The present study concluded that chronic diseases like diabetes affect the quality of life of patients.As the main goal of any medical care is the improvement of the patients’ overall quality of life, the clinical pharmacist imparted patient education through counseling has a major role in improving the physical as well as mental health outcomes.
Slides to Guide Reducing Cardiovascular Risk in Type 2 Diabetes: What I Do an...hivlifeinfo
Slides to Guide Reducing Cardiovascular Risk in Type 2 Diabetes: What I Do and Why.2018
Zachary T. Bloomgarden, MD, MACE
Program Director
Mikhail N. Kosiborod, MD
Pamela Kushner, MD, FAAFP
Format: Microsoft PowerPoint (.ppt)
File Size: 923 KB
Released: June 29, 2018
Approach to Support Diabetes through Data Visualization DivyaBastola
Used Tableau to created a Geo-map by zip codes, Bar chart by sex and race, and another Bar chart by age to display the dense of diabetes prevalence in 17 zip codes of North Texas.
Literature Review is conducted to demonstrate the reduction of hyperglycemia events after the implementation of an inpatient multidisciplinary glucose control management program.
Created Info-graphic to exhibit the ways to manage diabetes through education, counseling, meal/diet, and exercise and potential comorbidities in the diabetic patient that undergoes surgeries.
Obesity context of type 2 diabetes and medication perspectivesApollo Hospitals
Drug therapy of obesity has harsh antecedent that many earlier introduced drugs are withdrawn from market. The drugs in present use lack sufficient long-term efficacy and safety data. The difficulty of reversing changing dietary habits and decline in physical activity, however, offers major scope for anti-obesity therapeutics, implied in managing the epidemic chronic inflammatory maladies and cardiovascular sequel. Metabolic syndrome, pre-diabetes and type 2 diabetes mellitus, commonly associate with obesity. Weight reduction is crucial to prevent and control type 2 diabetes. This emphasizes rational choice of therapeutic regimens that do not themselves cause weight gain, and better promote weight loss. Such an aspect is addressed briefly focusing upon the available newer anti-obesity drug options, in particular.
Background: There are very a few studies on psychiatric symptoms in patients with Diabetes Mellitus (DM) patients and assessing glycemic controls.
Aim: To describe the level of glycemic control, complications and psychosocial functioning among DM patients using the Depression Anxiety Stress Scales (DASS-21) instrument and its predictors among diabetic Turkish population.
What Spine Surgeons Need to Know About Dietary Strategies for Heart Disease a...James McCarter
Presentation to the North American Spine Society Annual Meeting. Interdisciplinary Spine Forum: Obesity and Diabetes: Impact on the Spine and Evidence-Based Management Strategies. Organized by Dr. Carrie Diulus
Diabetes and obesity have reached epidemic proportion. It is imperative that spine providers take these factors into consideration. We also have the opportunity to be powerful motivators to our patients with some straight forward evidence-based strategies.
Upon completion of this session, participants should gain strategies to:
Understand impact of metabolic syndrome on spine conditions/degeneration and treatment outcomes
Learn dietary strategies to have a positive impact on these conditions and the most current science behind these recommendations
Understanding the impact of strategies on heart disease and lipids
How to implement recommendations in a busy clinical setting
Obesity and hyperlipidemia is international /worldwide problem causing heart disease leading to major predisposing factor for morbidity and death. Conventional medicine used in allopathy include statins, fibrates, niacin and resins but are going to defame due to their adverse effects. Herbal medicine ginger has proved itself as one of the potent anti hyperlipidemic and anti obesity herb with least adverse effects. We did try to compare its hypolipidemic effects with placebo effects when used in mild to moderate hyperlipidemic patients. It was placebo-controlled single blind research study. Research was conducted at National hospital, Lahore, from July to November 2016. Consent was taken from sixty hyperlipidemic patients age range from 25 to 60 years. Both gender male and female patients were enrolled. Patients were randomly divided in two groups, 30 patients were on drug ginger pasted-powder advised to take 5 grams in divided doses with their normal diet for the period of three months. Thirty patients were on placebo pasted-wheat powder, with same color as of ginger powder, advised to take 5 grams in divided doses with their normal diet for the period of three months. Their base line lipid profile and body weight was recorded at start of treatment and were advised to come for check-up, fortnightly.
