1. Outflow tract VT is the most common type of idiopathic VT, accounting for over 60% of cases in the study.
2. Pace mapping alone may not accurately locate ablation sites, especially for VT associated with scar tissue. Activation mapping and substrate identification are important complementary mapping techniques.
3. Successful ablation of substrate-based VT requires targeting abnormal electrograms within scar regions like late potentials or fractionated signals at the critical isthmus.
Ventricular tachycardia are difficult to understand. it is classified in to two types. 1. VT in structurally normal heart, 2. VT in heart with structural diseases. I have tried to simplify the VT in structurally normal heart, which may be helpful to many students and learners.
Idiopathic VT refers to VT occurring in structurally normal hearts in the absence of myocardial scarring. Classification of monomorphic idiopathic VT includes outflow tract VT, fascicular VT, papillary muscle VT,annular VT, and miscellaneous (VT from the body of the RV and crux of
the heart). It is commonly seen in young patients and usually has a benign course. The 12-lead lectrocardiogram is critical in distinguishing the specific form and locations of idiopathic VT. Treatment options include medical therapy specific to the underlying mechanism of VT or catheter
ablation.
Ventricular tachycardia are difficult to understand. it is classified in to two types. 1. VT in structurally normal heart, 2. VT in heart with structural diseases. I have tried to simplify the VT in structurally normal heart, which may be helpful to many students and learners.
Idiopathic VT refers to VT occurring in structurally normal hearts in the absence of myocardial scarring. Classification of monomorphic idiopathic VT includes outflow tract VT, fascicular VT, papillary muscle VT,annular VT, and miscellaneous (VT from the body of the RV and crux of
the heart). It is commonly seen in young patients and usually has a benign course. The 12-lead lectrocardiogram is critical in distinguishing the specific form and locations of idiopathic VT. Treatment options include medical therapy specific to the underlying mechanism of VT or catheter
ablation.
Ventricular tachycardia (VT) is a broad complex tachycardia originating from a ventricular ectopic focus. It is defined as three or more ventricular extrasystoles in succession at a rate of more than 120 beats per minute (bpm). Accelerated idioventricular rhythm refers to ventricular rhythms with rates of 100-120 bpm
Brief explanation of Junctional arrhythmia and Ventricular Arrhythmia. Slide 15, 16 and 18 are animations but cannot be viewed through the slide. Mail me if you need the animation or visit the website on the reference (number 7) and choose the animation according to your preference.
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Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
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Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Evaluation of antidepressant activity of clitoris ternatea in animals
Ventricular tachycardia_lecture
1. Ventricular Tachycardia
林彥璋 醫師,
Lin Yenn-Jiang MD. Chen Shih-Ann MD.
April 24, 2011
Advanced EP training, THRS
St. Jude Medical, Taipei
Division of Cardiology, Taipei Veterans General Hospital
and National Yang-Ming University, Taipei, Taiwan
6. Outflow Tract Ventricular
Tachycardia (OT-VT)
VT arises from the right ventricular outflow
tract (RVOT-VT, left ventricular outflow
tract (LVOT-VT), aortic cusps (Cusp VT),
and from the pulmonary artery (PA VT)
OT-VT tend to occur in the absence of
structural heart disease and are focal in
origin, the 12-lead ECG recorded during
VT is a precise localizing tool.
7. Clinical Features of RVOT-VT
RVOT VT constitutes 75% of all patients
with outflow tract VT
RVOT VT is more common in females 30-
50 years old.
Symptoms include palpitations, dizziness,
atypical chest pain, and syncope.
Exercise testing reproduces the patient’s
clinical VT 25 to 50% of the time.
8. Mechanism of RVOT-VT
Most forms of RVOT VT are sensitive to
adenosine
Most likely mechanism is catecholamine
mediated DAD and triggered activity.
Mediated by the activation of cyclic AMP.
Can be induced in the EP lab with
isoproterenol, aminophylline, atropine, and
rapid burst pacing but rarely with
programmed ventricular extrastimuli.
9. 1. Important overlapping
nature of the outflow
tract course!
2. RVOT and PA lie
anterior and to the left
of the LVOT and aorta.
16. LVOT and Aortic Cuspid VT
VT arising from the LVOT shares similar
characteristics to the RVOT VT because of a
common embryonic origin.
ECG: LBBB with inferior axis with small R-
waves in V1 and early precordial transition
(R/S 1 by V2 or V3) or RBBB morphology with
inferior axis and S-wave in V6.
