Tuberculosis is a chronic infectious disease caused by the bacterium Mycobacterium tuberculosis. It typically affects the lungs but can affect any part of the body. Risk factors include poverty, crowding, illnesses that weaken the immune system like HIV, and malnutrition. There are two main types - primary tuberculosis occurs in those never exposed before while secondary tuberculosis occurs from reactivation of a previous infection. Diagnosis involves physical exam, sputum tests, chest x-rays, and culture of bacteria. Treatment requires a combination of antibiotics taken for several months. Preventive measures include isolation during early treatment, ventilation, cough hygiene, and masks.
Tuberculosis (TB) is an infectious disease usually caused by Mycobacterium tuberculosis (MTB) bacteria. Tuberculosis generally affects the lungs, but can also affect other parts of the body. Most infections show no symptoms, in which case it is known as latent tuberculosis.
TB is spread from person to person through the air. When people with lung TB cough, sneeze or spit, they propel the TB germs into the air. A person needs to inhale only a few of these germs to become infected.
Tuberculosis (TB) is an infectious disease usually caused by Mycobacterium tuberculosis (MTB) bacteria. Tuberculosis generally affects the lungs, but can also affect other parts of the body. Most infections show no symptoms, in which case it is known as latent tuberculosis.
TB is spread from person to person through the air. When people with lung TB cough, sneeze or spit, they propel the TB germs into the air. A person needs to inhale only a few of these germs to become infected.
Clinical presentation of active TB
Differential diagnosis of TB
Etiology
Transmission
Factors influencing transmission
Pathogenesis of Latent
TB Disease
Co-pathogenesis
This is about tuberculosis , features, diagnosis and management. With reference to Uganda Clinical Guidelines
By Okeke Gloria, Kasule Steven, Sengooba Dennis Nyanzi
Tuberculosis (TB) is caused by bacteria (Mycobacterium tuberculosis) that most often affect the lungs. Tuberculosis is curable and preventable.
TB is spread from person to person through the air. When people with lung TB cough, sneeze or spit, they propel the TB germs into the air. A person needs to inhale only a few of these germs to become infected.
The causative agent is Mycobacterium tuberculosis (also known as the tubercle bacillus).
Tuberculosis (TB) is an infectious disease that primarily affects the lung parenchyma. The primary infection usually involves the middle or lower lung area.
It is also may be transmitted to other parts of the body, including the Meninges, kidneys, bone, joints, pericardium, GI tract and lymph nodes And this condition known as Extra pulmonary TB.
The disease also can affects animals such as cattle, this is known as “bovine tuberculosis” which may sometimes be transmitted to man.The primary infectious agent, “ M.Tuberculosis”, is an acid – fast aerobic (AFB) rod that grows slowly and is sensitive to heat and ultraviolet light.
tuberculosis lecture | pulmonary Tuberculosis
my self ritesh padghan
tuberculosis is infectious disease caused by mycobacterium tuberculosis in active and latent type of tuberculosis .
BRIEF DISCUSSION INCLUDE
:-LEARNING ABOUT
Introduction
Definition
Causative organism
Risk factor
Transmission
Clinical manifestation
Diagnostic evaluation
Medical management
In this lecture the pathophysiology and phathogenesis of tuberculosis has been discussed
HOPE YOU LIKE
#tuberculosis #respiratorysystem #chronicdiorder #TBkid #endTB #lunghealth # COVID19 #COMMUNIOTY #INFLUNZA #worldtbday # disease
Tuberculosis (TB) is an infectious disease usually caused by Mycobacterium tuberculosis (MTB) bacteria. Tuberculosis generally affects the lungs, but can also affect other parts of the body
These lecture notes were prepared by Dr. Hamdi Turkey- Pulmonologist- Department of internal medicine - Taiz university
Do Not Forget To Visit Our Pages On Facebook on the following Links:
https://www.facebook.com/groups/569435236444761/
AND
https://www.facebook.com/groups/690331650977113/
Clinical presentation of active TB
Differential diagnosis of TB
Etiology
Transmission
Factors influencing transmission
Pathogenesis of Latent
TB Disease
Co-pathogenesis
This is about tuberculosis , features, diagnosis and management. With reference to Uganda Clinical Guidelines
By Okeke Gloria, Kasule Steven, Sengooba Dennis Nyanzi
Tuberculosis (TB) is caused by bacteria (Mycobacterium tuberculosis) that most often affect the lungs. Tuberculosis is curable and preventable.
