Vertigo is a subtype of dizziness in which a patient inappropriately experiences the perception of motion (usually a spinning motion) due to dysfunction of the vestibular system.
Vertigo is a problem commonly encountered in daily clinical practice.So an uniform approach to a patient with Vertigo is essential to identify the underlying aetiology of Vertigo.
Vertigo is a subtype of dizziness in which a patient inappropriately experiences the perception of motion (usually a spinning motion) due to dysfunction of the vestibular system.
Vertigo is a problem commonly encountered in daily clinical practice.So an uniform approach to a patient with Vertigo is essential to identify the underlying aetiology of Vertigo.
Please find the power point on Benign Paroxysmal Positional Vertigo (BPPV). I tried to present it on understandable way and all the contents are reviewed by experts and from very reliable references. Thank you
HOW TO MANAGE PATIENTS WITH VERTIGO?
Andradi S.
Department of Neurology. University of Indonesia, Jakarta
disampaikan dalam Simposium PIT IDI Kota Bogor
A detailed description of benign paroxysmal positional vertigo (BPPV): the symptoms, causes, diagnosis, and treatment methods.For more information, please visit www.everydayhearing.com
Please find the power point on Benign Paroxysmal Positional Vertigo (BPPV). I tried to present it on understandable way and all the contents are reviewed by experts and from very reliable references. Thank you
HOW TO MANAGE PATIENTS WITH VERTIGO?
Andradi S.
Department of Neurology. University of Indonesia, Jakarta
disampaikan dalam Simposium PIT IDI Kota Bogor
A detailed description of benign paroxysmal positional vertigo (BPPV): the symptoms, causes, diagnosis, and treatment methods.For more information, please visit www.everydayhearing.com
Vertigo –the dizzy patient an evidence-based diagnosis and treatment strategySachin Verma
Vertigo is a symptom of illusory movement and not a diagnosis .It is due to asymmetry of vestibular system due to damage or dysfunction of the
Labyrinth and vestibular nerve, or
Central vestibular structures in the brainstem
A brief presentation on how to focus on histroy taking on neurology with case scenarios and imaging in the context of emergency medicine for emergency medicine residents
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Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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The four main behavioral effects of AUD are impaired control over
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Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
6. EVALUATION
HISTORY
Define symptom
Timing
Triggers
Otologic history
Drug history
Family history
Review systems
Previous studies
7. EVAL-PE
General
Balance
Otologic exam
Neurologic exam
Nystagmus-spontaneous,Dix –Hallpike ,head shake
test,neck vibration test,valsalva test,hyperventilation
test
VOR gain
8. dotted lines represent the planes containing the posterior semicircular canal (PSC) of the rightl abyrinth, the
superior and inferior recti of the left eye, and the superior and inferior oblique muscles of the right eye. This
corresponds to the main neuro anatomical connections of the vestibular ocular reflex . Activation of the PSC,
therefore, results in a mixed vertical and torsional nystagmus, with the contralateral eye having more upbeat, and
the ipsilateral eye more extorsional components.
11. Finding Peripheral Central
Latency Yes, typically 3-10 sec, rarely as long as 40 sec No
Fatigability* (habituation) Yes, individual episode typically lasts 10-30
sec, rarely as long as 1 min
No
Adaptability* (fatigability) Yes, maneuver done several times
consecutively provokes less of a response each
time
No
Nystagmus direction Direction fixed, typically mixed rotational
upbeating with small horizontal component;
quick phase of intorsion movement toward
the dependent ear, upbeat toward forehead
Direction changing, variable, often purely
vertical (either upbeating or downbeating) or
purely horizontal
Suppression of nystagmus by visual fixation Yes No
Severity Severe, marked vertigo, intense nystagmus,
nausea
Mild vertigo, less obvious nystagmus,
inconspicuous nausea
Consistency (reproducibility Less consistent More consistent
Past pointing In direction of nystagmus slow phase May be in direction of fast phase
21. In general the 7 most common
mistakes
1.Distinguishing vertigo from imbalance;
2.knowing how to do a positional test;
3.knowing how to do ahead impulse test;
4.Migraine is a frequent cause of vertigo without headache
5.Able to interpret an audiogram;
6.Arranging to review the patientduring a vertigo attack;
7. Ordering a magnetic resonanceimaging (MRI) instead of
examining the patient properly.
22. SUMMARY
In the patient with repeated attacks of isolated vertigo
(1) Always do a positional test.
(2) Learn to do the particle repositioning manoeuvre.
(3) Always order an audiogram.
(4) Try migraine treatment.
(5) Put vertebrobasilar insufficiency at the bottom of the list.
In the patient having the first ever attack of acute spontaneous
(1) Learn to do the head-impulse test.
(2) Always think of cerebellar infarction.
In the patient who is off-balance
(1) Think of vestibulotoxicity.
(2) Think of normal pressure hydrocephalus.
(3) Beware of the posterior fossa tumour or malformation.
(4) Think of orthostatic tremor.
(5) Consider spinal cord or peripheral nerve pathology and do a serum B12.
23. Q & A
1. A patient presents with vertigo, diplopia, dysarthria,
weakness and numbness. Which of the following is
the most likely location of the lesion?
A. brainstem
B. vestibulocochlear nerve
C. spinal cord
D. labyrinth
24. 2. A patient presents with vertigo, hearing loss, and
tinnitus. There are no other neurologic abnormalities.
Which is the following is the most likely location of
the lesion?
A. brainstem
B. vestibulocochlear nerve
C. spinal cord
D. cerebral cortex
25. 3. A patient describes short-lived episodes of vertigo
(rotary) precipitated by head movements, especially
when lying down (neck extension).
The vertigo usually lasts less than 45 seconds. There
are no other neurological symptoms except
nystagmus. What is the most likely diagnosis?
A. Meniere’s disease
B. Occlusion of the posterior inferior cerebellar artery
C. Multiple sclerosis
D. Benign paroxysmal positional vertigo (BPPV)
26. 4. A patient describes spells of vertigo lasting hrs,
preceded by ear fullness, tinnitus and hearing
dysfunction. No other neurological abnormalities.
What is the most likely diagnosis?
A. Meniere’s disease
B. Occlusion of the posterior inferior cerebellar artery
C. Multiple sclerosis
D. Benign paroxysmal positional vertigo (BPPV)