This document provides an overview of vector-borne disease (VBD) research at Tulane University, including an introduction to relevant concepts and specific disease transmission cycles. It discusses training opportunities in VBD research and Tulane's focus on diseases like dengue, West Nile virus, malaria, and Chagas disease. Key sections define vectors and types of transmission, describe important vector species and the diseases they transmit, and explain parameters important to understanding transmission like vector competence and extrinsic incubation period. Case studies of dengue, West Nile virus, and Chagas disease transmission are also presented.
emerging and re-emerging vector borne diseasesAnil kumar
this presentation in about emerging and re-emerging vector borne diseases and their spatial spread with reference to time, surveillance, monitoring and management program and other difficulties and suggestions for program
emerging and re-emerging vector borne diseasesAnil kumar
this presentation in about emerging and re-emerging vector borne diseases and their spatial spread with reference to time, surveillance, monitoring and management program and other difficulties and suggestions for program
Zoonoses (Greek “zoon” = animal) are the diseases or infections that are naturally transmissible from vertebrate animals to humans. This group of infections constitutes significant burdens on global public health. The World Health Organisation (WHO) estimates that 25% of the total 57 million annual deaths that occur globally are caused by microbes with a major proportion occurring in the developing world (Chugh, 2008). Of total identified 1,415 species of infectious organisms known to be pathogenic to humans (including 217 viruses and prions, 538 bacteria and rickettsia, 307 fungi, 66 protozoa and 287 helminths), zoonotic agents constitute 868 (61%), with humans serving as the primary reservoir for only 3% of them. Of the 175 diseases considered to be emerging, 132 (75%) are zoonotic in origin (Taylor et al., 2001). In low income countries, established and emerging zoonoses make up 26 % of the DALYs (Disability-adjusted life year) lost to infectious disease and 10 % of the total DALYs lost. In contrast, in high income countries it represent < 1 % of DALYs lost to infectious disease and only 0.02 % of the total disease burden (Grace et al., 2012).
Vectors are living organisms that can transmit infectious diseases between humans or from animals to humans. Vector-borne diseases are infections transmitted by the bite of infected arthropod species, such as mosquitoes, ticks, triatomine bugs, flies, fleas, sandflies, and blackflies (Confalonieri et al., 2007). Among these mosquitoes are the best known disease transmission vectors for many of the fatal and diseases of economic burden. Vector-borne diseases account for 17% of the estimated global burden of all infectious diseases (CDC, 2014). Every year > 1 billion people are infected and > 1 million people die from vector-borne diseases including malaria, dengue, schistosomiasis, leishmaniasis, yellow fever, lymphatic filariasis, Japanese encephalitis and onchocerciasis. One sixth of the illness and disability suffered worldwide is due to vector-borne diseases with more than half the world’s population currently estimated to be at risk of these diseases. Global trade, rapid international travel, unsustainable urbanization, environmental changes such as climate change and emerging insecticidal and drug resistances, are causing vectors and vector-borne diseases to spread beyond borders (WHO, 2014).
West Nile fever is an infection by the West Nile virus, which is typically spread by mosquitoes. It causes disease in humans, horses, and several species of birds
Emerging and reemerging infectious diseasesarijitkundu88
Various emerging and reemerging diseases. Factors contributing to the emergence of infectious diseases. Antibiotic resistance. The global response to control them. Laboratories network in surveillance.
Difference between a pandemic, an epidemic, endemic, and an outbreakBarryAllen149
The distinction between the concepts “pandemic,” “epidemic,” and “endemic” is typically dimmed, also by medical specialists. Because the definition of each term is liquid, and it varies as diseases become more or less prevalent over time. In conversation, maybe this is less important to know the exact definitions but to understand the overall condition of public health news and responses you should know the concepts.
Arthropods form a major group of disease vectors with mosquitoes, flies, sand flies, lice, fleas, ticks and mites transmitting a huge number of diseases.
