This document discusses anticholinesterase drugs and their mechanisms and uses. It describes how anticholinesterases inhibit the enzyme acetylcholinesterase, preventing the breakdown of acetylcholine and thereby increasing cholinergic neurotransmission. The main types discussed are reversible carbamate drugs like physostigmine and neostigmine, and irreversible organophosphate inhibitors. Their uses include treating glaucoma, myasthenia gravis, and as antidotes for organophosphate poisoning. The mechanisms and characteristics of specific drugs like physostigmine, neostigmine, and edrophonium are also compared.
Parasympatholytics are the drugs that block or inhibit the actions of acetylcholine at postganglionic nerve endings and cholinergic receptors. They are also referred to as anticholinergics or cholinergic blocking agents or antispasmodics.
Anticholinergic drugs include atropine and related drugs- atropine is the prototype. Atropine is obtained from the plant Atropa belladonna. Atropine and scopolamine (hyoscine) are the belladonna alkaloids. They compete with acetylcholine for muscarinic receptors and block this receptors-they are muscarinic antagonists.
Parasympatholytics are the drugs that block or inhibit the actions of acetylcholine at postganglionic nerve endings and cholinergic receptors. They are also referred to as anticholinergics or cholinergic blocking agents or antispasmodics.
Anticholinergic drugs include atropine and related drugs- atropine is the prototype. Atropine is obtained from the plant Atropa belladonna. Atropine and scopolamine (hyoscine) are the belladonna alkaloids. They compete with acetylcholine for muscarinic receptors and block this receptors-they are muscarinic antagonists.
Adrenoceptors are membrane bound receptors located throughout the body on neuronal and non-neuronal tissues where they mediate a diverse range of responses to the endogenous catecholamines- noradrenaline and adrenaline.
They are G protein coupled receptors.
Binding of catecholamine to the receptor is responsible for fight or flight response.
Sympatholytic drugs (Adrenergic blockers) bind to the adrenergic receptors and prevent the action of adrenergic drugs.
These are drugs which block the actions of sympathetic division or catecholamines (adrenaline and noradrenaline).
They are competitive antagonists at both α and β adrenergic receptors.
Adrenoceptors are membrane bound receptors located throughout the body on neuronal and non-neuronal tissues where they mediate a diverse range of responses to the endogenous catecholamines- noradrenaline and adrenaline.
They are G protein coupled receptors.
Binding of catecholamine to the receptor is responsible for fight or flight response.
Sympatholytic drugs (Adrenergic blockers) bind to the adrenergic receptors and prevent the action of adrenergic drugs.
These are drugs which block the actions of sympathetic division or catecholamines (adrenaline and noradrenaline).
They are competitive antagonists at both α and β adrenergic receptors.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
2. ANTICHOLINESTERASESANTICHOLINESTERASES
These are the agents which inhibit ChE, protectThese are the agents which inhibit ChE, protect
ACH from hydrolysis-produce and potentiatesACH from hydrolysis-produce and potentiates
cholinergic effects .cholinergic effects .
5. Mechanism of actionMechanism of action
Acetylated enzyme reacts with water veryAcetylated enzyme reacts with water very
rapidly and the esteretic site is freed in fractionrapidly and the esteretic site is freed in fraction
of milli sec.of milli sec.
Carbamylated enzyme reacts slowly (reversibleCarbamylated enzyme reacts slowly (reversible
inhibitors)inhibitors)
Phosphorylated enzyme reacts extremely slowly orPhosphorylated enzyme reacts extremely slowly or
not at all.not at all.
OPPs attaches only to the esteretic site whereas drugsOPPs attaches only to the esteretic site whereas drugs
like Tacrine & Endrophonium attaches to the anioniclike Tacrine & Endrophonium attaches to the anionic
site.site.
7. Carbamate Inhibitors :Carbamate Inhibitors :
NeostigmineNeostigmine
NeostigmineNeostigmine
synthetically prepared.synthetically prepared.
Quaternary amine
Less lipid soluble
Pyridostigmine resemblesPyridostigmine resembles
neostigmine but hasneostigmine but has
longer DOAlonger DOA
Some are used asSome are used as
insecticides, Carbarylinsecticides, Carbaryl
PropoxurPropoxur
8. FEATURES PHYSOSTIGMINE NEOSTIGMINE
1. Source
2. Chemistry
3. Oral absorption
4. CNS action
5. Corneal penetration
6. Action on Nm
7. Prominent effect
8. USE
9. DOA
Natural
Tertiary amine
Good
Present
Good
Absent
Autonomic effectors
Miotic (Glaucoma)
0.5-1mg oral/ parental
0.5-1% eye drops
4-6 hrs
Synthetic
Quaternary ammonium
Poor
Absent
Poor
Present
Skeletal muscles
Myasthenia gravis
0.5-2.5mg im/sc
15-30mg orally
3-4 hrs
Physostigmine and NeostigminePhysostigmine and Neostigmine
9. Competitive Inhibitors :Competitive Inhibitors :
EdrophoniumEdrophonium
Alcohol bearing aAlcohol bearing a
quaternary ammoniumquaternary ammonium
Very short durationVery short duration
Rapidly excreted by theRapidly excreted by the
kidneyskidneys
Resembles neostigmineResembles neostigmine
Suitable as diagnosticSuitable as diagnostic
agent for MGagent for MG
12. Mechanism of ActionMechanism of Action
Phosphorylating the active
Site of serine.
