Synthesis, characterisation and antibacterial activity of copolymer (n vinylp...eSAT Journals
Abstract A copolymer of N-vinylpyrrolidone (NVP) with maleic anhydride (MA) is synthesized by radical copolymerization with 2,2-Azo-bisisobutyronitrile(AIBN) as initiator at 650C in dioxane solution, under nitrogen atmosphere. The copolymer obtained is characterized by FTIR and NMR. The copolymer is made to interact with N,N-Diethylaminoethanol (DEAE) in different ratios. The susceptibility of some Gram - negative bacteria like Klebsiella aerogenes NCIM-2098, Escherichia coli NCIM-5051, Pseudomonasaeruginosa NCIM2242, Pseudomonas desmolyticum NCIM-2028 and a Gram positive bacteria Staphylococcus aureus NCIM-5022, to the copolymer and its compound with N,N-Diethylaminoethanol of different compositions in microbiological medium is studied by Agar well diffusion method. The resulting polymeric antibacterial material is useful in a number of medicines and food industry. Keywords: N-vinylpyrrolidone, Maleic anhydride, Copolymerization, N, N-diethylaminoethanol, FTIR, NMR, Antibacterial activity.
Synthesis, characterisation and antibacterial activity of copolymer (n vinylp...eSAT Publishing House
IJRET : International Journal of Research in Engineering and Technology is an international peer reviewed, online journal published by eSAT Publishing House for the enhancement of research in various disciplines of Engineering and Technology. The aim and scope of the journal is to provide an academic medium and an important reference for the advancement and dissemination of research results that support high-level learning, teaching and research in the fields of Engineering and Technology. We bring together Scientists, Academician, Field Engineers, Scholars and Students of related fields of Engineering and Technology
Phytochemical Screening and Gc-Ms Analysis of Garudan Samba Traditional Rice ...Agriculture Journal IJOEAR
Abstract— The Garudan Samba, an important Traditional variety of Tamil Nadu was investigated for its phytochemical screening and GCMS study. The brown rice was extracted using ethanol. The results obtained after GCMS studies were confirmed by spectral analysis. The analysis of the ethanol extract showed the presence of n-Hexadecanoic acid, 9,12-Octadecadienoic acid (Z,Z)-, and Oleic acid, as major constituents of the total compounds (76.33%), which have the capacity to prevent many health related disorders. It also contained the medicinally important compounds like Caryophyllene, Ethyl Oleate, Squalene, γ-Tocopherol, Lup-20(29)-en-3-ol, acetate, (3β)-, and phyto sterols like Campesterol, Stigmasterol and β-Sitosterol. Hence, Garudan samba may be considered as one of the important Traditional variety with high level of medicinally important phytoconstituents.
Environmental exposure and health risks of the insecticide monocrotophos - a ...Innspub Net
Monocrotophos is a organophosphate based insecticide used for crop protection. Monocrotophos use has induced heath issues and water pollution. From the ecotoxicology, human health and regulatory aspects, it is essential to restrict the emissions and release of the highly acutely toxic chemical from the industrial processes and agricultural applications. In this review, we present the toxicity and decomposition in media such as vegetables, human tissues, animal tissues and rations, synthesis of the analytical procedures and materials used to determine the monocrotophos and identification of cis and trans isomers of monocrotophos. Also the main physical spectroscopic methods have been discussed in this review. The analytical techniques which are presented permit to select the best analytical conditions to detect monocrotophos. These methods are widely applicable for remaining organophosphate and other polar pesticides. Get more articles at: http://www.innspub.net/volume-5-number-1-july-2014-jbes/
Synthesis, characterisation and antibacterial activity of copolymer (n vinylp...eSAT Journals
Abstract A copolymer of N-vinylpyrrolidone (NVP) with maleic anhydride (MA) is synthesized by radical copolymerization with 2,2-Azo-bisisobutyronitrile(AIBN) as initiator at 650C in dioxane solution, under nitrogen atmosphere. The copolymer obtained is characterized by FTIR and NMR. The copolymer is made to interact with N,N-Diethylaminoethanol (DEAE) in different ratios. The susceptibility of some Gram - negative bacteria like Klebsiella aerogenes NCIM-2098, Escherichia coli NCIM-5051, Pseudomonasaeruginosa NCIM2242, Pseudomonas desmolyticum NCIM-2028 and a Gram positive bacteria Staphylococcus aureus NCIM-5022, to the copolymer and its compound with N,N-Diethylaminoethanol of different compositions in microbiological medium is studied by Agar well diffusion method. The resulting polymeric antibacterial material is useful in a number of medicines and food industry. Keywords: N-vinylpyrrolidone, Maleic anhydride, Copolymerization, N, N-diethylaminoethanol, FTIR, NMR, Antibacterial activity.
