This document provides information on the drug Diazepam. It introduces Diazepam as a benzodiazepine drug first marketed as Valium, used to treat nervousness, muscle spasms, and seizures during pregnancy. The document summarizes Diazepam's trade names, dosage routes, mechanisms of action, pharmacokinetics, indications, contraindications, side effects for both mother and fetus, nursing responsibilities, and concludes that Diazepam is a benzodiazepine that works by enhancing neurotransmitters in the brain to treat anxiety and alcohol withdrawal symptoms.

1. DRUG PRESENTATION
ON
DIAZEPAM
PRESENTED BY
S.V.SUJAY
4th YEAR
B.SC(NURSING)
AGPCON

2. INTRODUCTION
Diazepam is first marketed as valium. It is
a Benzodiazepine drugs. It is used to treat a
nervousness, muscle spasms, seizures in during
pregnancy.

3. DEFINITION
Diazepam is used to treat status pregnancy
epileptics and as an adjunct in convulsive
disorders.

4. TRADE NAME
valium
AVAILABLE
 Valium
 Diastat

5. ROUTE
• Oral
• Intravenous
DOSAGE
• Orally – 5-10mg
• Initially 20-40mg IV
• Followed by 500ml of dextrose with 40mg of
diazepam.

6. MECHANISM OF ACTION
Benzodiazepam
|
Bind to GABA receptor
|
Facilitate GABA action
|
Increased the duration of opening chloride channel
|
Membrane hyperpolarization
|
CNS depression

7. PHARMACOKINETICS
Bioavailability: After oral administration more
then 90% of diazepam is absorbed from GI tract.
Peak plasma concentration: 30-90 min.
Metabolism: It is completely Metabolized in the
liver.
Elimination: Takes place in the kidney as urine.

8. INDICATIONS
Relieve anxiety
Muscle spasms
Seizures
This drug should not be commonly used during
pregnancy unless the benefits outweighs there risks
of the fetus.
It is mainly used anticonvulsant, anxiety, seizures
and muscle spasms.

9. CONTRAINDICATIONS
Hypersensitivity
Acute alcohol intoxication
Breastfeeding
Sleep apnea
Severe respiratory depression.

10. SIDE EFFECTS
MATERNAL
• Dizziness
• Drowsiness
• Low blood pressure
• Fatigue
• Confusion.

11. FETAL SIDE EFFECTS
•Respiratory depression
•Hypotonia
•Thermoregulatory problem.

12. NURSING RESPONSIBILITY
ASSESS:
Assess BP.
Assess studies CBC.
Assess hepatic studies.
ADMINISTER:
Administer through large vein to decrease
chances of extravasation.
Administer with milk or food.

13. PROVIDE:
 Provide safety measures during ambulation
and bed rest.
TEACH PATIENT:
 Teach patient avoid alcohol consumption.
 Teach patient not to discontinue medication
abruptly.
 Teach patient to rise slowly because fainting
Cont........

14. CONCLUSION
Diazepam is a benzodiazepine. It is thought
that benzodiazepines work by enhancing the
activity of certain neurotransmitters in the brain.
Diazepam is used to treat anxiety disorders, or
alcohol withdrawal symptoms.

15. BIBLIOGRAPHY
• SANDEEP KAUR, “Textbook of Midwifery and
Obstetrical nursing”, International standard colored
edition, CBS publishers.
• LAKSHMI SESHADRI, “Essential of Obstetrics
Wolters Kluwer publishers.

16. THANK YOU