TB is spread from person to person through the air. When people with lung TB cough, sneeze or spit, they propel the TB germs into the air. A person needs to inhale only a few of these germs to become infected.
The causative agent is Mycobacterium tuberculosis (also known as the tubercle bacillus).
Tuberculosis (TB) is an infectious disease that primarily affects the lung parenchyma. The primary infection usually involves the middle or lower lung area.
It is also may be transmitted to other parts of the body, including the Meninges, kidneys, bone, joints, pericardium, GI tract and lymph nodes And this condition known as Extra pulmonary TB.
The disease also can affects animals such as cattle, this is known as “bovine tuberculosis” which may sometimes be transmitted to man.The primary infectious agent, “ M.Tuberculosis”, is an acid – fast aerobic (AFB) rod that grows slowly and is sensitive to heat and ultraviolet light.
tuberculosis lecture | pulmonary Tuberculosis
my self ritesh padghan
tuberculosis is infectious disease caused by mycobacterium tuberculosis in active and latent type of tuberculosis .
BRIEF DISCUSSION INCLUDE
:-LEARNING ABOUT
Introduction
Definition
Causative organism
Risk factor
Transmission
Clinical manifestation
Diagnostic evaluation
Medical management
In this lecture the pathophysiology and phathogenesis of tuberculosis has been discussed
HOPE YOU LIKE
#tuberculosis #respiratorysystem #chronicdiorder #TBkid #endTB #lunghealth # COVID19 #COMMUNIOTY #INFLUNZA #worldtbday # disease
Tuberculosis (TB) is an infectious disease usually caused by Mycobacterium tuberculosis (MTB) bacteria. Tuberculosis generally affects the lungs, but can also affect other parts of the body
These lecture notes were prepared by Dr. Hamdi Turkey- Pulmonologist- Department of internal medicine - Taiz university
Do Not Forget To Visit Our Pages On Facebook on the following Links:
https://www.facebook.com/groups/569435236444761/
AND
https://www.facebook.com/groups/690331650977113/
Strategic Planning, Implementation, Monitoring and Evaluation (SPIME) for Edu...virgilio gundayao
The function of Implementation, Monitoring, and Evaluation (IME) in the Strategic Planning is a pivotal management and leadership component paving towards organizational success. The SPIME complements and completes the SWOT, environmental scanning, action plan to come out with an ideal but workable road map, blue print, milestone, in the attainment of organizational goals, values, and objectives.
On this oral and written reports, it is apparent that the SPIME is intertwined as a practical approach towards exploring the entire gamut of a CorPlan that are within the frame work of the organizational vision, mission, goals, objectives and values—in this case of an educational institution.
India is the highest TB burden country in the world & accounts for nearly 1/5th (20 per cent) of global burden of tuberculosis, 2/3rd of cases in SEAR. Every year approximately 1.8 million persons develop tuberculosis, of which about 0.8 million are new smear positive highly'- infectious cases.Annual risk of becoming infected with TB is 1.5 % and once infected there is 10 % life-time risk of developing TB disease
This presentation includes introduction, properties, transmission, epidemiology, pathogenesis, mechanism of infection, immunity and hypersensitivity, clinical manifestations, diagnosis, treatment, prevention and control of MYCOBACTERIUM TUBERCULOSIS.
There are nearly 100 viruses of the herpes group that infect many different animal species.
Official name of herpesviruses that commonly infect human is Humans herpesvirus (HHV)
herpes simplex virus types 1 (HHV 1)
Herpes simplex virus type 2 (HHV 2)
Varicella-zoster virus (HHV 3)
Epstein-Barr virus, (HHV 4)
Cytomegalovirus (HHV 5)
Human herpesvirus 6 (HHV 6)
Human herpesvirus 7 (HHV 7)
Human herpesvirus 8 (HHV 8) (Kaposi's sarcoma-associated herpesvirus).
Herpes B virus of monkeys can also infect humans
hELMINTHS#corona virus#Aspergillosis#BUGANDO#CUHAS#CUHAS#CUHAS
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
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micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
2. TUBECULOSIS
Tuberculosis is a communicable chronic granulomatous
disease caused by Mycobacterium tuberculosis. It usually
involves the lungs but may affect any organ or tissue in the
body.
Typically, the centers of
tubercular granulomas undergo
caseous necrosis.
3. Tuberculosis flourishes wherever there is poverty,
crowding, and chronic debilitating illness, elderly
persons, with their weakened defenses, are vulnerable.