Synthesis, characterisation and antibacterial activity of copolymer (n vinylp...eSAT Publishing House
IJRET : International Journal of Research in Engineering and Technology is an international peer reviewed, online journal published by eSAT Publishing House for the enhancement of research in various disciplines of Engineering and Technology. The aim and scope of the journal is to provide an academic medium and an important reference for the advancement and dissemination of research results that support high-level learning, teaching and research in the fields of Engineering and Technology. We bring together Scientists, Academician, Field Engineers, Scholars and Students of related fields of Engineering and Technology
Phytochemical Screening and Gc-Ms Analysis of Garudan Samba Traditional Rice ...Agriculture Journal IJOEAR
Abstract— The Garudan Samba, an important Traditional variety of Tamil Nadu was investigated for its phytochemical screening and GCMS study. The brown rice was extracted using ethanol. The results obtained after GCMS studies were confirmed by spectral analysis. The analysis of the ethanol extract showed the presence of n-Hexadecanoic acid, 9,12-Octadecadienoic acid (Z,Z)-, and Oleic acid, as major constituents of the total compounds (76.33%), which have the capacity to prevent many health related disorders. It also contained the medicinally important compounds like Caryophyllene, Ethyl Oleate, Squalene, γ-Tocopherol, Lup-20(29)-en-3-ol, acetate, (3β)-, and phyto sterols like Campesterol, Stigmasterol and β-Sitosterol. Hence, Garudan samba may be considered as one of the important Traditional variety with high level of medicinally important phytoconstituents.
Environmental exposure and health risks of the insecticide monocrotophos - a ...Innspub Net
Monocrotophos is a organophosphate based insecticide used for crop protection. Monocrotophos use has induced heath issues and water pollution. From the ecotoxicology, human health and regulatory aspects, it is essential to restrict the emissions and release of the highly acutely toxic chemical from the industrial processes and agricultural applications. In this review, we present the toxicity and decomposition in media such as vegetables, human tissues, animal tissues and rations, synthesis of the analytical procedures and materials used to determine the monocrotophos and identification of cis and trans isomers of monocrotophos. Also the main physical spectroscopic methods have been discussed in this review. The analytical techniques which are presented permit to select the best analytical conditions to detect monocrotophos. These methods are widely applicable for remaining organophosphate and other polar pesticides. Get more articles at: http://www.innspub.net/volume-5-number-1-july-2014-jbes/
Impact of Ethoxysulfuron on Lemna gibba L. and Recovery from Damage after Pro...theijes
The International Journal of Engineering & Science is aimed at providing a platform for researchers, engineers, scientists, or educators to publish their original research results, to exchange new ideas, to disseminate information in innovative designs, engineering experiences and technological skills. It is also the Journal's objective to promote engineering and technology education. All papers submitted to the Journal will be blind peer-reviewed. Only original articles will be published.
The papers for publication in The International Journal of Engineering& Science are selected through rigorous peer reviews to ensure originality, timeliness, relevance, and readability.