International Journal of Medical Science in Clinical Research and Review Vol 03, Issue 02,April – 2020 Page |
229
When duration of study was over, their lipid profile and body weight was measured and compared statistically with pre-treatment values. Three months treatment with 5 grams of ginger decreased total cholesterol from 233.11±1.53 mg/dl to 198.44±1.23 mg/dl, LDL cholesterol reduced from 202.21±1.88 mg/dl to 187.72± 1.98 mg/dl, reduced body weight from 76.01±2.66 kg to 72.80±1.87 kg. Both plasma total cholesterol and LDL cholesterol reduction was statistically significant, but body weight decrease was non-significant when analyzed biostatistically.
Effectiveness of health coaching on diabetic patients:A systematic review and...LucyPi1
Abstract
Background: Using health coaching to improve the quality of life and health outcomes of the patients with
diabetes mellitus, has emerged as a possible intervention. However, the few published randomized controlled trials
using health coaching for patients with diabetes mellitus have reported mixed results. The present meta-analysis
aimed to determine the effectiveness of health coaching on modifying health status and quality of life among
diabetic patients and to clarify the characteristics of coaching delivery that make it most effective. Methods: This
study searched for articles on randomized controlled trials of health coaching interventions targeting type 2 diabetic
patients that were published in the English language from January 2005 through December 2018 in the Cochrane,
Medline, PubMed, Trip, and Embase databases. Patients in the control group received usual diabetes mellitus care,
and those in the experimental group received health coaching based on usual diabetes mellitus care. The primary
outcomes included Hemoglobin A1c (HbA1c) and cardiovascular disease risk factors, including systolic blood
pressure, diastolic blood pressure, triglyceride, high-density lipoprotein cholesterol (HDL-C), low-density
lipoprotein cholesterol, total cholesterol, and body weight. The secondary outcomes included quality of life,
self-efficacy, self-care skills, and psychological outcomes. Results: Health coaching intervention has a significant
effect on HbA1c [mean difference (MD) = -0.35, confidence interval (CI) = -0.47, -0.22, I2 = 83%, P < 0.001] and
HDL-C (MD = -0.50, CI = -0.93, -0.07, I2 = 10%, P = 0.02). The most effective strategy for health coaching
delivery associated with improvement of HbA1c was decreasing the number of sessions and increasing the duration
of each session. However, no significant difference was found for weight, SBP, diastolic blood pressure,
triglyceride, low-density lipoprotein cholesterol, or total cholesterol. Mixed results were reported for the effect of
health coaching on quality of life, self-efficacy, self-care skills, and depressive symptoms outcome. Conclusion:
Health coaching intervention has a significant effect on HbA1c and HDL-C, and the most effective strategy is
decreasing the number of sessions while increasing session duration. However, these results should be interpreted
with caution as the evidence comes from studies at some risk of bias with considerable heterogeneity and
imprecision.
About the Ketogenic "Keto" Diet in One PageJames McCarter
Nutritional ketosis is a metabolic state where the body is predominantly fueled by dietary fat or body fat. It occurs when dietary carbohydrates are limited, dietary protein is moderate, and ketones are produced by the liver as part of fatty acid metabolism.
Abstract—Diabetes is a disease which is on continuous increase specialy in country like India. It involve is a multisystem so intend to affect quality of life of patients. So this study was conducted on 250 Diabetes Mellitus patients to observe their quality of life on various domains viz Physical, Mental, Social and environmental through WHOQOL-Bref questionnaire. It was found that 54.4% were unable to level their quality of life, they say neither good nor bad. But 23.2% were feeling bad and 22.4 % were feeling good about their quality of life. Whereas regarding patient's satisfaction about their health 39.2% were unable to level their quality of life and 35.6% were dissatisfied and 25.2 % were satisfied with their health. Significantly more cases were unable to understand about their quality of life than their satisfaction to their health. It was also found that Physical quality of life was affected most followed by environmental, psychological and social dimension of quality of life.