Many such vectors are haematophagous, which feed on blood at some or all stages of their lives.
Arthropods form a major group of disease vectors with mosquitoes, flies, sand flies, lice, fleas, ticks and mites transmitting a huge number of diseases.
Vector-borne diseases-Malaria, Filariasis, Dengue, JE, YF, Chikungunya, KFD, Leishmaniasis and the national program against vector-borne diseases NVBDCP.
Zoonoses (Greek “zoon” = animal) are the diseases or infections that are naturally transmissible from vertebrate animals to humans. This group of infections constitutes significant burdens on global public health. The World Health Organisation (WHO) estimates that 25% of the total 57 million annual deaths that occur globally are caused by microbes with a major proportion occurring in the developing world (Chugh, 2008). Of total identified 1,415 species of infectious organisms known to be pathogenic to humans (including 217 viruses and prions, 538 bacteria and rickettsia, 307 fungi, 66 protozoa and 287 helminths), zoonotic agents constitute 868 (61%), with humans serving as the primary reservoir for only 3% of them. Of the 175 diseases considered to be emerging, 132 (75%) are zoonotic in origin (Taylor et al., 2001). In low income countries, established and emerging zoonoses make up 26 % of the DALYs (Disability-adjusted life year) lost to infectious disease and 10 % of the total DALYs lost. In contrast, in high income countries it represent < 1 % of DALYs lost to infectious disease and only 0.02 % of the total disease burden (Grace et al., 2012).
Vectors are living organisms that can transmit infectious diseases between humans or from animals to humans. Vector-borne diseases are infections transmitted by the bite of infected arthropod species, such as mosquitoes, ticks, triatomine bugs, flies, fleas, sandflies, and blackflies (Confalonieri et al., 2007). Among these mosquitoes are the best known disease transmission vectors for many of the fatal and diseases of economic burden. Vector-borne diseases account for 17% of the estimated global burden of all infectious diseases (CDC, 2014). Every year > 1 billion people are infected and > 1 million people die from vector-borne diseases including malaria, dengue, schistosomiasis, leishmaniasis, yellow fever, lymphatic filariasis, Japanese encephalitis and onchocerciasis. One sixth of the illness and disability suffered worldwide is due to vector-borne diseases with more than half the world’s population currently estimated to be at risk of these diseases. Global trade, rapid international travel, unsustainable urbanization, environmental changes such as climate change and emerging insecticidal and drug resistances, are causing vectors and vector-borne diseases to spread beyond borders (WHO, 2014).
West Nile fever is an infection by the West Nile virus, which is typically spread by mosquitoes. It causes disease in humans, horses, and several species of birds
Emerging and reemerging infectious diseasesarijitkundu88
Various emerging and reemerging diseases. Factors contributing to the emergence of infectious diseases. Antibiotic resistance. The global response to control them. Laboratories network in surveillance.
Difference between a pandemic, an epidemic, endemic, and an outbreakBarryAllen149
The distinction between the concepts “pandemic,” “epidemic,” and “endemic” is typically dimmed, also by medical specialists. Because the definition of each term is liquid, and it varies as diseases become more or less prevalent over time. In conversation, maybe this is less important to know the exact definitions but to understand the overall condition of public health news and responses you should know the concepts.
Arthropods form a major group of disease vectors with mosquitoes, flies, sand flies, lice, fleas, ticks and mites transmitting a huge number of diseases.
Many such vectors are haematophagous, which feed on blood at some or all stages of their lives.
Arthropods form a major group of disease vectors with mosquitoes, flies, sand flies, lice, fleas, ticks and mites transmitting a huge number of diseases.
Vector-borne diseases-Malaria, Filariasis, Dengue, JE, YF, Chikungunya, KFD, Leishmaniasis and the national program against vector-borne diseases NVBDCP.
