Dox Tablets (Generic Doxycycline Hydrochloride Tablets)

Dox Tablets (Generic Doxycycline Tablets)
© The Swiss Pharmacy

Dox Tablets (Generic Doxycycline Hydrochloride tablets)
are tetracycline class medicines which are used for
Rickettsial infections, Sexually transmitted infections,
Respiratory tract infections, Specific bacterial infections,
Ophthalmic infections, Anthrax, including inhalational
anthrax (post-exposure).
Doxycycline tablets are also used as an alternative
treatment for selected infections when penicillin is
contraindicated as an adjunctive therapy for acute intestinal
amebiasis and severe acne and for the prophylaxis of
malaria.

Dox Tablets are manufactured by SGS
Pharmaceuticals Private Limited, India in the strength
of 100 mg.

Chemical Structure

The active ingredient contained in Dox tablets is Doxycycline
Hydrochloride. Each film-coated Dox tablet contains Doxycycline
Hydrochloride equivalent to 100 mg of Doxycycline.

Uses of Dox 100 mg Tablets:
Dox (Generic Doxycycline Tablets) is used to treat
bacterial infections in many different parts of the body. It is
also used to treat pimples and abscesses (usually on the
face) that are caused by rosacea, also known as acne
rosacea or adult acne.
Doxycycline tablets are also used to prevent malaria and
treat anthrax infection after possible exposure and other
conditions as determined by your doctor.
URL: https://www.theswisspharmacy.com/product_info.php?info=p9892_Doxycycline-Tablets.html

Doxycycline (Doxycycline Hydrochloride 100 mg Tablets) belongs to
the class of medicines known as tetracycline antibiotics. It works by
killing bacteria or preventing their growth.
It may be used to treat a wide range of infections caused by bacteria,
these include:
Chest, lung or nasal infections e.g. bronchitis, pneumonia, sinusitis
Infections of the kidneys and bladder e.g. cystitis, urethritis
Infections of the skin such as acne
Eye infections
Sexually transmitted diseases e.g. gonorrhoea, syphilis, chlamydia

Rickettsial infections such as Q fever or fevers associated with louse
or tick bites
Malaria, when chloroquine is not effective.
Other infections such as cholera, brucellosis, leptospirosis and
psittacosis
Doxycycline tablets are also used to prevent certain infections
developing such as scrub typhus, travellers’ diarrhoea, malaria and
leptospirosis (a bacterial infection caused by exposure to bacteria in
fresh water contaminated by animal urine).

Recommended Adult Dosage
For most adult patients, the dose of Dox Tablets
(Doxycycline Hydrochloride Tablets) is 200 mg on the
first day of treatment (administered 100 mg every 12
hours) followed by a maintenance dose of 100
mg/day.
In the management of more severe infections
(particularly chronic infections of the urinary tract), 100
mg every 12 hours is recommended.

Recommended Adult Dosage
For children above eight years of age the recommended
dosage schedule for children weighing 100 pounds or less is 2
mg/lb of body weight divided into two doses on the first
day of treatment, followed by 1 mg/lb of body weight
given as a single daily dose or divided into two doses on
subsequent days.
For more severe infections up to 2 mg/lb of body weight may
be used. For children over 100 lb, the usual adult dose should
be used.

Contraindications
➔
Dox is contraindicated in patients with a known hypersensitivity
to Doxycycline Hydrochloride, any of the tetracyclines or any
component of the tablet.
➔
Administration of Dox is contraindicated in pregnancy
➔
Tetracyclines are excreted into milk and are therefore
contraindicated in nursing mothers

Contraindications
➔
Sucrose intolerance: Patients with rare hereditary problems
of fructose intolerance, glucose galactose malabsorption or
sucrose-isomaltase insufficiency should not take
Doxycycline Hydrochloride tablets (Dox).

Storage Instructions
Dox Tablets (Generic Doxycycline Tablets) have to
be stored at controlled room temperature i.e. from
20°C to 25°C (68°F to 77°F) with excursions permitted
between 15° to 30°C (59° to 86°F).
Keep this as well as all other medicines away from
children and pets.

Warnings
The use of medicines of the Tetracycline class like Dox during
tooth development (last half of pregnancy, infancy and childhood
to the age of 8 years) may cause permanent discoloration of the
teeth (yellow-gray-brown).
Clostridium difficile-associated diarrhea: Evaluate patients in case
diarrhea occurs.
Photosensitivity manifested by an exaggerated sunburn reaction
has been observed in some patients taking Tetracyclines. Limit sun
exposure in patients.

Warnings
Overgrowth of non-susceptible organisms, including fungi,
may occur. Re
evaluate therapy if superinfection occurs.
Doxycycline should be administered with caution to patients
with hepatic impairment or those receiving potentially
hepatotoxic drugs.
Excretion of doxycycline by the kidney is about 40%/72
hours in individuals with normal renal function. This
percentage excretion may fall to a range as low as 1-5%/72
hours in individuals with severe renal insufficiency (creatinine
clearance below 10ml/min).