Aortic cusp VT accounts for up to 21% of
idiopathic VT.
More commonly arises from the LCC, than the
RCC and rarely arise from the NCC.
19. Mapping Tool for OT-VT
ECG morphology:
Could be non-inducible
Pacing morphology
could be large area 2 cm2: different chamber, scar, or
epicardium,
Activation map
More accurate: remain unsuccess: more mapping sites,
epicardium, different energy sources,
22. Schema of the Ventricular Arrhythmia Origin, Breakout Site, and
Preferential Conduction From the LCC Origin to the RVOT or
Left Ventricular Septum
T. Yamada, et al
JACC, 2007,
Vol. 50, No. 9: 884-91
24. Requirement of NCM
for VT mapping
Pacing mapping may not sensitive to
locate the sites of foci in certain patients
with focal VT, in the presence of large
scar area.
VT could be non-sustained and unstable.
It is difficult to map the entire chamber
One beat analysis of dynamic substrate by
NCM may be useful to treat these patients.
26. RVOT VPC form the LVZ border
(Higa S: University of the Ryukyus, Okinawa, Japan) 2010
Taipei VGH
27. Conclusions
Carefully ECG interpretation and EP study to
localize the optimum ablation site for VT.
Usually not life threatening, and could be treated
conservatively.
3D mapping system can be helpful (activation
map or substrate map), but correct chamber, far-
field sensing, preferential conduction need to be
considered.
30. Idiopathic RVOT-T
Right ventricular outflow tract tachycardia
(RVOT-T) represents up to 10% of all ventricular
tachycardias (VTs), and is considered as a
benign disease.
Symptoms: Ranging from none to palpitations,
lightheadedness, dyspnea, or syncope.
Arrhythmias: Frequent isolated PVCs, bursts of
nonsustained VT, or sustained tachycardia often
facilitated by catecholamines or exercise.
Ablation: Acute success rate of focal ablation of
RVOT-T is 65–97% with rare complications.
33. Arrhythmogenic RV Dysplasia
Cardiomyopathy begins in RV with poor contractile
function and dilatation, progresses to LV finally.
Histology: RV muscle becomes replaced by adipose
and fibrous tissue.
Arrhythmia: Re-entrant Type (scarring & late
Potentials) with LBBB type ECG;
ECG: Diffuse T wave inversion over precordial leads,
and Epsilon Wave.
Ablation: The effect of catheter ablation is
temporizing, 1/3 epicardium, mostly reentry.
Implanted cardioverter defibrillator (ICD) is the only
reliable therapy for sudden cardiac death.
34. Task Force Criteria
TF (Definite +) if meet 2 major or 1 major 2 minor criteria
McKenna et al. 1994, BMJ
36. Conclusions
Positive TF criteria is important to diagnose
ARVC/D and is specific to detect the future
VF/ICD implantation/ CV mortality
Malignant ventricular arrhythmia and late
recurrences may occur in patients with mild
or atypical form of arrhythmogenic RV
cardiomyopathy.
42. Where to Target
Diastolic potential (P1) in the
midseptum of LV. P1-QRS=28-130 msec
If P1 could not be identified, target the
fused and earliest Purkinje potential
(P2)
Successful ablation revealed P1 during
SR could be a marker of successful
ablation.
44. Structure heart related VT
• BBRT
• Ischemic heart disease (most common):
mostly Endocardium
• ARVC: Epi/Endo
• Non-ischemic cardiomyopathy: Epi/Edno
• Tetralogy of Fallot and other post
operation patients: Endo
45. Substrate VT
Identification of the critical ventricle
to be targeted (voltage mapping).
Identify the location of the scar
(bipolar voltage <0.5 mV, unipolar
PNV < 30%).
Conventional entrainment
techniques remain important.
58. RVOT-T Patient
Voltage of SR Spectral Analysis Activation of VT
3.5 cm
from PV
Successful site
septum
Free
wall
Eg during SR
Scar in the free wall site
59. Conclusions
Outflow tract VT is the commonest form of
idiopathic VT.
ECG morphology is important for localization of
focal VT and exit site of substrate VT before 3 D
mapping.
Pacing mapping may not sensitive to locate the
sites of foci in certain patients with focal VT, in
the presence of large scar area.
Substrate mapping and entrainment mapping
are important for the substrate VT.