National Vector Borne Disease Control Programme (NVBDCP)Vivek Varat
The National Vector Borne Disease Control Programme (NVBDCP) is an umbrella programme for prevention and control of malaria and other vector borne diseases. Under the programme, it is ensured that the disadvantaged and marginalised sections benefit from the delivery of services so that the desired National Health Policy and Rural Health Mission goals are achieved. The Directorate of NVBDCP under the Directorate General of Health Services, Ministry of Health and Family Welfare, Government of India, is the nodal agency responsible for planning, coordination, implementation, monitoring and evaluation of NVBDCP programme at all levels.
Vector-borne diseases are illnesses caused by pathogens and parasites in human populations. This presentation contains key facts about these diseases and global and European trends. WHO/Europe is making this presentation available to countries and partner organizations for use in their campaigns for World Health Day 2014.
Medical entomology "the need to know about little creatures"vckg1987
very important tpic for public health expertise. this presentation includes the from womgb to tomb of mosquitoes. which in clear sense means from their larval life cycle to control management.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
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micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
2. Overview
• Introduction
• General Concepts: vectors, types of vector-borne
transmission, vector incrimination, zoonoses,
surveillance
• Specific Pathogen-Arthropod-Vertebrate
Transmission Cycles: dengue virus, West Nile
virus, American trypanosomiasis (Chagas disease)
3. Introduction
• Training for VBD research
• VBD at Tulane (dengue, WNV, malaria,
chikungunya, Chagas dz, Lyme dz)
• Local vs. International research
• Funding sources (NIH, NSF, BMGF,
BORSF, etc.)
4. How do we define a vector?
An arthropod* responsible
for transmission of parasites
among vertebrate hosts.
* Arthropods include insects (mosquitoes, tsetse
flies, sandflies, blackflies, lice, fleas, kissing bugs)
and arachnids (mites, ticks, spiders and scorpions).
5. Aedes aegypti
Dengue and Yellow Fever
viruses
Culex quinquefasciatus
Filariasis, West Nile & other viruses
Anopheles gambiae
Major mosquito-borne
diseases and the most
important mosquito
vector species
Malaria
8. Types of VectorBorne Transmission
Mechanical Transmission – simplest form
(not necessary for pathogen survival – “flying/crawling
hypodermic needle” phenomenon)
Biological Transmission – more complex
(necessary for pathogen survival – results in
amplification or development in vector)
12. Horizontal Transmission Types
Multiplicative (Propagative)
(increase in number - Dengue)
Developmental
(change stage - Filariasis)
Cyclopropagative
(change stage and increase in number - Malaria)
13. Pathogen Infection in Arthropods
Extrinsic Incubation Period - EIP
Time interval between vector infection and
potential for pathogen transmission to
vertebrate host (determined by controlled
experimental studies)
If vector dies (is killed) before EIP is
completed, transmission will not occur.
14. Ecological Parameters Affecting
Vector Populations:
Availability of food
Space
(What do they eat, and when?)
(Where do they occur, and when?)
Water (Is their appearance seasonal – wet/dry?)
Temperature (Is their appearance seasonal – warm/cold?)
Predation ( Can we enhance or introduce predators to control them?)
Disease ( Can we identify pathogens to control them?)
15. Vector Incrimination
• Demonstrate an association in time and space
between arthropod and disease
• Demonstrate direct contact between the
arthropod and humans
• Demonstrate natural occurrence of the
infectious agent in the insect
• Demonstrate “transmission” of the agent by the
insect (laboratory-based vector competence)
16. How are these pathogen transmission
parameters determined?
