Core-shell nanoparticles consist of an inner core covered by an outer shell. They are classified based on their material properties as inorganic-inorganic, inorganic-organic, organic-inorganic, or organic-organic. Core-shell nanoparticles are widely used in biomedical applications due to their less cytotoxicity, increased dispersibility and biocompatibility, better conjugation with biomolecules, and greater thermal and chemical stability compared to single component nanoparticles. Examples of biomedical uses discussed in the document include using ZnO-DOX@ZIF-8 nanoparticles for pH-responsive drug delivery, hollow carbon spheres for enzyme immobilization in biosensors, and NaYF4:Nd/NaLuF4@PDA nanoparticles

2. Core-shell nanoparticles and its biomedical
applications

3. Core–shell nanoparticles
• Particles that contain an inner core
covered by a shell

4. Morphologies of CSNs
a) Spherical core-shell nanoparticles
b) Hexagonal core-shell nanoparticles
c) Multiple small core materials coated by single
shell material
a) Nanomatryushka material
b) Movable core within hollow shell material.

5. Fig 1 . General classification of CSNs based on material-type (along with the most prevalent synthetic methods)
and properties of their shells.

6. Classification of core-shell nanoparticles
Depending on their material properties
1) Inorganic-inorganic (Fe3O4@SiO2)
2) Inorganic-organic (Fe@PIB)
3) Organic-inorganic (PEG@SiO2)
4) Organic-organic (PS@NIPA )

7. Mechanism leading to the formation of core@shell
Deposition of phase
controlled seeds of the shell
forming agent

8. Importance of core-shell nanoparticles
Core-shell nanoparticles are widely used in different applications such as
• Biomedical and pharmaceutical applications
• Catalysis
• Electronics
• Enhancing photoluminescence
• Creating photonic crystals
• Sensors

9. Biomedical applications of Core-shell nanoparticles
Core-shell nanoparticles have
Less cytotoxicity
Increase in dispersibility, bio and cyto-
compatibility
Better conjugation with other bioactive
molecules
Increased thermal and chemical stability

10. Drug Delivery
DOX delivery by ZnO-
DOX@ZIF-8 core-shell
nanoparticles
• Mesoporous ZnO core
• Microporous ZIF-8 shell
Dispersiability
Stability
pH responsive

11. Biosensor
hollow carbon spheres used
as immobilization support for
enzyme
Polyaniline reserves activity
of enzyme
 AChE as indicator

12. Bioimaging
NaYF4:Nd/NaLuF4@PDA core-shell nanocomposite

13. Gene Delivery
• M-MSNs-based siRNA-delivery
platform functionalized with PEI
and fusogenic peptide KALA (M-
MSN-siRNA@PEI-KALA).
• Adsorption of short length RNA
inside mesopores of M-MSNs.
• PEI multilayer as the reaction sites
for further functionalization.

14. Conclusion
Due to enhanced properties and less toxicity core/shell nanoparticle
have better biomedical applications over nanoparticles.