International conference «Actual approaches to the extremely preterm babies: International experience and Ukrainian realities» (Kyiv, Ukraine, March 5-6, 2013)
This presentation discusses cranial hemorrhage in a newborn baby. We have included extracranial and intracranial bleed discussion in neonates. Intraventricular hemorrhage (IVH) is further discussed in details in terms of pathophysiology, management strategies and clinical studies related to it.
Hope this presentation is helpful for the knowledge and practice of medical students, pediatricians and neonatologists and helps in practical management of your NICU babies as well.
childhood hypertension is unique presentation by Dr. Hemraj Soni,
very compressive, complied,upgraded, presentation......will definative helpfull for paediatrician n resident doctor............
This presentation discusses cranial hemorrhage in a newborn baby. We have included extracranial and intracranial bleed discussion in neonates. Intraventricular hemorrhage (IVH) is further discussed in details in terms of pathophysiology, management strategies and clinical studies related to it.
Hope this presentation is helpful for the knowledge and practice of medical students, pediatricians and neonatologists and helps in practical management of your NICU babies as well.
childhood hypertension is unique presentation by Dr. Hemraj Soni,
very compressive, complied,upgraded, presentation......will definative helpfull for paediatrician n resident doctor............
Management of hypoxic ischemic encephalopathy (HIE) by Sunil Kumar Dahasunil kumar daha
Please find the power point on Management of hypoxic ischemic encephalopathy (HIE) . I tried to present it on understandable way and all the contents are reviewed by experts and from very reliable references. Thank you
Presentation by Andrei Romancenco at the International conference on Simulation-based training in medicine (Kyiv, Ukraine, March 19-20, 2015)
http://motherandchild.org.ua/eng/SimConf-2015
Система впровадження та реалізації симуляційного навчання в Одеському націона...MCH-org-ua
Володимир Артьоменко. Доповідь на Міжнародній конференції «Симуляційне навчання в медицині» (Київ, 19-20 березня 2015 р.)
http://motherandchild.org.ua/ukr/SimConf-2015
Стандартизація медичних практик в акушерстві та неонатологіїMCH-org-ua
Презентація на Національній підсумковій конференції за результатами впровадження україно-швейцарської Програми "Здоров’я матері та дитини" (Київ, 23 квітня 2015 р.)
http://motherandchild.org.ua/ukr/event/768
Telemedicine and electronic inventory: experience of the regionsMCH-org-ua
Presentation at the National Capitalization conference of the Swiss-Ukrainian Mother and Child Health Programme (Kyiv, Ukraine, April 23, 2015)
http://motherandchild.org.ua/eng/event/768
Presentation at the National Capitalization conference of the Swiss-Ukrainian Mother and Child Health Programme (Kyiv, Ukraine, April 23, 2015)
http://motherandchild.org.ua/eng/event/768
Efficient Management: Success Stories of Partner FacilitiesMCH-org-ua
Presentation at the National Capitalization conference of the Swiss-Ukrainian Mother and Child Health Programme (Kyiv, Ukraine, April 23, 2015)
http://motherandchild.org.ua/eng/event/768
Monitoring: approaches, achievements and perspectivesMCH-org-ua
Presentation at the National Capitalization conference of the Swiss-Ukrainian Mother and Child Health Programme (Kyiv, Ukraine, April 23, 2015)
http://motherandchild.org.ua/eng/event/768
Continuous post-graduate medical education at the local level: results and ma...MCH-org-ua
Presentation at the National Capitalization conference of the Swiss-Ukrainian Mother and Child Health Programme (Kyiv, Ukraine, April 23, 2015)
http://motherandchild.org.ua/eng/event/768
Заради кращих результатів в охороні здоров’я: Досвід та висновки Програми “Зд...MCH-org-ua
Презентація на Національній підсумковій конференції за результатами впровадження україно-швейцарської Програми "Здоров’я матері та дитини" (Київ, 23 квітня 2015 р.)
