The document summarizes evidence from animal studies and human clinical trials on the use of therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy (HIE). Animal studies showed that prolonged hypothermia starting within 6 hours and continuing for at least 24 hours reduced brain injury. The Cool Cap study was a randomized controlled trial in humans that found selective head cooling plus mild systemic hypothermia for 72 hours starting within 6 hours of birth reduced death and disability in infants with moderate to severe HIE, excluding those with the most severe brain abnormalities on EEG. Other trials also found benefits with whole body cooling.
Management of hypoxic ischemic encephalopathy (HIE) by Sunil Kumar Dahasunil kumar daha
Please find the power point on Management of hypoxic ischemic encephalopathy (HIE) . I tried to present it on understandable way and all the contents are reviewed by experts and from very reliable references. Thank you
Management of hypoxic ischemic encephalopathy (HIE) by Sunil Kumar Dahasunil kumar daha
Please find the power point on Management of hypoxic ischemic encephalopathy (HIE) . I tried to present it on understandable way and all the contents are reviewed by experts and from very reliable references. Thank you
Therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathyMCH-org-ua
International conference «Actual approaches to the extremely preterm babies: International experience and Ukrainian realities» (Kyiv, Ukraine, March 5-6, 2013)
What is pain
Understand the different types of pain
How to assess pain through visual scales
Know how to initiate pain medications
Learn to reassess pain and modify treatment strategies
Therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathyMCH-org-ua
International conference «Actual approaches to the extremely preterm babies: International experience and Ukrainian realities» (Kyiv, Ukraine, March 5-6, 2013)
What is pain
Understand the different types of pain
How to assess pain through visual scales
Know how to initiate pain medications
Learn to reassess pain and modify treatment strategies
This pattern discusses the various EEG patterns seen in term as well as pre term neonates. Normal Variations as well as pathological traces are discussed
A 100 years ago, when neonatal intensive care units (NICUs) started to be well established, the race never stopped trying to add new regimens to improve neonatal survival. On the other hand, long term sequelae of medications used at NICUs were usually not sufficiently studied and left mostly unnoticed for many years by neonatologists. Here we are trying to understand & & shed the light on some of these sequelae in a trial avoid those sequelae while working on NICU candidates.
Lecture given at the 6th Conference for Nile Basin Pediatrics 2-5 December 2015, Hurgada, Egypt
Hypoxic ischemic insult, by prof Ayman Galhom, ass prof neurosurgery, Suez ca...mohamed osama hussein
A lecture given by dr Ayman Galhom, assistant professor neurosurgery, Suez canal university, during Port said fourth neonatology conference, at 24-25 October, 2013. This lecture was a discussion of the pathophysiology & management of hypoxic ischaemic insult to an infant in PICU
Consultant Paediatric Neurologist and senior lecturer at the Institute of Child Health, Dr Peta Sharples, then provided an in-depth look at the effects that meningitis has on the brain and an comprehensive overview on the rehabilitation of children who have had the disease.Dr Sharples' presentation emphisised another of the day's themes, the need for early recognition and treatment not only to save lives but to aid rehabilitation for survivors.
BCC4: Anthony Delaney on Traumatic Brain Injury in the Real WorldSMACC Conference
Delaney helps highlight recent research into pre-hospital intubation and intracranial pressure monitoring for patients with TBI. This talk was recorded at Bedside Critical Care Conference 4 and is available with the Intensive Care Network on Libsyn and on www.intensivecarenetwork.com
Lessons from the TTM trial and planning for the nexstscanFOAM
A presentation by Niklas Nielsen, Tobias Cronberg and Gisela Lilja at the 2017 meeting of the Scandinavian Society of Anaestesiology and Intensive Care Medicine.
All available content from SSAI2017: https://scanfoam.org/ssai2017/
Delivered in collaboration between scanFOAM, SSAI & SFAI.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Couples presenting to the infertility clinic- Do they really have infertility...
Hypothermic Neuroprotection In The Newborn
1. HYPOTHERMIC NEUROPROTECTION IN THE NEWBORN: A COOL IDEA Steven M. Donn, M.D. Professor of Pediatrics Chief, Division of Neonatal-Perinatal Medicine C.S. Mott Children’s Hospital University of Michigan Health System
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12. EEG – dramatically improved Time (hours) EEG (µV) Seizures not suppressed Slide c/o Alistair Gunn
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14. The Cool Cap Study By parental permission, Dr Durand, Oakland
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25. BASELINE DATA Cooled Control Number 116 118 Initial pH (mean, SD) 6.9 (0.2) 6.9 (0.2) Five min Apgar 0 – 3 77% 68% Pre-randomization aEEG: Moderately Abnormal 54% 64% Severely Abnormal 36% 27% Seizures present 59% 64% Age at Randomization (h) 4.8 (2.6-6) 4.7 (2.1-6.1)
26. Primary Outcome # Enrolled 235 Final Count 234 Cancelled 1 Lost to Follow-up 16 18-Month Primary Outcome 218 Cooled 108 Control 110 Favorable 49 (45%) Unfavorable 59 (55%) Favorable 37 (34%) Unfavorable 73 (66%)
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28. Stratification by Baseline aEEG To allow for multiple comparisons, p<0.025 required for significance Excluding most severe abnormalities in aEEG < 6 hours A priori – anticipated to respond 172/218 In controls (n=88) 66% unfavourable outcome (39% mortality ) Most abnormal aEEG < 6 hours A priori – unlikely to respond 46/218 In controls (n=22) 68% unfavourable outcome (36% mortality)
29. Fisher’s exact p=0.02; logistic regression, OR: 0.42 (0.22, 0.80), p=0.009 A priori defined group excluding infants with severely abnormal aEEG with seizure n=172 Cooled 84 Control 88 Favorable 44 (52%) Unfavorable 40 (48%) Favorable 30 (34%) Unfavorable 58 (66%)
35. PERINATAL COMPLICATIONS Cooled Non-Cooled P Metabolic acidosis 22 20% 27 23% 0.63 Respiratory distress 94 84% 92 78% 0.31 Hypoglycemia 14 13% 20 17% 0.36 Infection 1 1% 2 2% 1.00 Acute Mortality 27 23% 26 22% 0.88 (Deaths in the first week of life are not defined an adverse event)
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39. “ South Carolina Body Cooling Trial” (II) 5 8 Lost/incomplete followup 4/17 (24%) (p=0.4) 5/12 (42%) Severe cognitive abnormality 4/17 (24%) (p=0.053) 7/11 (64%) Severe motor disability 10 (31%) (p=0.35) 14 (42%) Death 52% (p=0.019) 84% Death or severe disability Hypothermic (n=32) Normothermic (n=33) Outcome
43. NICHD NRN Body Cooling Trial (II) Shankaran et al . NEJM 353:1574 52% 40% MDI >85 NS 23% 21% MDI 70-84 25% 39% MDI < 70 .85 (.64-1.13) .69 (.44-1.07) .68 (.44-1.05) .68 (.38-1.22) .72 (.54-.95) OR (CI) 72% 85% Death/dis after Sev HIE 32% 48% Death/dis after Mod HIE 24% 37% Death by 18 mo. 19% 30% Disabling CP 44% 62% Death or mod/sev dis. HT NT Outcome