Here is the complete description about Citric Acid cycle

1. CITRIC ACID CYCLE
PRESENTED BY:
INCHARA R
5TH SEMESTER
MOLECULAR BIOLOGY
06/08/2019
GUIDED BY:
SADASHIVAIAH
DEPT. OF MOLECULAR
BIOLOGY
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2. CONTENTS
 Introduction
 Formation of Acetyl CoA
 Reactions of Citric Acid Cycle
 Significance
 Conclusion
 References
 Acknowledgement
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3. Sir Hans Adolf Kreb
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4. Fig 1: Citric acid cycle 4

5. Fig 2: Formation of Citrate
Reactions of Citric Acid Cycle
Citrate
synthase
Citrate synthase
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6. Fig 3: Formation of Isocitrate
OH
Aconitase Aconitase
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7. Fig 4: Oxidation of Isocitrate to α-Ketoglutarate
Isocitrate dehydrogenase Isocitrate
dehydrogenase
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8. Fig 5: Oxidation of α-Ketoglutarate to Succinyl-CoA
α-ketoglutarate
dehydrogenase
complex
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9. Fig 6: Conversion of Succinyl-CoA to Succinate
succinyl-CoA
synthetase
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10. Fig 7: Oxidation of Succinate to Fumarate
Succinate Dehydrogenase
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11. Fig 08: Hydration of Fumarate to Malate
Fumarase
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12. Fig 9: Oxidation of Malate to Oxaloacetate
L-malate dehydrogenase
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H H
H
H

13. SIGNIFICANCE
 Amphibolic pathway
 Important Biosynthetic Intermediates
 Anaplerotic Reactions
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14. CONCLUSION
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15. REFERENCES
 David L. Nelson & Michael M. Cox. 2008. Lehninger Principles Of
Biochemistry, 5th edition, W. H. Freeman & Company, New York, USA,
1303pp.
 Jeremy M. Berg, John L. Tymoczko & Lubert Stryer. 2007.
Biochemistry, 6th edition, W. H. Freeman & Company, New York, USA,
1158pp.
 Donald Voet & Judith G. Voet. 2011. Biochemistry, 4th edition, John
Wiley & Sons, Inc., New Jersey, UK, 1515pp.
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16.  http://www.biologydiscussion.com/organism/metabolism-
organism/the-krebs-cycle-notes-on-the-krebs-cycle-with-diagram-
metabolism/50314
 http://www.namrata.co/?s=tca+cycle
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17. ACKNOWLEGDEMENT
I would like to thank the dept. of Molecular Biology for
providing this opportunity to present this seminar.
I would also like to thank my guide Sadashivaiah sir for his
valuable guidance.
Thank you one and all.
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