http://motherandchild.org.ua/ukr/event/768
Телемедицина та електронна інвентаризація: досвід областейMCH-org-ua
Презентація на Національній підсумковій конференції за результатами впровадження україно-швейцарської Програми "Здоров’я матері та дитини" (Київ, 23 квітня 2015 р.)
http://motherandchild.org.ua/ukr/event/768
eHealth (електронна охорона здоров’я) та медичні інформаційні системи MCH-org-ua
Презентація на Національній підсумковій конференції за результатами впровадження україно-швейцарської Програми "Здоров’я матері та дитини" (Київ, 23 квітня 2015 р.)
http://motherandchild.org.ua/ukr/event/768
Ефективне управління: історії успіху партнерських закладівMCH-org-ua
Презентація на Національній підсумковій конференції за результатами впровадження україно-швейцарської Програми "Здоров’я матері та дитини" (Київ, 23 квітня 2015 р.)
http://motherandchild.org.ua/ukr/event/768
Моніторинг: підходи, досягнення та перспективиMCH-org-ua
Презентація на Національній підсумковій конференції за результатами впровадження україно-швейцарської Програми "Здоров’я матері та дитини" (Київ, 23 квітня 2015 р.)
http://motherandchild.org.ua/ukr/event/768
Новаторські підходи до навчання медичних працівників та адміністраторів закла...MCH-org-ua
Презентація на Національній підсумковій конференції за результатами впровадження україно-швейцарської Програми "Здоров’я матері та дитини" (Київ, 23 квітня 2015 р.)
http://motherandchild.org.ua/ukr/event/768
Безперервна післядипломна медична освіта на місцевому рівні: результати впров...MCH-org-ua
Презентація на Національній підсумковій конференції за результатами впровадження україно-швейцарської Програми "Здоров’я матері та дитини" (Київ, 23 квітня 2015 р.)
http://motherandchild.org.ua/ukr/event/768
Внесок Програми у систему безперервної медичної освіти в УкраїніMCH-org-ua
Презентація на Національній підсумковій конференції за результатами впровадження україно-швейцарської Програми "Здоров’я матері та дитини" (Київ, 23 квітня 2015 р.)
http://motherandchild.org.ua/ukr/event/768
Швейцарсько-українська програма «Здоров'я матері та дитини»: Огляд історії пр...MCH-org-ua
Презентація Мартіна Рааба на Національній підсумковій конференції за результатами впровадження Програми (Київ, 23 квітня 2015 р.)
http://motherandchild.org.ua/ukr/event/768
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
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Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy
1. Therapeutic hypothermia for
neonatal hypoxic-ischemic
encephalopathy
Olivier BAUD
Réanimation et Pédiatrie Néonatales
INSERM U676
DHU PROTECT
Hôpital Robert Debré, APHP
International Neonatology Conference Kiev 6th March 2013
2. HIE in the world
Major public health issue
23% of the total 4 M deaths in the world
20% of global incidence of cerebral palsy
1.44 million
0.94 million
1.1 million
Lawn JE et al, Lancet 2005
3. Etiologies of HIE
Maternal Fetal
Cardiac arrest Fetomaternal haemorrhage
Asphyxiation Twin to twin transfusion
Severe anaphylaxis Severe iso-immune haemolytic disease
Status epilepticus Cardiac arrhythmia
Hypovolemic shock
Uteroplacental
Placental abruption
Cord prolapse
Uterine rupture
Hyperstimulation with oxytocic
agents
4. HIE severity and morbidity/mortality
Moderately severe Severe
1-3 / 1000 livebirths 0.5-2 / 1000 livebirths
Neonatal mortality: 50-75%
Severe handicaps: 30-50% (epilepsy, Severe handicaps: 80%
cognitive impairment, CP…) ccccc
Mild handicaps: 10-20% Mild handicaps: 10-20%
Normal outcome at 2y: 30-40% Normal outcome at 2y: 10%
5. Sarnat & Sarnat staging (1976)
Stage 1 Stage 2 Stage 3
Consciousness hyperalert Lethargic of obtunded Stupor or coma
Activity Normal Decreased Absent
Neuromuscular control
Muscle tone Normal Mild hypotonia Flaccid
Posture Mild distal flexion Strong distal flexion Intermittent decerebration
Strech reflexes
Overactive Overactive Decreased or absent
Primitive reflexes
Suck Weak Weak or absent Absent
Moro Strong Weak, incomplete Absent
Tonic neck
Slight Strong Absent
Autonomic function
Pupils Normal Miosis Mydriase or variable, unequal
Heart rate Tachycardia Bradycardia Variable
Seizures None Common Uncommon
Stage 0 = Normal
6. Early evaluation of HIE
• Early and repeated clinical examination: Classification de Sarnat et Sarnat
staging+++
• Clinical investigations:
- EEG: early, continuous recording using either standart EEG or aEEG
- Ultra sonographic scan: easy and early but non specific
as early as possible
Short term prognosis. Therapeutic management: HYPOTHERMIA?