Cumulative effect of modified atmospheric packaging on the textural and chemi...SukhveerSingh31
Fruits and vegetables have been consumed by humans since ancient times. Scientific
investigations have proved that an increased consumption of fruits and vegetables is known to
reduce instances of cancer and cardiovascular mortality (Bhardwaj et al., 2014)
The Eco-friendly Marine Gastropod Turbo brunneus (L. 1758) and its Vital role...rahulmonikasharma
Molluscs form valuable fisheries in various parts of the coast of India providing shell fish as food and as source of lime, pearls and decorative shells, as constituents of medicinal preparations etc. In the present study, the eco-friendly Turbo brunneus and its vital role in future pharmaceutical industry through GC-MS analysis was carried out. Almost eighteen compounds are obtained through GC-MS which might be responsible for antimicrobial, pharmaceutical, insect repellent, anti-inflammatory, anticancer, antiasthmatic, diuretic and antiarthritic activities.
جستجو پیشرفته منابع علمی | ویژه دانشجویان شیمیArzhin
کارگاه آموزشی جستجو پیشرفته منابع علمی ویژه دانشجویان رشته شیمی | مدرس : مهندس حسین بابائی
این کارگاه در تاریخ 3 دی 94 در موسسه فناوران جوان خزر برگزار گردید.
۱- آشنایی با انواع اطلاعات و پایگاه های داده
۲- جستجوی موثر با کلیدواژه ها
۳- معرفی موتور های جستجوی مقالات و اسناد آکادمیک ( جستجوی عملی و تحلیل نتایج )
۴- جستجو در پایگاه های تخصصی رشته شیمی
۵- چگونه مجلات و کنفرانس های مناسب و معتبر پیدا کنیم ؟
۶- ساختار پتنت و نحوه جستجوی آن
۷- آموزش دانلود مقالات و کتاب
Impact of Ethoxysulfuron on Lemna gibba L. and Recovery from Damage after Pro...theijes
The International Journal of Engineering & Science is aimed at providing a platform for researchers, engineers, scientists, or educators to publish their original research results, to exchange new ideas, to disseminate information in innovative designs, engineering experiences and technological skills. It is also the Journal's objective to promote engineering and technology education. All papers submitted to the Journal will be blind peer-reviewed. Only original articles will be published.
The papers for publication in The International Journal of Engineering& Science are selected through rigorous peer reviews to ensure originality, timeliness, relevance, and readability.
Cumulative effect of modified atmospheric packaging on the textural and chemi...SukhveerSingh31
Fruits and vegetables have been consumed by humans since ancient times. Scientific
investigations have proved that an increased consumption of fruits and vegetables is known to
reduce instances of cancer and cardiovascular mortality (Bhardwaj et al., 2014)
The Eco-friendly Marine Gastropod Turbo brunneus (L. 1758) and its Vital role...rahulmonikasharma
Molluscs form valuable fisheries in various parts of the coast of India providing shell fish as food and as source of lime, pearls and decorative shells, as constituents of medicinal preparations etc. In the present study, the eco-friendly Turbo brunneus and its vital role in future pharmaceutical industry through GC-MS analysis was carried out. Almost eighteen compounds are obtained through GC-MS which might be responsible for antimicrobial, pharmaceutical, insect repellent, anti-inflammatory, anticancer, antiasthmatic, diuretic and antiarthritic activities.
جستجو پیشرفته منابع علمی | ویژه دانشجویان شیمیArzhin
کارگاه آموزشی جستجو پیشرفته منابع علمی ویژه دانشجویان رشته شیمی | مدرس : مهندس حسین بابائی
این کارگاه در تاریخ 3 دی 94 در موسسه فناوران جوان خزر برگزار گردید.
۱- آشنایی با انواع اطلاعات و پایگاه های داده
۲- جستجوی موثر با کلیدواژه ها
۳- معرفی موتور های جستجوی مقالات و اسناد آکادمیک ( جستجوی عملی و تحلیل نتایج )
۴- جستجو در پایگاه های تخصصی رشته شیمی
۵- چگونه مجلات و کنفرانس های مناسب و معتبر پیدا کنیم ؟
۶- ساختار پتنت و نحوه جستجوی آن
۷- آموزش دانلود مقالات و کتاب
Commonly known as its anionic form shikimate, is a cyclohexene, a cyclitol and a cyclohexanecarboxylic acid.
It is an important biochemical metabolite in plants and microorganisms.
Its name comes from the Japanese flower shikimi the Japanese star anise, Illicium anisatum), from which it was first isolated in 1885 by Johan Fredrik Eykman.
