drug delivery

3. CONTENTS
 Hydro gels Controlled Drug
Delivery
 Polymeric Micelles

4. A polymer is a large molecule constructed from
many small structural units called monomers,
covalently bounded together in any possible
pattern

6. Polymerization catalysts
Double bond broken
Resultant extra single bond
carbon atom in another ethylene

7. Condensation Polymers

8. Natural Synthetic

9.  Rubber
 Plastic
 Food


10. • Method of administering a pharmaceutical
compound
• To achieve a therapeutic effect in humans
• Technologies modify drug release profile,
absorption, distribution and elimination
• Improving product efficiency and safety
• Drug release is from: diffusion,
degradation, swelling.

13. Film Coating
Anti adherent
Lubricant
Disintegrate
Binder

14. TechnologyActionDosage Form
 Tablets Coating
 Capsule
 Granules/
Pallets
 Microcapsule
 Gel
 Protective
 Site Specific
 Matrix
Dissolution
•Polymer
dissolve slowly
 Matrix
Diffusion
•Through voids

16. Hydro gels Controlled Drug Delivery
Hydrogels are water swollen
polymeric material with huge
tendency to absorb water there
ability to swell under physiological
condition makes them ideal
material.

17. Ring cap Technology
• Tablet (usually film coated)
• Series of “rings”
• insoluble polymer does not degrade
• thickness of rings control
• rate of release of drug
• final dosage form

18. Pulsincap
• Capsule body contains drug and hydrogel polymer
capable of rapidly expelling the drug at the
predetermined time
• Water insoluble capsule body and a water soluble
cap
• As the soluble cap erodes, the hydrogel swells and
pushes out the drug
• The hydration rate depends on the hydrogel plug,
the length of the plug and the fit ratio (plug
diameter to body diameter)

19. Polymeric Micelles

21. Conclusion
 Great potential in drug delivery application
 Closest imitating of natural products
 Practice to potential---FDA approval requires
extensive toxicity investigation