Treat Hypertension with Generic Amlodipine Besylate Tablets

Treat Hypertension with Generic Amlodipine Tablets
© The Swiss Pharmacy

Generic Amlodipine Besylate Tablets is used to treat high
blood pressure (hypertension) by itself or together with
other medicines.
Lowering high blood pressure helps prevent strokes, heart
attacks, and kidney problems. Amlodipine is also used to
relieve chronic stable angina (chest pain) in adults.
Generic Amlodipine could help to increase the ability to
exercise and decrease the frequency of angina attacks.

Chemical Structure - Amlodipine Besylate

The active ingredient contained in
Generic Amlodipine tablets is Amlodipine
Besylate (Amlodipine Besilate).
Each uncoated Generic Amlodipine tablet
contains Amlodipine Besylate equivalent to
Amlodipine 2.5 mg, 5 mg or 10 mg.

Uses of Generic Amlodipine 2.5mg, 5mg and 10mg tablets:
Generic Amlodipine Besylate tablets is used for the first-line treatment of
hypertension and can be used as the sole agent to control blood pressure
in the majority of patients.
Amlodipine Besilate tablets are indicated for the first-line treatment of
myocardial ischaemia, whether due to fixed obstruction (stable angina)
and/or vasospasm/vasoconstriction (Prinzmetal’s or variant angina) of
coronary vasculature.
Generic Amlodipine could be used where the clinical presentation suggests a
possible vasospastic/vasoconstrictive component but where
vasospasm/vasoconstriction has not been confirmed.
Generic Amlodipine may be used alone as monotherapy, or in combination
with other antianginal drugs in patients with angina that is refractory to
nitrates and/or beta-blockers.

Uses of Generic Amlodipine 2.5mg, 5mg and 10mg tablets:
Amlodipine Besylate is a calcium channel blocker. It affects
the movement of calcium into the cells of the heart and blood
vessels. This relaxes the blood vessels and lowers blood
pressure.
A lower blood pressure will increase the supply of blood and
oxygen to the heart.

Stamlo Tablets

Stamlo Tablets
Manufactured By: Dr. Reddy's Laboratories Limited, India
Strengths Available: 2.5 mg, 5 mg and 10 mg Tablets.
More details on Stamlo Tablets

Amlopres Tablets

Amlopres Tablets
Manufactured By: Cipla Limited, India
Strengths Available: 2.5 mg, 5 mg and 10 mg Tablets.
More details on Amlopres Tablets

Recommended Dosage
For most adult patients, the starting dose of Generic
Amlodipine Besylate Tablets for the treatment of
Hypertension is 5 mg once daily, with a maximum dose of
10 mg once daily.
Small, fragile or elderly individuals or patients with hepatic
insufficiency may be started on 2.5 mg once daily and this
dose may be used when adding Amlodipine Besilate to
other anti-hypertensive therapy. The starting dose for
pediatric patients is 2.5 mg to 5 mg once daily.

Recommended Adult Dosage
Chronic Stable or Vasospastic Angina: The starting
dose of Amlodipine Besilate is 5 mg to 10 mg with a
lower dose (2.5 mg) in the elderly and in patients with
hepatic insufficiency.
The recommended dose range for patients with Coronary
Artery Disease (CAD) is 5mg to 10 mg once daily. During
clinical studies, the majority of patients required 10 mg.

Contraindications
➔
Generic Amlodipine tablets are contraindicated in patients with a
known hypersensitivity to Amlodipine Besylate, other dihydropyridines or
any component of the tablet.
➔
Amlodipine is transferred into human breast milk, therefore Generic
Amlodipine is contraindicated during breast-feeding.
➔
Generic Amlodipine Besylate Tablets are also contraindicated in patients
with severe hypotension, shock including cardiogenic shock, obstruction
of the outflow tract of the left ventricle (e.g. high grade aortic stenosis)
and haemodynamically unstable heart failure after acute myocardial
infarction

Storage Instructions
Generic Amlodipine Besylate Tablets have to be
stored at controlled room temperature i.e. from
20°C to 25°C (68°F to 77°F) with excursions
permitted between 15° to 30°C (59° to 86°F).
Keep this as well as all other medicines away
from children and pets.

Warnings
Symptomatic hypotension is possible, particularly in
patients with severe aortic stenosis. However, acute
hypotension is unlikely.
Worsening angina and acute myocardial infarction
can develop after starting or increasing the dose of
Generic Amlodipine tablets particularly in patients
with severe obstructive coronary artery disease.
Titrate slowly in patients with severe hepatic
impairment.

Warnings
No studies on the effects on the ability to drive and
use machines have been performed.
Patients who experience dizziness as an adverse
reaction should avoid driving vehicles or using
machines.