Covalent modification
Duration: days
13. ““Aging” of OrganophosphatesAging” of Organophosphates
By the loss of one of theBy the loss of one of the
alkyl group the phosporylatedalkyl group the phosporylated
enzyme may becomeenzyme may become
resistant to hydrolysis thusresistant to hydrolysis thus
causing irreversibility.causing irreversibility.
Reactivation time ofReactivation time of
carbamylated enzyme iscarbamylated enzyme is
less(30mins) whereasless(30mins) whereas
phospory. E is more thanphospory. E is more than
regeneration time.regeneration time.
14. c. Organophosphate Weaponsc. Organophosphate Weapons
Chemical warfare agents-nerve gasesChemical warfare agents-nerve gases
TabunTabun
SerinSerin
SomanSoman
15. Pharmacology of AChE InhibitorsPharmacology of AChE Inhibitors
Act at both muscarinic and nicotinicAct at both muscarinic and nicotinic
synapsessynapses
They potentiates synaptic transmission bothThey potentiates synaptic transmission both
parasympathetic and sympathetparasympathetic and sympatheticic
16. PHARMACOLOGICAL ACTIONSPHARMACOLOGICAL ACTIONS
a.a. Central nervous systemCentral nervous system::
Ache inhibitors are Lipid solubleAche inhibitors are Lipid soluble
(Physostigmine and Ops) Cross BBB(Physostigmine and Ops) Cross BBB
Low doses: CNS activationLow doses: CNS activation
High: coma and respiratory arrestHigh: coma and respiratory arrest
b.b. Eye, respiratory tract, GI & urinary tract:Eye, respiratory tract, GI & urinary tract:
The same as muscarinic agonistsThe same as muscarinic agonists
(regulated by parasympathetic neurons)(regulated by parasympathetic neurons)
17. PHARMACOLOGICAL ACTIONSPHARMACOLOGICAL ACTIONS
c.c. Cardiovascular:Cardiovascular:
ComplexComplex
Bradycardia, decrease contraction, cardiac outputBradycardia, decrease contraction, cardiac output
Blood vessels? No effectBlood vessels? No effect
d.d. Neuromuscular junction:Neuromuscular junction:
Increase force of contraction (low dose)Increase force of contraction (low dose)
Muscle fasciculation and depolarizing blockadeMuscle fasciculation and depolarizing blockade
(high dose) weakness and paralysis(high dose) weakness and paralysis
18. Therapeutic UsesTherapeutic Uses
A. Eye:A. Eye:
Miosis and constriction of the ciliary muscle, and areMiosis and constriction of the ciliary muscle, and are
used to treat glaucomaused to treat glaucoma
B. GI and urinary tractB. GI and urinary tract:: Neostigmine 0.5-1mg s.cNeostigmine 0.5-1mg s.c..
Paralysis of the stomach and intestinesParalysis of the stomach and intestines
(paralytic illeus)(paralytic illeus)
Postpartum urinary retentionPostpartum urinary retention
19. C. Neuromuscular junctionC. Neuromuscular junction::
Myastenia Gravis----Neostigmine 0.5-2mg i.v.Myastenia Gravis----Neostigmine 0.5-2mg i.v.
Post operative decurarization induced by NMBPost operative decurarization induced by NMB
Cobra biteCobra bite
D. CNSD. CNS::
Belladona poisoningBelladona poisoning
Alzheimer’s diseaseAlzheimer’s disease
Overdose of phenothiazides, TCAsOverdose of phenothiazides, TCAs
20. GlaucomaGlaucoma
Group of disease characterized by progressiveGroup of disease characterized by progressive
optic nerve damage ass. with raised IOToptic nerve damage ass. with raised IOT
Treatment aims:Treatment aims:
Lower IOT byLower IOT by :1.Reducing aqueous secretion:1.Reducing aqueous secretion
