Etiology, Pathology and presentation of Cirrhosis of live. signs and symptoms and complication of the disease. Its a basic level Presentation on this given topic to have an idea about the Cirrhosis of Liver.
basics about chronic liver disease for a pediatrician. fast and easy guide to common causes of chronic liver diseases in children
Please leave a comment if you like it..
This presentation includes basic important facts about cirrhosis in clinical point of view.This might helpful in clinical management of patient suspecting cirrhosis.
Etiology, Pathology and presentation of Cirrhosis of live. signs and symptoms and complication of the disease. Its a basic level Presentation on this given topic to have an idea about the Cirrhosis of Liver.
basics about chronic liver disease for a pediatrician. fast and easy guide to common causes of chronic liver diseases in children
Please leave a comment if you like it..
This presentation includes basic important facts about cirrhosis in clinical point of view.This might helpful in clinical management of patient suspecting cirrhosis.
Risk factors of chronic liver disease amongst patients receiving care in a Ga...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Detecting Early Liver Fibrosis - A Nutshell for Primary CareJarrod Lee
This presentation summarizes the latest technologies for detecting early liver fibrosis and their role in healthcare today. It is aimed at primary care doctors, to help them better utilize these new developments for their patients.
Cirrhosis is a late stage of scarring (fibrosis) of the liver caused by many forms of liver diseases and conditions, such as hepatitis and chronic alcoholism. ... As cirrhosis progresses, more and more scar tissue forms, making it difficult for the liver to function (decompensated cirrhosis)
Cirrhosis is a late stage of scarring (fibrosis) of the liver caused by many forms of liver diseases and conditions, such as hepatitis and chronic alcoholism.
A chronic, progressive disease characterized by widespread fibrosis(scarring) and nodule formation.
The development of cirrhosis is an insidious, prolonged course, usually after decades of chronic liver disease.
CASE PRESENTATION ONCIRRHOSIS OF LIVER WITH PORTAL HYPERTENSION, HEPATIC EN...Akhil Joseph
A DETAIL CASE PRESENTATION ON CIRRHOSIS OF LIVER WITH PORTAL HYPERTENSION, HEPATIC ENCEPHALOPATHY AND GRADE II OESOPHAGEAL VARICES WITH CONGESTIVE GASTROPATHY. LIVER CIRRHOSIS AND ALL ITS COMPLICATION IN A PATIENT.
Cirrhosis is a late stage of scarring (fibrosis) of the liver caused by many forms of liver diseases and conditions, such as hepatitis and chronic alcoholism
Almost 2 million people around the world die annually because of liver-inflicted diseases. According to scientists, the number is set to increase drastically by 2030. Liver cancer and cirrhosis account for 3.5% of all fatalities (death) globally.
Timely diagnosis and effective treatment can save a person from the complications of liver cirrhosis. Liver cirrhosis treatment in India is affordable and highly effective due to highly-qualified hepatologists concerning themselves with the condition.
Medical Surgical Nursing - I
UNIT: IV -Nursing Management of Patients With Disorder of Digestive System "Cirrhosis of liver"
the topic covers
- the stages, Pathophysiology and clinical manifestation of Cirrhosis of liver
- diagnostic evaluation and complication of Cirrhosis of liver
- medical, surgical and nursing management of patient with Cirrhosis of liver
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
4. A Close Look at Cirrhosis:
Cirrhosis is a liver disease characterized by extensive fibrosis
with regenerative nodule formation, and distortion of liver
structure.
It is referred to as the end stage of many chronic liver diseases.
The progression of a specific chronic liver disease to cirrhosis can
take many years and is dependent upon many factors such as the
severity of the liver disease, lifestyle, and overall health of the
individual.
Cirrhosis is an irreversible condition that also has serious
complications.
6. what is the sign and who is it name
for ?
medusa
7. causes
Liver cell necrosis
Inflammatory cell infiltate
Fibrosis
Nodular regeneration which may be macronodular (alcohol),
micronodular (viral) or mixed
Alcohol
Viral B/C
Cryptogenic
Primary Biliary Cirrhosis
Hemochromatosis
Wilsons
Alpha 1 antitrypsin deficiency
Autoimmune
Sclerosing Cholangitis
8.
9. What Are the Signs and Symptoms?
Fluid retention in the legs and abdomen –The liver produces a protein, called albumin, that
holds fluid in blood vessels. When the blood level of albumen falls, fluid seeps out of the
tissues into the legs and abdomen, causing edema (fluid accumulation) and swelling.
Jaundice –The liver produces bile that normally flows into the intestine.With advanced
cirrhosis, bile can back up into the blood, causing the skin and eyes to turn yellow and the
urine to darken.
Intense Itching –Certain types of cirrhosis, such as chronic bile duct blockage, can produce
troublesome itching.
Gallstones –Cirrhosis causes the abnormal metabolism of bile pigment. Because of this,
gallstones develop twice as often in cirrhosis patients as in those without the disorder.
Coagulation Defects –The liver makes certain proteins that help clot blood. When these
proteins are deficient, excessive or prolonged bleeding happens.
Mental Function Change –The liver processes toxins from the intestine. When these
substances escape into the bloodstream, as occurs in severe cases of cirrhosis, a variety of
changes in mental function can develop.
