- A secondary immune response occurs upon re-exposure to an antigen that was previously encountered. It is faster and stronger than the primary response. - Memory cells generated during the primary response allow the secondary response to have a very short lag phase with high levels of antibody production, mainly IgG. - The immune system's memory is maintained by long-lived memory B and T cells that were generated during the primary response. These memory cells trigger a rapid secondary response upon reexposure to the antigen.