Slides to Guide Reducing Cardiovascular Risk in Type 2 Diabetes: What I Do an...hivlifeinfo
Slides to Guide Reducing Cardiovascular Risk in Type 2 Diabetes: What I Do and Why.2018
Zachary T. Bloomgarden, MD, MACE
Program Director
Mikhail N. Kosiborod, MD
Pamela Kushner, MD, FAAFP
Format: Microsoft PowerPoint (.ppt)
File Size: 923 KB
Released: June 29, 2018
Approach to Support Diabetes through Data Visualization DivyaBastola
Used Tableau to created a Geo-map by zip codes, Bar chart by sex and race, and another Bar chart by age to display the dense of diabetes prevalence in 17 zip codes of North Texas.
Literature Review is conducted to demonstrate the reduction of hyperglycemia events after the implementation of an inpatient multidisciplinary glucose control management program.
Created Info-graphic to exhibit the ways to manage diabetes through education, counseling, meal/diet, and exercise and potential comorbidities in the diabetic patient that undergoes surgeries.
Obesity context of type 2 diabetes and medication perspectivesApollo Hospitals
Drug therapy of obesity has harsh antecedent that many earlier introduced drugs are withdrawn from market. The drugs in present use lack sufficient long-term efficacy and safety data. The difficulty of reversing changing dietary habits and decline in physical activity, however, offers major scope for anti-obesity therapeutics, implied in managing the epidemic chronic inflammatory maladies and cardiovascular sequel. Metabolic syndrome, pre-diabetes and type 2 diabetes mellitus, commonly associate with obesity. Weight reduction is crucial to prevent and control type 2 diabetes. This emphasizes rational choice of therapeutic regimens that do not themselves cause weight gain, and better promote weight loss. Such an aspect is addressed briefly focusing upon the available newer anti-obesity drug options, in particular.
Background: There are very a few studies on psychiatric symptoms in patients with Diabetes Mellitus (DM) patients and assessing glycemic controls.
Aim: To describe the level of glycemic control, complications and psychosocial functioning among DM patients using the Depression Anxiety Stress Scales (DASS-21) instrument and its predictors among diabetic Turkish population.
What Spine Surgeons Need to Know About Dietary Strategies for Heart Disease a...James McCarter
Presentation to the North American Spine Society Annual Meeting. Interdisciplinary Spine Forum: Obesity and Diabetes: Impact on the Spine and Evidence-Based Management Strategies. Organized by Dr. Carrie Diulus
Diabetes and obesity have reached epidemic proportion. It is imperative that spine providers take these factors into consideration. We also have the opportunity to be powerful motivators to our patients with some straight forward evidence-based strategies.
Upon completion of this session, participants should gain strategies to:
Understand impact of metabolic syndrome on spine conditions/degeneration and treatment outcomes
Learn dietary strategies to have a positive impact on these conditions and the most current science behind these recommendations
Understanding the impact of strategies on heart disease and lipids
How to implement recommendations in a busy clinical setting
Obesity and hyperlipidemia is international /worldwide problem causing heart disease leading to major predisposing factor for morbidity and death. Conventional medicine used in allopathy include statins, fibrates, niacin and resins but are going to defame due to their adverse effects. Herbal medicine ginger has proved itself as one of the potent anti hyperlipidemic and anti obesity herb with least adverse effects. We did try to compare its hypolipidemic effects with placebo effects when used in mild to moderate hyperlipidemic patients. It was placebo-controlled single blind research study. Research was conducted at National hospital, Lahore, from July to November 2016. Consent was taken from sixty hyperlipidemic patients age range from 25 to 60 years. Both gender male and female patients were enrolled. Patients were randomly divided in two groups, 30 patients were on drug ginger pasted-powder advised to take 5 grams in divided doses with their normal diet for the period of three months. Thirty patients were on placebo pasted-wheat powder, with same color as of ginger powder, advised to take 5 grams in divided doses with their normal diet for the period of three months. Their base line lipid profile and body weight was recorded at start of treatment and were advised to come for check-up, fortnightly.