Esophageal Vein Bleeding –In advanced cirrhosis, intestinal blood bypasses the liver and
flows up and around the esophagus (the food tube) to the heart. The veins in the esophagus
dilate (widen) and may rupture, causing slow or massive intestinal bleeding.
10. stigmata of liver disease
hand :
Palmar Erythema
Clubbing
Dupytrens
Leuconychia
FLAPPING TREMOR
HEENT/UPPER BODY
Jaundice
Spider Angiomata
Gynaecomastia and scant body hair
Scratch marks
ABDOMEN
Ascites
Hepatosplenomegal
Caput Medusa
Hemorrhoids on PR
Small testes
11. Diagnosis and Liver Biopsy
The physician can always suspect cirrhosis from the patient’s
medical history and physical examination. In addition, certain
blood tests and scans or ultrasound (sonography) can provide
helpful information. To make a definite diagnosis, however, a
liver biopsy (tissue sample) is required. This is performed by
anesthetizing the skin of the right-lower chest and inserting a
thin, needle into the liver. A core or specimen of tissue is
removed and examined under a microscope.
12.
13. Lab findings
Liver function tests - ALT and AST
Hepatitis
Autoimmune hepatitis
Primary Biliary Cirrhosis
Primary Sclerosing Cholangitis
Hemochromatosis
Wilsons
Gallstones and cholecystitis
Complications of end stage liver disease
Ascites
SBP
Hepatorenal Syndrome
Encephalopathy
14. What Is the Course of Cirrhosis?
When cirrhosis is diagnosed, the patient and
physician begin a plan of action designed to
preserve the remaining liver cells and correct
the complications mentioned above. By
following this plan, most patients can lead long,
productive lives.
15. Understanding Pathophysiology:
Normally, hepatocytes are capable of considerable regeneration. However,
chronic damage (from viral infection, heavy alcohol consumption, trauma
and other factors) can lead to scarring.
This scarring is referred to as fibrosis. Formation of scar tissue is a
normal bodily response to injury.
The injury or death (necrosis) of hepatocytes stimulates inflammatory
immune cells to release cytokines, growth factors, and other chemicals.
These chemical messengers direct support cells in the liver called hepatic
stellate cells to activate and produce collagen, a fibrous connective tissue
that gets deposited in the liver. In fibrosis, excessive scar tissue builds
up faster than it can be broken down and removed from the liver.
If the disease progresses, it can lead to cirrhosis, a condition in which
the liver is severely scarred, its blood flow is restricted, and its ability
to function is impaired.
The nodular regeneration of the liver tissue, permanently alters the
structure of the liver.
16. complications &
preventions
Complications:
The major complications of cirrhosis are similar in both alcoholic and nonalcoholic patients:
Portal hypertensive bleeding Increased blood pressure in the blood vessels supplying the liver
due to increased in vessel resistance. Portal hypertension leads to the development of new
veins called collateral veins, at the end of esophagus and at the upper portion of the stomach.
These collateral veins become varicose veins that are prone to bleeding. Ascites Excess fluid
in the peritoneal cavity Hepatic encephalopathy Mental confusion , change in the level of
consciousness Hepatocellular carcinoma Most common liver cancer Complications
Treatment and Prevention:
Cirrhosis cannot be cured. Treatments are geared to slow the progression of disease.
Treatments depend on the underlying cause of the disease, and also on the complications
present. For example, if the cause is chronic alcoholism, then the patient must cease
consumption of alcohol. In severe cases, liver transplant is necessary. Preventative measures
are extremely important. Limit alcohol intake, if possible, abstain Get Hepatitis B vaccination
Protect yourself from hazardous bodily fluids that may contain hepatitis virus Yearly physical
examinations Treatment and Prevention
17. Prevention
Perhaps 90 percent of cirrhosis is caused by excessive alcohol
consumption or hepatitis viruses. Of course, alcohol can be
avoided. Alcohol consumption should always be limited to no
more than 1 or 2 drinks per day. And type B hepatitis now has an
effective vaccine against it. Vaccination against B hepatitis
virus is safe and inexpensive. It should be taken especially by
certain high-risk groups: all health care professionals, persons
traveling to third world countries, homosexuals, intravenous
drug users, and prostitutes.
18. Treatment
Often, the only required treatment for cirrhosis is removing the offending
cause:
he alcoholic patient must permanently stop consuming alcohol.
When iron is being retained in the body, chronic removal of blood by vein
eliminates large amounts of iron.
Cortisone medicine helps treat autoimmune hepatitis and cirrhosis.
Restricting salt and using fluid pills (diuretics ) reduce edema and
abdominal swelling.
Toxins and injurious drugs must be avoided.
Decreasing dietary protein and using certain laxatives generally can
prevent changes in mental function.
Bleeding veins in the esophagus can be injected with sclerosing (clotting)
agents or closed with small rubber bands. Occasionally, surgery is
necessary to prevent recurrent massive bleeding.
Ursodiol (Actigall) and other drugs have been helpful in treating primary
biliary cirrhosis and primary sclerosing cholangitis.
20. summary
cheers think b4
Cirrhosis of the liver is a common disorder that has many
causes. With early diagnosis, much can be done to prevent
serious complications.
Various treatments are available, depending on the cause
of the liver injury and its complications.
Ongoing medical research promises major advances in
treating cirrhosis in the future.