nanoparticles

2. Core-shell nanoparticles and its biomedical
applications

3. Core–shell nanoparticles
• Particles that contain an inner core
covered by a shell

4. Morphologies of CSNs
a) Spherical core-shell nanoparticles
b) Hexagonal core-shell nanoparticles
c) Multiple small core materials coated by single
shell material
a) Nanomatryushka material
b) Movable core within hollow shell material.

5. Fig 1 . General classification of CSNs based on material-type (along with the most prevalent synthetic methods)
and properties of their shells.

6. Classification of core-shell nanoparticles
Depending on their material properties
1) Inorganic-inorganic (Fe3O4@SiO2)
2) Inorganic-organic (Fe@PIB)
3) Organic-inorganic (PEG@SiO2)
4) Organic-organic (PS@NIPA )

7. Mechanism leading to the formation of core@shell
Deposition of phase
controlled seeds of the shell
forming agent

8. Importance of core-shell nanoparticles
Core-shell nanoparticles are widely used in different applications such as
• Biomedical and pharmaceutical applications
• Catalysis
• Electronics
• Enhancing photoluminescence
• Creating photonic crystals
• Sensors

9. Biomedical applications of Core-shell nanoparticles
Core-shell nanoparticles have
Less cytotoxicity
Increase in dispersibility, bio and cyto-
compatibility
Better conjugation with other bioactive
molecules
Increased thermal and chemical stability

10. Drug Delivery
DOX delivery by ZnO-
DOX@ZIF-8 core-shell
nanoparticles
• Mesoporous ZnO core
• Microporous ZIF-8 shell
Dispersiability
Stability
pH responsive

11. Biosensor
hollow carbon spheres used
as immobilization support for
enzyme
Polyaniline reserves activity
of enzyme
 AChE as indicator

12. Bioimaging
NaYF4:Nd/NaLuF4@PDA core-shell nanocomposite

13. Gene Delivery
• M-MSNs-based siRNA-delivery
platform functionalized with PEI
and fusogenic peptide KALA (M-
MSN-siRNA@PEI-KALA).
• Adsorption of short length RNA
inside mesopores of M-MSNs.
• PEI multilayer as the reaction sites
for further functionalization.

14. Conclusion
Due to enhanced properties and less toxicity core/shell nanoparticle
have better biomedical applications over nanoparticles.