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Types of Obesity
& Dietary Pills
Guided By:
Dr. Raghavendra Hegde Katte
Dept. of Molecular Biology
Presented By:
Inchara R
7th Semester
Molecular Biology
08/12/2020
1
CONTENTS
• Introduction
• BMI
• Types of Obesity
• Treatment
– Dietary Pills
• Conclusion
• References
• Acknowledgement
2
INTRODUCTION
3
Body Mass Index
• The most widely used method to gauge obesity
is body mass index (BMI).
Eq 1: Formula to calculate
BMI
4
Fig 1: BMI & Nutritional State 5
Fig 2: BMI Chart
6
Types of Obesity
• Obesity can be classified into 2 types:
1. Physical obesity
2. Pathological Obesity
1. Physical Obesity
This is based on distribution of the fats in the body i.e.,
purely based on the appearance of a person.
Types: (A) Android Obesity
(B) Gynoid Obesity
7
Fig 3: Apple and Pear shaped
Obesity 8
2. Pathological Obesity
This is based on the structure of the fat tissue.
Types: (A) Hyperplastic type.
(B) Hypertrophic type.
Fig 4: Central & Peripheral Obesity 9
• Based on causes obesity can be further classified into 2
types.
a) Endogenous obesity - Obesity resulting from internal
conditions.
b) Exogenous Obesity - Overfeeding or gluttony with less
physical activity.
10
Treatment of Obesity
Fig 5: Pyramid of interventions in
the management of obesity 11
Dietary Pills
• There are 3 different mechanisms used to classify
pharmacological treatment of obesity.
a. Drugs that reduce appetite & food intake.
b. Drugs that increase energy expenditure.
c. Drugs that effect metabolism and nutrition
partitioning.
12
Orlistat
Naltrexone-
Bupropion
Lorcaserin Sibutramine
13
1. Orlistat
Fig 6: Molecular
Structure of Orlistat
Fig 7: Xenical
(Orlistat Capsules)
14
Fig 8: Mechanism of action of
Orlistat 15
2. Naltrexone-Bupropion
Fig 9: Molecular Structure
of Naltrexone-Bupropion
Fig 10: Contrave
(Naltrexone-Bupropion
Capsules)
16
Fig 11: Mechanism of action of
Naltrexone-Bupropion 17
3. Lorcaserin
Fig 12: Molecular
Structure of Lorcaserin
Fig 13: Belviq
(Lorcaserin Capsules)
18
Fig 14: Mechanism of action of
Lorcaserin 19
4. Sibutramine
Fig 15: Molecular
Structure of Sibutramine
Fig 16: Sibutril/leptos
(Sibutramine Capsules)
20
Fig 17: Mechanism of action of
Sibutramine 21
CONCLUSION
22
REFERENCES
• Chatterjea M. N. & Rana Shinde. 2012. Textbook of
Medical Biochemistry, 8th edition, Jaypee Brothers
Medical Publishers (P) Ltd, New Delhi, India, 894pp.
• George A. Bray, Claude Bouchard &. James W. P. T.
2004. Handbook of Obesity Clinical Applications, 2nd
edition, Marcel Dekker, inc., New York, USA, 414pp.
• Harsh Mohan. 2010. Textbook of Pathology, 6th
edition, Jaypee Brothers Medical Publishers (P) Ltd,
New Delhi, India, 949pp.
• Robert H. Glew & Miriam D. Rosenthal. 2007. Clinical
Studies in Medical Biochemistry, 3rd edition, Oxford
University Press, New York, USA, 387pp. 23
• https://pubmed.ncbi.nlm.nih.gov/28245771/
• https://www.sciencedirect.com/science/article/pii/S1043661
814000449
• https://go.drugbank.com/drugs/DB01083
• https://www.ncbi.nlm.nih.gov/books/Definitions,
Classification, and Epidemiology of Obesity/NBK279167/
• https://www.alfadoc.co.uk/weight-loss/xenical/
• https://www.semanticscholar.org/paper/Review-Paper%3A-
Current-Strategies-in-the-Development-
Elangbam/033190e774f9a8d9902fb69b4a0f01b6d9149c03
• https://youtu.be/B1xJhtROIw8
• https://youtu.be/eTCOi2Nslfs
• https://slideplayer.com/slide/ antiobesitydrugs-
170215131630/
24
ACKNOWLEDGEMENT
I would like to thank the Dept. of Molecular Biology
for providing this opportunity to present this
seminar.
I would also like to thank my guide Dr. Raghavendra
Hegde Katte for his valuable guidance.
Thank you one and all.