Certain disease states also increase the risk: diabetes
mellitus, Hodgkin disease, chronic lung disease, chronic
renal failure, malnutrition, alcoholism, and
immunosuppression.
In areas of the world where HIV infection is prevalent, it
has become the single most important risk factor for the
development of tuberculosis.
4. It is important that infection be differentiated from
disease. Infection implies seeding of a focus with
organisms, which may or may not cause clinically
significant tissue damage (i.e., disease).
In most persons, an asymptomatic focus of pulmonary
infection appears that is self-limited.
Generally, the only evidence of infection, if any remains,
is a tiny, telltale fibrocalcific nodule at the site of the
infection.
5. Viable organisms may remain dormant in such loci for
decades, and possibly for the life of the host. Such
persons are infected but do not have active disease and
so cannot transmit organisms to others.
However when their defenses are lowered, the infection
may reactivate to produce communicable and potentially
life-threatening disease.
6. Primary tuberculosis
It is the form of disease that develops in a previously
unexposed, and therefore unsensitized, person. Elderly persons
and profoundly immunosuppressed persons may lose their
sensitivity to the tubercle bacillus and so may develop primary
tuberculosis more than once. With primary tuberculosis, the
source of the organism is exogenous. About 5% of those newly
infected develop significant disease.
The chief implications of primary tuberculosis are that (1) it
induces hypersensitivity and increased resistance; (2) the foci of
scarring may harbor viable bacilli for years, perhaps for life, and
thus be the nidus for reactivation at a later time when host
defenses are compromised; and (3) uncommonly, the disease
may develop without interruption into so-called progressive
primary tuberculosis.
7. Progressive primary tuberculosis occurs in individuals
who are immunocompromised such as AIDS( CD4+
counts <200 cells/mm3 ) or in malnourished children or
in the elderly. Certain racial groups, such as Inuit.
Immunosuppression results in an inability to mount a
CD4+ T cell-mediated immunologic reaction. The lack of
a tissue hypersensitivity reaction results in the absence
of the characteristic caseating granulomas (nonreactive
tuberculosis).
8. Progressive primary tuberculosis more often resembles
an acute bacterial pneumonia, with lower and middle
lobe consolidation.
Lymphohematogenous dissemination is a dreaded
complication and may result in the development of
tuberculous meningitis and miliary tuberculosis.
11. Secondary (or postprimary)
tuberculosis:
is the pattern of disease that arises in a previously
sensitized host.
commonly it arises from reactivation of dormant primary
lesions many decades after initial infection, particularly
when host resistance is weakened.
It may also result from exogenous reinfection because of
waning of the protection afforded by the primary disease
or because of a large inoculum of virulent bacilli.
12. Reactivation of endogenous tuberculosis is more common in
low-prevalence areas.
Whatever the source of the organism, only a few individuals
(less than 5%) with primary disease subsequently develop
secondary tuberculosis.
Secondary pulmonary tuberculosis is classically localized to
the apex of one or both upper lobes.
Because of the preexistence of hypersensitivity, the bacilli
excite a prompt and marked tissue response that tends to
wall off the focus. As a result of this localization, the regional
lymph nodes are less prominently involved early in the
developing disease than they are in primary tuberculosis.
13. On the other hand, cavitation occurs readily in the
secondary form, resulting in dissemination along the
airways. Indeed, cavitation is almost inevitable in
neglected secondary tuberculosis, and erosion into an
airway becomes an important source of infectivity,
because the person now raises sputum containing
bacilli.
14. Symptoms –
Productive cough
Hemoptysis
Fever
Loss of appetite
Night sweat
15. Localized secondary tuberculosis may be asymptomatic.
Systemic symptoms,often appear early in the course
include malaise, anorexia, weight loss, and fever.
Commonly, the fever is low grade and remittent
(appearing late each afternoon and then subsiding), and
night sweats occur.
With progressive pulmonary involvement, increasing
amounts of sputum, at first mucoid and later purulent,
appear. When cavitation is present, the sputum contains
tubercle bacilli. Some degree of hemoptysis is present in
about half of all cases of pulmonary tuberculosis.
Pleuritic pain may result from extension of the infection
to the pleural surfaces.
16. Extrapulmonary manifestations of tuberculosis depend
on the organ system involved (for example, tuberculous
salpingitis may present as infertility, tuberculous
meningitis with headache and neurologic deficits, Pott
disease with paraplegia).