International Journal of Medical Science in Clinical Research and Review Vol 03, Issue 02,April – 2020 Page |
229
When duration of study was over, their lipid profile and body weight was measured and compared statistically with pre-treatment values. Three months treatment with 5 grams of ginger decreased total cholesterol from 233.11±1.53 mg/dl to 198.44±1.23 mg/dl, LDL cholesterol reduced from 202.21±1.88 mg/dl to 187.72± 1.98 mg/dl, reduced body weight from 76.01±2.66 kg to 72.80±1.87 kg. Both plasma total cholesterol and LDL cholesterol reduction was statistically significant, but body weight decrease was non-significant when analyzed biostatistically.
Effectiveness of health coaching on diabetic patients:A systematic review and...LucyPi1
Abstract
Background: Using health coaching to improve the quality of life and health outcomes of the patients with
diabetes mellitus, has emerged as a possible intervention. However, the few published randomized controlled trials
using health coaching for patients with diabetes mellitus have reported mixed results. The present meta-analysis
aimed to determine the effectiveness of health coaching on modifying health status and quality of life among
diabetic patients and to clarify the characteristics of coaching delivery that make it most effective. Methods: This
study searched for articles on randomized controlled trials of health coaching interventions targeting type 2 diabetic
patients that were published in the English language from January 2005 through December 2018 in the Cochrane,
Medline, PubMed, Trip, and Embase databases. Patients in the control group received usual diabetes mellitus care,
and those in the experimental group received health coaching based on usual diabetes mellitus care. The primary
outcomes included Hemoglobin A1c (HbA1c) and cardiovascular disease risk factors, including systolic blood
pressure, diastolic blood pressure, triglyceride, high-density lipoprotein cholesterol (HDL-C), low-density
lipoprotein cholesterol, total cholesterol, and body weight. The secondary outcomes included quality of life,
self-efficacy, self-care skills, and psychological outcomes. Results: Health coaching intervention has a significant
effect on HbA1c [mean difference (MD) = -0.35, confidence interval (CI) = -0.47, -0.22, I2 = 83%, P < 0.001] and
HDL-C (MD = -0.50, CI = -0.93, -0.07, I2 = 10%, P = 0.02). The most effective strategy for health coaching
delivery associated with improvement of HbA1c was decreasing the number of sessions and increasing the duration
of each session. However, no significant difference was found for weight, SBP, diastolic blood pressure,
triglyceride, low-density lipoprotein cholesterol, or total cholesterol. Mixed results were reported for the effect of
health coaching on quality of life, self-efficacy, self-care skills, and depressive symptoms outcome. Conclusion:
Health coaching intervention has a significant effect on HbA1c and HDL-C, and the most effective strategy is
decreasing the number of sessions while increasing session duration. However, these results should be interpreted
with caution as the evidence comes from studies at some risk of bias with considerable heterogeneity and
imprecision.
About the Ketogenic "Keto" Diet in One PageJames McCarter
Nutritional ketosis is a metabolic state where the body is predominantly fueled by dietary fat or body fat. It occurs when dietary carbohydrates are limited, dietary protein is moderate, and ketones are produced by the liver as part of fatty acid metabolism.
Abstract—Diabetes is a disease which is on continuous increase specialy in country like India. It involve is a multisystem so intend to affect quality of life of patients. So this study was conducted on 250 Diabetes Mellitus patients to observe their quality of life on various domains viz Physical, Mental, Social and environmental through WHOQOL-Bref questionnaire. It was found that 54.4% were unable to level their quality of life, they say neither good nor bad. But 23.2% were feeling bad and 22.4 % were feeling good about their quality of life. Whereas regarding patient's satisfaction about their health 39.2% were unable to level their quality of life and 35.6% were dissatisfied and 25.2 % were satisfied with their health. Significantly more cases were unable to understand about their quality of life than their satisfaction to their health. It was also found that Physical quality of life was affected most followed by environmental, psychological and social dimension of quality of life.