25
26
4. Phentermine
Fig 15: Molecular Structure
of Phentermine
Fig 16: Lamaira
(Phentermine Capsules)
27

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Types of obesity & its Dietary Pills

  • 1. Types of Obesity & Dietary Pills Guided By: Dr. Raghavendra Hegde Katte Dept. of Molecular Biology Presented By: Inchara R 7th Semester Molecular Biology 08/12/2020 1
  • 2. CONTENTS • Introduction • BMI • Types of Obesity • Treatment – Dietary Pills • Conclusion • References • Acknowledgement 2
  • 4. Body Mass Index • The most widely used method to gauge obesity is body mass index (BMI). Eq 1: Formula to calculate BMI 4
  • 5. Fig 1: BMI & Nutritional State 5
  • 6. Fig 2: BMI Chart 6
  • 7. Types of Obesity • Obesity can be classified into 2 types: 1. Physical obesity 2. Pathological Obesity 1. Physical Obesity This is based on distribution of the fats in the body i.e., purely based on the appearance of a person. Types: (A) Android Obesity (B) Gynoid Obesity 7
  • 8. Fig 3: Apple and Pear shaped Obesity 8
  • 9. 2. Pathological Obesity This is based on the structure of the fat tissue. Types: (A) Hyperplastic type. (B) Hypertrophic type. Fig 4: Central & Peripheral Obesity 9
  • 10. • Based on causes obesity can be further classified into 2 types. a) Endogenous obesity - Obesity resulting from internal conditions. b) Exogenous Obesity - Overfeeding or gluttony with less physical activity. 10
  • 11. Treatment of Obesity Fig 5: Pyramid of interventions in the management of obesity 11
  • 12. Dietary Pills • There are 3 different mechanisms used to classify pharmacological treatment of obesity. a. Drugs that reduce appetite & food intake. b. Drugs that increase energy expenditure. c. Drugs that effect metabolism and nutrition partitioning. 12
  • 14. 1. Orlistat Fig 6: Molecular Structure of Orlistat Fig 7: Xenical (Orlistat Capsules) 14
  • 15. Fig 8: Mechanism of action of Orlistat 15
  • 16. 2. Naltrexone-Bupropion Fig 9: Molecular Structure of Naltrexone-Bupropion Fig 10: Contrave (Naltrexone-Bupropion Capsules) 16
  • 17. Fig 11: Mechanism of action of Naltrexone-Bupropion 17
  • 18. 3. Lorcaserin Fig 12: Molecular Structure of Lorcaserin Fig 13: Belviq (Lorcaserin Capsules) 18
  • 19. Fig 14: Mechanism of action of Lorcaserin 19
  • 20. 4. Sibutramine Fig 15: Molecular Structure of Sibutramine Fig 16: Sibutril/leptos (Sibutramine Capsules) 20
  • 21. Fig 17: Mechanism of action of Sibutramine 21
  • 23. REFERENCES • Chatterjea M. N. & Rana Shinde. 2012. Textbook of Medical Biochemistry, 8th edition, Jaypee Brothers Medical Publishers (P) Ltd, New Delhi, India, 894pp. • George A. Bray, Claude Bouchard &. James W. P. T. 2004. Handbook of Obesity Clinical Applications, 2nd edition, Marcel Dekker, inc., New York, USA, 414pp. • Harsh Mohan. 2010. Textbook of Pathology, 6th edition, Jaypee Brothers Medical Publishers (P) Ltd, New Delhi, India, 949pp. • Robert H. Glew & Miriam D. Rosenthal. 2007. Clinical Studies in Medical Biochemistry, 3rd edition, Oxford University Press, New York, USA, 387pp. 23
  • 24. • https://pubmed.ncbi.nlm.nih.gov/28245771/ • https://www.sciencedirect.com/science/article/pii/S1043661 814000449 • https://go.drugbank.com/drugs/DB01083 • https://www.ncbi.nlm.nih.gov/books/Definitions, Classification, and Epidemiology of Obesity/NBK279167/ • https://www.alfadoc.co.uk/weight-loss/xenical/ • https://www.semanticscholar.org/paper/Review-Paper%3A- Current-Strategies-in-the-Development- Elangbam/033190e774f9a8d9902fb69b4a0f01b6d9149c03 • https://youtu.be/B1xJhtROIw8 • https://youtu.be/eTCOi2Nslfs • https://slideplayer.com/slide/ antiobesitydrugs- 170215131630/ 24
  • 25. ACKNOWLEDGEMENT I would like to thank the Dept. of Molecular Biology for providing this opportunity to present this seminar. I would also like to thank my guide Dr. Raghavendra Hegde Katte for his valuable guidance. Thank you one and all. 25
  • 26. 26
  • 27. 4. Phentermine Fig 15: Molecular Structure of Phentermine Fig 16: Lamaira (Phentermine Capsules) 27