Generic Elavil Tablets for Depression and Pain Relief - Uses, Dosage, Side Effects

Generic Elavil Tablets
Generic Elavil (Tryptomer Tablets) is used for
the relief of symptoms of depression.
Endogenous depression is more likely to be
alleviated than are other depressive states.
© The Swiss Pharmacy, Geneva Switzerland

Chemical Structure

Active Ingredient
The active pharmaceutical
ingredient contained in Generic
Elavil (Tryptomer Tablets) is
Amitriptyline Hydrochloride.
Each 10 mg Generic Elavil tablet for
oral administration contains 10 mg
of Amitriptyline Hydrochloride.

Indications
Treatment Of Depression:
Generic Elavil (Tryptomer Tablets) is used
for the relief of symptoms of depression.
Endogenous depression is more likely to be
alleviated than are other depressive states.
Pain Relief:
Amitriptyline Hydrochloride (Generic Elavil)
is different from other pain relief drugs and
is used to improve your pain control for
nerve pain, for example shooting, stabbing
or burning pains.

Recommended Adult Dosage
Treatment of Depression:
The recommended initial dosage for adults is
75 mg of Amitriptyline HCl (Tryptomer
Tablets) a day in divided doses. If necessary,
this may be increased to a total of 150 mg per
day. Increases are made preferably in the
late afternoon and/or bedtime doses.

Recommended Adult Dosage
Pain Relief:
The recommended starting dose for
Amitriptyline HCl for pain is 10mg once a day.
The dose is usually taken 1 or 2 hours before
normal sleep time. Take the dose regularly
every day. It may be 2 weeks before you start
to see a real benefit. Your dose of Generic
Elavil (Tryptomer Tablets) may be slowly
increased to between 50mg and 75mg a day
depending on how helpful it is for your pain
relief.

Missed Dose
If it is almost time for your next dose, skip
the dose you missed and take your next
dose on schedule. Otherwise, take it as
soon as you remember, and then go back
to taking Generic Elavil (Tryptomer
Tablets) as you would normally.
Do not take a double dose to make up for
the dose that you missed.

Contraindications
Generic Elavil (Tryptomer Tablets) is
contraindicated in patients with the following
conditions:
➔Hypersensitivity to Amitriptyline Hydrochloride or
any inactive component of this medication.
➔Should not be given concomitantly with a
monoamine oxidase inhibiting compound.
Hyperpyretic crises, severe convulsions, and
deaths have occurred in patients receiving tricyclic
antidepressant and monoamine oxidase inhibiting
medicines simultaneously.

Contraindications
➔Generic Elavil is not recommended
for use during the acute recovery
phase following myocardial infarction.
➔Amitriptyline HCl is contraindicated
for the treatment of depression in
patients 12 years of age and under.
➔Amitriptyline HCl is contraindicated
for the treatment of nocturnal enuresis.

Side Effects of Generic Elavil Tablets
The following side effects have been
reported with the use of Generic Elavil
(Tryptomer Tablets) :
Cardiovascular:
Cardiovascular Hypotension, syncope,
hypertension, tachycardia, palpitation,
myocardial infarction, arrhythmias, heart
block, stroke, non-specific ECG changes
and changes in AV conduction.

CNS and Neuromuscular:
Confusional states; disturbed concentration;
disorientation; delusions; hallucinations;
excitement; anxiety; restlessness; drowsiness;
insomnia; nightmares; numbness; tingling, and
paresthesias of the extremities; peripheral
neuropathy; incoordination; ataxia; tremors; coma;
seizures; alteration in EEG patterns;
extrapyramidal symptoms, including abnormal
involuntary movements and tardive dyskinesia;
dysarthria; tinnitus.

Anticholinergic:
Dry mouth, blurred vision, mydriasis,
disturbance of accommodation, increased
intraocular pressure, constipation, paralytic
ileus, hyperpyrexia, urinary retention,
dilatation of urinary tract.
Allergic:
Skin rash, urticaria, photosensitization,
oedema of face and tongue.

