USG guided thoracentesis is a procedure to aspirate pleural fluid using ultrasound guidance. It has several advantages over non-US guided thoracentesis, including being highly accurate which decreases complications. The key steps are to identify pleural anatomy like fluid, diaphragm and lung under ultrasound and then perform the procedure under real-time visualization of instruments to safely drain fluid. Post procedure chest x-ray is done to identify any complications like pneumothorax. USG guidance improves safety and accuracy of characterizing pleural disease and draining pleural fluid.