The elucidation of its structure was made nearly 50 years later.
Shikimic acid is also the glycoside part of some hydrolysable tannins.
The shikimate pathway is a seven step metabolic route used by bacteria, fungi, algae, parasites, and plants for the biosynthesis of aromatic amino acids (phenylalanine, tyrosine, and tryptophan).
This pathway is not found in animals; therefore, phenylalanine and tryptophan represent essential amino acids that must be obtained from the animal's diet
Animals can synthesize tyrosine from phenylalanine, and therefore is not an essential amino acid except for individuals unable to hydroxylate phenylalanine to tyrosine).
Comparative Analysis of Phytochemical compounds in Normal and root gall of Ok...iosrjce
IOSR Journal of Pharmacy and Biological Sciences(IOSR-JPBS) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of Pharmacy and Biological Science. The journal welcomes publications of high quality papers on theoretical developments and practical applications in Pharmacy and Biological Science. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Comparative analysis of antibacterial activity of Nigella sativa L and Rumex ...theijes
The present study presents the effectiveness of Nigella sativa and Rumex dentatus against some selected microorganisms which are known to cause diseases in human beings and the comparative study of extent of antimicrobial properties of various extracts. Petroleum ether, Methanol and Aqueous extracts of seeds and whole plant respectively were prepared and then tested against pathogenic microorganisms such as Pseudomonas aeruginosa, Salmonella typhimurium, Klebsiella pneumonia and Escherichia coli using agar well diffusion method. The zone of inhibition for Nigella sativa was found maximum in petroleum ether extract of 30 mm at a dose of 250μg/ml against Salmonella typhimurium while as at the same concentration the highest inhibition zone diameter of 21mm was recorded against K. pneumoniae for methanol extract in case of Rumex dentatus.
PHYTOCHEMICAL INVESTIGATION OF THE EUCALYPTUS GLOBULUS LEAF EXTRACT AND PIPER...Dr Dama
PHYTOCHEMICAL INVESTIGATION OF THE EUCALYPTUS GLOBULUS LEAF EXTRACT AND PIPER NIGRUM SEED EXTRACT AND SCREENING THE NEMATICIDAL ACTIVITY OF THEIR COMBINATION AGAINST NEMATODE PARASITES OF GALLUS GALLUS DOMESTICUS
*Dama L.B., *Masuldar A. A. and **Bangale P.P.
DOI: 10.21276/ijlssr.2016.2.3.18
ABSTRACT- Present investigations evaluated the effect of Argemone mexicana leaves extract on gut of Heliothis
armigera (Hub.) at different solvents. The effect of leaf extract of Argemone mexicana in ethanol and acetone solvent after
24 and 96 hours of treatment on Heliothis armigera shows severity of the damage of epithelial lining, epithelial cells
showed vacuoles at certain places. The gut lining was also found to be damaged and the lumen became wider after the
effect of ethanol extract of A. mexicana. In acetone extract of A. mexicana, the thickness of the fore gut wall has been
increased due to clumping of the tissue and hence the diameter of the foregut was reduced. The lumen therefore became
narrower and columnar epithelial cells showed the vacuoles.
Key-words- Heliothis armigera, Argemone mexicana, Ethanol, acetone, Epithelial lining, Epithelial cells, vacuoles, Gut
lining, Gut wall
ANTIMICROBIAL ACTIVITY AND PHYTOCHEMICAL SCREENING OF NEEM LEAVES AND LEMON G...IAEME Publication
In this study, the antimicrobial activity and phytochemical constituents of neem
leaves and lemon grass oil extracts were evaluated. Oil extracts of neem leaves and
lemon grass were obtained by solvent extraction method using hexane and ethanol.
Antimicrobial activity screening of plants’ oil extracts were conducted using agar well
diffusion method and the oil extracts were tested against three gram negative bacteria
(Pseudomonas aeruginosa, Klebsiella specie, Escherichia coli), one gram positive
bacteria (Staphylococcus aureus) and two fungi (Candida albicans, Rhizopus specie).
