Staphylococcus is a common cause of skin infections in humans. Staphylococcus aureus is an important pathogenic species. It is gram-positive, catalase-positive, and produces coagulase. S. aureus causes a variety of infections, including skin and soft tissue infections like boils and abscesses. It can also cause pneumonia, osteomyelitis, toxic shock syndrome, and food poisoning. Laboratory diagnosis involves culturing specimens on blood agar and performing tests like the coagulase test and mannitol fermentation. Treatment involves antibiotics like penicillin, cloxacillin, or vancomycin for resistant strains.
The genus Shigella exclusively infects human intestine.
Shigella dysenteriae is the causative agent of bacillary dysentery or shigellosis in humans.
It is a diarrheal illness which is characterized by frequent passage of blood stained mucopurulent stools.
The four important species of the genus Shigella are:
Shigella dysenteriae
Shigella flexneri
Shigella sonnei
Shigella boydii.
Clostridium are anerobic gram positive rod shaped spore forming organisms responsible to cause various life threatening diseases in humans like Gas gangrene, Tetanus, Botulism, etc
The genus Shigella exclusively infects human intestine.
Shigella dysenteriae is the causative agent of bacillary dysentery or shigellosis in humans.
It is a diarrheal illness which is characterized by frequent passage of blood stained mucopurulent stools.
The four important species of the genus Shigella are:
Shigella dysenteriae
Shigella flexneri
Shigella sonnei
Shigella boydii.
Clostridium are anerobic gram positive rod shaped spore forming organisms responsible to cause various life threatening diseases in humans like Gas gangrene, Tetanus, Botulism, etc
Staphylococcus aureus,a bunch of grapes
commonly found on the skin or in the nose of even healthy individuals
cause skin infections but can cause pneumonia, heart valve infections, and bone infections.
Lecture notes of Staphylococcus. A detailed account on the morphology, culture characteristics, biochemical characteristics, pathogenesis, laboratory diagnosis of S. aureus.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
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Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Evaluation of antidepressant activity of clitoris ternatea in animals
Staphylococcus
1. STAPHYLOCOCCUS
Gram positive cocci arranged in grape like
clusters
Commonest cause of localized suppurative
lesions in humans
Habitat includes skin ,hair,anterior nasal area
Imp sps- S.aureus,
S.epidermidis,S.saprophyticus etc
4. CULTURAL CHARACTERS
Grow readly on ordinary media
Temp range-10-42 degree Celsius,
Optimum-37
Ph-7.4-7.6
They are aerobes and facultative anaerobes
Common media are Nutrient agar & Blood
agar
5. On Nutrient agar
2-4mm diameter colony.circular ,smooth
,convex ,Most strains produce golden yellow
pigment
14. Following properties are imp to
distigush S.aureus from other non
pathogenic sps
Coagulase production
Mannilol fermentation
Golden yellow pigment
Liquefy gelatin
Phosphatase production
DNase production
15. ANTIGENIC STRUCTURE &
VIRULANCE FACTORS
ANTIGENIC STRUCTURE
Capsule
Some strains have a capsule. That inhibit phagocytosis, they
inhibit opsonisation
Capsulated strains are more virulent
Peptidoglycan
Give rigidity to the cell wall, activtes compliment
Teichoic acid
Major antigenic component
Protect cell from compliment mediated opsonisation
Protein A
It has chemotactic,antiphagocytic & anti complimentary action
16.
17. TOXINS & ENZYMES
Staph aureus produce a number of toxins &
extra cellular enzymes
TOXINS
1. Cytolytic toxin
2. Entero toxin
3. Toxic shock syndrome toxin
4. Exfoliative(epidrmolytic toxin)
19. ENTERO TOXIN
Responsible for staphylococcal food
poisoning
Nosiea,vomitting & diarrhea in 2-6 hrs after
consumption of contaminated food
Meat ,fish ,milk & milks products are the main
foods responsible for this condition
Source of infection is a food handler who is a
carrier.
20. TOXIC SHOCK SYNDROME
TOXIN
Causing toxic shock syndrome
It is a fatal multi system disease with fever
,hypotension,myalgia,vomitting, diarrhea,
erythematous rashes etc
It is potentially a a fatal diasease
22. ENZYMES
COAGULASE
It is the most important enzyme which brings the clotting of
human or rabbit plasma
2 types of coagulase engyme-
Bound coagulase-which is bound to the cell wall
Free coagulase-which is liberated free in to the surrounding
medium
This enzyme can be demonstrated by COAGULASE TEST
Coagulase test is the standard criteria for the identification of
Staph aureus
SLIDE Test (For bound coagulase) & TUBE Test(for free
coagulase) are there
42. Endo vascular infections
Bacteremia
Septicemia
Pyemia
Endocarditis
URINARY INFECTIONS
Staph are uncommon in UTI, but may cause
infections in association with lacal
instrumentation, implants or diabetes
48. LAB DIAGNOSIS
SPECIMENS
Specimens are to be depend on the type of lesions
1. Pus(suppurative lesions)
2. Sputum(respiratory infections)
3. Blood(endo vascular)
4. CSF(CNS infections)
5. Urine (UTI)
6. Feces,vomit,remains of suspected food(food
poisoning)
7. Nasal swab(carriers)
49. METHODS
Direct microscopy
Smears of material shows gram positive cocci
in clusters
Culture
Inoculated on to BLOOD AGAR ,NUTRIENT
AGAR etc
Look for typical colony
morphology,hemolysis,pigmentation etc
51. COAGULASE TEST
Itis the main lab test used to differenciate
staph aureus from other sps of
2 types –slide test & tube test
Slide coagulase test
Few colonies are emulsified in a drop of normal
saline on a slide and mixed with a drop of
rabbit or human plasma.
Clumping indicates positive reaction
53. TUBE COAGULASE test
Done to detect free coagulase
0.1 ml broth culture of the isolate is added to
0.5 ml of human or rabbit plasma in a narrow
test tube.
The tubes incubated at 37 degree Celsius for
3-6 hrs
If positive ,the plasma clots & does not flow
when the tube is tilted
56. tretment
Benzyl penicillin is most effective
Methicillin ,cloxacillin etc can be used in
penicillinase producing strains
MRSA(Methicillin resistant staph aureus)
They are causing grate problem to clinicians
They are resistant to penicillins & other beta lactam
antibiotics
They can be treated by vancomycin &teicoplanin
Treatment of carriers by local application of
antibiotics like as bacitracin