- MRI: standard sequences + Diffusion +/- DTI + MRSpectroscopy:
between day 3 and day 8 +/- day 10-15
Long term outcome.
8. HIE and MRI features
normal
- Basal ganglia and thalami
- Cortical enlighting
- Post limb of internal capsule
- White matter
Rutherforf et al., Lancet 2010
10. HIE and energy failures
• First energy failure during HIE
• Rapid recovery
• Secondary energy failure after
6-12h post HIE
• Mitochondrial insult
• Cell death and apoptosis
11. Brain metabolism is normal following
resuscitation but deteriorates later
31P MRS in asphyxiated infant
born at 37 weeks gestation
Azzopardi et al. Pediatr Res 1989;25:445-451)
12. Hypothermia: concept
• To induce a stable central temperature around 33.5°C +/- 0.5°C
• Before 6 hours of life
• In the most stable manner
• For a 72h duration
• Progressive and cautious rewarming 0.2°C / h
14. Hypothermia: cellular effects
Reduces cerebral metabolism, prevents edema
Decreases energy utilization
Reduces/suppresses cytotoxic amino acid accumulation
(glutamate) and nitric oxide
Inhibits platelet-activating factor, inflammatory cascade
Attenuates secondary neuronal damage and cell death
Reduces extent of brain damage
Prevention of blood brain barrier dysruption
15. Experimental evidence supporting
therapeutic hypothermia
Hypothermia applied after HIE:
Reduces elevation of dopamine, free fatty acid and glutamate
Stroke 1989 ;20:904-10.
Preserves cerebral energy metabolism
Pediatr Res 1995 ;37:667-670; Pediatr Res 1997 ;41:803-808
Reduces the delayed increase in extracellular glutamate
Neuroreport 1997 ;8:3359-62
Reduces the secondary rise in cortical impedance (cytotoxic oedema)
Pediatrics 1998 ;102:1098-1106
Inhibits apoptotic cell death
Neuropathol Appl Neurobiol 1997 ;23:16-25
16. Hypothermia
Head cooling
or
total body cooling
17. Hypothermie: monitoring is crucial
Brain regional temperatures
in pigglet Temperature stability according to
devices
Seizures during
rewarming
Thoresen et al., 2008
18. Acidosis
Hypothermia in human: Who? •pH≤7
•Base deficit ≥16 mmol/l
•Lactate ≥11 mmol/l
•Perinatal event leading to HIE or
•GA ≥ 36 wg et BW ≥ 1800 g
Apgar score ≤5 à M5
•Postnatal age < 6 hours
or
No spontaneous breathing
at M10
Biological and/or clinical markers for HIE at birth? or
Rescucitation at birth
YES
Clinical signs of HIE (Sarnat)
Clinical signs of neurological disorder linked to HIE?