Phytochemical components of the ethanolic oil extracts were anthocyanin and
betacyanin; quinones; terpenoids and acid for lemon grass. In addition to other
phytochemicals present in lemon grass ethanolic oil extract, neem ethanolic oil extracts
tested positive to flavonoids. Lemon grass oil extract shows high activity against
Escherichia coli, Staphylococcus aureus and Candida albicans which are
representative of the three categories of microorganisms considered. Neem leaves oil
extracts have relatively low activity against most of the selected microorganisms.
The ethanol extracts of Ficus asperifolia, Mormordica charantia, Anacardium
occidentals and Psidium guajava were evaluated sole and in treatment combinations at 25, 50 and
75mg ml-1 concentration levels against the mycelial growth of Macrophomina phaseolina of
Cowpea. The pathogen was cultured on plates containing botanicals amended Potato Dextrose
Agar (PDA) in three replicates while only ethanol treated PDA tested plates served the control
experiment. The radial growths were recorded at 4th, 6th and 8th day after inoculation. Data
obtained were analysed using the SAS software program version 9.2. The extract of Mormordica
charantia was the most effective in the botanical treatments alone. The most significant inhibition
of Macrophomina phaseolina were observed from the combined treatments of Ficus asperifolia,
Mormordica charantia and Anacardium occidentals (3.11 cm), followed by Mormordica
charantia and Psidium guajava (3.29 cm), then combination of four extracts; Ficus asperifolia,
Mormordica charantia, Anacardium occidentals and Psidium guajava (3.53 cm), then
Mormordica charantia and Anacardium occidentals (3.84 cm). Other treatments, either alone or in
combination produced significant result compared to the control experiment (6.94 cm). However,
the efficacy of botanicals increased with concentration and also significantly correlated with time
and reduction in mycelia extension of the pathogen. More so, variability in the antifungicidal
potentials of the botanicals on Macrophomina phaseolina ranges from 15.93% to 34.06%
according to Eigen proportions. The treatment combinations of; Ficus asperifolia, Mormordica
charantia and Anacardium occidentals at 75mg ml-1 concentration level produced the most
inhibitory effect against Macrophomina phaseolina in vitro. However, the untreated plates did not
show inhibitory effect on the mycelial growth of the pathogen. Therefore, combined treatments of
botanicals could be a potential source in the practice of plant disease control.
INVESTIGATION OF IN-VITRO ANTHELMINTIC AND CYTOTOXIC ACTIVITIES OF ARTABOTRYS...Syed Masudur Rahman Dewan
The methanolic extract of bark of Artabotrys hexapetalus were investigated for in-vitro anthelmintic and cytotoxic activities. Evaluation of cytotoxic activity was done using the brine shrimp lethality bio-assay. The crude methanolic extract showed significant cytotoxic potential (LC50 value of 7.688 μg/ml) comparing with that of standard vincristine (0.839 μg/ml). The other study was undertaken to evaluate anthelmintic activity where albendazole was used as reference standard. Methanolic extract of barks (50 mg/ml) caused paralysis of the worms at 68.33 minutes and death at 84.0 minutes while albendazole (positive control) paralyzed and killed the worms at 17 minutes and 48 minutes respectively at the concentration of 10 mg/ml. The study confirms the significant anthelmintic activities of bark extract of Artabotrys hexapetalus and therefore demands the isolation of active principles through bioassay.