Laboratory Experimentation
(vector competence, EIP)
Field Surveillance
(temporal and spatial association between
pathogen, vector and humans; other factors
affecting disease prevention – insecticide or
antibiotic resistance)
18. Specific Pathogen-ArthropodVertebrate Transmission Cycles
Highlighted Transmission Cycles
Mosquito-borne pathogens - arboviruses
(dengue and West Nile virus)
Bug-transmitted pathogens – Chagas disease
19. Arboviruses: ARthropod-BOrne VIRUSES
• Dengue viruses 1-4 – dengue fever, dengue hemorrhagic
fever (DHF) and dengue shock syndrome (DSS)
• West Nile virus - West Nile fever and WN neuroinvasive
disease (encephalitis, meningitis, etc.)
different vertebrate hosts and mosquito vectors
different transmission ecology
different control approaches
21. Dengue Viruses
• 40% of the world’s population is at risk
for dengue infection
• Each serotype provides specific lifetime
immunity, and short-term crossimmunity
• All serotypes can cause severe and
fatal disease
• Genetic variation within serotypes
22. Aedes aegypti
• Dengue transmitted by female
mosquitoes between humans
• Primarily a daytime feeder
• Lives in and around human
habitation
• Prefers to take blood from humans
• Lays eggs and produces larvae
preferentially in artificial containers
26. West Nile Neuroinvasive Disease (NID) in the
United States, 1999 - 2012
Year
WNV NID
Deaths
Mortality Rate
1999
59
7
11.9%
2000
19
2
10.5%
2001
64
9
14.1%
2002
2,946
284
9.6%
2003
2,860
264
9.2%
2004
1,142
100
8.8%
2005
1,294
119
9.2%
2006
1,459
177
12.1%
2007
1,217
124
10.2%
2008
687
44
6.4%
2009
335
30
9.0%
2010
601
45
7.5%
2011
486
46
9.5%
2012
2,734
243
8.9%
Total
15,903
1,494
9.4%
26
27. West Nile virus (WNV) activity reported to ArboNET, by state, United
States, 2012 (as of Dec. 11, 2012)
27
28. West Nile virus (WNV) Neuroinvasive Disease Incidence reported to
ArboNET, by county, United States, 2012 (as of Dec. 11, 2012)
28
29. •
•
•
At least 326 bird species have been reported to
CDC's West Nile Virus avian mortality database
from 1999-present.
At least 60 species of mosquitoes have been
found naturally infected with West Nile virus
since 1999.
40% of unvaccinated equines will die from WNV
infection.
29
32. Chagas’ Disease - General
• Trypanosoma cruzi, the causative agent of
Chagas disease, infects 8–11 million people.
• Triatomine bugs transmit Trypanosoma cruzi while
feeding on vertebrate host; pathogen defecated in
feces while bug feeds - host scratches infective
feces into site of bite or into mucous membrane
(eyes, etc.)
• Any triatomine bug can support development of T.
cruzi, but differing environmental conditions
enhance or suppress transmission to humans
• Important vectors: Triatoma infestans, Rhodnius
prolixus, Panstrongylus megistus, T. dimidiata
32
34. Non-human reservoirs for Chagas disease
Armadillo
Opossum
Also, rats and mice, squirrels, raccoons, skunks, carnivores,
monkeys, and domestic pets.
34
35. Nature, 2010
Migration routes from Latin America and estimation of the total
number of infected individuals in non-endemic countries.
35
36. Chagas in the United States
• In the United States, the disease exists almost exclusively
as a zoonosis.
• Only six autochthonous insect-borne cases have been
reported in humans. The most recent was documented in
New Orleans in 2006.
• The distribution of Chagas disease in the United States
includes approximately the southern half of the country.
• Twelve species of triatomines are known to occur in the
United States, the most important being Triatoma
sanguisuga in the eastern United States, Triatoma
gerstaeckeri in the region of Texas and New Mexico, and
Triatoma rubida and Triatoma protracta in Arizona and
36
California .
38. Triatomine bugs transmitting
Chagas disease feed at night,
and pass the parasite to new
hosts via fecal contamination.
Poor house construction
contributes to transmission.
Fumigation and home
improvement are two
successful control methods.
39. Careers in VBD
•
•
•
•
Research (academic, industry)
Vector control programs (municipal)
Pest control operator (industry)
International, national, regional, state
level surveillance, epidemiology, policy
• Monitoring and assessment
• NGO’s
• Funding agencies
