The High Renaissance in Italy occurred from 1480-1520, principally in Rome where Popes spent large amounts of money commissioning artworks. This era saw a focus on realistic human figures through the study of anatomy as well as the spread of classical ideas. The three masters of the High Renaissance were Leonardo da Vinci, Michelangelo, and Raphael, who created famous works like the Mona Lisa, David, and School of Athens through divine inspiration and classical ideals blended with observation.