ANTIMICROBIAL PROPERTY OF AQUEOUS AND PETROLEUM ETHER LEAF EXTRACTS OF JATRO...IJSIT Editor
The experiment was carried out to investigate the antimicrobial property of aqueous and Petroleum
ether leaf extracts of Jatrophacurcas against some gram positive micro-organisms: Staphylococcus aureus,
Bacillus subtilis and some gram negative micro-organisms: Escherichia coli, Salmonella typhi using
antibiotics; Gentamycin as control. The phytochemical screening of aqueous and petroleum ether extracts
showed the presences of cardiac glycosides, steroids and terpenes, tannins, phlobatannins, anthraguinones
and saponins. The disc diffusion techniques was used to test the sensitivity of the micro-organism to the
extracts of Jatrophacurcas the results obtained show mean zones of inhibition between (19 + 0.6mm) to (30 +
0.3mm) for aqueous extract and (24 + 0.5mm) to (35 + 0.8mm) for petroleum ether extract. Micro-organisms
showed sensitivity in the following order: E.coli;(17 + 0.3mm) and (25 + 0.8mm), S.aureus; (26 + 0.2mm) and
(28 + 0.6mm), B.subtilis; (16 + 0.1mm) and (20 + 0.7mm), and S.typhi (25 + 0.2mm) and (27 + 0.6mm) for
aqueous and petroleum ether extracts respectively. The minimum inhibition concentration (MIC) for both
extracts show that the extracts inhibited the growth of the entire test organism at concentration 0.6mg/ml.
This result thus suggests the potency of Jatrophacurcas as an antimicrobial agent especially at the
concentration employed.
— The diseases caused by bipartite Begomoviruses have emerged as overwhelming problem in various cropping systems of Pakistan. The study was conducted to evaluate the potential of induced resistance in mungbean to Mungbean yellow mosaic virus (MYMV) disease. In this work, resistance to MYMV infection was induced in mungbean plants by activating the Salicylic acid (SA) pathway using SA and Benzothiadiazole (BTH) as treatments. The resistance was characterized by evaluating symptom appearance and virus titter through ELISA. Elicitors i.e., SA and BTH were applied at different concentrations to enhance the innate resistance of mungbean by the induction of defense related compounds. All treatments were helpful in reducing plant infection but the most effective treatment was the combination of SA@5mM and BTH@150mg/L as compared to virus inoculated control. Three weeks analysis showed peak accumulation of defense related enzymatic antioxidants and phenols in the mungbean leaves treated with SA and BTH. Higher enzymatic activity was observed in elicitor treated plants followed by inoculation with MYMV. As the resistance increased due to the application of SA & BTH the enzymatic activities of SOD, POD, and CAT were also increased during second week after application of elicitors. This study revealed that SA and BTH are potential source for management of MYMV by enhancing the level of protection through induction of systemic acquired resistance.
Anti Bacterial and Anti Oxidant Activities of Evolvulus Alsinoides LinnIOSRJPBS
: Plants are very important sources of potential useful raw materials as natural chemotherapeutic agents. Shankhpushpi is botanically termed as Evolvulus alsinoides; the extracts have exhibited antioxidant, anti-ulcer, and immunomodulatory activities. The present work is to investigate the invitro therapeutic potential activities of methanolic extract of whole plant of Evolvulus alsinoides on the antimicrobial activity against five clinical pathogenic bacterial strains viz., Staphylococcus aureus, Bacillus cereus, Escherichia coli, Klebshiella pneumonia and Salmonella typhii, using agar well diffusion assay and Anti oxidant activity using 1-1-Diphenyl- 2-picryl-hydrazyl (DPPH) radical. Extract inhibited IC50: 40.2. Total phenolic content: 28.4 mg/ml & Total flavonoid content: 20.2 μg /ml. Evolvulus alsinoides (MIC): 512.5mg/ml possess 30 to 40 % inhibition, the antibacterial activity of the herbal extracts was more pronounced on the gram- negative bacteria Klebshiella pneumonia than the gram-positive bacteria Staphylococcus aureus. The free radical scavenging activity of methanolic activity of whole plant of Evolvulus alsinoides increase in a concentration dependent manner, and posses statistically significance DPPH free radical scavenging & Anti microbial activities
International Journal of Engineering Research and Applications (IJERA) is an open access online peer reviewed international journal that publishes research and review articles in the fields of Computer Science, Neural Networks, Electrical Engineering, Software Engineering, Information Technology, Mechanical Engineering, Chemical Engineering, Plastic Engineering, Food Technology, Textile Engineering, Nano Technology & science, Power Electronics, Electronics & Communication Engineering, Computational mathematics, Image processing, Civil Engineering, Structural Engineering, Environmental Engineering, VLSI Testing & Low Power VLSI Design etc.