Satish K. Gupta, Ramesh C. Sawhney, Lajpat Rai , V. D. Chavan, Sameer Dani, Ramesh C. Arora,
W. Selvamurthy, H. K. Chopra, Navin C. Nanda
Indian Heart Journal 2011; 63:461-469
A SYSTEMATIC REVIEW ON SELF-REPORTED QUESTIONNAIRES TO ASSESS MEDICATION ADH...Aji Wibowo
Adherence to pharmacological therapies are keys to effective treatments in diabetic patients. Previous reviews found that most adherence measurement studies on chronic diseases used a self-reported scale. However, there is no consensus on the best scale to measure adherence in diabetic patients. The purpose of this systematic review was to identify the potential self-reported scale that could be considered for measuring medication adherence in diabetic patients and to provide recommendations for researchers or clinicians to determine appropriate adherence selfreported scales in diabetic patients. This review follows general guidelines in the implementation of systematic reviews. After further review, it was found that 33 studies met all inclusion criteria from 4 databases (Wiley, Science Direct, Scopus, and PubMed). The articles were done by the PRISMA, while the keywords were determined by the PICO method. Most research was conducted in Asia (69.7%) and America (18.2%) on patients with type 2 diabetes (81.3%), patients in hospitals (54.5%), suffering for 1-6 months (54.5%), and using a cross-sectional study design (78.8%). HbA1c clinic data (57.6%) were used in most studies as biological markers of adherence. The measurement scales of medication adherence in diabetic patients are MMAS-8 (57,.5%), MMAS-4 (12.1%), BMQ (9%), MCQ (6%), ARMS (3%), ARMS-D (3%), GMAS (3%), LMAS-14 (3%), and MARS-5 (3%). This review provides information on the different self-reported scales most widely used in diabetic medication adherence research. Various aspects need to be considered before choosing the scale of adherence.
Rice bran is fabricated from the rice milling enterprise and contains about 10% of the entire weight of rough rice. It is especially composed of aleurone, pericarp, subaleurone layer, and germ. Rice bran is a fertile supply of nutrients, minerals, vital fatty acids, dietary fiber, and different sterols. The quantification of γ-oryzanol in rice bran can be conducted by many methods that require drawing out of rice bran oil (RBO) from the bran, accompanied by way of evaluation of the quantity of γ-oryzanol in the RBO with the aid of high-performance liquid chromatography. RBO is the oil drain out of the outer rigid surface of rice called chaff (rice husk). It is identified for its excessive smoke factor of 232°C (450°F) and soft taste, making it pleasant for excessive-temperature cooking strategies such as blend and deep frying. It is healthy for human expenditure, which is employed in the system of vegetable ghee. Wax was drawn out of RBO and palpanese extract, which is employed for carnauba wax in makeup, confectionery, shoe lotions, and sharpening compounds. It is accepted as a food preparation oil in numerous Asian countries, along with Bangladesh, Japan, India, and China. Regarding the importance of RBO, this overview intends to pay attention at the phytochemistry and therapeutic functions of RBO.
Corticosteroids are the steroid hormones, which are mainly used in the treatment of rheumatoid arthritis, osteoarthritis, rheumatic fever, gout, allergic reactions, renal disease, haematological disorders and shock. The use of glucocorticoids in supra physiological doses for more than 2-3 weeks causes a number of undesirable effects. Most of the adverse effects are extension of pharmacological actions such as hyperglycaemia, Cushing syndrome, oedema, hypertension, CCF, steroid myopathy, glaucoma, various fungal infections etc. Diclofenac is a Non-Steroidal Anti Inflammatory Drug; it is high potent anti-inflammatory and analgesic drug. The mechanism of acute bronchitis due to the diclofenac still not known but increased production of leukotrienes may cause bronchitis. Here we report a 45 years old female patient was experienced moon face, pedal oedema, increased RBS, LDL, total cholesterol, abdominal striae, acute bronchitis and increased blood presser due to the prolonged using of corticosteroids and NSAIDs since 2 years regularly.