Warnings
What medications must not be taken with Amlodipine Tablets?
The FDA recommends limiting the dosage of Simvastatin to 20 mg daily
while also taking Generic Amlodipine Besylate Tablets.
Medicines that inhibit an enzyme called CYP3A4 can increase the
concentration of Amlodipine in the blood. These medications include
Diltiazem, Ketoconazole, Itraconazole, And Ritonavir. The FDA
recommends that doctors monitor people who are taking both CYP3A4
inhibitors and Amlodipine for symptoms of edema and low blood
pressure.
In patients who have had a kidney transplant, taking Amlodipine and
Cyclosporine together Could increase the levels of Cyclosporine in the
body.

Possible Side Effects
Most common Amlodipine Besylate tablets side
effects are headache and edema which occurred in a
dose related manner. Other side effects not dose
related but reported with an incidence of more than
1.0% are headache, fatigue, nausea, abdominal pain,
and somnolence.

The following events occurred in less than 1% but more than 0.1% of patients in
controlled clinical trials or under conditions of open trials or marketing
experience:
Cardiovascular: arrhythmia (including ventricular tachycardia and atrial
fibrillation), bradycardia, chest pain, peripheral ischemia, syncope, tachycardia,
vasculitis.
Central and Peripheral Nervous System: hypoesthesia, neuropathy peripheral,
paresthesia, tremor, vertigo.
Gastrointestinal: anorexia, constipation, dysphagia, diarrhea, flatulence,
pancreatitis, vomiting, gingival hyperplasia.
General: allergic reaction, asthenia1,back pain, hot flushes, malaise, pain, rigors,
weight gain, weight decrease.
Musculoskeletal System: arthralgia, arthrosis, muscle cramps, myalgia.

The following events occurred in less than 1% but more than 0.1% of patients in
controlled clinical trials or under conditions of open trials or marketing
experience:
Psychiatric: sexual dysfunction (male and female), insomnia, nervousness,
depression, abnormal dreams, anxiety, depersonalization.
Respiratory System: dyspnea, epistaxis.
Skin and Appendages: angioedema, erythema multiforme, pruritus, rash, rash
erythematous, rash maculopapular.
Special Senses: abnormal vision, conjunctivitis, diplopia, eye pain, tinnitus.
Urinary System: micturition frequency, micturition disorder, nocturia.
Autonomic Nervous System: dry mouth, sweating increased.
Metabolic and Nutritional: hyperglycemia, thirst.
Hemopoietic: leukopenia, purpura, thrombocytopenia.

Amlodipine Besylate Tablets Overdosage
Amlodipine Besylate tablets overdosage might be
expected to cause excessive peripheral vasodilation with
marked hypotension and possibly a reflex tachycardia.
In humans, experience with intentional overdosage of
Amlodipine Besylate (Amlodipine Besilate) is limited.

Treatment of Amlodipine Besylate Tablets Overdosage
If massive Amlodipine tablets overdose should occur, active cardiac and
respiratory monitoring should be instituted. Frequent blood pressure
measurements are necessary.
Should hypotension occur, cardiovascular support including elevation of
the extremities and the judicious administration of fluids should be started.
If hypotension remains unresponsive to these conservative measures,
administration of vasopressors (such as phenylephrine) should be
considered with attention to circulating volume and urine output.
Intravenous calcium gluconate may help to reverse the effects of calcium
entry blockade. As Amlodipine is highly protein bound, hemodialysis is not
likely to be of benefit.

Generic Amlodipine Tablets During Pregnancy
Amlodipine Besylate has been classified by the US FDA as Pregnancy
Category C. There are no adequate and well-controlled studies in pregnant
women. Amlodipine should be used during pregnancy only if the potential
benefit justifies the risk to the fetus.
During animal reproduction studies, there was no evidence of adverse
developmental effects when pregnant rats and rabbits were treated orally
with Amlodipine Besilate during organogenesis at doses up to 10 mg
Amlodipine/kg/day (approximately 8 and 23-times the maximum
recommended human dose (MRHD), respectively).
However for rats, litter size was significantly decreased (by about 50%)
and the number of intrauterine deaths was significantly increased.

Treat Hypertension with Generic Amlodipine Besylate Tablets

Recommended

Recommended

More Related Content

What's hot

What's hot (20)

Similar to Treat Hypertension with Generic Amlodipine Besylate Tablets

Similar to Treat Hypertension with Generic Amlodipine Besylate Tablets (20)

More from The Swiss Pharmacy

More from The Swiss Pharmacy (20)

Recently uploaded

Recently uploaded (20)

Treat Hypertension with Generic Amlodipine Besylate Tablets