Streptococcus pyogenes, also known as Group A Streptococcus, is a common human pathogen. It causes a variety of infections including pyogenic infections, pharyngitis, impetigo, erysipelas, necrotizing fasciitis, and can lead to post-infectious complications like rheumatic fever and glomerulonephritis. S. pyogenes is a Gram-positive coccus that grows in chains and produces several virulence factors like streptolysins and pyrogenic exotoxins that contribute to its pathogenicity. It is identified through culture, antigen detection, and serological tests. Treatment involves penicillin and prevention focuses on vaccination to reduce rheumatic fever