YES
If possible, abnormalities:
• EEG
• aEEG (staging)
Therapeutic hypothermia
19. Hypothermia and biological markers
Heart rate: 14 bpm/min
PaCO2: 2 mmHg
pH: 0,12 unité
Leak of NaCl, KCl and Mg2+
blood viscosity
Platelets
Insulin resistance
WBC
Pharmacokinetics of morphine and anti-epileptic drugs
20. Beneficial effect of hypothermie
according to HIE severity
NNT 6-8
Tagin et al., Cochrane 2012
21. Beneficial effect of hypothermie
according to cooling technique
Tagin et al., Cochrane 2012
23. Impact of hypothermia on MRI findings
Therapeutic hypothermia makes
Therapeutic hypothermia reduces basal
ganglia and WM lesions… MRI abormalities more specific to
poor outcome
… but has no effect on cortical damage
Rutherford et al., 2009
25. Chilhood outcomes after hypothermia
for HIE
Objective
Long term evaluation (6-7 y) of infants having experienced
hypothermia for HIE
Methods and patients
208 infants with HIE 2-3 at birth
93 controls (6 y 8 m) vs 97 hypothermia( 6 y 7 m)
18 lost (15% of surviving)
Motor : GMFCS / Intellect : WPPSI-III & WISC-IV / Attention, FE, Visuo-
spatial : NEPSY / Emotional & Social : Child Health Questionnaire
Shankaran et al., NEJM 2012
26. Chilhood outcomes after
hypothermia for HIE
Results
Hypothermia ( n = 97)
27 deaths (28 %)
5 lost (5 %) death lost CP
12/69 CP (17 %) blindness deafness
1/67 blindness (1 %)
3/63 deafness (5%) 50
Controls (n = 93) 40
41 deaths (44 %) (%)
30
13 lost (14 %) 20
15/52 CP (29 %) 10
2/50 blindness (4 %) 0
1/50 deafness (2%) Hypothermia Controls
Shankaran et al., NEJM 2012
27. Chilhood outcomes after
hypothermia for HIE
Results
Hypothermia
19/70 IQ < 70 (27 %)
2/48 dysexecutive functions (< 70) (4 %)
2/53 visuo-spatial impairment (< 70) (4 %)
Controls
17/52 IQ < 70 (33 %)
4/32 dysexecutive functions (< 70) (13 %)
1/36 visuo-spatial impairment (< 70) (3 %)
Shankaran et al., NEJM 2012
28. Chilhood outcomes after
hypothermia for HIE
Interpretation
No significant difference:
CP
IQ at 6-7 y
Emotional skills
15% lost of follow up
Behavior and school performances?
Appropriate scales?
31. Hypothermia and melatonine
Anti-oxidant, anti-excitotoxic Melatonin in neonatal rat models of
and anti-inflammatory agent HIE
High inocuity Reduced lesion score
(p<0,05)
Reduced ROS accumulation
(p<0,05)
Better behavioral scores
(p<0,05)
Fulia F et al, J Pineal Res 2001; 31(4):343-9
Signorini C et al, J Pineal Res 2009; 46(2):148-54
Carloni S et al, J Pineal Res 2008; 44(2):157-64
Gitto E et al, J Pineal Res 2009; 46(2):128-39
32. Hypothermia and inhaled Xenon
Synergistic effect of hypothermia in pre-clinical model using hypothermia (32°C) and inhaled
Xenon (50%) (rats subjected to HIE) :
Hypothermia alone was associated with early and long-term behavior improvement
(p<0.001)
Xenon alone was associated with long-term behavior improvement (p<0.05)
Both hypothermia and Xenon were associated with better histological scores (p<0.05)
Hobbs C et al., Stroke 2008; 39:1307-
13
33. Deleterious co-factors to be avoided
Prevention of additional insult :
Pain
Subclinical seizures
Neurosensory dystimulation
Ionic disorders
Adequat use of oxygen
Rewarming
Developmental care
34. Conclusion
HIE trigger is poorly understood public health issue
More than 1M deaths and 2M infants with neurocognitive
impairments / year
Therapeutic hypothermia is feasible, safe in referral centers
and efficient at mid-term if initiated before 6h of life
… but impact in long-term outcomes?
Hot topics for neuroprotective strategies
… the future combination of hypothermia + other
pharmacological agent(s)