Phytochemical Screening and In-vitro Antibacterial Activity of Mangifera indi...iosrphr_editor
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
Evaluation of In-vitro neuroprotective effect of Ethanolic extract of Canariu...AI Publications
The ethanolic extract of canarium solomonense leaves (ecsl) was studied for its neuroprotective activity. The neuroprotective activity of ECSL was found to have a significant impact on neuronal cell death triggered by hydrogen peroxide (MTT assay) in human SH-SY5Y neuroblastoma cells. Scopolamine, a muscarinic receptor blocker, is frequently used to induce cognitive impairment in laboratory animals. Injections of scopolamine influence multiple cognitive functions, including motor function, short-term memory, and attention. Using the Morris water maze, the Y maze, and the passive avoidance paradigm, memory enhancing activity in scopolamine-induced amnesic rats was evaluated. Using the Morris water maze, the Y maze, and the passive avoidance paradigm, ECSL was found to have a substantial effect on the memory of scopolamine- induced amnesic rats. Our experimental data indicated that ECSL can reverse scopolamine induced amnesia and assist with memory issues.
International Journal of Pharmaceutical Science Invention (IJPSI) is an international journal intended for professionals and researchers in all fields of Pahrmaceutical Science. IJPSI publishes research articles and reviews within the whole field Pharmacy and Pharmaceutical Science, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online.
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Tyrosinase İnhibitory Effect Studies on the Aerial Parts of Wiedemannia Multifida (L.) Bentham
1. Abstract of Applied Sciences and Engineering, 2016, Vol.9
DOI: 10.18488/journal.1001/2016.9/1001.9
9th
International Scientific Conference on Applied
Sciences and Engineering
6-7 June 2016
Nippon Hotel, İstanbul-Turkey
Conference Website: www.scihost.org
26
Paper ID: 26/16/ 9
th
ISCASE
Tyrosinase İnhibitory Effect Studies on the Aerial Parts of
Wiedemannia Multifida (L.) Bentham
Esen Sezen Karaoğlan1
--- Sıla Özlem Şener2
--- Merve Badem3
--- Meryem Şengül
Köseoğlu4
--- Ufuk Özgen5
1
Department of Pharmaceutical Botany, Faculty of Pharmacy, Atatürk University, Erzurum
Turkey
2,3,5
Department of Pharmacognosy, Faculty of Pharmacy, Karadeniz Tecnical University,
Erzurum, Turkey
4
Department of Biology, Faculty of Science, Atatürk University, Erzurum, Turkey
Abstract
Tyrosinase is a copper-containing enzyme which is mostly deployed in
microorganism, plants, human, and animals. This enzyme is involved in melanin
synthesis. The abnormal melanin accumulation causes hiperpigmentation in human
skins and browning of foods. Tyrosinase inhibitors gained importance in
medicine,cosmetic and food industries1-4. Kojic acid, arbutin, hydroquinon known as
a powerful tyrosinase inhibitory agent. Natural compounds with anti-pigmenting
effect are preferred rather than synthetic substances such as kojic acid and
hydroquinone, which can cause skin inflammations 5-7. The genus Wiedemannia
(Lamiaceae) is represented by two species in Turkey. Methanol extract of
Wiedemannia multifida has shown strong antioxidant and antibacterial activity 8-9.
The tyrosinase inhibitory activities of the methanol, dichloromethane, ethyl acetate,
butanol, and aqueous extracts of the W. multifida have been evaluated in this study.
Modified Masuda’s colorimetric method was used to evaluate the mushroom
tyrosinase inhibitory effect10. Kojic acid was used as positive control. The value of
%inhibition of the dichloromethane extract (39.47 ± 0.662, 47.36 ± 1.449) is higher
than kojic acid (23.29 ± 0.113, 43.37 ± 0.080) against mushroom tyrosinase at 25
and 100 µg/mL concentration and ethyl acetat extract (26.31 ± 0.760) is higher than
kojic acid (23,29 ± 0,113) against mushroom tyrosinase at 25 µg/mL concentration.
W. multifida may be evaluated a natural alternative in the treatment of
hyperpigmentation and cosmetic and food industry.