Amlodipine is a 4th generation dihydropyridine calcium channel blocker which is permitted for the treatment ofessential hypertension and angina pectoris. The main mechanism of calcium channel blockers are blocks the voltage sensitive L-type calcium channels by binding to alpha-1 subunit, so prevent the entry of calcium in to the cells finally no excitation-contraction coupling in the heart and vascular smooth muscles. It is absorbed slowly after oral administration. But its bioavailability is high. It has a longer duration of action than ahenefidipine. It dilates both peripheral as well as coronary vessels. It is an alternative anti-hypertensive drug for patients with Nefidipine induced pedaledema. This drug is expected to produce a more incidence of pedal oedema, as compared to Nefidipine and other calcium channel blockers, based on the limited data available from clinical trials. The common adverse effects of Amlodipine are nausea, abdominal pain, vomiting, dry mouth, constipation, gingival hypertrophy, dizziness, heartburn, photosensitivity, headache, light headedness and insomnia. We report a case of Amlodipine induced pedal edema.
There are numerous studies that report anemia and hematological
abnormalities in patients with human immunodeficiency virus (HIV) infection
and acquired immunodeficiency syndrome (AIDS). Highly Active Antiretroviral
therapy (HAART) is the best suited regimen that is potent enough to reduce the
viral load in patients with HIV/AIDS. On the other hand, this regimen has the
tendency to cause anemia and bone marrow suppression. We report a case of 26
years female patient confirmed with HIV infection since 6 months and is on
Zidovudine, Lamivudine and Nevirapine therapy for the past 4 months. While the
patient was in this regimen it leads to severe anemia and acute gastritis. The
relationship between the suspected drug and reaction was established by
performing casualty assessment. There is a need of close monitoring at regular
intervals to find the development of bone marrow toxicity and other
complications which help in prevention and better management of disease and
therapy problems
Enoxaparin is extensively used in the treatment of venousthrombo-embolic disease (VTED) which inhibits blood clotting inside the blood vessels by the inhibition of factor Xa activity through antithrombin. Local hypersensitivity reactions are one of the rare adverse drug reactions (ADR) of enoxaparin which may lead to hospitalization and excessive burden to the patient. A 72 years male patient was admitted in general medicine department with retrosternal pain even at rest and was diagnosed with unstable angina pectoris. He was administered with anti-coagulantEnoxaparin 0.4ml (40 I.U)subcutaneouslyalong with other supportive medications. Patient have developed severe local hyper sensitivity reactions like erythema,pain,swelling,irritation at the site of injection, and suspected as an ADR of Enoxaparin and immediately drug was withdrawn, then it was confirmed through causality assessment and this ADR have shown +ve for rechallenge;patient was fallowed for improvement and the symptoms especially swelling and irritations were not subsidedeven on 9th day. By this case study we strongly recommend the testingof drug sensitivity before initiating Enoxaparin therapy,and need to collect past history comprehensively for safe and effective outcome of therapy.
The intention with the suicidal thoughts, hair dye (super vasmol-33) poisoning cases are increasing in many parts of world to free their souls. Hence we felt it as a social need to conduct this type of study. Objective to understand the prevalence of ―Vasmol‖ poisoning cases and to analyze the presenting features, clinical course and their outcome in general medicine and emergency units of a tertiary care teaching hospital. This is a Prospective observational Study conducted for a period of six months. Any adult individual who consumed the vasmol poison intentionally were included as the study subjects. A total number of 380 vasmol poisoning cases have been collected. Out of them, 168(44.21%) cases were in the age group of 11-20 years, 120 (31.57%) were in between 21-30 years. 347 (91.31%) patients were illiterates. Out of 380 cases, 258 (67.89%) were recovered with the supportive therapy, 14 (3.68%) were died and 83 (21.84%) were referred to higher institution for better treatment. The death rate was found to be 1:27 i.e. out of every 27 cases 1 death was observed. Out of 14 deaths, 8 were due to cardio-respiratory failure, 3 were due to Myocarditis, 1 due to cardiac arrest, and 2 were due to acute renal failure. Vasmol hair dye ingestion is a life threatening condition and is a serious social issue to be addressed immediately. Early recognition, prompt referral, and supportive therapy are the factors on which clinical outcomes depend.
