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Abstract of Applied Sciences and Engineering, 2016, Vol.9
DOI: 10.18488/journal.1001/2016.9/1001.9
9th
International Scientific Conference on Applied
Sciences and Engineering
6-7 June 2016
Nippon Hotel, İstanbul-Turkey
Conference Website: www.scihost.org
22
Paper ID: 22/16/ 9
th
ISCASE
Some Biochemical Markers that Can Predict Pre-Eclampsia
Mohammad Sayyed Bakheet1
--- Mohamed Ismail Seddik2
--- M H Abdelzaher3
---
Mohammad Mohammad Abolfotoh4
--- Abdelaziz eldarwesh5
--- Alomairi Mostafa M6
---
Maher Abdelshakor7
1,3,4,6
Department of Biochemistry, Faculty of Medicine, Al-Azhar University, Assuit, Egypt,
2
Department of clinical pathology, Faculty of Medicine, Assuit University, Egypt,
5
Department of obstetrics and gynecology, Faculty of Medicine, Al-Azhar University, Assuit,
Egypt
7
Department of physiology, Faculty of Medicine, Al-Azhar University, Assuit, Egypt
Abstract
TNF– α directly damages the vascular endothelial cells, reduces regional blood flow,
causes occlusion of vessels and increases endothelial permeability. Endothelial cell
injury after TNF– α mediated activation of immune system may result in secretion of
vasoactive substances and increase in vascular permeability and intravascular
coagulation. TNF-α may be involved in the pathogenesis of preeclampsia and may
identify the patients who are at high risk of PE and can be a potential marker of the
severity of the preeclamptic syndrome. Preeclamptic women had deranged lipid profile
due to abnormal lipid metabolism; this alteration of lipid metabolism may play a key
role in the development of symptoms of Pre-eclampsia. Furthermore, changes to lipid
metabolism may contribute towards the endothelial lesions observed in pre-eclampsia.
Keywords: Preeclampsia, TNF– Α, Lipid Per-Oxidation and nitric oxide.

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Some Biochemical Markers that Can Predict Pre-Eclampsia

  • 1. Abstract of Applied Sciences and Engineering, 2016, Vol.9 DOI: 10.18488/journal.1001/2016.9/1001.9 9th International Scientific Conference on Applied Sciences and Engineering 6-7 June 2016 Nippon Hotel, İstanbul-Turkey Conference Website: www.scihost.org 22 Paper ID: 22/16/ 9 th ISCASE Some Biochemical Markers that Can Predict Pre-Eclampsia Mohammad Sayyed Bakheet1 --- Mohamed Ismail Seddik2 --- M H Abdelzaher3 --- Mohammad Mohammad Abolfotoh4 --- Abdelaziz eldarwesh5 --- Alomairi Mostafa M6 --- Maher Abdelshakor7 1,3,4,6 Department of Biochemistry, Faculty of Medicine, Al-Azhar University, Assuit, Egypt, 2 Department of clinical pathology, Faculty of Medicine, Assuit University, Egypt, 5 Department of obstetrics and gynecology, Faculty of Medicine, Al-Azhar University, Assuit, Egypt 7 Department of physiology, Faculty of Medicine, Al-Azhar University, Assuit, Egypt Abstract TNF– α directly damages the vascular endothelial cells, reduces regional blood flow, causes occlusion of vessels and increases endothelial permeability. Endothelial cell injury after TNF– α mediated activation of immune system may result in secretion of vasoactive substances and increase in vascular permeability and intravascular coagulation. TNF-α may be involved in the pathogenesis of preeclampsia and may identify the patients who are at high risk of PE and can be a potential marker of the severity of the preeclamptic syndrome. Preeclamptic women had deranged lipid profile due to abnormal lipid metabolism; this alteration of lipid metabolism may play a key role in the development of symptoms of Pre-eclampsia. Furthermore, changes to lipid metabolism may contribute towards the endothelial lesions observed in pre-eclampsia. Keywords: Preeclampsia, TNF– Α, Lipid Per-Oxidation and nitric oxide.