Nolvadol Tablets (Generic Tamoxifen Citrate Tablets)

Nolvadol Tablets (Generic Tamoxifen Citrate Tablets)
© The Swiss Pharmacy

Nolvadol (Generic Tamoxifen Citrate Tablets) a nonsteroidal
antiestrogen, is used for the treatment of breast cancer and
the treatment of anovulatory infertility.
Nolvadol which is indicated for the treatment of breast
cancer has a response which is similar to that seen with
either estrogens or androgens but Tamoxifen (Nolvadol
Tablets) appears to produce less marked side-effects and to
be more acceptable to the patient.

Nolvadol Tablets are
manufactured by Phoenix
Remedies Limited, India in
the strength of 20 mg.

Chemical Structure

The active ingredient
contained in Nolvadol
tablets is Tamoxifen
Citrate. Each Nolvadol
tablet contains 30.4 mg
Tamoxifen Citrate, an
amount equivalent to 20
mg of Tamoxifen.

Uses of Nolvadol 20 mg Tablets:
Tamoxifen belongs to a group of medicines called anti-
oestrogens. Anti-oestrogens block the effects of a
hormone called oestrogen in your body.
Nolvadol (Generic Tamoxifen Citrate Tablets) is used in
the treatment of breast cancer and to stimulate ovulation
(the production of an egg) in women who suffer from a
condition called anovulatory infertility.
This is when you may have regular, or irregular,
menstruation (periods) but you do not ovulate (release an
egg).
URL: https://www.theswisspharmacy.com/product_info.php?info=p9956_Nolvadol-Tablets.html

Uses of Nolvadol 20 mg Tablets:
Nolvadol can also reduce the risk of breast cancer occurring in
those women who have an increased likelihood of developing
breast cancer (your risk).
It is important that your healthcare professional calculates your
risk of developing breast cancer and discusses the result with
you before commencing treatment. There are a number of
specific tools available to calculate breast cancer risk, based on
information such as your age, family history, genetics,
reproductive factors and a history of breast disease.

Recommended Adult Dosage
Breast cancer: The dosage range of Nolvadol Tablets
(Generic Tamoxifen Citrate Tablets) for adults (including the
elderly) is 20 to 40 mg daily given either in divided doses
twice daily or as a single dose once daily. Dosages greater
than 20 mg per day should be given in divided doses
(morning and evening). In early disease, it is currently
recommended that treatment is given for not less than 5
years. The optimal duration of Tamoxifen therapy remains
to be determined.

Ductal Carcinoma in Situ (DCIS): The recommended dose
is Nolvadol tablets 20 mg daily for 5 years.
Reduction in Breast Cancer Incidence in High Risk Women:
The recommended dose is Nolvadol tablets 20 mg daily
for 5 years. There are no data to support the use of
Tamoxifen other than for 5 years.

Anovulatory Infertility: Prior to starting any course of
treatment with Nolvadol, whether initial or subsequent, the
possibility of pregnancy must be excluded.
In women who are menstruating regularly, but with
anovular cycles, the initial course of treatment consists of
20 mg given daily on the second, third, fourth and fifth
days of the menstrual cycle.

Contraindications
➔
Nolvadol is contraindicated in patients with a known
hypersensitivity to Tamoxifen Citrate or any component of the
tablet.
➔
In patients who require concomitant warfarin therapy or have a
history of deep vein thrombosis or pulmonary embolus, if the
indication for treatment is either reduction of breast cancer
incidence in high-risk patients or risk reduction of invasive breast
cancer after treatment of DCIS.

Storage Instructions
have to be stored at controlled room temperature i.e.
from 20°C to 25°C (68°F to 77°F) with excursions
permitted between 15° to 30°C (59° to 86°F).
Keep this as well as all other medicines away from
children and pets.

Warnings
Uterine malignancies: Promptly evaluate abnormal vaginal bleeding in
a woman with current or past Tamoxifen use.
Thromboembolic events: Risk increases with coadministered
chemotherapy. For treatment of breast cancer, consider risks and
benefits in patients with a history of thromboembolic events.
Embryo-fetal toxicity: Can cause fetal harm. Advise females of
reproductive potential of the potential risk to a fetus and to use
effective contraception.

Warnings
Effects on the liver: Liver cancer and liver abnormalities, some fatal,
have occurred. Perform periodic liver function testing.
A number of second primary tumors, occurring at sites other than the
endometrium, have been reported following the treatment of breast
cancer with tamoxifen in clinical trials.
Ocular disturbances, including corneal changes, decrement in color
vision perception, retinal vein thrombosis, and retinopathy have been
reported in patients receiving Tamoxifen. An increased incidence of
cataracts and the need for cataract surgery have been reported in
patients receiving Tamoxifen.

Nolvadol Tablets and Alcohol
Alcohol can raise the risk of side effects with Tamoxifen (Nolvadol
Tablets), some of which can be serious. Alcohol makes it harder for
Tamoxifen to work properly and should be limited or avoided while
you're taking this medication. Alcohol can raise your risk of developing
breast cancer.
Alcohol consumption is a modifiable behavior that is linked to
increased breast cancer risks and is associated with the development
of hormone-dependent breast cancers as well as disease progression
and recurrence following endocrine treatment.
Alcohol also largely blocks a dose of Tamoxifen after 72 hours of
treatment, suggesting a role for alcohol in breast cancer insensitivity to
Selective estrogen receptor modulators (SERMs).

Possible Side Effects
Most common Nolvadol (Generic Tamoxifen Tablets)
side effects include hot flashes, mood disturbances,
vaginal discharge, vaginal bleeding, nausea, and fluid
retention.

Nolvadol Tablets Overdosage
Acute overdosage in humans has not been reported. In a study of advanced
metastatic cancer patients which specifically determined the maximum
tolerated dose of Tamoxifen in evaluating the use of very high doses to
reverse multidrug resistance, acute neurotoxicity manifested by tremor,
hyperreflexia, unsteady gait and dizziness were noted.
These symptoms occurred within 3 to 5 days of beginning tamoxifen and
cleared within 2 to 5 days after stopping therapy. No permanent neurologic
toxicity was noted. One patient experienced a seizure several days after
tamoxifen was discontinued and neurotoxic symptoms had resolved. The
causal relationship of the seizure to tamoxifen therapy is unknown.
No specific treatment for Tamoxifen overdosage is known; treatment must be
symptomatic.

Nolvadol Tablets During Pregnancy
Tamoxifen Citrate (Nolvadol tablets) has been classified by the US
FDA as Pregnancy Category D.
Tamoxifen may cause fetal harm when administered to a pregnant
woman. Women should be advised not to become pregnant while
taking Tamoxifen or within 2 months of discontinuing Tamoxifen and
should use barrier or nonhormonal contraceptive measures if sexually
active. Tamoxifen does not cause infertility, even in the presence of
menstrual irregularity. Effects on reproductive functions are expected
from the antiestrogenic properties of the drug.

Nolvadol Tablets During Nursing
There is no information regarding the presence of Tamoxifen (Nolvadol
tablets) or its metabolites in human milk or its effects on the breastfed
infant. Additional information from juvenile animal studies suggests a
potential for serious long-term adverse effects for breastfed infants
exposed to tamoxifen through breast milk.
Because of the potential for serious adverse reactions in breastfed
infants from Tamoxifen, advise a woman not to breastfeed during
treatment with Nolvadol tablets and for 3 months following the last
dose.

Nolvadol Tablets (Generic Tamoxifen Citrate
Tablets) are manufactured by Phoenix Remedies
Private Limited, India.

Nolvadol Tablets (Generic Tamoxifen Citrate Tablets)

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