Haematologic:
Bone marrow depression including
agranulocytosis, leukopenia, eosinophilia,
purpura, thrombocytopenia.
Gastrointestinal:
Nausea, epigastric distress, vomiting,
anorexia, stomatitis, peculiar taste,
diarrhoea, parotid swelling, black tongue,
rarely hepatitis (including altered liver
function and jaundice).

Endocrine:
Testicular swelling and gynecomastia in the male,
breast enlargement and galactorrhea in the female,
increased or decreased libido, impotence,
elevation or lowering of blood sugar levels,
syndrome of inappropriate ADH (antidiuretic
hormone) secretion.
Other:
Dizziness, weakness, fatigue, headache, weight
gain or loss, oedema, increased perspiration,
urinary frequency, mydriasis, drowsiness, alopecia.

Warnings And Precautions
➔Patients of any age with Major Depressive Disorder may
experience worsening of their depression and/or the
emergence of suicidal ideation and behaviour (suicidality),
whether or not they are taking antidepressant medications,
and this risk may persist until significant remission occurs.
➔A major depressive episode may be the initial
presentation of bipolar disorder.
➔Patients and their families should be alerted about the
need to monitor for the emergence of anxiety, agitation,
panic attacks, insomnia, irritability, hostility, impulsivity,
akathisia, hypomania, mania, worsening of depression,
and suicidal ideation, especially early during
antidepressant treatment.

➔Amitriptyline HCl should be used with caution in patients
with a history of seizures, in patients with impaired liver
function and, because of its atropine-like action, in patients
with a history of urinary retention, or with narrow angle
glaucoma or increased intraocular pressure. In patients
with narrow-angle glaucoma, even average doses may
precipitate an attack.
➔Hyperpyrexia has been reported when tricyclic
antidepressants are administered with anticholinergic
agents or with neuroleptic medicines, particularly during
hot weather.
➔Close supervision is required when amitriptyline is given
to hyperthyroid patients or those receiving thyroid
medication.

➔Tricyclic antidepressant medicines, including
amitriptyline, particularly when given in high doses, have
been reported to produce arrhythmias, sinus tachycardia,
and prolongation of the conduction time. Myocardial
Infarction and stroke have been reported with medicines of
this class.
➔When Amitriptyline HCl is used to treat the depressive
component of schizophrenia, psychotic symptoms may be
aggravated.
➔Epidemioioqical studies have suggested an increased
risk of congenital abnormalities associated with use of
tricyclic antidepressants in pregnancy.

Storage Instructions
Keep Generic Elavil (Tryptomer Tablets)
in a cool, dry place where the temperature
stays below 30° C. Do not store Generic
Elavil, or any other medicine, in a
bathroom or near a sink. Keep away from
children and pets.

Overdose Symptoms
High doses of Amitriptyline Hcl (Generic Elavil
Tablets) may cause temporary confusion,
disturbed concentration or transient visual
hallucinations. Over dosage may cause
drowsiness; hypothermia; tachycardia and other
arrhythmic abnormalities, such as bundle branch
block; ECG evidence of impaired conduction;
congestive heart failure; dilated pupils; disorders of
ocular motility; convulsions; severe hypotension;
stupor; coma and polyradiculoneuropathy;
constipation.
Other symptoms may be agitation, hyperactive
reflexes, muscle rigidity, vomiting, hyperpyrexia, or
any of the symptoms listed under side effects.

Overdose Treatment
All patients suspected of having taken an overdose
should be admitted to a hospital as soon as
possible. Treatment is symptomatic and supportive.
The stomach should be emptied as quickly as
possible by emesis followed by gastric lavage upon
arrival at the hospital. Following gastric lavage,
activated charcoal may be administered.
An ECG should be taken and close monitoring of
cardiac function instituted if there is any sign of
abnormality.An open airway should be maintained
along with an adequate fluid intake. Body
temperature should be regulated.

Tryptomer Tablets
Manufactured by Wockhardt Ltd.,
India.
For more information click here

Generic Elavil Tablets for Depression and Pain Relief - Uses, Dosage, Side Effects

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