Warnings
Instances of oesophagitis and oesophageal ulcerations have been
reported in patients receiving capsule and tablet forms of drugs in the
tetracycline class, including doxycycline.
Bulging fontanelles in infants and benign intracranial hypertension in
juveniles and adults have been reported in individuals receiving full
therapeutic dosages. These conditions disappeared rapidly when the
drug was discontinued.
There have been rare reports of porphyria in patients receiving
tetracyclines.

Warnings
When treating venereal disease, where co-existent syphilis is
suspected, proper diagnostic procedures, including dark-field
examinations, should be utilized.
Infections due to Group A beta-haemolytic streptococci should be
treated for at least 10 days.
Due to a potential for weak neuromuscular blockade, care should be
taken in administering tetracyclines to patients with myasthenia gravis.
Tetracyclines can cause exacerbation of systemic lupus
erythematosus (SLE).

Warnings
Some patients with spirochete infections may experience a
Jarisch-Herxheimer reaction shortly after doxycycline treatment
is started. Patients should be reassured that this is a usually self-
limiting consequence of antibiotic treatment of spirochete
infections.
Caution is advised in administering Tetracyclines with
Methoxyflurane.

Effects On Ability To Drive And Use Machines
Visual disturbances such as blurring of vision may occur
during treatment with Doxycycline Hydrochloride
tablets (Dox) and in such cases; patients must refrain
from driving or operating machinery.

Dox Tablets and Alcohol
Mixing Doxycycline and alcohol won't cause any
serious health issues. But drinking enough alcohol to
get to the point of feeling drunk can affect your
recovery.
It's best not to drink alcohol with Doxycycline because
it can stop it working properly. Speak to your doctor or
pharmacist if you have questions about this.

Possible Side Effects
Side effects observed in patients receiving tetracyclines like Dox
(Generic Doxycycline Hydrochloride 100 mg Tablets) include
anorexia, nausea, vomiting, diarrhea, rash, photosensitivity,
urticaria, and hemolytic anemia.

The following side effects have been identified during post-marketing use of
Doxycycline tablets (Dox):
Gastrointestinal: Anorexia, nausea, vomiting, diarrhea, glossitis, dysphagia, enterocolitis,
and inflammatory lesions (with monilial overgrowth) in the anogenital region.
Hepatotoxicity has been reported. Esophagitis and esophageal ulcerations have
been reported in patients receiving capsule and tablet forms of medicines in the
tetracycline-class. Most of these patients took medications immediately before
going to bed.
Skin: Maculopapular and erythematous rashes, Stevens-Johnson syndrome, toxic epi-
dermal necrolysis, exfoliative dermatitis, and erythema multiforme have been
reported.
Renal: Rise in BUN has been reported and is apparently dose-related
Hypersensitivity Reactions: Urticaria, angioneurotic edema, anaphylaxis, anaphylactoid
purpura, serum sickness, pericarditis, and exacerbation of systemic lupus
erythematosus.

The following side effects have been identified during post-marketing
use of Doxycycline tablets (Dox):
Blood: Hemolytic anemia, thrombocytopenia, neutropenia, and
eosinophilia have been reported.
Intracranial Hypertension: Intracranial hypertension (IH, pseudotumor
cerebri) has been associated with the use of tetracycline
Thyroid Gland Changes: When given over prolonged periods,
tetracyclines have beenreported to produce brown-black microscopic
discoloration of thyroid glands. No abnormalities of thyroid function
are known to occur.

Dox Tablets Overdosage
In case of overdosage, discontinue medication, treat
symptomatically and institute supportive measures.
Dialysis does not alter serum half-life and thus would not be of benefit
in treating cases of Dox overdosage.

Dox Tablets During Pregnancy
Doxycycline Hydrochloride (Dox Tablets) has been classified by the US
FDA as Pregnancy Category D.
There are no adequate and well-controlled studies on the use of
Doxycycline in pregnant women. The vast majority of reported experience
with Doxycycline during human pregnancy is short-term, first trimester
exposure.
There are no human data available to assess the effects of long-term
therapy of doxycycline in pregnant women such as that proposed for the
treatment of anthrax exposure. An expert review of published data on
experiences with Doxycycline use during pregnancy by TERIS - the
Teratogen Information System - concluded that therapeutic doses during
pregnancy are unlikely to pose a substantial teratogenic risk (the quantity
and quality of data were assessed as limited to fair), but the data are
insufficient to state that there is no risk.

Dox Tablets During Nursing
Tetracyclines are excreted in human milk, however, the extent of
absorption of tetracyclines including Doxycycline (Dox tablets), by the
breastfed infant is not known. Short-term use by lactating women is
not necessarily contraindicated.
The effects of prolonged exposure to doxycycline in breast milk are
unknown. Because of the potential for serious adverse reactions in
nursing infants from doxycycline, a decision should be made whether
to discontinue nursing or to discontinue Doxycycline Hydrochloride
(Dox Tablets), taking into account the importance of the drug to the
mother.

Dox Tablets (Generic Doxycycline Tablets) are
manufactured by SGS Pharmaceuticals Private Limited,
India.

Dox Tablets (Generic Doxycycline Hydrochloride Tablets)

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