Candidiasis is a fungal infection caused by yeasts from the genus Candida. It is commonly called oral candidiasis or thrush when it affects the mouth. It is one of the common side effects associated with the long term use of steroid inhalers. Nebulizing therapy with corticosteroids is widely accepted treatment approach for patients with acute exacerbations of Chronic Obstructive Pulmonary Disease. The other side effects of steroid inhalers include hoarseness of voice and dysphonia, which are usually ignorable. We report this case of 74 year old male patient who was on metered dosage inhaler and nebulizer therapy with corticosteroid and presented with oral candidiasis. If oral thrush develops, treatment with oral fluconazole or nystatin mouth wash is beneficial. Proper patient education by the clinical pharmacist to the patient regarding safe and effective usage of inhalers and nebulizers especially corticosteroids can minimize these drug related problems.
The trend of consuming hair dyes intentionally to free their souls is increasing day by day especially among rural indian population. Among them super vasmol 33 is a well known emulsion base type hair dye brand. The main content in vasmol is paraphenylenediamine (PPD).the major toxic effects of this chemical were found to be cervicofacial edema, rhabdomyolysis and renal failure. Quick recognition and immediate supportive therapy helps to recover completely. We report a case which highlights the toxic effects upon vasmol ingestion.
Number of people exposed to traumatic events is on rise
day by day. Despite of this increased rate of exposure, little
is known about the disease, treatments available for
preventing/relieving PTSD symptoms. As research is a
continuous process and huge body of evidence is being
added to the existing literature, it is very important to
update ourselves. All the conclusions made by various
researchers are the result of experiments performed in
their set up which is different from ours. The applicability
of those conclusions in our kind of population has to be
evaluated and build our own body of evidence.
A PILOT STUDY ON DRUG - DRUG INTERACTIONS AMONG THE SCHIZOPHRENIA PATIENTS IN...Gangula Amareswara Reddy
As the improvement in schizophrenia patients is seen with only long term therapy, being adhered to the regimen all the way is very important. Development of drug-drug interactions among prescribed agents is the main reason for drug non adherence.Hence prior assessment of prescriptions is mandatory for the prescriptions with multiple drug therapy.The study opens door for larger studies to emphasize the role of pharmacist in identifying and preventing drug-drug interactions.
Digoxin is extensively used in the treatment of congestive heart failure
(CHF). It improves blood circulation to peripheral tissues by increasing
contractility of myocardial cells by binding to Na+-K+ ATPase pump.
Arrhythmias are the major Adverse Drug Reaction (ADR) of Digoxin which
may lead to hospitalization, morbidity and even mortality. A 60 years male
patient was admitted with breathlessness, pedal edema and was diagnosed as
CHF. He was prescribed with Digoxin 5 day therapy along with other
medications, on 5th day we observed Electro Cardio Gram (ECG) changes
indicating ventricular tachycardia as a suspected ADR of Digoxin and was
confirmed by causality assessment, immediately suspected drug was stopped,
patient was monitored for progression and on 9 th day ECG showed no
tachycardia changes. We strongly recommends to monitor the patients receiving
digoxin (especially those aged > 60years of age) for safe and effective outcome
of therapy.
ASSESSMENT OF SELF MEDICATION AMONG RURAL VILLAGE POPULATION IN A HEALTH SCRE...Gangula Amareswara Reddy
THE STUDY AIMS AT IDENTIFYING SELF MEDICATION PATTERN AMONG RURAL POPULATION AND VARIOUS FACTORS INFLUENCING IT LIKE OCCUPATION, HABITS, LITERACY RATE, EXTENT OF AWARENESS, SOURCE FOR DRUG INFORMATION ETC.......
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
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- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.