This document summarizes the anatomy, pathophysiology, diagnosis, and treatment of spontaneous esophageal rupture (SER), also known as Boerhaave's syndrome. It describes the anatomy of the esophagus and explains that SER usually occurs due to vomiting against a closed upper esophageal sphincter, which increases intraesophageal pressure and can cause a tear. Diagnosis involves considering the patient's history, symptoms of chest and abdominal pain, and findings on imaging tests. Treatment involves antibiotics, nothing by mouth, gastric decompression, and possibly surgery if symptoms do not improve with initial non-operative management. Early diagnosis and treatment are important for prognosis.