the
These individuals have a low pontine or upper medullary abdomen outward during inspiration (Figure 43 .2) . This
lesion . Unlike the more classic Cheyne-Stokes respiration, reflects the passive movement of the chest wall . The pattern
these individuals are cyanotic and have CO 2 retention . They results from the tidal breath being produced by diaphrag-
have reduced sensitivity to CO 2 . Oxygen will enhance this matic contraction . Diaphragmatic paralysis can be diagnosed
pattern, while it may reduce the more classic picture . or suggested by an inward movement of the diaphragm
Biot respiration, or cluster breathing, is also periodic in during inspiration . This movement is accentuated in the
nature but does not have the crescendo-decrescendo pat- supine position . In that position, diaphragmatic contraction
tern seen with Cheyne-Stokes respiration . It is clusters of produces approximately two-thirds of the inspiratory vol-
irregular breaths that alternate with periods of apnea . This ume as compared to one-third in the upright position .
breathing pattern is seen in individuals with pontine lesions . Diaphragmatic dysfunction can also be diagnosed with
Ataxic breathing is one of varying tidal volumes and rates . the finding of the same paradoxical inward abdominal
Figure 43 .2
Chest wall and abdominal coordination during tidal breathing .
5. 230 III . THE PULMONARY SYSTEM
movement during inspiration . This pattern of respiration over one minute is the alveolar ventilation and is inversely
is seen in some individuals with severe emphysema and air related to the Paco 2 . Hyperventilation reduces Paco 2 , lead-
trapping . The air trapping leads to a low, flat diaphragm. ing to decreased respiratory drive and a patient who does
The diaphragm no longer can contract effectively . This not "trigger" the ventilator . Hypoventilation produces CO 2
inability to contract is demonstrated by the inward inspi- retention and increased respiratory drive by the patient .
ratory movement of the abdomen. The movement results This leads to either rapid ventilation rates triggered by the
from the ineffective diaphragm being pulled into the thorax patient or a patient demonstrating marked discomfort . Con-
during inspiration . This breathing pattern has been re- sideration of dead space is important . Diseases can increase
ported to have a predictive value for impending respiratory the dead space by reducing the capillary bed . Therefore,
failure . larger tidal volumes may be necessary to get adequate gas
Another value of determining changes in chest wall ab- exchange . Finally, volumes that are too large lead to asy-
dominal breathing patterns has been seen in individuals chrony by the patient who tries to start the next breath
being weaned from mechanical ventilation . They develop before the ventilator is ready . This may relate to stretch
a respiratory alternans pattern . A series of tidal breaths al- receptor responses, but is a fatiguing and inefficient mode
ternates between a short period of abdominal inward move- of gas exchange .
ment during inspiration followed by a period of chest wall
inward movement during inspiration . This has been dem-
onstrated to be associated with fatigue and indicates wean- References
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Understanding respiratory rate and pattern is a very im-
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portant addition in dealing with many respiratory, cardiac,
Pathophysiology of respiration . New York : Wiley, 1981 ;103-
and neurological diseases . Nevertheless, understanding the
22 .
role of rate and tidal volume is also essential in managing
Mead J . Control of respiratory frequency . J Appl Physiol 1960 ;
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priate arterial blood gases . The sum of each alveolar volume