Dx. The diagnosis of pulmonary disease is based in part
on the history and on physical and radiographic findings
of consolidation or cavitation in the apices of the lungs.
Ultimately, however, tubercle bacilli must be identified.
17. Diagnostic discoveries
24th March 1882 (Robert Koch)
TB Day
Discovery of staining technique
that identified Tuberculosis bacillus
Definite diagnosis made possible
and thus treatment could begin
1890 (Robert Koch)
Tuberculin discovered
Diagnostic use when injected into
skin
1895 (Roentgen)
Discovery of X-rays
Early diagnosis of pulmonary
disease
18. Diagnostics of Mycobacterium
Initial screening:
-TB skin test (Purified Protein Derivative).
Drawbacks: BCG injected subjects are positive, 3 days
delay for result
- QFT-G test (measures INF- response to TB specific
antigen)
TB tests Active, depending on the suspected location
of bacterium:
-3-5 samples of sputum
- multiple gastric aspirate
- urine (UTI)
- CSF (meningeal)2
Cultures
Samples are processed for fast acid stain (FAS smear
positive indicates Mycobacterium) and cultured after
alkali decontamination (30s in 1-2% NaOH)
Molecular methods use species-specific genes,
including light and heave ribosomal RNA3
Clinical specimen/
decontamination
culture Direct detection:
- Microscopy
- PCR
- MTB rifampin resistance
Species identification:
- 16S rRNA hybridization (MTB and MAC)
-16S rRNA gene PCR sequencing (NTM)
- restriction fragment length polymorphism
Susceptibility testing
Rifampin resistance
(PCR oligohybridization sequencing)
18
Dr.T.V.Rao MD
19. Diagnosis of tuberculosis
Physical Examination
Microscopy (Ziehl Neelson Method)
Culture
oIdentification of cultural properties
Animal inoculation
Typing
oto trace the source of infection
Tuberculin tests
Chest X-rays
Lung biopsy
20. diagnosis
• Physical Examination : lymph nodes for swelling and use a
stethoscope to listen carefully to the sounds your lungs make while
you breathe.
• Blood tests : confirm or rule out latent or active tuberculosis. These
tests use sophisticated technology to measure your immune
system's reaction to TB bacteria.
Imaging tests : If a positive skin test, then doctor is likely to order a
chest X-ray or a CT scan. This may show white spots in your lungs.
Sputum tests : If chest X-ray shows signs of tuberculosis, then
doctor may take samples of your sputum — the mucus that comes
up when you cough. The samples are tested for TB bacteria.
21. Treatment
1st line treatment – ethambutol
(or streptomycin), isoniazid, pyrazinamide and
rifamycins.(rifampin, rifabutin, rifapentine)
2nd line – aminoglycoside, macrolides, cycloserine,
flouroquinolones.
Vaccine – bcg(not in US)
22. Reserve drugs which may be used when first line
drugs have failed are:
Ethionamide
Prothionamide
Amikacin
Kanamycin
Capreomycin
Viomycin
Cycloserine
Quinolones (ofloxacin, ciprofloxacin, sparfloxacin)
26. The prognosis of tuberculosis is generally favorable if infections are
localized to the lungs, but it worsens significantly when the disease
occurs in the setting of aged, debilitated, or immunosuppressed
persons, who are at high risk for developing miliary tuberculosis,
and in those with MDR-TB.
Amyloidosis may appear in persistent cases.
27. Medication side effects
Serious side effects of TB drugs aren't common but can be
dangerous when they do occur. All tuberculosis medications
can be highly toxic to your liver. When taking these
medications, call your doctor immediately if you experience
any of the following:
Nausea or vomiting
Loss of appetite
A yellow color to your skin (jaundice)
Dark urine
A fever that lasts three or more days and has no obvious
cause
28. Prevention Protect your family and friends
Stay home. Don't go to work or school or sleep in a room with
other people during the first few weeks of treatment for active
tuberculosis.
Ventilate the room. Tuberculosis germs spread more easily in
small closed spaces where air doesn't move. If it's not too cold
outdoors, open the windows and use a fan to blow indoor air
outside.
Cover your mouth. Use a tissue to cover your mouth anytime
you laugh, sneeze or cough. Put the dirty tissue in a bag, seal it
and throw it away.
Wear a mask. Wearing a surgical mask when you're around other
people during the first three weeks of treatment may help lessen
the risk of transmission.