2. Promoting its drainage.2. Promoting its drainage.
TypesTypes--
Open angle glaucomaOpen angle glaucoma (wide angle, chronic simple)(wide angle, chronic simple)
Closed angle glaucomaClosed angle glaucoma (narrow angle, acute congestive)(narrow angle, acute congestive)
25. Myasthenia GravisMyasthenia Gravis
Myasthenia gravis (MG) is the most common primary disorder of neuromuscular
transmission. The usual cause is an acquired immunological abnormality, but
some cases result from genetic abnormalities at the neuromuscular junction
26. Myasthenia Gravis – Effect on theMyasthenia Gravis – Effect on the
Neuromuscular JunctionNeuromuscular Junction
NormalNormal Myasthenia gravisMyasthenia gravis
27. Myasthenia GravisMyasthenia Gravis
Symptoms:Symptoms:
Specific muscle weakness, and not ofSpecific muscle weakness, and not of
generalized fatigue. Ocular motorgeneralized fatigue. Ocular motor
disturbances, ptosis or diplopia,disturbances, ptosis or diplopia,
Oropharyngeal muscle weakness, difficultyOropharyngeal muscle weakness, difficulty
chewing, swallowing, or talking, limbchewing, swallowing, or talking, limb
weakness.weakness.
The severity of weakness fluctuates during theThe severity of weakness fluctuates during the
day, usually being least severe in the morningday, usually being least severe in the morning
and worse as the day progresses, especiallyand worse as the day progresses, especially
after prolonged use of affected muscles.after prolonged use of affected muscles.
Prognosis:Prognosis:
With treatment, most MG patients will haveWith treatment, most MG patients will have
excellent improvement of their muscleexcellent improvement of their muscle
weakness.weakness.
28. Drugs Used in Myasthenia GravisDrugs Used in Myasthenia Gravis
Diagnosis:Diagnosis:
EdrophoniumEdrophonium iv (improvement)iv (improvement) 5-15 min5-15 min
TreatmentTreatment::
ANTICHOLINESTERASESANTICHOLINESTERASES
NeostigmineNeostigmine 0.5-2 hours0.5-2 hours
PyridostigminePyridostigmine 3-6 hours3-6 hours
CORTICOSTEROIDS AND THYMECTOMYCORTICOSTEROIDS AND THYMECTOMY
29. Alzheimer’s Disease - SymptomsAlzheimer’s Disease - Symptoms
AD is a neurodegenerative disorderAD is a neurodegenerative disorder
Charcterized by progressive dementiaCharcterized by progressive dementia
primarily affecting cholinergic neuronesprimarily affecting cholinergic neurones
in the brain.in the brain.
32. AChE Inhibitors Used to TreatAChE Inhibitors Used to Treat
Alzheimer’s DiseaseAlzheimer’s Disease
The first to becomeThe first to become
availableavailable
The first to becomeThe first to become
passpasséé
33. AChE Inhibitors Used to TreatAChE Inhibitors Used to Treat
Alzheimer’s DiseaseAlzheimer’s Disease
34. Are They Worth It?Are They Worth It?
Effect of Rivastigmine in Alzheimer’s DiseaseEffect of Rivastigmine in Alzheimer’s Disease
RivastigmineRivastigmine PlaceboPlacebo
ImprovedImproved 37%37% 20%20%
Adverse EffectsAdverse Effects 23%23% 7%7%
36. Organophosphorous poisoningOrganophosphorous poisoning
Skeletal MuscleSkeletal Muscle:: Fasciculations, weakness, paralysisFasciculations, weakness, paralysis
CNSCNS:: Ataxia, confusion, convulsions, coma, paralysisAtaxia, confusion, convulsions, coma, paralysis
Death:Death:
Respiratory depression due to bronchoconstriction,Respiratory depression due to bronchoconstriction,
increased secretions, paralysis of diaphragm andincreased secretions, paralysis of diaphragm and
intercostal muscles and central respiratory depressionintercostal muscles and central respiratory depression
37. Treatment of AChE PoisoningTreatment of AChE Poisoning
Atropine:Atropine:
Reverses muscarinic but not nicotinicReverses muscarinic but not nicotinic
2 mg i.v. repeated every 10 mins till2 mg i.v. repeated every 10 mins till
signs of full atropinization i.e dilatationsigns of full atropinization i.e dilatation
of pupils ,tachycardia.of pupils ,tachycardia.
Pralidoxime (2-PAM):Pralidoxime (2-PAM):
39. Clinical pharmacology of acetylcholinesterase inhibitorsClinical pharmacology of acetylcholinesterase inhibitors
Drug
Type of
inhibition
Route of
administration Clinical Use
Edrophonium Rev IM or IV Diagnostic for Myasthenia Gravis
Neostigmine Rev IM, IV, or oral Myasthenia Gravis, post-operative ileus and
bladder distention, surgical adjunct
Physostigmine Rev IM, IV, or local Glaucoma, Alzheimer’s disease, antidote to
anticholinergic overdose
Tacrine Rev Oral Alzheimer’s disease
Donepezil Rev Oral Alzheimer’s disease
Isofluorophate Irrev Local Glaucoma
Echothiophate Irrev Local Glaucoma